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  1. Article ; Online: The COVID-19 pandemic and mental health outcomes in CKD patients.

    Hilbrands, Luuk B

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 12, Page(s) 2673–2674

    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Outcome Assessment, Health Care ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Depression
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad177
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    Zs.A 2198: Show issues Location:
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  2. Article ; Online: Latest developments in living kidney donation.

    Hilbrands, Luuk B

    Current opinion in organ transplantation

    2019  Volume 25, Issue 1, Page(s) 74–79

    Abstract: Purpose of review: Although the first successful kidney transplantation 65 years ago was performed with a living donor kidney, the number of living donor kidney transplantations has increased especially during the last 2 decades. The enlargement of ... ...

    Abstract Purpose of review: Although the first successful kidney transplantation 65 years ago was performed with a living donor kidney, the number of living donor kidney transplantations has increased especially during the last 2 decades. The enlargement of living donor programs was made possible by new modes of living donation and by expansion of the living donor pool. At the same time, the long-term risks of kidney donation have been better delineated. In this review, the latest developments on these topics are summarized.
    Recent findings: While the results of ABO-incompatible living kidney transplantation are superior to those of deceased donor transplantation, recent meta-analyses show a reduced patient and graft survival as compared with ABO compatible transplantation as well as increased risk of severe infection and bleeding. Kidney paired donation programs can be extended by including compatible couples and by advanced donation, although the latter raises ethical concerns. Living donors appear to have a higher risk of end-stage renal disease and this is especially true for obese donors and probably also for black donors with an APOL1 high-risk genotype. The importance of psychosocial outcomes after living kidney donation is increasingly recognized.
    Summary: Living donor kidney transplantation remains the optimal treatment option for patients with end-stage renal disease. To increase the donor pool, a well developed paired kidney donation program and sufficient reimbursement of costs associated with donation are essential ingredients. Other ways of expanding the donor pool, such as ABO-incompatible transplantation, use of higher risk donors, providing donors with financial incentives and advanced donation are associated with medical, ethical and logistical complications. There should be a careful selection and follow-up of living kidney donors with attention for medical consequences as well as for psychosocial outcomes.
    MeSH term(s) Humans ; Kidney Transplantation/methods ; Living Donors/statistics & numerical data ; Tissue and Organ Procurement/methods
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000724
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  3. Article ; Online: Informing clinical decision making during a pandemic - a call for better preparedness.

    Vart, Priya / Hilbrands, Luuk B / Gansevoort, Ron T

    Nature reviews. Nephrology

    2023  Volume 19, Issue 3, Page(s) 149–150

    MeSH term(s) Humans ; Pandemics ; Clinical Decision-Making ; Decision Making
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00677-1
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  4. Article ; Online: The clinical characteristics of coronavirus-associated nephropathy.

    Meijers, Björn / Hilbrands, Luuk B

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 35, Issue 8, Page(s) 1279–1281

    MeSH term(s) Acute Kidney Injury ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Renal Insufficiency, Chronic ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfaa197
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  5. Article ; Online: CKD is a key risk factor for COVID-19 mortality.

    Gansevoort, Ron T / Hilbrands, Luuk B

    Nature reviews. Nephrology

    2020  Volume 16, Issue 12, Page(s) 705–706

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-00349-4
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  6. Article ; Online: Histopathological examination of removed kidney allografts: Is it useful? A retrospective cohort study.

    Bunthof, Kim L W / Steenbergen, Eric J / Hilbrands, Luuk B

    Transplant international : official journal of the European Society for Organ Transplantation

    2020  Volume 33, Issue 12, Page(s) 1693–1699

    Abstract: The incidence and relevance of histological findings in removed allografts is unknown. In this study, we investigated the outcome of routine histopathological examination of removed allografts. We performed a retrospective cohort study in patients with ... ...

