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Article ; Online: Complications of tubeless versus standard percutaneous nephrolithotomy.

Hill, Hayden / Talamini, Susan / Vetter, Joel / Nottingham, Charles

2023 Volume 56, Issue 1, Page(s) 63–67

Abstract: Purpose: The necessity of nephrostomy tube after percutaneous nephrolithotomy (PCNL) has been called into question in modern series. We sought to examine differences in postoperative complications and outcomes of tubeless PCNL versus standard PCNL at ... ...

Abstract	Purpose: The necessity of nephrostomy tube after percutaneous nephrolithotomy (PCNL) has been called into question in modern series. We sought to examine differences in postoperative complications and outcomes of tubeless PCNL versus standard PCNL at our institution. Methods: A retrospective review of our institutional stone database was conducted from January 2016 to December 2021 for patients who had undergone either tubeless PCNL, defined by placement of only an internal ureteral stent, or standard PCNL, which involved placement of an externalized nephrostomy tube. Patients were excluded if they underwent totally tubeless PCNL. Results: A total of 438 patients were included for analysis: 329 patients underwent tubeless PCNL and 109 patients underwent standard PCNL. Between tubeless and standard groups, there was no difference in readmission rates 6.1% vs. 9.2% (p = 0.268), Clavien 2 or > complications 18.5% vs. 19.3% (p = 0.923), and Clavien 3 or > complications 4.0% vs. 7.3% (p = 0.151). The tubeless group experienced shorter operative duration 121.5 vs. 144.8 min (p = 0.012), shorter length of stay 2.5 vs. 3.8 days (p = 0.002), and higher stone-free rates 72.3% vs. 60.2% (p = 0.014), but also increased blood transfusion rates 6.4% vs. 0.9% (p = 0.022). Conclusion: In comparing tubeless with standard PCNL, there was no difference in readmission rates, or significant Clavien complication rates. Patients undergoing tubeless PCNL experienced higher stone-free rates, but more number of patients required postoperative blood transfusion. The decision to leave a nephrostomy tube after PCNL appears unlikely to impact overall complication rates and can be left to surgeon experience and case-based discretion.
MeSH term(s)	Humans ; Nephrolithotomy, Percutaneous/adverse effects ; Kidney Calculi/surgery ; Kidney Calculi/etiology ; Treatment Outcome ; Nephrostomy, Percutaneous/adverse effects ; Ureter/surgery ; Length of Stay
Language	English
Publishing date	2023-09-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-023-03772-1
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Zs.A 733: Show issues

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Article ; Online: A novel sacral neuromodulation protocol is associated with reduction in removal for device infection.

Goudelocke, Colin / Hill, Hayden / Major, Nicholas / Couvaras, Anastasia / Long, Amy

International urogynecology journal

2023 Volume 34, Issue 10, Page(s) 2421–2428

Abstract: Introduction and hypothesis: Sacral neuromodulation (SNM) has been established as an effective third-line therapy for non-obstructive urinary retention and urinary urgency-frequency syndrome. Device infection, ranging from 2-10%, is a severe ... ...

Abstract	Introduction and hypothesis: Sacral neuromodulation (SNM) has been established as an effective third-line therapy for non-obstructive urinary retention and urinary urgency-frequency syndrome. Device infection, ranging from 2-10%, is a severe complication usually necessitating device explanation. This study sought to demonstrate an infection protocol founded upon established device implantation risk factors and novel approaches to reduce the incidence of device infection, while maintaining good antibiotic stewardship following best practice statements. Methods: A single-surgeon protocol was enacted from 2013 to 2022. Preoperatively, nasal swabs were cultured from each patient. If positive for methicillin-resistant Staphylococcus aureus or methicillin-sensitive Staphylococcus aureus, preoperative treatment with intranasal mupirocin was employed. Preoperative cefazolin was administered in patients with negative cultures or MSSA-positive. All protocol patients were given chlorhexidine wipes before surgery and prepped with a chlorhexidine scrub followed by alcohol/iodine paint. Post-procedural antibiotics were not given. Pre-protocol patients from 2011 to 2013 served as controls. Results: Pre-protocol (n = 87) patients had a significantly higher rate of device infection compared to protocol patients (n = 444) in both the percentage of patients experiencing device infection (4.6% vs 0.9%, p = 0.01) and percentage of procedures associated with device infection (2.9% vs 0.5%, p < 0.05). A successful culture of the nares was achieved in 91.4% of protocol patients, with 11.6% MRSA-positive. Risk ratio for infection of pre-protocol/protocol patients was 0.19 (0.05-0.77) with odds ratio 5.1 (1.3-20.0). Conclusions: Utilization of a novel SNM infection protocol tailored to a patient's preoperative MRSA colonization is associated with a reduction in the overall incidence of explant for device infection while avoiding prolonged postoperative antibiotic regimens. Clinical trial registration: The study was initiated prior to January 18, 2017 and does not meet the definition of an applicable clinical trial (ACT) as defined in section 402 (J) of the US PHS Act.
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-023-05543-z
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Article: Successful Percutaneous Ultrasonic Lithotripsy of Gallstones.

