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  1. Article ; Online: Extracorporeal Photopheresis Improves Graft Survival in a Full-Mismatch Rat Model of Kidney Transplantation.

    Piñeiro, Gaston J / Lazo-Rodriguez, Marta / Ventura-Aguiar, Pedro / Ramirez-Bajo, Maria J / Banon-Maneus, Elisenda / Lozano, Miquel / Cid, Joan / Hierro-Garcia, Natalia / Cucchiari, David / Revuelta, Ignacio / Montagud-Marrahi, Enrique / Palou, Eduard / Bayés-Genís, Beatriu / Campistol, Josep M / Diekmann, Fritz / Rovira, Jordi

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 10840

    Abstract: Extracorporeal photopheresis (ECP) is an immunomodulatory therapy based on the infusion of autologous cellular products exposed to ultraviolet light (UV) in the presence of a photosensitizer. The study evaluates the ECP efficacy as induction therapy in a ...

    Abstract Extracorporeal photopheresis (ECP) is an immunomodulatory therapy based on the infusion of autologous cellular products exposed to ultraviolet light (UV) in the presence of a photosensitizer. The study evaluates the ECP efficacy as induction therapy in a full-mismatch kidney transplant rat model. Dark Agouti to Lewis (DA-L) kidney transplant model has been established. ECP product was obtained from Lewis rat recipients after DA kidney graft transplantation (Lew
    MeSH term(s) Rats ; Animals ; Kidney Transplantation ; Photopheresis ; Graft Survival ; Rats, Inbred Lew ; Graft Rejection/prevention & control ; Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.10840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients.

    Rovira, Jordi / Ramirez-Bajo, Maria Jose / Bañón-Maneus, Elisenda / Hierro-Garcia, Natalia / Lazo-Rodriguez, Marta / Piñeiro, Gaston J / Montagud-Marrahi, Enrique / Cucchiari, David / Revuelta, Ignacio / Cuatrecasas, Miriam / Campistol, Josep M / Ricart, Maria Jose / Diekmann, Fritz / Garcia-Criado, Angeles / Ventura-Aguiar, Pedro

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10639

    Abstract: Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We ... ...

    Abstract Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-matched cohort (
    MeSH term(s) Humans ; Leukocytes, Mononuclear ; Pancreas Transplantation ; Retrospective Studies ; Pancreas ; Kidney
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Impact of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Rat Model of Kidney Rejection.

    Ramirez-Bajo, Maria Jose / Rovira, Jordi / Lazo-Rodriguez, Marta / Banon-Maneus, Elisenda / Tubita, Valeria / Moya-Rull, Daniel / Hierro-Garcia, Natalia / Ventura-Aguiar, Pedro / Oppenheimer, Federico / Campistol, Josep M / Diekmann, Fritz

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 10

    Abstract: Background: Mesenchymal stromal cells (MSCs) from different sources possess great therapeutic potential due to their immunomodulatory properties associated with allograft tolerance. However, a crucial role in this activity resides in extracellular ... ...

    Abstract Background: Mesenchymal stromal cells (MSCs) from different sources possess great therapeutic potential due to their immunomodulatory properties associated with allograft tolerance. However, a crucial role in this activity resides in extracellular vesicles (EVs) and signaling molecules secreted by cells. This study aimed to evaluate the immunomodulatory properties of donor and recipient MSCs isolated from adipose tissue (AD) or bone marrow (BM) and their EVs on kidney outcome in a rat kidney transplant model.
    Methods: The heterotopic-kidney-transplant Fisher-to-Lewis rat model (F-L) was performed to study mixed cellular and humoral rejection. After kidney transplantation, Lewis recipients were assigned to 10 groups; two control groups; four groups received autologous MSCs (either AD- or BM- MSC) or EVs (derived from both cell types); and four groups received donor-derived MSCs or EVs. AD and BM-EVs were purified by ultracentrifugation. Autologous cell therapies were administered three times intravenously; immediately after kidney transplantation, 4 and 8 weeks, whereas donor-derived cell therapies were administered once intravenously immediately after transplantation. Survival and renal function were monitored. Twelve weeks after kidney transplantation grafts were harvested, infiltrating lymphocytes were analyzed by flow cytometry and histological lesions were characterized.
    Results: Autologous AD- and BM-MSCs, but not their EVs, prolonged graft and recipient survival in a rat model of kidney rejection. Autologous AD- and BM-MSCs significantly improved renal function during the first 4 weeks after transplantation. The amelioration of graft function could be associated with an improvement in tubular damage, as well as in T, and NK cell infiltration. On the other side, the application of donor-derived AD-MSC was harmful, and all rats died before the end of the protocol. AD-EVs did not accelerate the rejection. Contrary to autologous MSCs results, the single dose of donor-derived BM-MSCs is not enough to ameliorate kidney graft damage.
    Conclusion: EVs treatments did not exert any benefit in our experimental settings. In the autologous setting, BM-MSCs prompted as a potentially promising therapy to improve kidney graft outcomes in rats with chronic mixed rejection. In the donor-derived setting, AD-MSC accelerated progression to end-stage kidney disease. Further experiments are required to adjust timing and dose for better long-term outcomes.
    Language English
    Publishing date 2020-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization.

    Cucchiari, David / Tubita, Valeria / Rovira, Jordi / Ramirez-Bajo, Maria J / Banon-Maneus, Elisenda / Lazo-Rodriguez, Marta / Hierro-Garcia, Natalia / Borràs, Francesc E / Ventura-Aguiar, Pedro / Piñeiro, Gastón J / Martorell, Jaume / Peri, Lluís / Musquera, Mireia / Hertig, Alexandre / Oppenheimer, Federico / Campistol, Josep M / Diekmann, Fritz / Revuelta, Ignacio

    Frontiers in medicine

    2021  Volume 8, Page(s) 781239

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.781239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tofacitinib Halts Progression of Graft Dysfunction in a Rat Model of Mixed Cellular and Humoral Rejection.

