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  1. Book ; Online ; E-Book: Neuropathology simplified

    Hilton, David A. / Shivane, Aditya G.

    a guide for clinicians and neuroscientists

    2021  

    Author's details David A. Hilton, Aditya G. Shivane
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (ix, 211 Seiten), Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020902914
    ISBN 978-3-030-66830-3 ; 9783030668297 ; 3-030-66830-4 ; 3030668290
    DOI 10.1007/978-3-030-66830-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Neuropathology simplified

    Hilton, David A. / Shivane, Aditya G.

    a guide for clinicians and neuroscientists

    2015  

    Author's details David A. Hilton ; Aditya G. Shivane
    Keywords neuropathology ; neuropathological disorder ; clinico-pathologic correlation ; basic neuropathology ; Interpret neuropathological test
    Language English
    Size XV, 247 S. : Ill., 235 mm x 155 mm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018592456
    ISBN 978-3-319-14604-1 ; 3-319-14604-1 ; 9783319146058 ; 331914605X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 1021 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Denis Dewhurst Hilton.

    Hilton, David

    BMJ (Clinical research ed.)

    2016  Volume 355, Page(s) i6665

    MeSH term(s) Community Medicine/history ; England ; History, 20th Century ; History, 21st Century ; Humans ; Nigeria
    Language English
    Publishing date 2016-12-13
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.i6665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What does the ISN do?

    Hilton, David

    Brain pathology (Zurich, Switzerland)

    2014  Volume 24, Issue 6, Page(s) iii–iv

    MeSH term(s) Awards and Prizes ; Congresses as Topic ; Humans ; Internationality ; Neurology/economics ; Neurology/education ; Pathology/economics ; Pathology/education ; Publishing ; Societies, Medical/economics
    Language English
    Publishing date 2014-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.12213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3585: Show issues Location:
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  5. Article ; Online: Application of Raman Spectroscopy to Dynamic Binding Capacity Analysis.

    Beattie, James W / Rowland-Jones, Ruth C / Farys, Monika / Bettany, Hamish / Hilton, David / Kazarian, Sergei G / Byrne, Bernadette

    Applied spectroscopy

    2023  Volume 77, Issue 12, Page(s) 1393–1400

    Abstract: Protein A affinity chromatography is a key step in isolation of biotherapeutics (BTs) containing fragment crystallizable regions, including monoclonal and bispecific antibodies. Dynamic binding capacity (DBC) analysis assesses how much BT will bind to a ... ...

    Abstract Protein A affinity chromatography is a key step in isolation of biotherapeutics (BTs) containing fragment crystallizable regions, including monoclonal and bispecific antibodies. Dynamic binding capacity (DBC) analysis assesses how much BT will bind to a protein A column. DBC reduces with column usage, effectively reducing the amount of recovered product over time. Drug regulatory bodies mandate chromatography resin lifetime for BT isolation, through measurement of parameters including DBC, so this feature is carefully monitored in industrial purification pipelines. High-performance affinity chromatography (HPAC) is typically used to assess the concentration of BT, which when loaded to the column results in significant breakthrough of BT in the flowthrough. HPAC gives an accurate assessment of DBC and how this changes over time but only reports on protein concentration, requires calibration for each new BT analyzed, and can only be used offline. Here we utilized Raman spectroscopy and revealed that this approach is at least as effective as both HPAC and ultraviolet chromatogram methods at monitoring DBC of protein A resins. In addition to reporting on protein concentration, the chemical information in the Raman spectra provides information on aggregation status and protein structure, providing extra quality controls to industrial bioprocessing pipelines. In combination with partial least square (PLS) analysis, Raman spectroscopy can be used to determine the DBC of a BT without prior calibration. Here we performed Raman analysis offline in a 96-well plate format, however, it is feasible to perform this inline. This study demonstrates the power of Raman spectroscopy as a significantly improved approach to DBC monitoring in industrial pipelines.
    MeSH term(s) Spectrum Analysis, Raman ; Chromatography, Affinity/methods ; Proteins/chemistry ; Staphylococcal Protein A/chemistry ; Calibration
    Chemical Substances Proteins ; Staphylococcal Protein A
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3530
    ISSN (online) 1943-3530
    DOI 10.1177/00037028231210293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cyclotron resonance spectroscopy in a high mobility two dimensional electron gas using characteristic matrix methods.

