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  1. Article: Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers.

    Hilderink, Bashar N / Crane, Reinier F / van den Bogaard, Bas / Pillay, Janesh / Juffermans, Nicole P

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 37

    Abstract: Introduction: Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in clinical practice remain ... ...

    Abstract Introduction: Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in clinical practice remain unresolved. The novel PpIX technique measures the mitochondrial oxygen tension in the skin (mitoPO
    Results: During hypoxemia, SpO
    Conclusions: Hypoxemia decreases mitoPO
    Language English
    Publishing date 2024-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00619-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A simulation of skin mitochondrial Po

    Hilderink, Bashar N / Crane, Reinier F / Baysan, Meryem / Arbous, Sesmu M / van den Bogaard, Bas / Mik, Egbert G / Ince, Can / Pillay, Janesh / Juffermans, Nicole P

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 134, Issue 5, Page(s) 1165–1176

    Abstract: Circulatory shock is the inadequacy to supply mitochondria with enough oxygen to sustain aerobic energy metabolism. A novel noninvasive bedside measurement was recently introduced to monitor the mitochondrial oxygen tension in the skin ( ... ...

    Abstract Circulatory shock is the inadequacy to supply mitochondria with enough oxygen to sustain aerobic energy metabolism. A novel noninvasive bedside measurement was recently introduced to monitor the mitochondrial oxygen tension in the skin (mitoPo
    MeSH term(s) Humans ; Microcirculation/physiology ; Mitochondria/metabolism ; Oxygen/metabolism ; Hypoxia/metabolism ; Oxygen Consumption ; Shock/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00621.2022
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.249: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Novel CineECG enables anatomical 3D localization and classification of bundle branch blocks.

    Boonstra, Machteld J / Hilderink, Bashar N / Locati, Emanuela T / Asselbergs, Folkert W / Loh, Peter / van Dam, Peter M

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2021  Volume 23, Issue 23 Suppl 1, Page(s) i80–i87

    Abstract: Aims: Ventricular conduction disorders can induce arrhythmias and impair cardiac function. Bundle branch blocks (BBBs) are diagnosed by 12-lead electrocardiogram (ECG), but discrimination between BBBs and normal tracings can be challenging. CineECG ... ...

    Abstract Aims: Ventricular conduction disorders can induce arrhythmias and impair cardiac function. Bundle branch blocks (BBBs) are diagnosed by 12-lead electrocardiogram (ECG), but discrimination between BBBs and normal tracings can be challenging. CineECG computes the temporo-spatial trajectory of activation waveforms in a 3D heart model from 12-lead ECGs. Recently, in Brugada patients, CineECG has localized the terminal components of ventricular depolarization to right ventricle outflow tract (RVOT), coincident with arrhythmogenic substrate localization detected by epicardial electro-anatomical maps. This abnormality was not found in normal or right BBB (RBBB) patients. This study aimed at exploring whether CineECG can improve the discrimination between left BBB (LBBB)/RBBB, and incomplete RBBB (iRBBB).
    Methods and results: We utilized 500 12-lead ECGs from the online Physionet-XL-PTB-Diagnostic ECG Database with a certified ECG diagnosis. The mean temporo-spatial isochrone trajectory was calculated and projected into the anatomical 3D heart model. We established five CineECG classes: 'Normal', 'iRBBB', 'RBBB', 'LBBB', and 'Undetermined', to which each tracing was allocated. We determined the accuracy of CineECG classification with the gold standard diagnosis. A total of 391 ECGs were analysed (9 ECGs were excluded for noise) and 240/266 were correctly classified as 'normal', 14/17 as 'iRBBB', 55/55 as 'RBBB', 51/51 as 'LBBB', and 31 as 'undetermined'. The terminal mean temporal spatial isochrone contained most information about the BBB localization.
    Conclusion: CineECG provided the anatomical localization of different BBBs and accurately differentiated between normal, LBBB and RBBB, and iRBBB. CineECG may aid clinical diagnostic work-up, potentially contributing to the difficult discrimination between normal, iRBBB, and Brugada patients.
    MeSH term(s) Action Potentials ; Arrhythmias, Cardiac/diagnosis ; Bundle-Branch Block/diagnosis ; Electrocardiography ; Heart Ventricles ; Humans
    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euaa396
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5434: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Venous thromboembolism is not a risk factor for the development of bloodstream infections in critically ill COVID-19 patients.

    Haksteen, Wolmet E / Hilderink, Bashar N / Dujardin, Romein W G / Jansen, Rogier R / Hodiamont, Caspar J / Tuinman, Pieter R / Smit, Jasper M / Müller, Marcella C A / Juffermans, Nicole P

    Thrombosis research

    2021  Volume 206, Page(s) 128–130

    MeSH term(s) Anticoagulants ; COVID-19 ; Critical Illness ; Humans ; Risk Factors ; SARS-CoV-2 ; Sepsis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2021.08.019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
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  5. Article ; Online: Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients.