    Rovira, Jordi / Ramírez-Bajo, María José / Banon-Maneus, Elisenda / Lazo-Rodríguez, Marta / Moya-Rull, Daniel / Hierro-Garcia, Natalia / Tubita, Valeria / Piñeiro, Gastón J / Revuelta, Ignacio / Ventura-Aguiar, Pedro / Cucchiari, David / Oppenheimer, Federico / Brunet, Mercè / Campistol, Josep M / Diekmann, Fritz

    Transplantation

    2018  Volume 102, Issue 7, Page(s) 1075–1084

    Abstract: Background: The progression from acute to chronic antibody-mediated rejection in kidney transplant recipients is usually not prevented by current therapeutic options. Here, we investigated whether the use of tofacitinib (TOFA), a Janus kinase 3 ... ...

    Abstract Background: The progression from acute to chronic antibody-mediated rejection in kidney transplant recipients is usually not prevented by current therapeutic options. Here, we investigated whether the use of tofacitinib (TOFA), a Janus kinase 3 inhibitor, was capable of preventing the progression of allograft dysfunction in a Fisher-to-Lewis rat model of kidney transplantation.
    Methods: Rats were treated from the third week after transplantation to allow the development of rejection. Treatment was based on cyclosporin A, rapamycin or TOFA. Renal function was assessed at 1, 4, 8, and 12 weeks after transplantation, whereas rat survival, histological lesions, and infiltrating lymphocytes were analyzed at 12 weeks.
    Results: Tofacitinib prolonged graft survival, preserved tubular and glomerular structures and reduced humoral damage characterized by C4d deposition. Tofacitinib was able to reduce donor-specific antibodies. In addition, T and natural killer cell graft infiltration was reduced in TOFA-treated rats. Although rapamycin-treated rats also showed prolonged graft survival, glomerular structures were more affected. Moreover, only TOFA treatment reduced the presence of T, B and natural killer cells in splenic parenchyma.
    Conclusions: Tofacitinib is able to reduce the immune response generated in a rat model of kidney graft rejection, providing prolonged graft and recipient survival, better graft function, and less histological lesions.
    MeSH term(s) Animals ; Chronic Disease/prevention & control ; Complement C4b/immunology ; Complement C4b/metabolism ; Disease Models, Animal ; Disease Progression ; Graft Rejection/immunology ; Graft Rejection/pathology ; Graft Rejection/prevention & control ; Graft Survival/drug effects ; Humans ; Immunity, Cellular/drug effects ; Immunity, Humoral/drug effects ; Immunosuppressive Agents/therapeutic use ; Janus Kinase 3/antagonists & inhibitors ; Janus Kinase 3/metabolism ; Kidney/immunology ; Kidney/pathology ; Kidney Transplantation/adverse effects ; Male ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Pyrroles/pharmacology ; Pyrroles/therapeutic use ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Jak3 protein, rat ; Peptide Fragments ; Piperidines ; Protein Kinase Inhibitors ; Pyrimidines ; Pyrroles ; Complement C4b (80295-50-7) ; complement C4d (80295-52-9) ; tofacitinib (87LA6FU830) ; Janus Kinase 3 (EC 2.7.10.2)
    Language English
    Publishing date 2018-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000002204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  6. Article: mTOR Inhibition: Reduced Insulin Secretion and Sensitivity in a Rat Model of Metabolic Syndrome.

    Rovira, Jordi / Ramírez-Bajo, María Jose / Banon-Maneus, Elisenda / Moya-Rull, Daniel / Ventura-Aguiar, Pedro / Hierro-Garcia, Natalia / Lazo-Rodriguez, Marta / Revuelta, Ignacio / Torres, Armando / Oppenheimer, Federico / Campistol, Josep M / Diekmann, Fritz

    Transplantation direct

    2016  Volume 2, Issue 2, Page(s) e65

    Abstract: Background: Sirolimus (SRL) has been associated with new-onset diabetes mellitus after transplantation. The aim was to determine the effect of SRL on development of insulin resistance and β -cell toxicity.: Methods: Lean Zucker rat (LZR) and obese ... ...

    Abstract Background: Sirolimus (SRL) has been associated with new-onset diabetes mellitus after transplantation. The aim was to determine the effect of SRL on development of insulin resistance and β -cell toxicity.
    Methods: Lean Zucker rat (LZR) and obese Zucker rat (OZR) were distributed into groups: vehicle and SRL (0.25, 0.5, or 1.0 mg/kg) during 12 or 28 days. Intraperitoneal glucose tolerance test (IPGTT) was evaluated at days 0, 12, 28, and 45. Islet morphometry, β-cell proliferation, and apoptosis were analyzed at 12 days. Islets were isolated to analyze insulin content, insulin secretion, and gene expression.
    Results: After 12 days, SRL treatment only impaired IPGTT in a dose-dependent manner in OZR. Treatment prolongation induced increase of area under the curve of IPGTT in LZR and OZR; however, in contrast to OZR, LZR normalized glucose levels after 2 hours. The SRL reduced pancreas weight and islet proliferation in LZR and OZR as well as insulin content. Insulin secretion was only affected in OZR. Islets from OZR + SRL rats presented a downregulation of Neurod1, Pax4, and Ins2 gene. Genes related with insulin secretion remained unchanged or upregulated.
    Conclusions: In conditions that require adaptive β -cell proliferation, SRL might reveal harmful effects by blocking β -cell proliferation, insulin production and secretion. These effects disappeared when removing the therapy.
    Language English
    Publishing date 2016-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000000576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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