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  1. Article ; Online: Pediatric Pulmonology 2022 year in review: Rare and diffuse lung disease.

    Barber, Andrew T / Liptzin, Deborah R / Gower, William A / Hinds, Daniel M

    Pediatric pulmonology

    2023  Volume 58, Issue 10, Page(s) 2719–2724

    Abstract: The field of rare and diffuse pediatric lung disease continues to evolve and expand rapidly as clinicians and researchers make advancements in the diagnosis and treatment of children's interstitial and diffuse lung disease, non-cystic fibrosis ... ...

    Abstract The field of rare and diffuse pediatric lung disease continues to evolve and expand rapidly as clinicians and researchers make advancements in the diagnosis and treatment of children's interstitial and diffuse lung disease, non-cystic fibrosis bronchiectasis, and primary ciliary dyskinesia. Papers published on these topics in Pediatric Pulmonology and other journals in 2022 describe newly recognized disorders, elucidate disease mechanisms and courses, explore potential biomarkers, and assess novel treatments. In this review, we will discuss these important advancements and place them in the context of existing literature.
    MeSH term(s) Child ; Humans ; Pulmonary Medicine ; Lung Diseases/diagnosis ; Lung Diseases/therapy ; Bronchiectasis/diagnosis ; Bronchiectasis/therapy ; Lung ; Thorax
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26603
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  2. Article ; Online: Depleting transforming growth factor beta receptor 2 signalling in the cartilage of

    St Amant, Jennifer / Michaud, Jana / Hinds, Daniel / Coyle, Madison / Pozzi, Ambra / Clark, Andrea L

    Osteoarthritis and cartilage open

    2023  Volume 5, Issue 4, Page(s) 100399

    Abstract: Objectives: Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integrin α1β1 moderates transforming ... ...

    Abstract Objectives: Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integrin α1β1 moderates transforming growth factor β receptor II (TGFBR2) signalling, a critical regulator of chondrocyte anabolic activity. To this end, mice lacking integrin α1β1 have increased baseline activation of TGFBR2 signalling and overall fibrosis. The purpose of this study was to evaluate the interplay between integrin α1β1 and TGFBR2 in the development of spontaneous OA. We hypothesized that dampening TGFBR2 signalling in the cartilage of
    Methods: Behavioural and histological manifestations of spontaneous knee OA were measured at 4, 8, 12 and 16 months in mice with and without a ubiquitous
    Results: Knee cartilage degeneration, collateral ligament ossification and pain responses increased with age.
    Conclusion: Intact TGFBR2 signalling drives early and worse knee OA in
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ISSN 2665-9131
    ISSN (online) 2665-9131
    DOI 10.1016/j.ocarto.2023.100399
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  3. Article ; Online: Vaping and diffuse alveolar hemorrhage: All EVALI is not created equal.

    Hoekstra, Nadia E / Dannull, Kimberly A / Weinman, Jason P / Liptzin, Deborah R / Hinds, Daniel M

    Pediatric pulmonology

    2021  Volume 56, Issue 12, Page(s) 4057–4059

    Abstract: E-cigarette, or vaping product, use associated lung injury (EVALI) refers to respiratory illness in patients with recent vaping and no signs of infection or underlying illness. EVALI can cause severe acute respiratory distress syndrome and death. A ... ...

    Abstract E-cigarette, or vaping product, use associated lung injury (EVALI) refers to respiratory illness in patients with recent vaping and no signs of infection or underlying illness. EVALI can cause severe acute respiratory distress syndrome and death. A spectrum of diagnoses can fit the description of EVALI since it relies heavily on nonspecific, radiographic findings. We present a rare case of EVALI in which a patient with a history of vaping presented with acute hypoxemia and was diagnosed with diffuse alveolar hemorrhage (DAH). The mechanism of injury of DAH due to vaping is unknown, and further research into the topic is required.
    MeSH term(s) Electronic Nicotine Delivery Systems ; Hemorrhage/etiology ; Humans ; Lung Injury ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/etiology ; Vaping/adverse effects
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25675
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  4. Article ; Online: Case 1: Persistent Tachypnea in an Infant.

