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Article ; Online: Independent verification of circulating miRNA as diagnostic biomarkers for urothelial carcinoma.

Urabe, Fumihiko / Matsuzaki, Juntaro / Takeshita, Fumitaka / Kishida, Takeshi / Ochiya, Takahiro / Hirai, Kotaro

2022 Volume 113, Issue 10, Page(s) 3510–3517

Abstract: Urothelial carcinoma (UC) is an umbrella term for bladder cancers (BCa) and upper-tract urothelial carcinoma (UTUC), with BCa and UTUC sometimes detected concomitantly. The methods of detection for UC are often inaccurate or highly invasive, and, ... ...

Abstract	Urothelial carcinoma (UC) is an umbrella term for bladder cancers (BCa) and upper-tract urothelial carcinoma (UTUC), with BCa and UTUC sometimes detected concomitantly. The methods of detection for UC are often inaccurate or highly invasive, and, therefore, are thought to be unsatisfactory. Previously, we reported seven serum miRNAs as diagnostic markers for BCa. Here, we re-evaluated potential diagnostic miRNAs in different institutions. We prospectively analyzed serum samples obtained from 126 UC patients (BCa: 106 samples; UTUC: 14 samples; UTUC with BCa: six samples) and 50 noncancer controls by microarray analysis. We randomly assigned these samples into a training or a validation set. Biomarker candidate miRNAs were selected based on cross-validation scores in the training set of samples, with diagnostic power confirmed in the validation set. Among the diagnostic miRNAs identified in this way, miR-1343-5p and miR-6087 had been identified as potential diagnostic miRNAs in our previous study. In addition, we evaluated the association between the serum levels of identified miRNAs and the presence of UC risk conditions. The expression levels of several miRNAs correlate with the risk factors in participants without UC, which may be explained by the presence of a microscopic tumor or a precancerous lesion. In conclusion, we identified two robust miRNA diagnostic markers for UC detection. Further functional analysis is required to elucidate the mechanism by which alterations in the expression of these miRNAs occur.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/genetics ; Carcinoma, Transitional Cell/metabolism ; Circulating MicroRNA ; Humans ; MicroRNAs/genetics ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics
Chemical Substances	Biomarkers, Tumor ; Circulating MicroRNA ; MicroRNAs
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15496
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pyoderma Gangrenosum after Breast Cancer Resection: A Less-invasive and Early Treatment Using the Skin around Ulcers.

Hirai, Kotaro / Tsuge, Itaru / Usui, Shunya / Takada, Masahiro / Yamanaka, Hiroki / Katsube, Motoki / Sakamoto, Michiharu / Morimoto, Naoki

Plastic and reconstructive surgery. Global open

2022 Volume 10, Issue 2, Page(s) e4111

Abstract: Surgical invasion is a risk factor of pyoderma gangrenosum (PG). A total of 25% of postoperative PG cases were reported to occur after breast surgeries, including bilateral breast reduction and breast reconstruction following cancer resection. ... ...

Abstract	Surgical invasion is a risk factor of pyoderma gangrenosum (PG). A total of 25% of postoperative PG cases were reported to occur after breast surgeries, including bilateral breast reduction and breast reconstruction following cancer resection. Immunosuppressive therapy and less-invasive wound therapy are necessary; however, the complete healing of ulcers takes 5.1 months on average. We herein report a case of skin grafting under a surgical concept of less-invasive and short-term treatment. An 82-year-old woman complained of a high fever and severe pain at her breast wounds after bilateral breast cancer resection. Although we performed emergency debridement surgery to remove the necrotic tissue, suspecting surgical site infection and inflammation, her high fever persisted. She was diagnosed with PG because of the physical findings of characteristic painful, sterile ulcerations, bullae and pustules, and the pathological abundance of neutrophils in the absence of infection and vasculitis. Oral administration of prednisolone 30 mg/day improved the symptoms, and we applied negative-pressure wound therapy (NPWT) from day 16 following debridement surgery. After the gradual reduction of oral steroid intake to 12.5 mg/day, we performed skin grafting surgery. To limit the surgical invasion, we used the surplus skin around the ulcers. Split-thickness mesh skin grafts were fixed by NPWT to avoid the use of tie-over sutures. We achieved short-term treatment of PG with a less-invasive surgical strategy using skin around the ulcers and NPWT.
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000004111
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Article: [An Intravesical Foreign Body after Caesarean Section and Tissue Fixing System (TFS) Operation : Two Case Reports].

Mori, Kohei / Yanagisawa, Masahiro / Hirai, Kotaro

Hinyokika kiyo. Acta urologica Japonica

2016 Volume 62, Issue 10, Page(s) 549–552

Abstract: Foreign body in the bladder is a relatively rare case. We encountered two cases of foreign bodies in the bladder after gynecological surgery. Case 1 was a 72-year-old woman. When she was 70 years old,an operation for her pelvic organ prolapse was ... ...

