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  1. Article ; Online: Fast-track extubation in minimally invasive mitral valve surgery: moving beyond the biases.

    Higginbotham, Simon / Almoghrabi, Omar / Crawford, Todd C

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2024  Volume 65, Issue 3

    MeSH term(s) Humans ; Mitral Valve/surgery ; Airway Extubation ; Hospitalization ; Intensive Care Units ; Bias
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezae083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: We all deserve broadband - [Internet of Everything]

    Higginbotham, Stacey

    IEEE Spectrum

    Abstract: LIKE CLEAN WATER and electricity, broadband access has become a modern-day necessity The spread of COVID-19 and the ensuing closure of schools and workplaces and even the need for telemedicine make this seem like a new imperative, but the idea is over a ... ...

    Abstract LIKE CLEAN WATER and electricity, broadband access has become a modern-day necessity The spread of COVID-19 and the ensuing closure of schools and workplaces and even the need for telemedicine make this seem like a new imperative, but the idea is over a decade old Broadband is a fundamental human right, essential in times like now, but just as essential when the world isn't in chaos
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #826202
    Database COVID19

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  3. Article: CONTAGION CURTAILED. Can you stop disease with smart devices?

    Higginbotham, Stacey

    Fortune

    2016  Volume 173, Issue 1, Page(s) 33

    MeSH term(s) Child ; Communicable Diseases, Emerging/transmission ; Epidemiologic Methods ; Humans ; Internet ; Thermometers ; United States
    Language English
    Publishing date 2016-01-01
    Publishing country United States
    Document type News
    ZDB-ID 2066352-3
    ISSN 0015-8259
    ISSN 0015-8259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Society of Family Planning: closing in on our first decade and still going strong.

    Higginbotham, Susan

    Contraception

    2014  Volume 89, Issue 3, Page(s) 143–144

    MeSH term(s) Contraception ; Family Planning Services ; Humans ; Societies/organization & administration
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2014.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Contraceptive considerations in obese women: release date 1 September 2009, SFP Guideline 20091.

    Higginbotham, Susan

    Contraception

    2009  Volume 80, Issue 6, Page(s) 583–590

    Abstract: Contraceptive failure is the primary cause of unintended pregnancy in the United States. With obesity rates at epidemic proportions, any association between obesity and strategies that prevent undesired pregnancies constitutes a significant public health ...

    Abstract Contraceptive failure is the primary cause of unintended pregnancy in the United States. With obesity rates at epidemic proportions, any association between obesity and strategies that prevent undesired pregnancies constitutes a significant public health and economic concern. Unfortunately, the relationship between obesity and contraception has not been extensively studied. Evidence from several epidemiological studies suggests that obesity may increase failure of some hormonal contraceptives resulting in unplanned pregnancies. Obesity may make procedure-dependent contraceptive methods (i.e., sterilization and intrauterine devices) more technically challenging for the provider to perform. Hormonal contraceptives, on the whole, do not appear to adversely affect body weight and provide important noncontraceptive benefits (i.e., cancer protection). Some surgical interventions to treat bariatric issues may compromise the efficacy of orally dosed contraceptive methods. Overall, the Society of Family Planning strongly encourages the use of both hormonal and nonhormonal methods of contraception in obese women desiring pregnancy prevention with very few restrictions. Further studies are needed to determine the interrelationship between obesity and contraception. In addition, future contraceptive efficacy studies need to include women of differing BMIs to better reflect the population of women using these methods.
    MeSH term(s) Body Mass Index ; Body Weight ; Contraception Behavior ; Contraceptive Devices ; Contraceptives, Oral, Hormonal/therapeutic use ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Obesity ; Patient Compliance ; Pregnancy ; Pregnancy, Unplanned
    Chemical Substances Contraceptives, Oral, Hormonal
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Journal Article ; Practice Guideline
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2009.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: The Woodvilles

    Higginbotham, Susan

    The Wars of the Roses and England's Most Infamous Family

    2013  

    Abstract: In 1464, the most eligible bachelor in England, Edward IV, stunned the nation by revealing his secret marriage to Elizabeth Woodville, a beautiful, impoverished widow whose father and brother Edward himself had once ridiculed as upstarts. Edward's ... ...