    Hinds, Daniel / Cooper, Matthew / Daftary, Ameet

    Pediatrics in review

    2017  Volume 38, Issue 7, Page(s) 330–331

    MeSH term(s) Humans ; Infant ; Male ; Pulmonary Emphysema/complications ; Pulmonary Emphysema/congenital ; Pulmonary Emphysema/diagnostic imaging ; Tachypnea/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2016-0027
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  5. Article ; Online: Pulmonary eosinophilic vasculitis with granulomas and benralizumab in children.

    Hinds, Daniel M / Bloom, Jessica L / Cooper, Jennifer C / Dutmer, Cullen M / Galambos, Csaba / Weinman, Jason P / Wechsler, Michael E / Liptzin, Deborah R

    Pediatric pulmonology

    2021  Volume 56, Issue 6, Page(s) 1789–1792

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Asthma/drug therapy ; Child ; Eosinophils ; Granuloma ; Humans ; Vasculitis
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25286
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  6. Article ; Online: Acute vaping in a golden Syrian hamster causes inflammatory response transcriptomic changes.

    Hinds, Daniel M / Nick, Heidi J / Vallin, Tessa M / Bloomquist, Leslie A / Christeson, Sarah / Bratcher, Preston E / Cooper, Emily H / Brinton, John T / Bosco-Lauth, Angela / White, Carl W

    American journal of physiology. Lung cellular and molecular physiology

    2022  Volume 323, Issue 5, Page(s) L525–L535

    Abstract: E-cigarette vaping is a major aspect of nicotine consumption, especially for children and young adults. Although it is branded as a safer alternative to cigarette smoking, murine and rat models of subacute and chronic e-cigarette vaping exposure have ... ...

    Abstract E-cigarette vaping is a major aspect of nicotine consumption, especially for children and young adults. Although it is branded as a safer alternative to cigarette smoking, murine and rat models of subacute and chronic e-cigarette vaping exposure have shown many proinflammatory changes in the respiratory tract. An acute vaping exposure paradigm has not been demonstrated in the golden Syrian hamster, and the hamster is a readily available small animal model that has the unique benefit of becoming infected with and transmitting respiratory viruses, including SARS-CoV-2, without genetic alteration of the animal or virus. Using a 2-day, whole body vaping exposure protocol in male golden Syrian hamsters, we evaluated serum cotinine, bronchoalveolar lavage cells, lung, and nasal histopathology, and gene expression in the nasopharynx and lung through reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Depending on the presence of nonnormality or outliers, statistical analysis was performed by ANOVA or Kruskal-Wallis tests. For tests that were statistically significant (
    MeSH term(s) Animals ; Cricetinae ; Male ; Angiotensin-Converting Enzyme 2 ; Angiotensins ; Cotinine ; Electronic Nicotine Delivery Systems ; Fibrosis ; Inflammation/pathology ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 9 ; Mesocricetus ; Nicotine/pharmacology ; Renin ; Superoxide Dismutase ; Thromboplastin ; Transcriptome ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Vaping/adverse effects ; Vascular Endothelial Growth Factor A
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Angiotensins ; Cotinine (K5161X06LL) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Nicotine (6M3C89ZY6R) ; Renin (EC 3.4.23.15) ; Superoxide Dismutase (EC 1.15.1.1) ; Thromboplastin (9035-58-9) ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00162.2022
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  7. Article ; Online: Oral antibiotic prescribing patterns for treatment of pulmonary exacerbations in two large pediatric CF centers.

    Hoppe, Jordana E / Hinds, Daniel M / Colborg, Adrianne / Wagner, Brandie D / Morgan, Wayne J / Rosenfeld, Margaret / Zemanick, Edith T / Sanders, Don B

    Pediatric pulmonology

    2020  Volume 55, Issue 12, Page(s) 3400–3406

    Abstract: Introduction: Oral antibiotics are frequently prescribed for outpatient pulmonary exacerbations (PEx) in children with cystic fibrosis (CF). This study aimed to characterize oral antibiotic use for PEx and treatment outcomes at two large US CF centers.!# ...

