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  1. Article ; Online: The impact of rheumatoid foot on disability in Colombian patients with rheumatoid arthritis.

    Rojas-Villarraga, Adriana / Bayona, Javier / Zuluaga, Natalia / Mejia, Santiago / Hincapie, Maria-Eugenia / Anaya, Juan-Manuel

    BMC musculoskeletal disorders

    2009  Volume 10, Page(s) 67

    Abstract: Background: Alterations in the feet of patients with rheumatoid arthritis (RA) are a cause of disability in this population. The purpose of this research was to evaluate the impact that foot impairment has on the patients' global quality of life (QOL) ... ...

    Abstract Background: Alterations in the feet of patients with rheumatoid arthritis (RA) are a cause of disability in this population. The purpose of this research was to evaluate the impact that foot impairment has on the patients' global quality of life (QOL) based on validated scales and its relationship to disease activity.
    Methods: This was a cross-sectional study in which 95 patients with RA were enrolled. A complete physical examination, including a full foot assessment, was done. The Spanish versions of the Health Assessment Questionnaire (HAQ) Disability Index and of the Disease Activity Score (DAS 28) were administered. A logistic regression model was used to analyze data and obtain adjusted odds ratios (AORs).
    Results: Foot deformities were observed in 78 (82%) of the patients; hallux valgus (65%), medial longitudinal arch flattening (42%), claw toe (lesser toes) (39%), dorsiflexion restriction (tibiotalar) (34%), cock-up toe (lesser toes) (25%), and transverse arch flattening (25%) were the most frequent. In the logistic regression analysis (adjusted for age, gender and duration of disease), forefoot movement pain, subtalar movement pain, tibiotalar movement pain and plantarflexion restriction (tibiotalar) were strongly associated with disease activity and disability. The positive squeeze test was significantly associated with disability risk (AOR = 6,3; 95% CI, 1.28-30.96; P = 0,02); hallux valgus, and dorsiflexion restriction (tibiotalar) were associated with disease activity.
    Conclusion: Foot abnormalities are associated with active joint disease and disability in RA. Foot examinations provide complementary information related to the disability as an indirect measurement of quality of life and activity of disease in daily practice.
    MeSH term(s) Activities of Daily Living ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/physiopathology ; Colombia/epidemiology ; Comorbidity ; Cross-Sectional Studies ; Disability Evaluation ; Female ; Foot/pathology ; Foot/physiopathology ; Foot Deformities, Acquired/diagnosis ; Foot Deformities, Acquired/epidemiology ; Foot Deformities, Acquired/physiopathology ; Foot Joints/pathology ; Foot Joints/physiopathology ; Humans ; Male ; Middle Aged ; Mobility Limitation ; Physical Examination ; Prevalence ; Quality of Life ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2009-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/1471-2474-10-67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of rheumatoid foot on disability in Colombian patients with rheumatoid arthritis

    Rojas-Villarraga Adriana / Bayona Javier / Zuluaga Natalia / Mejia Santiago / Hincapie Maria-Eugenia / Anaya Juan-Manuel

    BMC Musculoskeletal Disorders, Vol 10, Iss 1, p

    2009  Volume 67

    Abstract: Abstract Background Alterations in the feet of patients with rheumatoid arthritis (RA) are a cause of disability in this population. The purpose of this research was to evaluate the impact that foot impairment has on the patients' global quality of life ( ...

    Abstract Abstract Background Alterations in the feet of patients with rheumatoid arthritis (RA) are a cause of disability in this population. The purpose of this research was to evaluate the impact that foot impairment has on the patients' global quality of life (QOL) based on validated scales and its relationship to disease activity. Methods This was a cross-sectional study in which 95 patients with RA were enrolled. A complete physical examination, including a full foot assessment, was done. The Spanish versions of the Health Assessment Questionnaire (HAQ) Disability Index and of the Disease Activity Score (DAS 28) were administered. A logistic regression model was used to analyze data and obtain adjusted odds ratios (AORs). Results Foot deformities were observed in 78 (82%) of the patients; hallux valgus (65%), medial longitudinal arch flattening (42%), claw toe (lesser toes) (39%), dorsiflexion restriction (tibiotalar) (34%), cock-up toe (lesser toes) (25%), and transverse arch flattening (25%) were the most frequent. In the logistic regression analysis (adjusted for age, gender and duration of disease), forefoot movement pain, subtalar movement pain, tibiotalar movement pain and plantarflexion restriction (tibiotalar) were strongly associated with disease activity and disability. The positive squeeze test was significantly associated with disability risk (AOR = 6,3; 95% CI, 1.28–30.96; P = 0,02); hallux valgus, and dorsiflexion restriction (tibiotalar) were associated with disease activity. Conclusion Foot abnormalities are associated with active joint disease and disability in RA. Foot examinations provide complementary information related to the disability as an indirect measurement of quality of life and activity of disease in daily practice.
    Keywords Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the musculoskeletal system ; RC925-935
    Subject code 796
    Language English
    Publishing date 2009-06-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: THREE STATE MARKOV MODEL