    Abstract In 1464, the most eligible bachelor in England, Edward IV, stunned the nation by revealing his secret marriage to Elizabeth Woodville, a beautiful, impoverished widow whose father and brother Edward himself had once ridiculed as upstarts. Edward's controversial match brought his queen's large family to court and into the thick of the Wars of the Roses. This is the story of the family whose fates would be inextricably intertwined with the fall of the Plantagenets and the rise of the Tudors: Richard, the squire whose marriage to a duchess would one day cost him his head; Jacquetta, mother to the
    Language English
    Size Online-Ressource (383 p)
    Publisher The History Press
    Publishing place New York
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780752488127 ; 0752488120
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: The impact of a pharmacist-led naloxone education and community distribution project on local use of naloxone.

    Wright, Quintin E / Higginbotham, Suzanne / Bunk, Elizabeth / Covvey, Jordan R

    Journal of the American Pharmacists Association : JAPhA

    2020  Volume 60, Issue 3S, Page(s) S56–S60

    Abstract: Objective: To assess the use and public perception of naloxone through distribution and education by pharmacists at local health screenings in low-income communities in Western Pennsylvania.: Methods: A prospective study was conducted, offering ... ...

    Abstract Objective: To assess the use and public perception of naloxone through distribution and education by pharmacists at local health screenings in low-income communities in Western Pennsylvania.
    Methods: A prospective study was conducted, offering education on opioid use disorder and naloxone to individuals attending community outreach events in Allegheny County, PA. Participants with interest and willingness to use naloxone in the event of an opioid overdose were offered naloxone nasal spray and additional training. These individuals were asked to complete a survey at the time of naloxone provision and were recontacted by telephone at a later date to collect follow-up data. The primary objective of the study was to ascertain naloxone use at follow-up. Secondary objectives of the study were to measure the difficulty of obtaining naloxone, identify any change in knowledge of naloxone before and after pharmacist intervention, and assess public perception of stigma associated with naloxone initiatives. Data were analyzed using descriptive and univariate comparative statistics.
    Results: A total of 265 people received naloxone, and 132 (49.8%) completed the initial survey. Fifty-seven participants subsequently completed both surveys (43.2% follow-up). Naloxone was utilized by 3.5% of respondents over an average of 3 months. Participants' perception of obtaining naloxone before the study was evenly distributed (35.8% never tried, 32.1% difficult, and 30.2% not difficult). A total of 52.6% of respondents believed that naloxone initiatives decreased the stigma of illicit opioid use.
    Conclusion: Naloxone provided in the community setting was utilized by a small percentage of the general public in the 2- to 4-month follow-up. Pharmacists can provide naloxone education and training within communities affected by high opioid overdose rates.
    MeSH term(s) Analgesics, Opioid/therapeutic use ; Drug Overdose/drug therapy ; Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; North Carolina ; Opioid-Related Disorders/drug therapy ; Pennsylvania ; Pharmacists ; Prospective Studies ; Virginia
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2019.11.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Myofibroblast transdifferentiation is associated with changes in cellular and extracellular vesicle miRNA abundance.

    Zainal Abidin, Siti Amalina Inche / Paterson, Ian Charles / Hunt, Stuart / Lambert, Daniel W / Higginbotham, Samuel / Pink, Ryan Charles

    PloS one

    2021  Volume 16, Issue 11, Page(s) e0256812

    Abstract: Transforming growth factor-beta 1 (TGF-β1), a pro-fibrotic tumour-derived factor promotes fibroblast differentiation in the tumour microenvironment and is thought to contribute to the development of pro-tumourigenic cancer-associated fibroblasts (CAFs) ... ...