    Abstract Introduction: Oral antibiotics are frequently prescribed for outpatient pulmonary exacerbations (PEx) in children with cystic fibrosis (CF). This study aimed to characterize oral antibiotic use for PEx and treatment outcomes at two large US CF centers.
    Methods: Retrospective, descriptive study of oral antibiotic prescribing practices among children with CF ages 6-17 years over 1 year. The care setting for antibiotic initiation (clinic or phone encounter) was determined and outcomes were compared.
    Results: A total of 763 oral antibiotic courses were prescribed to 312 patients aged 6-17 years (77% of 403 eligible patients) with a median of two courses per year (range: 1-10). Fifty-eight percent of prescriptions were provided over the phone. Penicillin was the most commonly prescribed antibiotic class (36% of prescriptions) but differences in antibiotic class prescriptions were noted between the two centers. Hospitalizations occurred within 3 months following 19% of oral antibiotic courses. Forced expiratory volume in 1 s (FEV
    Conclusions: Phone prescriptions, commonly excluded in studies of PEx, made up more than half of all oral antibiotic courses. Heterogeneity in prescribing patterns was observed between the two centers. Most patients had improvement in FEV
    MeSH term(s) Administration, Oral ; Adolescent ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Child ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Drug Prescriptions/statistics & numerical data ; Female ; Forced Expiratory Volume ; Humans ; Lung/drug effects ; Lung/physiopathology ; Male ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25092
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  8. Article ; Online: Cystic fibrosis in El Salvador.

    Hinds, Daniel M / Sanders, Don B / Slaven, James E / Romero, Mauricio / Davis, Stephanie D / Stevens, John C

    Pediatric pulmonology

    2019  Volume 54, Issue 4, Page(s) 369–371

    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24232
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  9. Article ; Online: Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo.

    Li, Fang / Downing, Brandon D / Smiley, Lucy C / Mund, Julie A / Distasi, Matthew R / Bessler, Waylan K / Sarchet, Kara N / Hinds, Daniel M / Kamendulis, Lisa M / Hingtgen, Cynthia M / Case, Jamie / Clapp, D Wade / Conway, Simon J / Stansfield, Brian K / Ingram, David A

    Circulation

    2013  Volume 129, Issue 11, Page(s) 1213–1224

    Abstract: Background: Neurofibromatosis type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin, the protein product of NF1, functions as a negative regulator of Ras activity in circulating hematopoietic and ... ...

    Abstract Background: Neurofibromatosis type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin, the protein product of NF1, functions as a negative regulator of Ras activity in circulating hematopoietic and vascular wall cells, which are critical for maintaining vessel wall homeostasis. NF1 patients have evidence of chronic inflammation resulting in the development of premature cardiovascular disease, including arterial aneurysms, which may manifest as sudden death. However, the molecular pathogenesis of NF1 aneurysm formation is unknown.
    Method and results: With the use of an angiotensin II-induced aneurysm model, we demonstrate that heterozygous inactivation of Nf1 (Nf1(+/-)) enhanced aneurysm formation with myeloid cell infiltration and increased oxidative stress in the vessel wall. Using lineage-restricted transgenic mice, we show that loss of a single Nf1 allele in myeloid cells is sufficient to recapitulate the Nf1(+/-) aneurysm phenotype in vivo. Finally, oral administration of simvastatin or the antioxidant apocynin reduced aneurysm formation in Nf1(+/-) mice.
    Conclusion: These data provide genetic and pharmacological evidence that Nf1(+/-) myeloid cells are the cellular triggers for aneurysm formation in a novel model of NF1 vasculopathy and provide a potential therapeutic target.
    MeSH term(s) Aneurysm/drug therapy ; Aneurysm/genetics ; Aneurysm/metabolism ; Animals ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Myeloid Cells/metabolism ; Neurofibromin 1/deficiency ; Neurofibromin 1/genetics ; Simvastatin/therapeutic use
    Chemical Substances Neurofibromin 1 ; Simvastatin (AGG2FN16EV)
    Language English
    Publishing date 2013-12-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.113.006320
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