Ostergar, Adam / Alkazemi, Muhammad Hassan / Hill, Hayden / Awad, Michael M / Ushinsky, Alexander / Darcy, Michael / Desai, Alana C / Figenshau, Robert Sherburne

Ochsner journal

2024 Volume 24, Issue 1, Page(s) 84–86

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Case Reports
ISSN	1524-5012
ISSN	1524-5012
DOI	10.31486/toj.23.0071
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Article ; Online: An Enhancing Mass Abutting the Collecting System.

Hill, Hayden / Williams, John / Larsen, Gregory

Urology

2020 Volume 146, Page(s) e3–e4

Abstract: We present a clinical imaging question focusing on a patient with a history of gross hematuria and an enhancing mass abutting the left renal collecting system. In patients with nondiagnostic cytology and imaging, upper tract urothelial carcinoma should ... ...

Abstract	We present a clinical imaging question focusing on a patient with a history of gross hematuria and an enhancing mass abutting the left renal collecting system. In patients with nondiagnostic cytology and imaging, upper tract urothelial carcinoma should be explored as a potential etiology prior to definitive surgical management.
MeSH term(s)	Aged ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Tubules, Collecting ; Male ; Ureteroscopy
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2020.08.042
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A Multi-Institutional Matched-Pair Analysis of Robotic Partial Nephrectomy for Single

Biebel, Mark G / Hill, Hayden / Patel, Brijesh / Okhawere, Kennedy E / Vetter, Joel / Venkatesh, Ramakrishna / Badani, Ketan K / Figenshau, R Sherburne

Journal of endourology

2023 Volume 37, Issue 7, Page(s) 781–785

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Robotic Surgical Procedures ; Retrospective Studies ; Matched-Pair Analysis ; Kidney/surgery ; Kidney/physiology ; Kidney/pathology ; Nephrectomy ; Kidney Neoplasms/pathology ; Glomerular Filtration Rate ; Treatment Outcome
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2023.0103
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A Contemporary Analysis of the 30-day Morbidity and Mortality Associated With Cytoreductive Nephrectomy.

May, Danica N / Hill, Hayden / Matrana, Marc R / Lata-Arias, Kathleen / Canter, Daniel J

Urology

2020 Volume 147, Page(s) 186–191

Abstract: Objective: To examine the rates of adverse surgical outcomes in patients undergoing cytoreductive nephrectomy (CN) compared to patients undergoing radical nephrectomy in the nonmetastatic setting using a large administrative database.: Methods: ... ...

Abstract	Objective: To examine the rates of adverse surgical outcomes in patients undergoing cytoreductive nephrectomy (CN) compared to patients undergoing radical nephrectomy in the nonmetastatic setting using a large administrative database. Methods: Patients in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) who underwent a radical nephrectomy between 2011 and 2016 were included. Patients were stratified by the preoperative variable of presence or absence of metastatic cancer. Perioperative outcomes were compared. A multivariable logistic regression analysis was performed to test the association between patients with metastatic cancer and perioperative morbidity and 30-day mortality. Results: There were 15,869 total patients included in this analysis of whom 1322 (8%) patients had metastatic cancer. Of the entire cohort, the majority of patients were over 60 years old (58%) and 9621 (61%) were male. Seventy-three of the patients were Caucasian. Patients with metastatic cancer had more minor (P< .01) and major (P< .01) complications, a higher rate of reoperation (P< .01), and a higher rate of unplanned readmissions (P< .01). Finally, the cohort with metastatic cancer had a higher rate of postoperative 30-day mortality (P< .01) than patients without metastatic cancer. Conclusion: Patients undergoing a CN have significantly worse perioperative outcomes than patients undergoing a radical nephrectomy without evidence of metastases. Careful surgical risk stratification and appropriate patient counseling should be undertaken when selecting candidates for CN.
MeSH term(s)	Adult ; Cytoreduction Surgical Procedures/adverse effects ; Databases, Factual ; Female ; Functional Status ; Hospitalization ; Humans ; Kidney Neoplasms/complications ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Nephrectomy/adverse effects ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Quality Improvement ; Reoperation ; Risk Assessment ; Time Factors
Language	English
Publishing date	2020-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2020.10.016
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Single-port vs multi-port robot-assisted renal surgery: analysis of perioperative outcomes for excision of high and low complexity renal masses.

Berry, James M / Hill, Hayden / Vetter, Joel M / Bhayani, Sam B / Henning, Grant M / Pickersgill, Nicholas A / Sivaraman, Arjun / Figenshau, R Sherburne / Kim, Eric H

Journal of robotic surgery

2023 Volume 17, Issue 5, Page(s) 2149–2155

Abstract: There is emerging but limited data assessing single-port (SP) robot-assisted surgery as an alternative to multi-port (MP) platforms. We compared perioperative outcomes between SP and MP robot-assisted approaches for excision of high and low complexity ... ...

