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  1. Article ; Online: Elexacaftor, tezacaftor and ivacaftor: a case of severe rash and approach to desensitisation.

    Cheng, Ann / Baker, Olivia / Hill, Uta

    BMJ case reports

    2022  Volume 15, Issue 3

    Abstract: We present a case of severe rash following induction of elexacaftor, tezacaftor and ivacaftor (ELX/TEZ/IVA) in a young adult male cystic fibrosis patient. While rash is a commonly reported side effect which resolves in 1-2 weeks with minimal intervention, ...

    Abstract We present a case of severe rash following induction of elexacaftor, tezacaftor and ivacaftor (ELX/TEZ/IVA) in a young adult male cystic fibrosis patient. While rash is a commonly reported side effect which resolves in 1-2 weeks with minimal intervention, our patient had presented with fever and widespread rash prompting medication cessation. After a washout period, reintroduction with 1/2 tablet of ELX/TEZ/IVA produced a similar systemic response within 24 hours. Repeat attempt, this time with 1/8 tablet and increasing in increments of an eighth daily, was successful and has allowed our patient to experience the transformative benefits of ELX/TEZ/IVA including improved pulmonary function and reduced episodes of infective exacerbation. This case illustrates one of the most common side effects of ELX/TEZ/IVA triple therapy, and our experience of desensitisation to ELX/TEZ/IVA in a challenging case of rash.
    MeSH term(s) Aminophenols ; Benzodioxoles ; Chloride Channel Agonists/adverse effects ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Drug Combinations ; Exanthema/chemically induced ; Humans ; Indoles ; Male ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones ; Young Adult
    Chemical Substances Aminophenols ; Benzodioxoles ; Chloride Channel Agonists ; Drug Combinations ; Indoles ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones ; tezacaftor, ivacaftor drug combination ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; elexacaftor (RRN67GMB0V)
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-247042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-tuberculous mycobacteria in cystic fibrosis.

    Hill, Uta G / Floto, R Andres / Haworth, Charles S

    Journal of the Royal Society of Medicine

    2012  Volume 105 Suppl 2, Page(s) S14–8

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Comorbidity ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/microbiology ; Cystic Fibrosis/physiopathology ; Drug Therapy, Combination ; Ethambutol/therapeutic use ; Female ; Humans ; Macrolides/therapeutic use ; Male ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology ; Nontuberculous Mycobacteria/isolation & purification ; Prognosis ; Respiratory Function Tests ; Rifampin ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Macrolides ; Ethambutol (8G167061QZ) ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2012-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1258/jrsm.2012.12s003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.114: Show issues Location:
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  3. Article ; Online: Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT.

    Farahi, Neda / Gillett, Daniel / Southwood, Mark / Rassl, Doris / Tregay, Nicola / Hill, Uta / Preston, Stephen Denis / Loutsios, Chrystalla / Lok, Laurence Si Chong / Heard, Sarah / Buscombe, John / Rintoul, Robert Campbell / Peters, A Michael / Summers, Charlotte / Chilvers, Edwin R

    Thorax

    2020  Volume 75, Issue 11, Page(s) 1020–1023

    Abstract: Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell ...

    Abstract Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.
    MeSH term(s) Adult ; Biopsy ; Female ; Humans ; Indium Radioisotopes ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Male ; Neoplasm Staging ; Neutrophils ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Indium Radioisotopes ; Indium-111 (E9NGC49E0T)
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2020-214642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
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  4. Article: Has Lemierre's syndrome become a bacteriological diagnosis?

    Hill, Uta G / Vallis, Martin P / Cotter, Tim / Hegarty, Michael A

    British journal of hospital medicine (London, England : 2005)

    2010  Volume 71, Issue 3, Page(s) 169

    MeSH term(s) Adult ; Female ; Fever/microbiology ; Fusobacterium Infections/diagnosis ; Fusobacterium necrophorum ; Humans ; Pharyngitis/microbiology ; Syndrome
    Language English
    Publishing date 2010-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2010.71.3.46983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The BRICS (Bronchiectasis Radiologically Indexed CT Score): A Multicenter Study Score for Use in Idiopathic and Postinfective Bronchiectasis.

