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  1. Article ; Online: Pronounced Olfactory Habituation with Age.

    Hintschich, Constantin A / Ma, Cindy / Hähner, Antje / Hummel, Thomas

    The Laryngoscope

    2024  

    Abstract: Objectives: Olfactory habituation is a transient decrease in olfactory sensitivity caused by prolonged odor exposure, aiding in the discernment of new olfactory stimuli against the background. We explored the impact of subclinical olfactory impairment ... ...

    Abstract Objectives: Olfactory habituation is a transient decrease in olfactory sensitivity caused by prolonged odor exposure, aiding in the discernment of new olfactory stimuli against the background. We explored the impact of subclinical olfactory impairment on odor habituation using age as a proxy.
    Methods: Before the actual experiment, the individual olfactory threshold for the rose-like odorant phenylethyl alcohol (PEA) was assessed separately for the left and right nostril using the "Sniffin' Sticks" test, and ratings for odor intensity and pleasantness were collected. After applying a nasal clip continuously delivering PEA odor to one nostril for 10 min and 2 h, respectively, threshold, intensity, and pleasantness were reassessed immediately after clip removal.
    Results: In the group of 80 participants (younger adults-mean age 27.7 ± 4.5 years; older adults-mean age 61.5 ± 4.7 years), olfactory thresholds were already significantly elevated after just 10 min, and this habituation was even more pronounced after 2 h. This effect could be observed bilaterally even though significantly more distinct on the exposed side. Older participants generally exhibited a more pronounced habituation on the exposed side after 2 h compared to the younger participants.
    Conclusion: The results indicate that older people experience more notable habituation after extended exposure to odors. This is most likely due to the compromised olfactory function in age. Although older and younger subjects scored in the normosmic range when tested with standardized olfactory tests, the stress on the system after exposure to an odor clearly revealed the lower functionality of the aging sense of smell.
    Level of evidence: 3 Laryngoscope, 2024.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31442
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  2. Article ; Online: The psychophysical assessment of gustatory dysfunction in COVID-19.

    Hintschich, Constantin A / Liu, David T / Hummel, Thomas

    Chemical senses

    2023  Volume 48

    MeSH term(s) Humans ; COVID-19 ; Taste Disorders/diagnosis ; Taste Disorders/etiology ; SARS-CoV-2 ; Olfaction Disorders
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 754122-3
    ISSN 1464-3553 ; 0379-864X
    ISSN (online) 1464-3553
    ISSN 0379-864X
    DOI 10.1093/chemse/bjad011
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  3. Article ; Online: Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration.

    Louie, Jonathan D / Barrios-Camacho, Camila M / Bromberg, Benjamin H / Hintschich, Constantin A / Schwob, James E

    iScience

    2024  Volume 27, Issue 5, Page(s) 109600

    Abstract: Horizontal basal cells (HBCs) mediate olfactory epithelium (OE) regeneration following severe tissue injury. The dynamism of the post-injury environment is well illustrated ... ...

    Abstract Horizontal basal cells (HBCs) mediate olfactory epithelium (OE) regeneration following severe tissue injury. The dynamism of the post-injury environment is well illustrated by
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109600
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  4. Article ; Conference proceedings: New diagnoses of head and neck squamous cell carcinoma during the COVID-19 pandemic.

    Hintschich, Constantin / Gerken, Michael / Bohr, Christopher / Künzel, Julian

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767148
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  5. Article ; Conference proceedings: Neudiagnosen der Plattenepithelkarzinome des Kopf-Hals-Bereichs während der COVID-19-Pandemie

    Hintschich, Constantin / Gerken, Michael / Bohr, Christopher / Künzel, Julian

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766551
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  6. Article: Topical Administration of Mometasone Is Not Helpful in Post-COVID-19 Olfactory Dysfunction.

    Hintschich, Constantin A / Dietz, Melanie / Haehner, Antje / Hummel, Thomas

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 10

    Abstract: Persistent olfactory dysfunction is a major concern post-COVID-19, affecting up to 5% of all patients. Different therapeutic options, including mometasone nasal spray, have been recommended, only some of which have been validated for post-COVID-19 ... ...

    Abstract Persistent olfactory dysfunction is a major concern post-COVID-19, affecting up to 5% of all patients. Different therapeutic options, including mometasone nasal spray, have been recommended, only some of which have been validated for post-COVID-19 olfactory dysfunction. In this study we psychophysically assessed the effect of intranasally applied mometasone furoate on the recovery of olfaction. The spray was applied with a long applicator so that the olfactory cleft could be reached effectively. After olfactory dysfunction had been confirmed psychophysically using Sniffin' Sticks, patients were randomly assigned to two different treatment arms: the study group (
    Language English
    Publishing date 2022-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12101483
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  7. Article ; Online: Primary Diagnoses of Squamous Cell Carcinoma of the Head and Neck During the COVID-19 Pandemic.

    Hintschich, Constantin A / Gerken, Michael / Spoerl, Steffen / Bohr, Christopher / Künzel, Julian

    Deutsches Arzteblatt international

    2023  Volume 120, Issue 42, Page(s) 719–720

    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Pandemics ; COVID-19 ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/therapy ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/therapy
    Language English
    Publishing date 2023-11-16
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2023.0177
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  8. Article ; Online: Presurgical olfactory function as an indicator of the outcome of functional endoscopic sinus surgery in chronic rhinosinusitis with nasal polyps.

    Hintschich, Constantin A / Pade, Jürgen / Petridis, Petros / Hummel, Thomas

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 12, Page(s) 5727–5733

    Abstract: Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) often leads to impaired olfactory function and reduced quality of life. When conservative treatments such as nasal irrigation and topical steroids fail, functional endoscopic sinus surgery ( ...

