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  1. Article ; Online: Concomitant Transcatheter Tricuspid Annuloplasty and Edge-to-Edge Repair in Torrential Tricuspid Regurgitation.

    Sánchez-Recalde, Ángel / Salido-Tahoces, Luisa / García-Martín, Ana / Carrión-Sánchez, Irene / González-Gomez, Ariana / Pardo-Sanz, Ana / García-Sebastian, Cristina / Hinojar-Baydes, Rocío / Fernández-Golfín, Covadonga / Zamorano, José L

    JACC. Cardiovascular interventions

    2023  Volume 17, Issue 1, Page(s) 99–100

    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Cardiac Catheterization
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.10.066
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    Zs.A 6669: Show issues Location:
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  2. Article ; Online: Tricuspid Annulus Reduction Mechanism After Transcatheter Annuloplasty and its Impact on Right Ventricular Remodeling.

    Sánchez-Recalde, Ángel / Pardo-Sanz, Ana / Hinojar-Baydes, Rocío / Salido-Tahoces, Luisa / García-Sebastian, Cristina / González-Gomez, Ariana / García-Martín, Ana / Fernández-Golfín, Covadonga / Zamorano, José Luis

    JACC. Cardiovascular interventions

    2023  Volume 17, Issue 1, Page(s) 108–110

    MeSH term(s) Humans ; Ventricular Remodeling ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Cardiac Valve Annuloplasty/adverse effects
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.10.067
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  3. Article ; Online: Long-term right heart remodeling after transcatheter tricuspid annuloplasty assessed by cardiac tomography.

    Pardo-Sanz, Ana / Zamorano, José L / Hinojar-Baydes, Rocío / Salido-Tahoces, Luisa / García-Sebastián, Cristina / González-Gomez, Ariana / García-Martín, Ana / Fernández-Golfín, Covadonga / Sánchez-Recalde, Ángel

    Journal of cardiovascular computed tomography

    2023  Volume 18, Issue 2, Page(s) 215–216

    MeSH term(s) Humans ; Predictive Value of Tests ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Mitral Valve/surgery ; Tomography ; Treatment Outcome ; Heart Valve Prosthesis Implantation/adverse effects
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Letter
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2023.12.004
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  4. Article ; Online: Prognostic value of diastolic function parameters in significant aortic regurgitation: the role of the left atrial strain.

    García Martín, Ana / Abellás Sequeiros, María / González Gómez, Ariana González / Rincón Díaz, Luis Miguel / Monteagudo Ruiz, Juan Manuel / Hinojar Baydés, Rocío / Moya Mur, Jose Luis / Zamorano, José Luis / Fernández-Golfín, Covadonga

    Journal of echocardiography

    2022  Volume 20, Issue 4, Page(s) 216–223

    Abstract: Background: The management of patients with asymptomatic significant aortic regurgitation (sAR) is often challenging and appropriate timing of aortic valve surgery remains controversial. Prognostic value of diastolic parameters has been demonstrated in ... ...

    Abstract Background: The management of patients with asymptomatic significant aortic regurgitation (sAR) is often challenging and appropriate timing of aortic valve surgery remains controversial. Prognostic value of diastolic parameters has been demonstrated in several cardiac diseases. The aim of this study was to analyze the prognostic significance of the diastolic function evaluated by echocardiography, in asymptomatic patients with sAR.
    Methods: A total of 126 patients with asymptomatic sAR evaluated in the Heart Valve Clinic were retrospective included. Conventional echocardiographic systolic and diastolic function parameters were assessed. Left atrial (LA) auto-strain analysis was performed in a sub-group of 57 patients. A combined end-point of hospital admission due to heart failure, cardiovascular mortality, or aortic valve surgery was defined.
    Results: During a median follow-up of 34.1 (interquartile range 16.5-48.1) months, 25 (19.8%) patients reached the combined end-point. Univariate analysis showed that LV volumes, LV ejection fraction (LVEF), LV-GLS, E wave, E/e' ratio, LA volume and LA reservoir strain (LASr) were significant predictors of events. Multivariate analysis that tested all classical echocardiographic variables statistically significant in the univariate model showed that LVEDV (HR = 1.02; 95% CI 1.01-1.03; p < 0.001) and E/e' ratio (HR = 1.12; 95% CI 1.03-123; p = 0.01) were significant predictors of events. Kaplan-Meier curve, stratified by median value of LASr, showed that lower LASr values (less than median of 34%) were associated with higher rates of events (p = 0.013).
    Conclusion: In this population of asymptomatic patients with sAR and normal LV systolic function, baseline diastolic parameters were prognostic markers of cardiovascular events; among them, LASr played a significant predictor role.
    MeSH term(s) Humans ; Aortic Valve Insufficiency/diagnostic imaging ; Prognosis ; Retrospective Studies ; Ventricular Dysfunction, Left/diagnostic imaging ; Diastole ; Ventricular Function, Left ; Stroke Volume
    Language English
    Publishing date 2022-05-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-022-00577-6
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  5. Article ; Online: Prognostic implications of cardiac magnetic resonance feature tracking derived multidirectional strain in patients with chronic aortic regurgitation.

