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Article ; Online: Outcomes of kidney injury including dialysis and kidney transplantation in pediatric oncology and hematopoietic cell transplant patients.

Wu, Natalie L / Hingorani, Sangeeta

2021 Volume 36, Issue 9, Page(s) 2675–2686

Abstract: Pediatric oncology and hematopoietic cell transplant (HCT) patients are susceptible to both acute kidney injury (AKI) and chronic kidney disease (CKD). The etiologies of AKI vary but include tumor infiltration, radiation, drug-induced toxicity, and fluid ...

Abstract	Pediatric oncology and hematopoietic cell transplant (HCT) patients are susceptible to both acute kidney injury (AKI) and chronic kidney disease (CKD). The etiologies of AKI vary but include tumor infiltration, radiation, drug-induced toxicity, and fluid and electrolyte abnormalities including tumor lysis syndrome. HCT patients can also have additional complications such as sinusoidal obstructive syndrome, graft-versus-host disease, or thrombotic microangiopathy. For patients with severe AKI requiring dialysis, multiple modalities can be used successfully, although continuous kidney replacement therapy (CKRT) is often the principal modality for critically ill patients. While increasing numbers of pediatric cancer and HCT patients are now surviving long term, they remain at risk for a number of chronic medical conditions, including CKD. Certain high-risk patients, due to underlying risk factors or treatment-related complications, eventually develop kidney failure and may require kidney replacement therapies. Management of co-morbidities and complications associated with kidney failure, including use of erythropoietin for anemia and potential need for ongoing cancer-related treatment while on dialysis, is an additional consideration in this patient population. Kidney transplantation can be successfully performed in pediatric cancer survivors, although additional features such as specific cancer diagnosis and duration of remission should be considered.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Child ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Kidney Transplantation ; Neoplasms/complications ; Neoplasms/therapy ; Renal Dialysis ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/therapy ; Risk Factors
Language	English
Publishing date	2021-01-07
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-020-04842-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Food Insecurity and Kidney Disease: Symptoms of Structural Racism.

Mokiao, Reya / Hingorani, Sangeeta

Clinical journal of the American Society of Nephrology : CJASN

2021 Volume 16, Issue 12, Page(s) 1903–1905

MeSH term(s)	Humans ; Systemic Racism ; Socioeconomic Factors ; Racism ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/therapy ; Food Insecurity
Language	English
Publishing date	2021-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.07860621
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Article ; Online: More than Creatinine but Less than Perfect: Challenges of Estimated Kidney Function in HCT Patients.

Whelan, Russell / Hingorani, Sangeeta

Transplantation and cellular therapy

2021 Volume 27, Issue 5, Page(s) 355–356

MeSH term(s)	Creatinine ; Glomerular Filtration Rate ; Humans ; Kidney
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-05-06
Document type	Journal Article ; Comment
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2021.04.005
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Article ; Online: Renal Complications of Hematopoietic-Cell Transplantation.

Hingorani, Sangeeta

The New England journal of medicine

2016 Volume 374, Issue 23, Page(s) 2256–2267

MeSH term(s)	Acute Kidney Injury/classification ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Kidney Diseases/etiology ; Kidney Diseases/therapy ; Nephrotic Syndrome/etiology ; Risk Factors ; Thrombotic Microangiopathies/etiology
Language	English
Publishing date	2016-06-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMra1404711
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Article ; Online: Fluid: Too Much or Too Little-Transplant Mortality May Hang in the Balance.

Hingorani, Sangeeta R

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2017 Volume 23, Issue 12, Page(s) 2020–2022

MeSH term(s)	Fluid Therapy ; Hematopoietic Stem Cell Transplantation ; Transplants
Language	English
Publishing date	2017-10-20
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2017.10.032
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Zs.A 5082: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 462: Show issues

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Article ; Online: Randomized controlled trial of remote ischemic preconditioning in children having cardiac surgery.

Law, Yuk M / Hsu, Christine / Hingorani, Sangeeta R / Richards, Michael / McMullan, David M / Jefferies, Howard / Himmelfarb, Jonathan / Katz, Ronit

Journal of cardiothoracic surgery

2024 Volume 19, Issue 1, Page(s) 5

Abstract: Background: Children undergoing cardiac surgery are at risk for acute kidney injury (AKI) and cardiac dysfunction. Opportunity exists in protecting end organ function with remote ischemic preconditioning. We hypothesize this intervention lessens kidney ... ...

