LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

    Toshio Kanno / Takahiro Nakajima / Satoru Yokoyama / Hikari K. Asou / Shigemi Sasamoto / Yasuhiro Kamii / Koji Hayashizaki / Yasuo Ouchi / Taishi Onodera / Yoshimasa Takahashi / Kazutaka Ikeda / Yoshinori Hasegawa / Yuki Kinjo / Osamu Ohara / Toshinori Nakayama / Yusuke Endo

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction ... ...

    Abstract Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction between fatty acid metabolism and the acquired immune response.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

    Mulki Angela / Yusuke Endo / Hikari K. Asou / Takeshi Yamamoto / Damon J. Tumes / Hirotake Tokuyama / Koutaro Yokote / Toshinori Nakayama

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Volume 15

    Abstract: PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells. ...

    Abstract PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.
    Keywords Science ; Q
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

    Takeshi Yamamoto / Yusuke Endo / Atsushi Onodera / Kiyoshi Hirahara / Hikari K. Asou / Takahiro Nakajima / Toshio Kanno / Yasuo Ouchi / Satoshi Uematsu / Hiroshi Nishimasu / Osamu Nureki / Damon J. Tumes / Naoki Shimojo / Toshinori Nakayama

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 ... ...

    Abstract T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.
    Keywords Science ; Q
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

    Takeshi Yamamoto / Yusuke Endo / Atsushi Onodera / Kiyoshi Hirahara / Hikari K. Asou / Takahiro Nakajima / Toshio Kanno / Yasuo Ouchi / Satoshi Uematsu / Hiroshi Nishimasu / Osamu Nureki / Damon J. Tumes / Naoki Shimojo / Toshinori Nakayama

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 ... ...

    Abstract T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.
    Keywords Science ; Q
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

    Yusuke Endo / Hikari K. Asou / Nao Matsugae / Kiyoshi Hirahara / Kenta Shinoda / Damon J. Tumes / Hirotake Tokuyama / Koutaro Yokote / Toshinori Nakayama

    Cell Reports, Vol 12, Iss 6, Pp 1042-

    2015  Volume 1055

    Abstract: Chronic inflammation due to obesity contributes to the development of metabolic diseases, autoimmune diseases, and cancer. Reciprocal interactions between metabolic systems and immune cells have pivotal roles in the pathogenesis of obesity-associated ... ...

    Abstract Chronic inflammation due to obesity contributes to the development of metabolic diseases, autoimmune diseases, and cancer. Reciprocal interactions between metabolic systems and immune cells have pivotal roles in the pathogenesis of obesity-associated diseases, although the mechanisms regulating obesity-associated inflammatory diseases are still unclear. In the present study, we performed transcriptional profiling of memory phenotype CD4 T cells in high-fat-fed mice and identified acetyl-CoA carboxylase 1 (ACC1, the gene product of Acaca) as an essential regulator of Th17 cell differentiation in vitro and of the pathogenicity of Th17 cells in vivo. ACC1 modulates the DNA binding of RORγt to target genes in differentiating Th17 cells. In addition, we found a strong correlation between IL-17A-producing CD45RO+CD4 T cells and the expression of ACACA in obese subjects. Thus, ACC1 confers the appropriate function of RORγt through fatty acid synthesis and regulates the obesity-related pathology of Th17 cells.
    Keywords Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2015-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top