    Dujardin, Romein W G / Hilderink, Bashar N / Haksteen, Wolmet E / Middeldorp, S / Vlaar, Alexander P J / Thachil, J / Müller, Marcella C A / Juffermans, Nicole P

    Thrombosis research

    2020  Volume 196, Page(s) 308–312

    Abstract: Background: Venous thromboembolism (VTE) is a frequent complication in critically ill patients with coronavirus disease 2019 (COVID-19) and is associated with mortality. Early diagnosis and treatment of VTE is warranted.: Objective: To develop a ... ...

    Abstract Background: Venous thromboembolism (VTE) is a frequent complication in critically ill patients with coronavirus disease 2019 (COVID-19) and is associated with mortality. Early diagnosis and treatment of VTE is warranted.
    Objective: To develop a prediction model for VTE in critically ill COVID-19 patients.
    Patients and methods: In this retrospective cohort study, 127 adult patients with confirmed COVID-19 infection admitted to the intensive care unit of two teaching hospitals were included. VTE was diagnosed with either ultrasound or computed tomography scan. Univariate receiver operating characteristic (ROC) curves were constructed for Positive End Expiratory Pressure, PaO
    Results: Variables associated with VTE in both univariate and multivariate analysis were D-dimer and CRP with an area under the curve (AUC) of 0.64, P = 0.023 and 0.75, P = 0.045, respectively. Variables indicating hypoxemia were not predictive. The ROC curve of D-dimer and CRP combined had an AUC of 0.83, P < 0.05. Categorized values of D-dimer and CRP were used to compute a mean absolute risk for the combination of these variables with a high positive predictive value. The predicted probability of VTE with a D-dimer > 15 in combination with a CRP > 280 was 98%. The negative predictive value of D-dimer was low.
    Conclusion: Elevated CRP and D-dimer have a high positive predictive value for VTE in critically ill COVID-19 patients. We developed a prediction table with these biomarkers that can aid clinicians in the timing of imaging in patients with suspected VTE.
    MeSH term(s) Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/complications ; Critical Illness ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4)
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.09.017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients

    Dujardin, Romein W G / Hilderink, Bashar N / Haksteen, Wolmet E / Middeldorp, S / Vlaar, Alexander P J / Thachil, J / Müller, Marcella C A / Juffermans, Nicole P

    Thromb Res

    Abstract: BACKGROUND: Venous thromboembolism (VTE) is a frequent complication in critically ill patients with coronavirus disease 2019 (COVID-19) and is associated with mortality. Early diagnosis and treatment of VTE is warranted. OBJECTIVE: To develop a ... ...

    Abstract BACKGROUND: Venous thromboembolism (VTE) is a frequent complication in critically ill patients with coronavirus disease 2019 (COVID-19) and is associated with mortality. Early diagnosis and treatment of VTE is warranted. OBJECTIVE: To develop a prediction model for VTE in critically ill COVID-19 patients. PATIENTS AND METHODS: In this retrospective cohort study, 127 adult patients with confirmed COVID-19 infection admitted to the intensive care unit of two teaching hospitals were included. VTE was diagnosed with either ultrasound or computed tomography scan. Univariate receiver operating characteristic (ROC) curves were constructed for Positive End Expiratory Pressure, PaO2/FiO2 ratio, platelet count, international normalized ratio, activated partial thromboplastin time as well as levels of fibrinogen, antithrombin, D-dimer and C-reactive protein (CRP). Multivariate analysis was done using binary linear regression. RESULTS: Variables associated with VTE in both univariate and multivariate analysis were D-dimer and CRP with an area under the curve (AUC) of 0.64, P = 0.023 and 0.75, P = 0.045, respectively. Variables indicating hypoxemia were not predictive. The ROC curve of D-dimer and CRP combined had an AUC of 0.83, P < 0.05. Categorized values of D-dimer and CRP were used to compute a mean absolute risk for the combination of these variables with a high positive predictive value. The predicted probability of VTE with a D-dimer > 15 in combination with a CRP > 280 was 98%. The negative predictive value of D-dimer was low. CONCLUSION: Elevated CRP and D-dimer have a high positive predictive value for VTE in critically ill COVID-19 patients. We developed a prediction table with these biomarkers that can aid clinicians in the timing of imaging in patients with suspected VTE.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #759380
    Database COVID19

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  7. Article ; Online: Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients

    Dujardin, Romein W.G. / Hilderink, Bashar N. / Haksteen, Wolmet E. / Middeldorp, S. / Vlaar, Alexander P.J. / Thachil, J. / Müller, Marcella C.A. / Juffermans, Nicole P.

    Thrombosis Research

    2020  Volume 196, Page(s) 308–312

    Keywords Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.09.017
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
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