Abstract	There is emerging but limited data assessing single-port (SP) robot-assisted surgery as an alternative to multi-port (MP) platforms. We compared perioperative outcomes between SP and MP robot-assisted approaches for excision of high and low complexity renal masses. Retrospective chart review was performed for patients undergoing robot-assisted partial or radical nephrectomy using the SP surgical system (n = 23) at our institution between November 2019 and November 2021. Renal masses were categorized as high complexity (7+) or low complexity (4-6) using the R.E.N.A.L. nephrometry scoring system. Adjusting for baseline characteristics, patients were matched using a prospectively maintained MP database in a 2:1 (MP:SP) ratio. For high complexity tumors (n = 12), SP surgery was associated with a significantly longer operative time compared to MP (248.4 vs 188.1 min, p = 0.02) but a significantly shorter length of stay (1.9 vs 2.8 days, p = 0.02). For low complexity tumors (n = 11), operative time (177.7 vs 161.4 min, p = 0.53), estimated blood loss (69.6.0 vs 142.0 mL, p = 0.62), and length of stay (1.6 vs 1.8 days, p = 0.528) were comparable between SP and MP approaches. Increasing nephrometry score was associated with a greater relative increase in operative time for SP compared to MP renal surgery (p = 0.07) using best of fit linear modeling. SP robot-assisted partial and radical nephrectomy is safe and feasible for low complexity renal masses. For high complexity renal masses, the SP system is associated with a significantly longer operative time compared to the MP technique. Careful consideration should be given when selecting patients for SP robot-assisted kidney surgery.
MeSH term(s)	Humans ; Robotic Surgical Procedures/methods ; Robotics ; Retrospective Studies ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Kidney/surgery ; Kidney/pathology ; Nephrectomy/methods ; Treatment Outcome
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-023-01637-4
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Article: A Nurse-Driven Protocol for Foley Catheter Utilization Decreases the Incidence of Traumatic Foley Catheterization.

Laborde, Eric / Hill, Hayden / Dukovac, Thomas E / Carriere, Stephen P / Lata-Arias, Kathleen / Hebert, Kristi / Patel, Raunak / Gills, Jessie

The Ochsner journal

2021 Volume 21, Issue 1, Page(s) 41–62

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-03-19
Publishing country	United States
Document type	Journal Article
ISSN	1524-5012
ISSN	1524-5012
DOI	10.31486/toj.20.0004
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Article ; Online: The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.

Hughes, Francis M / Hill, Hayden M / Wood, Case M / Edmondson, Andrew T / Dumas, Aliya / Foo, Wen-Chi / Oelsen, James M / Rac, Goran / Purves, J Todd

The Journal of urology

2015 Volume 195, Issue 5, Page(s) 1598–1605

Abstract: Purpose: While bladder outlet obstruction is well established to elicit an inflammatory reaction in the bladder that leads to overactive bladder and fibrosis, little is known about the mechanism by which this is initiated. NLRs (NOD-like receptors) and ... ...

Abstract	Purpose: While bladder outlet obstruction is well established to elicit an inflammatory reaction in the bladder that leads to overactive bladder and fibrosis, little is known about the mechanism by which this is initiated. NLRs (NOD-like receptors) and the structures that they form (inflammasomes) have been identified as sensors of cellular damage, including pressure induced damage, and triggers of inflammation. Recently we identified these structures in the urothelium. In this study we assessed the role of the NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome in bladder dysfunction resulting from bladder outlet obstruction. Materials and methods: Bladder outlet obstruction was created in female rats by inserting a 1 mm outer diameter transurethral catheter, tying a silk ligature around the urethra and removing the catheter. Untreated and sham operated rats served as controls. Rats with bladder outlet obstruction were given vehicle (10% ethanol) or 10 mg/kg glyburide (a NLRP3 inhibitor) orally daily for 12 days. Inflammasome activity, bladder hypertrophy, inflammation and bladder function (urodynamics) were assessed. Results: Bladder outlet obstruction increased urothelial inflammasome activity, bladder hypertrophy and inflammation, and decreased voided volume. Glyburide blocked inflammasome activation, reduced hypertrophy and prevented inflammation. The decrease in voided volume was also attenuated by glyburide mechanistically as an increase in detrusor contraction duration and voiding period. Conclusion: Results suggest the importance of the NLRP3 inflammasome in the induction of inflammation and bladder dysfunction secondary to bladder outlet obstruction. Arresting these processes with NLRP3 inhibitors may prove useful to treat the symptoms that they produce.
MeSH term(s)	Animals ; Disease Models, Animal ; Female ; Immunity, Innate ; Immunohistochemistry ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats ; Rats, Sprague-Dawley ; Urinary Bladder Neck Obstruction/immunology ; Urinary Bladder Neck Obstruction/metabolism ; Urinary Bladder Neck Obstruction/pathology ; Urothelium/immunology ; Urothelium/metabolism ; Urothelium/pathology
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat
Language	English
Publishing date	2015-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2015.12.068
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Zs.MO 331: Show issues

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