Abstract	Background: Children undergoing cardiac surgery are at risk for acute kidney injury (AKI) and cardiac dysfunction. Opportunity exists in protecting end organ function with remote ischemic preconditioning. We hypothesize this intervention lessens kidney and myocardial injury. Methods: We conducted a randomized, double blind, placebo controlled trial of remote ischemic preconditioning in children undergoing cardiac surgery. Pre-specified end points are change in creatinine, estimated glomerular filtration rate, development of AKI, B-type natriuretic peptide and troponin I at 6, 12, 24, 48, 72 h post separation from bypass. Results: There were 45 in the treatment and 39 patients in the control group, median age of 3.5 and 3.8 years, respectively. There were no differences between groups in creatinine, cystatin C, eGFR at each time point. There was a trend for a larger rate of decrease, especially for cystatin C (p = 0.042) in the treatment group but the magnitude was small. AKI was observed in 21 (54%) of control and 16 (36%) of treatment group (p = 0.094). Adjusting for baseline creatinine, the odds ratio for AKI in treatment versus control was 0.31 (p = 0.037); adjusting for clinical characteristics, the odds ratio was 0.34 (p = 0.056). There were no differences in natriuretic peptide or troponin levels between groups. All secondary end points of clinical outcomes were not different. Conclusions: There is suggestion of RIPC delivering some kidney protection in an at-risk pediatric population. Larger, higher risk population studies will be required to determine its efficacy. Trial registration and date: Clinicaltrials.gov NCT01260259; 2021.
MeSH term(s)	Humans ; Child ; Child, Preschool ; Cystatin C ; Creatinine ; Cardiac Surgical Procedures/adverse effects ; Ischemic Preconditioning ; Acute Kidney Injury/etiology ; Acute Kidney Injury/prevention & control ; Ischemic Preconditioning, Myocardial
Chemical Substances	Cystatin C ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02450-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prematurity and future kidney health: the growing risk of chronic kidney disease.

Starr, Michelle C / Hingorani, Sangeeta R

Current opinion in pediatrics

2018 Volume 30, Issue 2, Page(s) 228–235

Abstract: Purpose of review: The purpose of this review is to describe the role prematurity plays in the development of chronic kidney disease (CKD) and to discuss potential reasons for this association including decreased nephron mass, as well as postnatal ... ...

Abstract	Purpose of review: The purpose of this review is to describe the role prematurity plays in the development of chronic kidney disease (CKD) and to discuss potential reasons for this association including decreased nephron mass, as well as postnatal insults such as neonatal acute kidney injury (nAKI). Recent findings: New observational studies in humans and experimental studies in animal models have strengthened the association between prematurity, low birth weight and CKD. Growing evidence suggests increased susceptibility to CKD is caused by decreased nephron mass at birth. Beginning with a low nephron count may cause only subtle abnormalities during childhood, however may result in CKD, hypertension and albuminuria in adolescence or adulthood. Recent studies in premature infants reveal a high incidence of nAKI, which may also contribute to ongoing CKD risk. Summary: Children born at low birth weights (both due to prematurity and/or intrauterine growth restriction) show increased risk of kidney dysfunction during adulthood. A better understanding of the modulators of nephron mass in premature infants as well as the effects of the extrauterine environment is essential. Additionally, improved awareness of at-risk infants is important as is early evaluation and detection of kidney dysfunction, allowing interventions to slow the progression to CKD.
MeSH term(s)	Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/etiology ; Infant, Premature, Diseases/therapy ; Nephrons/growth & development ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/therapy ; Risk Factors
Language	English
Publishing date	2018-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0000000000000607
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Zs.A 3049: Show issues

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Article ; Online: Food insecurity during COVID-19 in children with end-stage kidney disease: a pilot study.

Chan, Melvin / Mokiao, Reya / Wilson, Amy C / Pottanat, Neha / Hingorani, Sangeeta / Starr, Michelle C

BMC pediatrics

2022 Volume 22, Issue 1, Page(s) 420

Abstract: Background: Food insecurity, an important social determinant of health among children, has become more common during the COVID-19 pandemic. Children with chronic diseases including end-stage kidney disease (ESKD) are at higher risk of food insecurity ... ...

