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Article: Gleichtakt im Gehirn. Im höheren Alter lässt die Geisteskraft oft nach. Aber warum eigentlich? Schuld daran scheint ein mangelndes Zusammenspiel zwischen den verschiedenen Hirnarealen zu sein, weil es zu einem Abbau von Nervenfasern kommt. Doch es gibt Hoffnung: Gezielte Übungen könnten dem entgegenwirken, so dass das Gehirnorchester den gemeinsamen Rhythmus wiederfinden kann

Hinault, Thomas

2021 Volume -, Issue 6, Page(s) 52

Language	German
Document type	Article
ZDB-ID	2072879-7
ISSN	1618-8519
Database	Current Contents Medicine

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Article ; Online: The role of depressive symptoms in the interplay between aging and temporal processing.

Buzi, Giulia / Eustache, Francis / D'Argembeau, Arnaud / Hinault, Thomas

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11375

Abstract: Temporal processing, the ability to mentally represent and process the dynamical unfolding of events over time, is a fundamental feature of cognition that evolves with advancing age. Aging has indeed been associated with slower and more variable ... ...

Abstract	Temporal processing, the ability to mentally represent and process the dynamical unfolding of events over time, is a fundamental feature of cognition that evolves with advancing age. Aging has indeed been associated with slower and more variable performance in timing tasks. However, the role of depressive symptoms in age-related changes in temporal processing remains to be investigated. Therefore, the present work aims to shed light on the link between temporal processing and depressive symptoms, which are frequent with advancing age. We relied on the multicentric "Blursday Project" database, providing measures of temporal processing together with questionnaires investigating psychological wellbeing. Results reveal that aging influences several timing abilities, from the reproduction of short time intervals to verbal estimations of longer temporal distances. Furthermore, the slowing down of felt passage of time regarding the last few days with age was fully mediated by the intensity of depressive symptoms. Overall, these findings suggest that depressive symptoms may play a pivotal role in age-related temporal processing changes.
MeSH term(s)	Depression/psychology ; Time Perception ; Cognition
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38500-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: M/EEG Dynamics Underlying Reserve, Resilience, and Maintenance in Aging: A Review.

Jauny, Gwendolyn / Eustache, Francis / Hinault, Thomas Thierry

Frontiers in psychology

2022 Volume 13, Page(s) 861973

Abstract: Cognitive reserve and resilience refer to the set of processes allowing the preservation of cognitive performance in the presence of structural and functional brain changes. Investigations of these concepts have provided unique insights into the ... ...

Abstract	Cognitive reserve and resilience refer to the set of processes allowing the preservation of cognitive performance in the presence of structural and functional brain changes. Investigations of these concepts have provided unique insights into the heterogeneity of cognitive and brain changes associated with aging. Previous work mainly relied on methods benefiting from a high spatial precision but a low temporal resolution, and thus the temporal brain dynamics underlying these concepts remains poorly known. Moreover, while spontaneous fluctuations of neural activity have long been considered as noise, recent work highlights its critical contribution to brain functions. In this study, we synthesized the current state of knowledge from magnetoencephalography (MEG) and electroencephalography (EEG) studies that investigated the contribution of maintenance of neural synchrony, and variability of brain dynamics, to cognitive changes associated with healthy aging and the progression of neurodegenerative disease (such as Alzheimer's disease). The reviewed findings highlight that compensations could be associated with increased synchrony of higher (>10 Hz) frequency bands. Maintenance of young-like synchrony patterns was also observed in healthy older individuals. Both maintenance and compensation appear to be highly related to preserved structural integrity (brain reserve). However, increased synchrony was also found to be deleterious in some cases and reflects neurodegenerative processes. These results provide major elements on the stability or variability of functional networks as well as maintenance of neural synchrony over time, and their association with individual cognitive changes with aging. These findings could provide new and interesting considerations about cognitive reserve, maintenance, and resilience of brain functions and cognition.
Language	English
Publishing date	2022-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.861973
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Linking structural and functional changes during aging using multilayer brain network analysis.

Jauny, Gwendolyn / Mijalkov, Mite / Canal-Garcia, Anna / Volpe, Giovanni / Pereira, Joana / Eustache, Francis / Hinault, Thomas

Communications biology

2024 Volume 7, Issue 1, Page(s) 239

Abstract: Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity ... ...

Abstract	Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity changes that influence functional network dynamics. Here, we use the multilayer brain network analysis on structural (diffusion weighted imaging) and functional (magnetoencephalography) data from the Cam-CAN database. We found that the level of similarity of connectivity patterns between brain structure and function in the parietal and temporal regions (alpha frequency band) is associated with cognitive performance in healthy older individuals. These results highlight the impact of structural connectivity changes on the reorganisation of functional connectivity associated with the preservation of cognitive function, and provide a mechanistic understanding of the concepts of brain maintenance and compensation with aging. Investigation of the link between structure and function could thus represent a new marker of individual variability, and of pathological changes.
MeSH term(s)	Humans ; Brain/pathology ; Aging/pathology ; Cognition ; Brain Mapping ; Magnetoencephalography/methods
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05927-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology.