    Hilton, David J

    Optics express

    2012  Volume 20, Issue 28, Page(s) 29717–29726

    Abstract: We develop a new characteristic matrix-based method to analyze cyclotron resonance experiments in high mobility two-dimensional electron gas samples where direct interference between primary and satellite reflections has previously limited the frequency ... ...

    Abstract We develop a new characteristic matrix-based method to analyze cyclotron resonance experiments in high mobility two-dimensional electron gas samples where direct interference between primary and satellite reflections has previously limited the frequency resolution. This model is used to simulate experimental data taken using terahertz time-domain spectroscopy that show multiple pulses from the substrate with a separation of 15 ps that directly interfere in the time-domain. We determine a cyclotron dephasing lifetime of 15.1 ± 0.5 ps at 1.5 K and 5.0 ± 0.5 ps at 75 K.
    Language English
    Publishing date 2012-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.20.029717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Primer on consensus in guide selection for performance of transradial coronary angioplasty.

    Hilton, David

    Journal of the Indian Medical Association

    2009  Volume 107, Issue 9, Page(s) 595–596

    MeSH term(s) Angioplasty, Balloon, Coronary/instrumentation ; Cardiac Catheterization/instrumentation ; Cardiovascular Diseases/therapy ; Consensus ; Decision Making ; Equipment Design ; Humans ; Radial Artery
    Language English
    Publishing date 2009-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 390814-8
    ISSN 0019-5847
    ISSN 0019-5847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.415: Show issues Location:
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  8. Article ; Online: Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.

    Diaz, Laura R / Gil-Ranedo, Jon / Jaworek, Karolina J / Nsek, Nsikan / Marques, Joao Pinheiro / Costa, Eleni / Hilton, David A / Bieluczyk, Hubert / Warrington, Oliver / Hanemann, C Oliver / Futschik, Matthias E / Bossing, Torsten / Barros, Claudia S

    EMBO reports

    2024  Volume 25, Issue 1, Page(s) 168–197

    Abstract: Cell commitment to tumourigenesis and the onset of uncontrolled growth are critical determinants in cancer development but the early events directing tumour initiating cell (TIC) fate remain unclear. We reveal a single-cell transcriptome profile of brain ...

    Abstract Cell commitment to tumourigenesis and the onset of uncontrolled growth are critical determinants in cancer development but the early events directing tumour initiating cell (TIC) fate remain unclear. We reveal a single-cell transcriptome profile of brain TICs transitioning into tumour growth using the brain tumour (brat) neural stem cell-based Drosophila model. Prominent changes in metabolic and proteostasis-associated processes including ribogenesis are identified. Increased ribogenesis is a known cell adaptation in established tumours. Here we propose that brain TICs boost ribogenesis prior to tumour growth. In brat-deficient TICs, we show that this dramatic change is mediated by upregulated HEAT-Repeat Containing 1 (HEATR1) to promote ribosomal RNA generation, TIC enlargement and onset of overgrowth. High HEATR1 expression correlates with poor glioma patient survival and patient-derived glioblastoma stem cells rely on HEATR1 for enhanced ribogenesis and tumourigenic potential. Finally, we show that HEATR1 binds the master growth regulator MYC, promotes its nucleolar localisation and appears required for MYC-driven ribogenesis, suggesting a mechanism co-opted in ribogenesis reprogramming during early brain TIC development.
    MeSH term(s) Animals ; Humans ; Brain/metabolism ; Brain Neoplasms/metabolism ; Carcinogenesis/pathology ; Cell Transformation, Neoplastic/pathology ; DNA-Binding Proteins/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Glioblastoma/metabolism ; Glioma/pathology ; Minor Histocompatibility Antigens/metabolism ; Neoplastic Stem Cells/metabolism ; RNA-Binding Proteins/metabolism ; Proto-Oncogene Proteins c-myc/metabolism
    Chemical Substances DNA-Binding Proteins ; Drosophila Proteins ; HEATR1 protein, human ; Minor Histocompatibility Antigens ; RNA-Binding Proteins ; MYC protein, human ; Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-023-00017-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Isolated Intracranial Rosai-Dorfman Disease: Case Report and Review of the Literature.