    Salazar Juan Carlos / Palomino René Iral / Calvo Enrique / Rojas Adriana / Hincapié María Eugenia / Anaya Juan Manuel / Díaz Francisco Javier

    Revista Colombiana de Estadística, Vol 30, Iss 2, Pp 213-

    COMPARING THREE PARAMETERIZATIONS OF THE TRANSITION INTENSITY RATE. APPLICATION TO RHEUMATOID ARTHRITIS DATA MODELO DE MARKOV DE TRES ESTADOS: COMPARACIÓN DE PARAMETRIZACIONES DE LA TASA DE INTENSIDAD DE TRANSICIÓN. APLICACIÓN A DATOS DE ARTRITIS REUMATOIDEA

    2007  Volume 229

    Abstract: We consider a three state model with an absorbing state assuming an underlying Markov process to explain the dependence among observations within subjects. We compare, using a simulation study, three different parameterizations of the transition ... ...

    Abstract We consider a three state model with an absorbing state assuming an underlying Markov process to explain the dependence among observations within subjects. We compare, using a simulation study, three different parameterizations of the transition intensity rate: the first one is based on the Andersen-Gill’s multiplicative hazard model (Andersen et al. 1993), the second one is based on the logistic model, and the third one depends on the complementary log-log model. The method to estimate the effect of the parameters is based on the likelihood function which can be optimized using the exact solutions of a Kolmogorov forward differential equations system in conjunction with the Newton-Raphson algorithm (Abramowitz & Stegun 1972). We use the relative bias to select the best estimation estrategy. The methodology is ilustrated using longitudinal data about rheumatoid arthritis (RA) from the Corporación para Investigaciones Biológicas, CIB. Se considera un modelo múltiple de tres estados donde uno de ellos es absorbente. Se asume que la dependencia entre las observaciones registradas para un mismo sujeto sigue un proceso de Markov. Se comparan, vía simulación, tres diferentes parametrizaciones de la tasa de intensidad de transición: la primera está basada en el modelo de hazard multiplicativo de Andersen- Gill (Andersen et al. 1993), la segunda, en el modelo logístico, y la tercera depende del modelo log-log complementario. El método de estimación de parámetros se basa en la función de verosimilitud la cual se optimiza usando las soluciones exactas de un sistema de ecuaciones de Kolmogorov hacia adelante junto con el algoritmo de Newton-Raphson (Abramowitz & Stegun 1972). Usando el sesgo relativo, se selecciona el mejor método de parametrización y se ilustra usando datos recopilados en la Corporación para Investigaciones Biológicas, CIB1, acerca de pacientes con artritis reumatoidea.
    Keywords Stochastic processes ; Intensity rates ; Longitudinal data ; Rheumatoid Arthritis ; Statistics ; HA1-4737 ; Social Sciences ; H ; DOAJ:Statistics ; DOAJ:Mathematics and Statistics
    Language Spanish
    Publishing date 2007-11-01T00:00:00Z
    Publisher Universidad Nacional de Colombia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.

    Castiblanco, John / Varela, Diana-Cristina / Castaño-Rodríguez, Natalia / Rojas-Villarraga, Adriana / Hincapié, María-Eugenia / Anaya, Juan-Manuel

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2008  Volume 8, Issue 5, Page(s) 541–544

    Abstract: Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in ... ...

    Abstract Background and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D).
    Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing.
    Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed.
    Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.
    MeSH term(s) Adult ; Case-Control Studies ; Colombia ; Female ; Gene Frequency ; Genotype ; Humans ; Lupus Erythematosus, Systemic/genetics ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Polymorphism, Genetic ; Receptors, Interleukin-1/genetics ; Tuberculosis/genetics
    Chemical Substances Membrane Glycoproteins ; Receptors, Interleukin-1 ; TIRAP protein, human
    Language English
    Publishing date 2008-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2008.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An antibody profile of systemic lupus erythematosus detected by antigen microarray

    Fattal, Ittai / Shental, Noam / Mevorach, Dror / Anaya, Juan-Manuel / Livneh, Avi / Langevitz, Pnina / Zandman-Goddard, Gisele / Pauzner, Rachel / Lerner, Miriam / Blank, Miri / Hincapie, Maria-Eugenia / Gafter, Uzi / Naparstek, Yaakov / Shoenfeld, Yehuda / Domany, Eytan / Cohen, Irun R

    Immunology. 2010 July, v. 130, no. 3

    2010  

    Abstract: Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to ... ...

    Abstract Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states - SLE patients with acute lupus nephritis, SLE patients in renal remission, and SLE patients who had never had renal involvement. The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), Epstein-Barr virus (EBV) and hyaluronic acid; the profile also includes decreases in specific IgM reactivities to myeloperoxidase (MPO), CD99, collagen III, insulin-like growth factor binding protein 1 (IGFBP1) and cardiolipin. The reactivities together showed high sensitivity (> 93%) and high specificity for SLE (> 88%). A healthy control subject who had the SLE antibody profile was later found to develop clinical SLE. The present study did not detect antibody reactivities that differentiated among the various subgroups of SLE subjects with statistical significance. Thus, SLE is characterized by an enduring antibody profile irrespective of clinical state. The association of SLE with decreased IgM natural autoantibodies suggests that these autoantibodies might enhance resistance to SLE.
    Keywords autoantibodies ; autoimmune diseases
    Language English
    Dates of publication 2010-07
    Size p. 337-343.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/j.1365-2567.2010.03245.x
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Risk factors associated with different stages of atherosclerosis in Colombian patients with rheumatoid arthritis.