    Abstract Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) often leads to impaired olfactory function and reduced quality of life. When conservative treatments such as nasal irrigation and topical steroids fail, functional endoscopic sinus surgery (FESS) is often necessary, because it improves symptoms and enhances quality of life.
    Materials and methods: A total of 88 patients was included in this prospective study. All subjects underwent an extensive examination both presurgically and 4 months after operations including nasal endoscopy and psychophysical olfactory testing (Sniffin' Sticks). Moreover, disease-specific quality of life was assessed and presurgical CT scans were rated regarding the opacification of the paranasal sinuses.
    Results: Presurgically psychophysical tests showed an overall olfactory dysfunction. Olfactory test results (TDI score) correlated with endoscopic (Lund-Kennedy and Lildtholdt score) and CT scores (Lund-Mackay and TOCS scores). Four months after surgery olfactory function was enhanced and quality of life significantly showed an overall improvement. However, the outcome was dependent on the extent of presurgical olfactory function: olfaction and quality of life improved most pronounced in anosmics compared to hyposmic and especially normosmic patients.
    Conclusions: This study confirmed that FESS in CRSwNP leads to a significant improvement of both olfaction and disease-specific quality of life. Moreover, preoperative psychophysical assessment of the extent of olfactory dysfunction can help to objectively assess possible risks and expected benefits of the surgery in terms of olfaction and quality of life.
    MeSH term(s) Humans ; Nasal Polyps/complications ; Nasal Polyps/surgery ; Rhinitis/complications ; Rhinitis/surgery ; Prospective Studies ; Quality of Life ; Sinusitis/complications ; Sinusitis/diagnostic imaging ; Sinusitis/surgery ; Endoscopy/methods ; Chronic Disease ; Smell ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Olfaction Disorders/surgery
    Language English
    Publishing date 2022-06-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07496-3
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  9. Article ; Online: Effect of hypoglossal nerve stimulation on snoring: an evaluation using objective acoustic parameters.

    Fischer, René / Vielsmeier, Veronika / Kuehnel, Thomas S / Bohr, Christopher / Hintschich, Constantin A / Spoerl, Steffen / Rohrmeier, Christian

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  Volume 20, Issue 3, Page(s) 363–370

    Abstract: Study objectives: Hypoglossal nerve stimulation is an established therapy for sleep apnea syndrome. Whether or not this therapy on snoring and nighttime noise exposure is effective and how strong this effect may be has not been objectively investigated ... ...

    Abstract Study objectives: Hypoglossal nerve stimulation is an established therapy for sleep apnea syndrome. Whether or not this therapy on snoring and nighttime noise exposure is effective and how strong this effect may be has not been objectively investigated thus far and was the aim of this study.
    Methods: In 15 participants (14 males; age: 30-72 years; mean: 51.7 years), polysomnography and acoustic measurements were performed before and after hypoglossal nerve stimulation.
    Results: The therapy led to a significant improvement in sleep apnea (apnea-hypopnea index from 35.8 events/h to 11.2 events/h,
    Conclusions: This study was able to show for the first time by means of objective acoustic and psychoacoustic parameters that hypoglossal nerve stimulation can not only cause a significant improvement in sleep apnea but also has a positive effect on snoring and thus noise annoyance experienced by the bed partner.
    Clinical trial registration: Registry: German Clinical Trials Register; Name: Effect of Hypoglossal Nerve Stimulation on Snoring: An Evaluation Using Objective Acoustic Parameters; URL: https://drks.de/search/de/trial/DRKS00032354; Identifier: DRKS00032354.
    Citation: Fischer R, Vielsmeier V, Kuehnel TS, et al. Effect of hypoglossal nerve stimulation on snoring: an evaluation using objective acoustic parameters.
    MeSH term(s) Adult ; Aged ; Humans ; Male ; Middle Aged ; Acoustics ; Hypoglossal Nerve/physiology ; Polysomnography ; Sleep Apnea Syndromes ; Snoring/therapy ; Female
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10868
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  10. Article ; Online: The taste of the pandemic-contemporary review on the current state of research on gustation in coronavirus disease 2019 (COVID-19).

    Hintschich, Constantin A / Niv, Masha Y / Hummel, Thomas

    International forum of allergy & rhinology

    2021  Volume 12, Issue 2, Page(s) 210–216

    Abstract: Subjectively perceived impairment of taste is a common and distinct symptom of coronavirus disease 2019 (COVID-19). Large meta-analyses identified this symptom in approximately 50% of cases. However, this high prevalence is not supported by blinded and ... ...

    Abstract Subjectively perceived impairment of taste is a common and distinct symptom of coronavirus disease 2019 (COVID-19). Large meta-analyses identified this symptom in approximately 50% of cases. However, this high prevalence is not supported by blinded and validated psychophysical gustatory testing, which showed a much lower prevalence in up to 26% of patients. This discrepancy may be due to misinterpretation of impaired retronasal olfaction as gustatory dysfunction. In addition, we hypothesized that COVID-19-associated hyposmia is involved in the decrease of gustatory function, as found for hyposmia of different origin. This indirect mechanism would be based on the central-nervous mutual amplification between the chemical senses, which fails in COVID-19-associated olfactory loss. However, further research is necessary on how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) may directly impair the gustatory pathway as well as its subjective perception.
    MeSH term(s) COVID-19 ; Humans ; Olfaction Disorders/epidemiology ; Pandemics ; SARS-CoV-2 ; Smell ; Taste
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22902
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