    Fernández-Golfín, Covadonga / Hinojar-Baydes, Rocío / González-Gómez, Ariana / Monteagudo, Juan Manuel / Esteban, Amparo / Alonso-Salinas, Gonzalo / Fernández, Maria Angeles / García-Martín, Ana / Santoro, Ciro / Pascual-Izco, Marina / Jiménez-Nacher, Jose Julio / Zamorano, Jose Luis

    European radiology

    2021  Volume 31, Issue 7, Page(s) 5106–5115

    Abstract: Objective: Speckle-tracking echocardiography (STE) deformation parameters detect latent LV dysfunction in chronic aortic regurgitation (AR) and are associated with outcomes. The aim of the study was to evaluate cardiac magnetic resonance (CMR) feature ... ...

    Abstract Objective: Speckle-tracking echocardiography (STE) deformation parameters detect latent LV dysfunction in chronic aortic regurgitation (AR) and are associated with outcomes. The aim of the study was to evaluate cardiac magnetic resonance (CMR) feature tracking (FT) deformation parameters in asymptomatic patients with AR and implications in outcomes.
    Methods: Fifty-five patients with AR and 54 controls were included. Conventional functional CMR parameters, aortic regurgitant volume, and fraction were assessed. CMR-FT analysis was performed with a dedicated software. Clinical data was obtained from hospital records. A combined endpoint included all-cause mortality, cardiovascular mortality, aortic valve surgery, or cardiovascular hospital admission due to heart failure.
    Results: Left ventricular (LV) mechanics is impaired in patients with significant AR. Significant differences were noted in global longitudinal strain (GLS) between controls and AR patients (- 19.1 ± 2.9% vs - 16.5 ± 3.2%, p < 0.001) and among AR severity groups (- 18.3 ± 3.1% vs - 16.2 ± 1.6% vs - 15 ± 3.5%; p = 0.02 for AR grades I-II, III, and IV). In univariate and multivariate analyses, circumferential strain (GCS) and global radial strain (GRS) but not GLS were associated with and increased risk of the end point with a HR of 1.26 (p = 0.016, 1.04-1.52) per 1% worsening for GCS and 0.90 (p = 0.012, 0.83-0.98) per 1% worsening for GRS.
    Conclusions: CMR-FT myocardial deformation parameters are impaired in patients with AR not meeting surgical criteria. GLS decreases early in the course of the disease and is a marker of AR severity while GCS and GRS worsen later but predict a bad prognosis, mainly the need of aortic valve surgery.
    Key points: • CMR feature tracking LV mechanic parameters may be reduced in significant chronic AR with normal EF. • LV mechanics, mainly global longitudinal strain, worsens as AR severity increases. • LV mechanics, specially global radial and circumferential strain, is associated with a worse prognosis in AR patients.
    MeSH term(s) Aortic Valve Insufficiency/diagnostic imaging ; Echocardiography ; Humans ; Magnetic Resonance Imaging, Cine ; Magnetic Resonance Spectroscopy ; Predictive Value of Tests ; Prognosis ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Function, Left
    Language English
    Publishing date 2021-01-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-07651-6
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  6. Article ; Online: Alcohol Ablation in Hypertrophic Cardiomyopathy: Localization and Quantification of Target Septal Artery-dependent Myocardium With 3-Dimensional Echocardiography.