Mijalkov, Mite / Veréb, Dániel / Canal-Garcia, Anna / Hinault, Thomas / Volpe, Giovanni / Pereira, Joana B

Alzheimer's research & therapy

2023 Volume 15, Issue 1, Page(s) 112

Abstract: Background: Alzheimer's disease is a neurodegenerative disorder associated with the abnormal deposition of pathological processes, such as amyloid-ß and tau, which produces nonlinear changes in the functional connectivity patterns between different ... ...

Abstract	Background: Alzheimer's disease is a neurodegenerative disorder associated with the abnormal deposition of pathological processes, such as amyloid-ß and tau, which produces nonlinear changes in the functional connectivity patterns between different brain regions across the Alzheimer's disease continuum. However, the mechanisms underlying these nonlinear changes remain largely unknown. Here, we address this question using a novel method based on temporal or delayed correlations and calculate new whole-brain functional networks to tackle these mechanisms. Methods: To assess our method, we evaluated 166 individuals from the ADNI database, including amyloid-beta negative and positive cognitively normal subjects, patients with mild cognitive impairment, and patients with Alzheimer's disease dementia. We used the clustering coefficient and the global efficiency to measure the functional network topology and assessed their relationship with amyloid and tau pathology measured by positron emission tomography, as well as cognitive performance using tests measuring memory, executive function, attention, and global cognition. Results: Our study found nonlinear changes in the global efficiency, but not in the clustering coefficient, showing that the nonlinear changes in functional connectivity are due to an altered ability of brain regions to communicate with each other through direct paths. These changes in global efficiency were most prominent in early disease stages. However, later stages of Alzheimer's disease were associated with widespread network disruptions characterized by changes in both network measures. The temporal delays required for the detection of these changes varied across the Alzheimer's disease continuum, with shorter delays necessary to detect changes in early stages and longer delays necessary to detect changes in late stages. Both global efficiency and clustering coefficient showed quadratic associations with pathological amyloid and tau burden as well as cognitive decline. Conclusions: This study suggests that global efficiency is a more sensitive indicator of network changes in Alzheimer's disease when compared to clustering coefficient. Both network properties were associated with pathology and cognitive performance, demonstrating their relevance in clinical settings. Our findings provide an insight into the mechanisms underlying nonlinear changes in functional network organization in Alzheimer's disease, suggesting that it is the lack of direct connections that drives these functional changes.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; tau Proteins/metabolism ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/pathology ; Amyloid ; Positron-Emission Tomography ; Magnetic Resonance Imaging/methods
Chemical Substances	tau Proteins ; Amyloid beta-Peptides ; Amyloid
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-023-01252-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Do Musicians Have Better Mnemonic and Executive Performance Than Actors? Influence of Regular Musical or Theater Practice in Adults and in the Elderly.

Groussard, Mathilde / Coppalle, Renaud / Hinault, Thomas / Platel, Hervé

Frontiers in human neuroscience

2020 Volume 14, Page(s) 557642

Abstract: The effects of musical practice on cognition are well established yet rarely compared with other kinds of artistic training or expertise. This study aims to compare the possible effect of musical and theater regular practice on cognition across the ... ...

Abstract	The effects of musical practice on cognition are well established yet rarely compared with other kinds of artistic training or expertise. This study aims to compare the possible effect of musical and theater regular practice on cognition across the lifespan. Both of these artistic activities require many hours of individual or collective training in order to reach an advanced level. This process requires the interaction between higher-order cognitive functions and several sensory modalities (auditory, verbal, visual and motor), as well as regular learning of new pieces. This study included participants with musical or theater practice, and healthy controls matched for age (18-84 years old) and education. The objective was to determine whether specific practice in these activities had an effect on cognition across the lifespan, and a protective influence against undesirable cognitive outcomes associated with aging. All participants underwent a battery of cognitive tasks that evaluated processing speed, executive function, fluency, working memory, verbal and visual long-term memories, and non-verbal reasoning abilities. Results showed that music and theater artistic practices were strongly associated with cognitive enhancements. Participants with musical practice were better in executive functioning, working memory and non-verbal reasoning, whereas participants with regular acting practice had better long-term verbal memory and fluency performance. Thus, taken together, results suggest a differential effect of these artistic practices on cognition across the lifespan. Advanced age did not seem to reduce the benefit, so future studies should focus on the hypothetical protective effects of artistic practice against cognitive decline.
Language	English
Publishing date	2020-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2020.557642
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Article: Modulation of Peak Alpha Frequency Oscillations During Working Memory Is Greater in Females Than Males.

Ghazi, Tara R / Blacker, Kara J / Hinault, Thomas T / Courtney, Susan M

Frontiers in human neuroscience

2021 Volume 15, Page(s) 626406

Abstract: Peak alpha frequency is known to vary not just between individuals, but also within an individual over time. While variance in this metric between individuals has been tied to working memory performance, less understood are how short timescale ... ...