Abstract	Background: Food insecurity, an important social determinant of health among children, has become more common during the COVID-19 pandemic. Children with chronic diseases including end-stage kidney disease (ESKD) are at higher risk of food insecurity due to their complex care needs, medication burden, and dietary restrictions. No data exists describing food insecurity prevalence in pediatric ESKD patients during the COVID-19 pandemic. Methods: Food insecurity was assessed among families of children (age 0-18 years) with ESKD on chronic dialysis at two pediatric academic medical centers. Families were screened in April 2020 using the Hunger Vital Sign, a validated 2-question screening tool. We assessed impact of COVID-19 on food insecurity. We compared serum phosphorus "pre-COVID" (January/February 2020) to "during COVID" (April/May 2020). Results: A total of 29 families enrolled in this study. 62% (18/29) of children with ESKD lived in food insecure households, and of those, 72% (13/18) reported that COVID-19 had worsened their food insecurity status. During the COVID-19 pandemic, food insecure patients experienced greater rise in their serum phosphorus levels (1.1 mg/dL vs. 0 mg/dL, p = 0.03) and decreased likelihood of having adequate phosphorus control (50% vs. 11%, p = 0.03). Conclusion: Food insecurity was common among children with ESKD on chronic dialysis during the COVID-19 pandemic. Children with food insecurity had a greater increase in their phosphorus levels during the pandemic than did food secure children. Further exploration into how food resources such as an onsite food pantry impacts food insecurity and phosphorus control in children with ESKD is essential.
MeSH term(s)	Adolescent ; COVID-19/epidemiology ; Child ; Child, Preschool ; Food Insecurity ; Food Supply ; Humans ; Infant ; Infant, Newborn ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Pandemics ; Phosphorus ; Pilot Projects
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03472-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Food Insecurity During COVID-19 in Children with End-Stage Kidney Disease: A Pilot Study.

Chan, Melvin / Mokiao, Reya / Wilson, Amy C / Pottanat, Neha / Hingorani, Sangeeta / Starr, Michelle

Research square

2022

Abstract: Background Food insecurity, an important social determinant of health among children, has become more common during the COVID-19 pandemic. Children with chronic diseases including end-stage kidney disease (ESKD) are at higher risk of food insecurity due ... ...

Abstract	Background Food insecurity, an important social determinant of health among children, has become more common during the COVID-19 pandemic. Children with chronic diseases including end-stage kidney disease (ESKD) are at higher risk of food insecurity due to their complex care needs, medication burden, and dietary restrictions. No data exists describing food insecurity prevalence in pediatric ESKD patients during the COVID-19 pandemic. Methods Food insecurity was assessed among families of children (age 0-18 years) with ESKD on chronic dialysis at two pediatric academic medical centers. Families were screened in April 2020 using the Hunger Vital Sign, a validated 2-question screening tool. We assessed impact of COVID-19 on food insecurity. We compared serum phosphorus "pre-COVID" (January/February 2020) to "during COVID" (April/May 2020). Results A total of 29 families enrolled in this study. 62% (18/29) of children with ESKD lived in food insecure households, and of those, 72% (13/18) reported that COVID-19 had worsened their food insecurity status. During the COVID-19 pandemic, food insecure patients experienced greater rise in their serum phosphorus levels (
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-910466/v1
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Article ; Online: Incidence and Risk Factors of Transplantation-Associated Thrombotic Microangiopathy: A Systematic Review and Meta-Analysis.

Van Benschoten, Victoria / Roy, Cayla / Gupta, Rohit / Ouellette, Lara / Hingorani, Sangeeta / Li, Ang

Transplantation and cellular therapy

2022 Volume 28, Issue 5, Page(s) 266.e1–266.e8

Abstract: Transplantation-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized post-transplantation complication, yet the overall incidence of the disease remains under debate. To determine the pooled incidence of TA-TMA in a systematic ... ...

Abstract	Transplantation-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized post-transplantation complication, yet the overall incidence of the disease remains under debate. To determine the pooled incidence of TA-TMA in a systematic review of literature and to identify consistent risk factors. We performed a systematic review using the MEDLINE, Embase, and CENTRAL databases to identify cohort studies that reported incidence of and risk factors for TA-TMA from 2004 to 2020. We conducted a meta-analysis of proportion to estimate the pooled incidence of TA-TMA using a random-effects model. We assessed moderators of heterogeneity through subgroup analysis, risk of bias through ROBINS-I, and publication bias through funnel plot. Among 21 cohort studies with a total of 36,163 adult and pediatric patients who underwent allogeneic transplantation, the pooled incidence of TA-TMA was 12% (95% confidence interval, 9% to 16%). The diagnostic criteria used to define the disease was the most significant contributor identified to the high interstudy heterogeneity (I
MeSH term(s)	Adult ; Child ; Graft vs Host Disease/epidemiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Incidence ; Risk Factors ; Thrombotic Microangiopathies/epidemiology
Language	English
Publishing date	2022-01-15
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2022.01.009
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