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  1. Article ; Online: Response to Protocol Review Scenario: No IACUC approval necessary, but inspect potential risks.

    Hill, Lori R

    Lab animal

    2017  Volume 46, Issue 6, Page(s) 237–238

    Language English
    Publishing date 2017--22
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 1548-4475
    ISSN (online) 1548-4475
    DOI 10.1038/laban.1281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: No need to duplicate prior pilots.

    Hill, Lori R / Norton, William B

    Lab animal

    2020  Volume 49, Issue 2, Page(s) 30–31

    MeSH term(s) Aerospace Medicine ; Animal Care Committees ; Animals ; Aviation ; Humans ; Pilots ; Reproducibility of Results
    Language English
    Publishing date 2020-01-24
    Publishing country United States
    Document type Letter ; Comment
    ISSN 1548-4475
    ISSN (online) 1548-4475
    DOI 10.1038/s41684-019-0462-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pathology in Practice.

    Piotrowski, Stacey L / Gagea, Mihai / Huang, Steven Y / Shetty, Gunapala / Hill, Lori R

    Journal of the American Veterinary Medical Association

    2021  Volume 258, Issue 2, Page(s) 161–164

    MeSH term(s) Animals
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.258.2.161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 423: Show issues Location:
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  4. Article: Multiple campuses, one IACUC: how many AVs? Delegate authority.

    Hill, Lori R

    Lab animal

    2009  Volume 38, Issue 4, Page(s) 112–113

    MeSH term(s) Animal Care Committees/legislation & jurisprudence ; Animal Care Committees/organization & administration ; Animal Welfare/legislation & jurisprudence ; Animal Welfare/standards ; Animals ; Animals, Laboratory ; Humans ; Universities/organization & administration ; Veterinarians/standards
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Comment ; Journal Article
    ISSN 0093-7355
    ISSN 0093-7355
    DOI 10.1038/laban0409-112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Diaphragmatic Hernia of the Stomach with Gastric Rupture in a Domestic Pig.

    Hill, Lori R / Huang, Steven Y / Gagea, Mihai

    Comparative medicine

    2016  Volume 66, Issue 5, Page(s) 399–404

    Abstract: A 5.5-mo-old castrated, male Red Duroc pig presented acutely with depression and abdominal pain 9 d after an altercation with another pig. A CT examination indicated right pneumothorax and herniation of the stomach into the thoracic cavity. Due to a poor ...

    Abstract A 5.5-mo-old castrated, male Red Duroc pig presented acutely with depression and abdominal pain 9 d after an altercation with another pig. A CT examination indicated right pneumothorax and herniation of the stomach into the thoracic cavity. Due to a poor prognosis, the pig was euthanized. A necropsy and gross examination revealed a tear of the diaphragmatic muscle in the region of the esophageal hiatus through which the stomach was displaced into the right side of the thoracic cavity. In addition, the herniated stomach had a rupture of the stomach wall through which the gastric mucosa was everted and exposed into the right thoracic cavity. The right thoracic cavity had acute fibrinous pleuritis, and the right lung was collapsed. CT scans performed every 1 to 2 wk for 2 mo prior to the pig's death did not reveal any abnormalities in the diaphragm. Trauma was considered the most likely cause of the diaphragmatic tear and subsequent herniation and rupture of the stomach.
    MeSH term(s) Animals ; Hernia, Diaphragmatic/diagnostic imaging ; Hernia, Diaphragmatic/veterinary ; Swine ; Swine Diseases/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-10-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2006425-1
    ISSN 1532-0820 ; 0023-6764
    ISSN 1532-0820 ; 0023-6764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 601: Show issues Location:
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  6. Article: Clinical trial trouble: did the right thing.

    Hill, Lori R

    Lab animal

    2006  Volume 35, Issue 6, Page(s) 15–16

    MeSH term(s) Animal Care Committees ; Animal Welfare/ethics ; Animals ; Clinical Trials as Topic/ethics ; Clinical Trials as Topic/veterinary ; Dogs ; Male ; Mandatory Reporting/ethics ; United States
    Language English
    Publishing date 2006-06
    Publishing country United States
    Document type Comment ; Journal Article
    ISSN 0093-7355
    ISSN 0093-7355
    DOI 10.1038/laban0606-15b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Tissues from privately owned dogs. CRC is correct.

    Swain, Jody / Hill, Lori R

    Lab animal

    2010  Volume 39, Issue 3, Page(s) 68–69

    MeSH term(s) Animal Care Committees/legislation & jurisprudence ; Animal Welfare/legislation & jurisprudence ; Animals ; Animals, Domestic ; Dogs ; Tissue and Organ Procurement/legislation & jurisprudence
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Comment ; Journal Article
    ISSN 0093-7355
    ISSN 0093-7355
    DOI 10.1038/laban0310-68a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.