    Moya-Mur, José Luis / Mestre-Barcelo, José Luis / Salido-Tahoces, Luisa / Hinojar-Baydes, Rocío / Hernández-Antolín, Rosana / Zamorano-Gómez, José Luis

    Revista espanola de cardiologia (English ed.)

    2015  Volume 68, Issue 6, Page(s) 531–533

    MeSH term(s) Ablation Techniques/methods ; Aged ; Cardiomyopathy, Hypertrophic/surgery ; Echocardiography, Three-Dimensional/methods ; Ethanol/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Solvents/therapeutic use ; Ultrasonography, Interventional/methods
    Chemical Substances Solvents ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2015-06
    Publishing country Spain
    Document type Evaluation Studies ; Letter
    ISSN 1885-5857
    ISSN (online) 1885-5857
    DOI 10.1016/j.rec.2015.01.006
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  7. Article ; Online: High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus.

    Winau, Lea / Hinojar Baydes, Rocio / Braner, Axel / Drott, Ulrich / Burkhardt, Harald / Sangle, Shirish / D'Cruz, David P / Carr-White, Gerry / Marber, Mike / Schnoes, Katrin / Arendt, Christophe / Klingel, Karin / Vogl, Thomas J / Zeiher, Andreas M / Nagel, Eike / Puntmann, Valentina O

    Annals of the rheumatic diseases

    2018  Volume 77, Issue 11, Page(s) 1590–1598

    Abstract: Background: Cardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker ...

    Abstract Background: Cardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic resonance (CMR).
    Methods and results: This is a two-centre (London and Frankfurt) CMR imaging study at 3.0 Tesla of consecutive 92 patients with SLE free of cardiac symptoms, undergoing screening for cardiac involvement. Venous samples were drawn and analysed post-hoc for cardiac biomarkers, including hs-TropT, high-sensitive C reactive protein and N-terminal pro brain natriuretic peptide. Compared with age-matched/gender-matched non-SLE controls (n=78), patients had significantly raised cardiac biomarker levels, native T1 and T2, aortic and ventricular stiffness, and reduced global longitudinal strain (p<0.01). In SLE, hs-TropT was significantly and independently associated with native T2, followed by the models including native T1 and aortic stiffness (Χ
    Conclusions: Patients with SLE have a high prevalence of subclinical myocardial injury as demonstrated by raised high-sensitive troponin levels. CMR with T2 mapping reveals myocardial oedema as the strongest predictor of hs-TropT release, underscoring the inflammatory interstitial remodelling as the main mechanism of injury. Patients without active myocardial inflammation demonstrate diffuse interstitial remodelling and increased vascular stiffness. These findings substantiate the role of CMR in screening of subclinical cardiac involvement.
    Trial registration numer: NCT02407197; Results.
    MeSH term(s) Adult ; Biomarkers/blood ; Biopsy ; Case-Control Studies ; Endocardium/pathology ; Female ; Heart/diagnostic imaging ; Humans ; Lupus Erythematosus, Systemic/complications ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Myocarditis/diagnosis ; Myocarditis/diagnostic imaging ; Myocarditis/etiology ; Myocarditis/pathology ; Troponin T/blood
    Chemical Substances Biomarkers ; Troponin T
    Language English
    Publishing date 2018-08-04
    Publishing country England
    Document type Evaluation Studies ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2018-213661
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  8. Article ; Online: Aortic stiffness and interstitial myocardial fibrosis by native T1 are independently associated with left ventricular remodeling in patients with dilated cardiomyopathy.

    Puntmann, Valentina O / Arroyo Ucar, Eduardo / Hinojar Baydes, Rocio / Ngah, Ning Binti / Kuo, Yen-Shu / Dabir, Darius / Macmillan, Alexandra / Cummins, Ciara / Higgins, David M / Gaddum, Nicholas / Chowienczyk, Phil / Plein, Sven / Carr-White, Gerry / Nagel, Eike

    Hypertension (Dallas, Tex. : 1979)

    2014  Volume 64, Issue 4, Page(s) 762–768

    Abstract: Increased aortic stiffness is related to increased ventricular stiffness and remodeling. Myocardial fibrosis is the pathophysiological hallmark of failing heart. We investigated the relationship between noninvasive imaging markers of myocardial fibrosis, ...