    Boissaud-Cooke, Matthew A / Bhatt, Kush / Hilton, David A / Muquit, Samiul

    World neurosurgery

    2020  Volume 137, Page(s) 239–242

    Abstract: Background: Rosai-Dorfman disease (RDD) is a rare idiopathic benign proliferative disorder of histiocytes, predominantly affecting the lymph nodes. RDD can also present in extranodal tissues and is occasionally found within the central nervous system.!## ...

    Abstract Background: Rosai-Dorfman disease (RDD) is a rare idiopathic benign proliferative disorder of histiocytes, predominantly affecting the lymph nodes. RDD can also present in extranodal tissues and is occasionally found within the central nervous system.
    Case description: We report the case of a 52-year-old man presenting with a short episode of dizziness. Imaging identified a right frontal, extraaxial, dural-based lesion, suspicious for a meningioma. The patient underwent a craniotomy for tumor resection and, although not entirely typical, the pathology was consistent with RDD. No other evidence of RDD was identified.
    Conclusions: RDD should be considered as a differential diagnosis of dural-based lesions, more commonly meningiomas.
    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Craniotomy ; Diagnosis, Differential ; Dizziness/etiology ; Histiocytes/pathology ; Histiocytosis, Sinus/diagnostic imaging ; Histiocytosis, Sinus/pathology ; Histiocytosis, Sinus/surgery ; Humans ; Lymph Nodes/pathology ; Male ; Meningioma/diagnosis ; Meningioma/diagnostic imaging ; Middle Aged ; Neurosurgical Procedures ; Treatment Outcome
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.01.229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: BRAIN UK: Accessing NHS tissue archives for neuroscience research.

    Nicoll, James A R / Bloom, Tabitha / Clarke, Amelia / Boche, Delphine / Hilton, David

    Neuropathology and applied neurobiology

    2021  Volume 48, Issue 2, Page(s) e12766

    Abstract: The purpose of BRAIN UK (the UK BRain Archive Information Network) is to make the very extensive and comprehensive National Health Service (NHS) Neuropathology archives available to the national and international neuroscience research community. The ... ...

    Abstract The purpose of BRAIN UK (the UK BRain Archive Information Network) is to make the very extensive and comprehensive National Health Service (NHS) Neuropathology archives available to the national and international neuroscience research community. The archives comprise samples of tumours and a wide range of other neurological disorders, not only from the brain but also spinal cord, peripheral nerve, muscle, eye and other organs when relevant. BRAIN UK was founded after the recognition of the importance of this large tissue resource, which was not previously readily accessible for research use. BRAIN UK has successfully engaged the majority of the regional clinical neuroscience centres in the United Kingdom to produce a centralised database of the extensive autopsy and biopsy archive. Together with a simple application process and its broad ethical approval, BRAIN UK offers researchers easy access to most of the national archives of neurological tissues and tumours (http://www.brain-uk.org). The range of tissues available reflects the spectrum of disease in society, including many conditions not covered by disease-specific brain banks, and also allows relatively large numbers of cases of uncommon conditions to be studied. BRAIN UK has supported 141 studies (2010-2020) that have generated 70 publications employing methodology as diverse as morphometrics, genetics, proteomics and methylomics. Tissue samples that would otherwise have been unused have supported valuable neuroscience research. The importance of this unique resource will only increase as molecular techniques applicable to human tissues continue to develop and technical advances permit large-scale high-throughput studies.
    MeSH term(s) Biological Specimen Banks ; Brain/pathology ; Humans ; Neuropathology ; Neurosciences ; Research ; State Medicine ; United Kingdom
    Language English
    Publishing date 2021-09-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80371-6
    ISSN 1365-2990 ; 0305-1846
    ISSN (online) 1365-2990
    ISSN 0305-1846
    DOI 10.1111/nan.12766
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