    Abstract The incidence and relevance of histological findings in removed allografts is unknown. In this study, we investigated the outcome of routine histopathological examination of removed allografts. We performed a retrospective cohort study in patients with kidney graft failure ≥3 months after transplantation. In this cohort, 244 allograft nephrectomies were performed. We routinely sent removed grafts for histopathological examination. In 197 cases, a pathology report was available for analysis. In 21 of the 197 grafts, gross necrosis precluded adequate interpretation. Signs of rejection were reported in 163 of the remaining 176 allografts. Recurrences of the original disease were found in 13 cases. These were all known from prior biopsies. Relevant secondary findings were present in eight cases: renal cell carcinoma (n = 2), urothelial cell carcinoma, candida pyelonephritis (n = 2), post-transplant lymphoproliferative disease, polyomavirus inclusions, and membranous nephropathy. All conditions were diagnosed before graft nephrectomy, except for one case of papillary renal cell carcinoma of 0.8 cm. As expected, signs of acute and/or chronic rejection are the main histopathological finding in grafts that are removed after late graft failure. Unexpected secondary findings are very rare. Therefore, it is justifiable to restrict histopathological examination of removed kidney allografts to specific cases.
    MeSH term(s) Allografts ; Graft Rejection ; Humans ; Kidney ; Kidney Transplantation/adverse effects ; Neoplasm Recurrence, Local ; Retrospective Studies
    Language English
    Publishing date 2020-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13724
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  9. Article ; Online: CKD is a key risk factor for COVID-19 mortality

    Gansevoort, Ron T. / Hilbrands, Luuk B.

    Nature Reviews Nephrology ; ISSN 1759-5061 1759-507X

    2020  

    Keywords Nephrology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1038/s41581-020-00349-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Dialysis or kidney transplantation in older adults? A systematic review summarizing functional, psychological, and quality of life-related outcomes after start of kidney replacement therapy.

    Schoot, Tessa S / Goto, Namiko A / van Marum, Rob J / Hilbrands, Luuk B / Kerckhoffs, Angèle P M

    International urology and nephrology

    2022  Volume 54, Issue 11, Page(s) 2891–2900

    Abstract: Background: In older patients, the choice between kidney transplantation (KT) and dialysis may be complicated because of a high prevalence of comorbidities and geriatric syndromes. Ideally, this decision-making process focusses on older patients' ... ...

    Abstract Background: In older patients, the choice between kidney transplantation (KT) and dialysis may be complicated because of a high prevalence of comorbidities and geriatric syndromes. Ideally, this decision-making process focusses on older patients' outcome priorities, which frequently include functional, psychological, and quality of life (QOL)-related outcomes.
    Purpose: This systematic review aims to summarize functional, psychological (including cognition), and QOL-related outcomes after start of kidney replacement therapy (KRT) in older adults.
    Methods: We searched PubMed and Embase for research that investigated change in these variables after start of KRT in patients aged ≥ 60 years. Data were extracted using the summary measures reported in the individual studies. Risk of bias was assessed with the ROBINS-I tool.
    Results: Sixteen observational studies (prospective n = 9, retrospective n = 7; KT-recipients n = 3, dialysis patients n = 13) were included. The results show that QOL improves in the majority of the older KT recipients. After start of dialysis, QOL improved or remained stable for most patients, but this seems less prevalent than after KT. Functional status decreases in a substantial part of the older dialysis patients. Furthermore, the incidence of serious fall injuries increases after start of dialysis. Nutritional status seems to improve after start of dialysis.
    Conclusion: The interpretability and comparability of the included studies are limited by the heterogeneity in study designs and significant risk of bias in most studies. Despite this, our overview of functional, psychological (including cognition), and QOL-related outcomes is useful for older adults and their clinicians facing the decision between KT and dialysis.
    MeSH term(s) Aged ; Humans ; Kidney Failure, Chronic ; Kidney Transplantation ; Prospective Studies ; Quality of Life/psychology ; Renal Dialysis/psychology ; Renal Replacement Therapy ; Retrospective Studies
    Language English
    Publishing date 2022-05-06
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-022-03208-2
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