    Hyun, Insoo / Clayton, Ellen Wright / Cong, Yali / Fujita, Misao / Goldman, Steven A / Hill, Lori R / Monserrat, Nuria / Nakauchi, Hiromitsu / Pedersen, Roger A / Rooke, Heather M / Takahashi, Jun / Knoblich, Jürgen A

    Stem cell reports

    2021  Volume 16, Issue 6, Page(s) 1409–1415

    Abstract: The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ... ...

    Abstract The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.
    MeSH term(s) Animals ; Chimera ; Embryo Research/ethics ; Humans ; Pluripotent Stem Cells ; Practice Guidelines as Topic ; Societies, Scientific/ethics ; Societies, Scientific/standards ; Stem Cell Research/ethics ; Stem Cell Transplantation/ethics ; Stem Cell Transplantation/standards
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2021.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect of Radiation on DCE-MRI Pharmacokinetic Parameters in a Rabbit Model of Compromised Maxillofacial Wound Healing: A Pilot Study.

    Piotrowski, Stacey L / Wilson, Lindsay / Maldonado, Kiersten L / Tailor, Ramesh / Hill, Lori R / Bankson, James A / Lai, Stephen / Kasper, F Kurtis / Young, Simon

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2020  Volume 78, Issue 6, Page(s) 1034.e1–1034.e10

    Abstract: Purpose: Osteoradionecrosis (ORN), a potentially debilitating complication of maxillofacial radiation, continues to present a challenging clinical scenario, with limited treatment options that often fail. Translational animal models that can accurately ... ...

    Abstract Purpose: Osteoradionecrosis (ORN), a potentially debilitating complication of maxillofacial radiation, continues to present a challenging clinical scenario, with limited treatment options that often fail. Translational animal models that can accurately mimic the human characteristics of the condition are lacking. In the present pilot study, we aimed to characterize the effects of radiation on the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters in a rabbit model of compromised maxillofacial wound healing to determine its potential as a translational model of ORN.
    Materials and methods: An experimental group underwent fractionated radiation of the mandible totaling 36 Gy. At 4 weeks after irradiation, the experimental and control groups (n = 8 rabbits each) underwent a surgical procedure to create a critical size defect in the mandibular bone. DCE-MRI scans were acquired 1 week after arrival (baseline; time point 1), 4 weeks after completion of irradiation in the experimental group (just before surgery, time point 2), and 4 weeks after surgery (time point 3).
    Results: No differences in the analyzed DCE-MRI parameters were noted within the experimental or control group between the baseline values (time point 1) and those after irradiation (time point 2). The whole blood volume fraction (v
    Conclusions: The results of the present study suggest that DCE-MRI of a rabbit model of compromised maxillofacial wound healing could reflect the DCE-MRI characteristics of human patients with ORN and those at risk of developing the condition. Future studies will focus on further characterization of this rabbit model as a translational preclinical model of ORN.
    MeSH term(s) Animals ; Contrast Media ; Humans ; Magnetic Resonance Imaging ; Pilot Projects ; Rabbits ; Wound Healing
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2020.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.113: Show issues Location:
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  10. Article ; Online: Clarifying the Ethics and Oversight of Chimeric Research.

    Johnston, Josephine / Hyun, Insoo / Neuhaus, Carolyn P / Maschke, Karen J / Marshall, Patricia / Craig, Kaitlynn P / Matthews, Margaret M / Drolet, Kara / Greely, Henry T / Hill, Lori R / Hinterberger, Amy / Hurley, Elisa A / Kesterson, Robert / Kimmelman, Jonathan / King, Nancy M P / Lopes, Melissa J / O'Rourke, P Pearl / Parent, Brendan / Peckman, Steven /
    Piotrowska, Monika / Schwarz, May / Sebo, Jeff / Stodgell, Chris / Streiffer, Robert / Wilkerson, Amy

    The Hastings Center report

    2022  Volume 52 Suppl 2, Page(s) S2–S23

    Abstract: This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. ...

    Abstract This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human-nonhuman chimeric research. Led by bioethics researchers working closely with an interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human-nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics' previous focus on human-centered questions about the ethics of "humanization" and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less-siloed governance and oversight and more-comprehensive public communication.
    MeSH term(s) Animals ; Humans ; Animal Welfare ; Stem Cell Research ; Chimera ; Bioethics
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194940-8
    ISSN 1552-146X ; 0093-0334
    ISSN (online) 1552-146X
    ISSN 0093-0334
    DOI 10.1002/hast.1427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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