    Abstract Increased aortic stiffness is related to increased ventricular stiffness and remodeling. Myocardial fibrosis is the pathophysiological hallmark of failing heart. We investigated the relationship between noninvasive imaging markers of myocardial fibrosis, native T1, and late gadolinium enhancement, respectively, and aortic stiffness in ventricular remodeling. Consecutive patients with known dilated cardiomyopathy (n=173) underwent assessment of cardiac volumes and function, T1 mapping, scar imaging, and pulse wave velocity, a measure of aortic stiffness. Asymptomatic healthy volunteers served as controls (n=47). Controls and patients showed an increase in pulse wave velocity with age, which was accelerated in the presence of cardiovascular disease. On the contrary, native T1 increased with age in patients, but not in controls. Pulse wave velocity was associated with native T1 in the presence of disease, but not in health. Native T1 showed a strong relationship with markers of structural and functional left ventricular remodeling and diastolic impairment. Ischemic and nonischemic pathophysiology of ventricular remodeling showed a similar slope of relationship between pulse wave velocity and native T1. However, in nonischemic patients, increase in pulse wave velocity was associated with greater increase in native T1. Aortic stiffness is related to age, and this process is accelerated in the presence of disease. On the contrary, increase in interstitial myocardial fibrosis is associated with age in the presence of disease. Patients with ischemic and nonischemic dilated cardiomyopathy have a similar relationship between native T1 and pulse wave velocity, which is stronger in the latter group.
    MeSH term(s) Adult ; Aged ; Blood Pressure ; Cardiomyopathy, Dilated/pathology ; Cardiomyopathy, Dilated/physiopathology ; Female ; Fibrosis ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Myocardium/pathology ; Pulse Wave Analysis ; Vascular Stiffness ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling
    Language English
    Publishing date 2014-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.114.03928
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    Zs.A 1488: Show issues Location:
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  9. Article ; Online: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations.

    López-Fernández, Teresa / Martín García, Ana / Santaballa Beltrán, Ana / Montero Luis, Ángel / García Sanz, Ramón / Mazón Ramos, Pilar / Velasco Del Castillo, Sonia / López de Sá Areses, Esteban / Barreiro-Pérez, Manuel / Hinojar Baydes, Rocío / Pérez de Isla, Leopoldo / Valbuena López, Silvia Cayetana / Dalmau González-Gallarza, Regina / Calvo-Iglesias, Francisco / González Ferrer, Juan José / Castro Fernández, Antonio / González-Caballero, Eva / Mitroi, Cristina / Arenas, Meritxell /
    Virizuela Echaburu, Juan Antonio / Marco Vera, Pascual / Íñiguez Romo, Andrés / Zamorano, José Luis / Plana Gómez, Juan Carlos / López Sendón Henchel, José Luis

    Revista espanola de cardiologia (English ed.)

    2017  Volume 70, Issue 6, Page(s) 474–486

    Abstract: Improvements in early detection and treatment have markedly reduced cancer-related mortality. However survival not only depends on effectively cure cancer, but prevention, diagnosis and treatment of cancer-related complications is also needed. ... ...

    Abstract Improvements in early detection and treatment have markedly reduced cancer-related mortality. However survival not only depends on effectively cure cancer, but prevention, diagnosis and treatment of cancer-related complications is also needed. Cardiovascular toxicity is a widespread problem across many classes of therapeutic schemes, however scientific evidence in the management of cardiovascular complications of onco-hematological patients is scarce, as these patients have been systematically excluded from clinical trials and current recommendations are based on expert consensus. Multidisciplinary teams are mandatory to decrease morbidity and mortality from both cardiotoxicity and cancer itself. An excessive concern for the occurrence of cardiovascular toxicity, can avoid potentially curative therapies, while underestimating this risk, increases long-term mortality of cancer survivors. The objective of this consensus document, developed in collaboration of the Spanish Society of Cardiology, the Spanish Society of Medical Oncology, the Spanish Society of Radiation Oncology and the Spanish Society of Hematology, is to update the necessary concepts and expertise on cardio-onco-hematology that enable its application in daily clinical practice and to promote the development of local multidisciplinary teams, to improve the cardiovascular health of patients with cancer.
    Language Spanish
    Publishing date 2017-06
    Publishing country Spain
    Document type Journal Article
    ISSN 1885-5857
    ISSN (online) 1885-5857
    DOI 10.1016/j.rec.2016.12.041
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