    Bedi, Pallavi / Chalmers, James D / Goeminne, Pieter C / Mai, Cindy / Saravanamuthu, Pira / Velu, Prasad Palani / Cartlidge, Manjit K / Loebinger, Michael R / Jacob, Joe / Kamal, Faisal / Schembri, Nicola / Aliberti, Stefano / Hill, Uta / Harrison, Mike / Johnson, Christopher / Screaton, Nicholas / Haworth, Charles / Polverino, Eva / Rosales, Edmundo /
    Torres, Antoni / Benegas, Michael N / Rossi, Adriano G / Patel, Dilip / Hill, Adam T

    Chest

    2017  Volume 153, Issue 5, Page(s) 1177–1186

    Abstract: Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.: Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable ...

    Abstract Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.
    Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients.
    Results: A total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV
    Conclusions: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis.
    MeSH term(s) Aged ; Bronchiectasis/diagnosis ; Bronchiectasis/etiology ; Cohort Studies ; Female ; Hospitalization ; Humans ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Respiratory Function Tests ; Severity of Illness Index ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-12-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2017.11.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Book: Fuers Ueberleben handeln lernen

    Bitz, Andreas / Blitz, Inge / Joos, Hans-Juergen / Marks, Reinhard / Neeb-Hill, Uta

    Dokumentation des Symposions zur Umweltbildung

    1994  , Page(s) 235

    Abstract: Fuer eine zukunftsorientierte, Handlungsmoeglichkeiten aufweisende Umweltbildung stand das Symposion 'Fuers Ueberleben handeln lernen' vom 13.-15. September 1993 in Mainz. Es wandte sich gegen die Formen von Belehrungs- und Katastrophenpaedagogik und ... ...

    Abstract Fuer eine zukunftsorientierte, Handlungsmoeglichkeiten aufweisende Umweltbildung stand das Symposion 'Fuers Ueberleben handeln lernen' vom 13.-15. September 1993 in Mainz. Es wandte sich gegen die Formen von Belehrungs- und Katastrophenpaedagogik und versuchte Wege aufzuzeigen, wie in Kindergarten, Schule und Erwachsenenbildung eine das Leben bejahende, die Wirklichkeit nicht ausblendende Bildungs- und Erziehungsarbeit geleistet werden kann. Es wurde aber auch deutlich, dass der Umweltpaedagogik Grenzen gesetzt sind: Gibt es gesamtgesellschaftlich keine Wendung, so muessen auch die paedagogischen Bemuehungen letztendlich erfolglos bleiben. Daher muessen ErzieherInnen und LehrerInnen ueber Ihre Bemuehungen in Methodik, Didaktik und Paedagogik hinaus ins oeffentliche Leben hineinwirken. Die durchgefuehrten 18 ganztaegigen Werkstaetten werden ausfuehrlich dargestellt als bunte Vielfalt paedagogischer Zugangswege. Der Band enthaelt die Texte der beiden grundlegenden Vortraege von Ernst Ulrich von Weizsaecker zu 'Umweltkrise und Generationenvertrag' und Otto Herz 'Die Bedingungen des Aufwachsens von Kindern und Jugendlichen'. Ein dritter Hauptteil hat die spezifische (umwelt-)bildungspolitische Situation in Rheinland-Pfalz zum Inhalt, ueber die referien und intensiv diskutiert wurde.
    Keywords Tagungsbericht ; Umwelterziehung ; Gesellschaftspolitische Aspekte ; Ausserschulische Umwelterziehung ; Bildungspolitik ; Bildungswesen ; Juvenile ; Politische Bildung ; Kindertagesstaette ; Schule ; Erwachsenenbildung ; Didaktik ; Paedagogik
    Language German
    Document type Book
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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