    Rojas-Villarraga, Adriana / Ortega-Hernandez, Oscar-Danilo / Gomez, Luis F / Pardo, Aryce L / López-Guzmán, Silvia / Arango-Ferreira, Camila / Hincapie, Maria-Eugenia / Betancur, Juan F / Pineda-Tamayo, Ricardo / Diaz, Francisco J / Anaya, Juan-Manuel

    Seminars in arthritis and rheumatism

    2008  Volume 38, Issue 2, Page(s) 71–82

    Abstract: Objectives: Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype-genotype correlation of complex ... ...

    Abstract Objectives: Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype-genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA.
    Methods: A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV <5%), increased IMT (0.91-1.29 mm), and plaque (IMT >1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age.
    Results: Rheumatoid factor seropositivity was significantly associated with endothelial dysfunction (adjusted odds ratio, AOR = 3.0). A duration of RA >10 years (AOR = 29.0) and being a carrier of an HLA-DRB1 shared epitope allele (AOR = 4.8) were associated with atherosclerotic plaque. No association of extra-articular manifestations, anticyclic citrullinated peptide (anti-CCP3) antibodies, and tumor necrosis factor -308 polymorphism with CVD was found.
    Conclusions: Our results reveal the presence of RA-related risk factors for CVD which act independently of traditional risk factors. These factors can be used by clinicians to predict CVD in RA patients, and this data should assist in the development of public health policies in our population for the improvement of patient outcomes.
    MeSH term(s) Adult ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/etiology ; Carotid Artery Diseases/pathology ; Colombia ; Endothelium, Vascular/diagnostic imaging ; Endothelium, Vascular/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Rheumatoid Factor/blood ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Tunica Intima/diagnostic imaging ; Tunica Intima/pathology ; Tunica Media/diagnostic imaging ; Tunica Media/pathology ; Ultrasonography
    Chemical Substances Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2008-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2008.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An antibody profile of systemic lupus erythematosus detected by antigen microarray.

    Fattal, Ittai / Shental, Noam / Mevorach, Dror / Anaya, Juan-Manuel / Livneh, Avi / Langevitz, Pnina / Zandman-Goddard, Gisele / Pauzner, Rachel / Lerner, Miriam / Blank, Miri / Hincapie, Maria-Eugenia / Gafter, Uzi / Naparstek, Yaakov / Shoenfeld, Yehuda / Domany, Eytan / Cohen, Irun R

    Immunology

    2010  Volume 130, Issue 3, Page(s) 337–343

    Abstract: Summary: Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim ... ...

    Abstract Summary: Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states--SLE patients with acute lupus nephritis, SLE patients in renal remission, and SLE patients who had never had renal involvement. The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), Epstein-Barr virus (EBV) and hyaluronic acid; the profile also includes decreases in specific IgM reactivities to myeloperoxidase (MPO), CD99, collagen III, insulin-like growth factor binding protein 1 (IGFBP1) and cardiolipin. The reactivities together showed high sensitivity (> 93%) and high specificity for SLE (> 88%). A healthy control subject who had the SLE antibody profile was later found to develop clinical SLE. The present study did not detect antibody reactivities that differentiated among the various subgroups of SLE subjects with statistical significance. Thus, SLE is characterized by an enduring antibody profile irrespective of clinical state. The association of SLE with decreased IgM natural autoantibodies suggests that these autoantibodies might enhance resistance to SLE.
    MeSH term(s) 12E7 Antigen ; Adult ; Antibodies, Anticardiolipin/immunology ; Antibodies, Antinuclear/blood ; Antibodies, Antinuclear/immunology ; Antigens, CD/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Cell Adhesion Molecules/immunology ; Collagen Type III/immunology ; Down-Regulation/immunology ; Female ; Herpesvirus 4, Human/immunology ; Humans ; Hyaluronic Acid/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Insulin-Like Growth Factor Binding Protein 1/immunology ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/immunology ; Lupus Nephritis/diagnosis ; Lupus Nephritis/immunology ; Male ; Middle Aged ; Peroxidase/immunology ; Protein Array Analysis ; Sensitivity and Specificity ; Up-Regulation/immunology
    Chemical Substances 12E7 Antigen ; Antibodies, Anticardiolipin ; Antibodies, Antinuclear ; Antigens, CD ; Autoantibodies ; CD99 protein, human ; Cell Adhesion Molecules ; Collagen Type III ; IGFBP1 protein, human ; Immunoglobulin G ; Immunoglobulin M ; Insulin-Like Growth Factor Binding Protein 1 ; Hyaluronic Acid (9004-61-9) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2010-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/j.1365-2567.2010.03245.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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