    Abstract Transforming growth factor-beta 1 (TGF-β1), a pro-fibrotic tumour-derived factor promotes fibroblast differentiation in the tumour microenvironment and is thought to contribute to the development of pro-tumourigenic cancer-associated fibroblasts (CAFs) by promoting myofibroblast differentiation. miRNA dysregulation has been demonstrated in myofibroblast transdifferentiation and CAF activation, however, their expression varies among cell types and with the method of fibroblast induction. Here, the expression profile of miRNA in human primary oral fibroblasts treated with TGF-β1, to derive a myofibroblastic, CAF-like phenotype, was determined compared to untreated fibroblasts. Myofibroblast transdifferentiation was determined by the expression of alpha-smooth muscle actin (α-SMA) and fibronectin-1 extra domain A (FN-EDA1) using quantitative real-time PCR (qRT-PCR) and western blot. The formation of stress fibres was assessed by fluorescence microscopy, and associated changes in contractility were assessed using collagen contraction assays. Extracellular vesicles (EVs) were purified by using size exclusion chromatography and ultracentrifugation and their size and concentration were determined by nanoparticle tracking analysis. miRNA expression profiling in oral fibroblasts treated with TGF-β1 and their extracellular vesicles was carried out using tiling low-density array cards. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was used to perform functional and pathway enrichment analysis of target genes. In this study, TGF-β1 induced a myofibroblastic phenotype in normal oral fibroblasts as assessed by expression of molecular markers, the formation of stress fibres and increased contractility. TaqMan Low-Density Array (TLDA) analysis demonstrated that miR-503 and miR-708 were significantly upregulated, while miR-1276 was significantly downregulated in TGF-β1-treated oral fibroblasts (henceforth termed experimentally-derived CAF, eCAF). The gene functional enrichment analysis showed that the candidate miRNAs have the potential to modulate various pathways; including the Ras associated protein 1 (Rap1), PI3K-Akt, and tumour necrosis factor (TNF) signalling pathways. In addition, altered levels of several miRNAs were detected in eCAF EV, including miR-142 and miR-222. No differences in size or abundance of EV were detected between eCAF and normal oral fibroblast (NOF). Little overlap was observed between changes in cellular and EV miRNA profiles, suggesting the possibility of selective loading of EV miRNA. The study reveals miRNA expression signature could be involved in myofibroblast transdifferentiation and the miRNA cargo of their EV, providing novel insight into the involvement of miRNA in CAF development and function.
    MeSH term(s) Actins/metabolism ; Cell Transdifferentiation/drug effects ; Cell Transdifferentiation/physiology ; Cells, Cultured ; Collagen/metabolism ; Extracellular Vesicles/drug effects ; Extracellular Vesicles/metabolism ; Gene Expression Profiling ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myofibroblasts/cytology ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction/physiology ; Transforming Growth Factor beta1/pharmacology
    Chemical Substances ACTA2 protein, human ; Actins ; MicroRNAs ; Transforming Growth Factor beta1 ; Collagen (9007-34-5)
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0256812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The monitoring of disease levels in organic and conventionally managed wheat

    Higginbotham, S

    Rotations and cropping systems, 16-18 December 1996, Churchill College, Cambridge /

    1996  

    Keywords Mycosphaerella graminicola ; Erysiphe graminis ; Triticum aestivum
    Language English
    Size p. 167-172.
    Publisher AAB Office c/o Horticulture Research International, [1996]
    Publishing place Wellesbourne, Warwick, UK
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Development of a community residency program with a focus on specialty pharmacy.

    Koerner, Pamela H / Miller, Richard T / Higginbotham, Suzanne

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2014  Volume 71, Issue 23, Page(s) 2067–2072

    Abstract: Purpose: An innovative community residency program that provides training in the clinical and administrative aspects of specialty pharmacy practice is described.: Summary: An ongoing rapid rise in U.S. approvals of specialty therapies for chronic ... ...

    Abstract Purpose: An innovative community residency program that provides training in the clinical and administrative aspects of specialty pharmacy practice is described.
    Summary: An ongoing rapid rise in U.S. approvals of specialty therapies for chronic diseases and conditions (e.g., Crohn's disease, cystic fibrosis, infertility, hepatitis C infection, multiple sclerosis) is fueling demand for pharmacists trained to meet the complex needs of patients receiving those therapies, which are typically subject to risk evaluation and mitigation strategy (REMS) requirements and limited distribution arrangements. In 2011, Duquesne University Mylan School of Pharmacy partnered with Walgreens Specialty Pharmacy to launch a one-year community residency program designed to (1) provide enhanced education on diseases and conditions targeted by specialty therapies, (2) develop well-rounded clinicians who are fully knowledgeable of the medications used to treat those disorders, and (3) prepare trainees for the operational and business-related challenges of specialty pharmacy practice. The first half of the residency year emphasizes direct patient care experiences, with team-based rotations focusing on specific disease states and health conditions; the second half of the residency program emphasizes operational-administrative training in areas such as clinical program development, resource utilization review, REMS compliance, contracting, and navigating manufacturer-sponsored patient assistance programs. Other program components include a one-month external rotation at a managed care organization, research projects, and teaching experiences.
    Conclusion: A unique community residency program jointly developed by Duquesne University and Walgreens Specialty Pharmacy prepares trainees for careers in diverse clinical, managed care, community-based, and academic practice settings.
    MeSH term(s) Community Pharmacy Services/organization & administration ; Health Knowledge, Attitudes, Practice ; Humans ; Medication Therapy Management/organization & administration ; Pharmacy Residencies/organization & administration ; Program Development ; United States
    Language English
    Publishing date 2014-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.2146/ajhp130732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 419: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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