Abstract	Peak alpha frequency is known to vary not just between individuals, but also within an individual over time. While variance in this metric between individuals has been tied to working memory performance, less understood are how short timescale modulations of peak alpha frequency during task performance may facilitate behavior. This gap in understanding may be bridged by consideration of a key difference between individuals: sex. Inconsistent findings in the literature regarding the relationship between peak alpha frequency and cognitive performance, as well as known sex-related-differences in peak alpha frequency and its modulation motivated our hypothesis that cognitive and neural processes underlying working memory-modulation of peak alpha frequency in particular-may differ based upon sex. Targeting sex as a predictive factor, we analyzed the EEG data of participants recorded while they performed four versions of a visual spatial working memory task. A significant difference between groups was present: females modulated peak alpha frequency more than males. Task performance did not differ by sex, yet a relationship between accuracy and peak alpha frequency was present in males, but not in females. These findings highlight the importance of considering sex as a factor in the study of oscillatory activity, particularly to further understanding of the neural mechanisms that underlie working memory.
Language	English
Publishing date	2021-04-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2021.626406
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Article ; Online: Aging and List-Wide Modulations of Strategy Execution:A Study in Arithmetic.

Hinault, Thomas / Lemaire, Patrick

Experimental aging research

2017 Volume 43, Issue 4, Page(s) 323–336

Abstract: Background/Study Context: This study aimed at further our understanding of the cognitive processes involved during strategy execution, and how the processes involved change with age. More specifically, the main goal was to investigate whether poorer- ... ...

Abstract	Background/Study Context: This study aimed at further our understanding of the cognitive processes involved during strategy execution, and how the processes involved change with age. More specifically, the main goal was to investigate whether poorer-strategy effects (i.e., poorer performance when a cued strategy is not the best) and sequential modulations of poorer-strategy effects (i.e., decreased poorer-strategy effects on current problems following poorer-strategy problems compared with after better-strategy problems) are influenced by proportions of poorer-strategy problems. Methods: We used a computational estimation task (i.e., providing approximate products to two-digit multiplication problems such as 38 × 74) with problems sets including 75%, 50%, or 25% of poorer-strategy problems (i.e., participants have to estimate products with another strategy than the better strategy). The remaining problems were cued with the better strategy. Age-related differences were also investigated. Results: We found that proportions of poorer-strategy problems influenced sequential modulations of poorer-strategy effects. Indeed, sequential modulations of poorer-strategy effects were larger when proportions of poorer-strategy problems were equal than unequal. Moreover, proportion effects were different for young and older adults, as older adults benefited more from low proportions of poorer-strategy problems compared with young adults. Conclusion: These findings have important implications regarding cognitive control mechanisms underlying both list-wide and trial-to-trial modulations of strategy execution, and how these processes change during aging.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	753202-7
ISSN	1096-4657 ; 0361-073X
ISSN (online)	1096-4657
ISSN	0361-073X
DOI	10.1080/0361073X.2017.1333817
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Aging, rule-violation checking strategies, and strategy combination: An EEG study in arithmetic.

Hinault, Thomas / Lemaire, Patrick

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

2017 Volume 120, Page(s) 23–32

Abstract: In arithmetic, rule-violation checking strategies are used while participants solve problems that violate arithmetic rules, like the five rule (i.e., products of problems including five as an operand end with either five or zero; e.g., 5×14=70) or the ... ...

Abstract	In arithmetic, rule-violation checking strategies are used while participants solve problems that violate arithmetic rules, like the five rule (i.e., products of problems including five as an operand end with either five or zero; e.g., 5×14=70) or the parity rule (i.e., when at least one of the two operands is even, the product is also even; otherwise the product is odd; e.g., 4×13=52). When problems violate both rules, participants use strategy combination and have better performance on both-rule than on one-rule violation problems (i.e., five or parity rule). Aging studies found that older adults efficiently use one-rule violation checking strategies but have difficulties to combine two strategies. To better understand these aging effects, we used EEG and found important age-related changes while participants used rule-violation checking strategies. We compared participants' performance while they verified arithmetic problems that differ in number and type of violated rule. More specifically, both-rule violation problems elicited larger negativity than one-rule violation problems between 600 and 800ms. Five-rule violation problems differed from parity-rule violation problems between 1100 and 1200ms. Moreover, rule-violation checking strategies and strategy combination involved delta, theta, and lower alpha frequencies. Age-related changes in ERPs and frequency were associated with less efficient strategy combination. Moreover, efficient use of one-rule violation checking strategies in older adults was associated with changes in ERPs and frequency. These findings contribute to further our understanding of age-related changes and invariance in arithmetic strategies, and in combination of arithmetic strategies.
Language	English
Publishing date	2017-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605645-3
ISSN	1872-7697 ; 0167-8760
ISSN (online)	1872-7697
ISSN	0167-8760
DOI	10.1016/j.ijpsycho.2017.07.003
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Article ; Online: What does EEG tell us about arithmetic strategies? A review.

Hinault, Thomas / Lemaire, Patrick

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

2016 Volume 106, Page(s) 115–126

Language	English
Publishing date	2016-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605645-3
ISSN	1872-7697 ; 0167-8760
ISSN (online)	1872-7697
ISSN	0167-8760
DOI	10.1016/j.ijpsycho.2016.05.006
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