Abstract	Foreign body in the bladder is a relatively rare case. We encountered two cases of foreign bodies in the bladder after gynecological surgery. Case 1 was a 72-year-old woman. When she was 70 years old,an operation for her pelvic organ prolapse was performed. She visited our hospital because of discomfort in urination. We performed a transurethral lithotripsy of the bladder stone and detected a foreign body,and it was an anchor used for the Tissue Fixation System(TFS)operation (a pelvic organ prolapse operation). Case 2 was a 34-year-old woman. She delivered a baby by Caesarean section when she was 30 years old. She visited our hospital because of recurring urinary tract infection. The ultrasound examination of the bladder showed high echoic area in the posterior bladder wall. The cystoscope examination showed a small black foreign body that was protruding from the posterior wall of the bladder. The foreign body in the bladder was a surgical suture. The component of the suture was similar to silk. The foreign body in the bladder may have been the cause of infection. Artificial material used for an operation of an organ in the pelvic area sometimes slips into the bladder and causes inflammation. If a patient had undergone an operation for an organ in the pelvic area in the past,and there is recurring urinary tract infection,the presence of a foreign body in the bladder should be suspected.
MeSH term(s)	Adult ; Aged ; Cesarean Section ; Female ; Foreign Bodies/surgery ; Humans ; Recurrence ; Urinary Tract Infections ; Urination
Language	Japanese
Publishing date	2016-10
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604331-8
ISSN	0018-1994
ISSN	0018-1994
DOI	10.14989/ActaUrolJap_62_10_549
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Article ; Online: Case report: retroperitoneal aspergilloma in a patient with rheumatoid arthritis presenting as malignant tumor.

Shinoki, Risa / Takeshima, Teppei / Horie, Koichiro / Matsui, Toshihiro / Horita, Ayako / Saito, Ikuo / Hirai, Kotaro

BMC urology

2018 Volume 18, Issue 1, Page(s) 67

Abstract: Background: Aspergillosis in patients with impaired immunity usually presents with invasive pulmonary infection and dissemination to a variety of organs via hematogenous spread. Aspergilloma in the retroperitoneal cavity is a rare disease with only a ... ...

Abstract	Background: Aspergillosis in patients with impaired immunity usually presents with invasive pulmonary infection and dissemination to a variety of organs via hematogenous spread. Aspergilloma in the retroperitoneal cavity is a rare disease with only a few cases reported in the literature. To the best of our knowledge, the present case of a retroperitoneal aspergilloma with no surgical history is only the second report in the literature. Case presentation: A 65 year-old man, who had been receiving immunosuppressive treatment for rheumatoid arthritis with vasculitis for 9 years, was referred to the Urology Department with a retroperitoneal mass. This was confirmed by computed tomography performed during treatment for pulmonary aspergilloma. Because it was not possible to rule out malignant disease (e.g., liposarcoma), surgical exploration was performed. Pathological examination revealed aspergillus hyphae with fat necrosis, and retroperitoneal aspergilloma was diagnosed and appropriately treated. The tumor did not recur subsequently. Conclusion: Our present case emphasizes that pharmacological treatments for aspergilloma in the retroperitoneal cavity have poor drug transitivity, so the relative effectiveness of pharmacological response is not useful for differentiating retroperitoneal aspergilloma from malignant disease.
MeSH term(s)	Aged ; Arthritis, Rheumatoid/complications ; Aspergillosis/diagnosis ; Aspergillosis/microbiology ; Aspergillus fumigatus/isolation & purification ; Diagnosis, Differential ; Humans ; Immunocompromised Host ; Male ; Neoplasms/diagnosis ; Retroperitoneal Space ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2018-07-31
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-018-0381-0
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Article ; Online: Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat.

Kanegi, Ryoji / Yasugi, Mayo / Nabetani, Tomoyo / Tanaka, Toshiyuki / Wada, Yusuke / Hirai, Kotaro / Sugiura, Kikuya / Hatoya, Shingo

The Journal of veterinary medical science

2019 Volume 81, Issue 12, Page(s) 1842–1849

Abstract: A cat was referred because of diffuse parenchymal lung disease. Close examinations revealed a swollen abdominal lymph node and multiple nodules of the liver. Mycobacterium avium subspecies hominissuis infection was confirmed by culture and single ... ...

Abstract	A cat was referred because of diffuse parenchymal lung disease. Close examinations revealed a swollen abdominal lymph node and multiple nodules of the liver. Mycobacterium avium subspecies hominissuis infection was confirmed by culture and single nucleotide polymorphism analysis of samples recovered from the liver and bronchoalveolar lavage. After administration of combination antibiotics for 6 months, culture results were negative. Though atonic seizures were observed during the treatment, it disappeared after isoniazid discontinuation and pyridoxal phosphate administration. On day 771 of illness, no clinical signs, lung diseases, or obvious swelling of lymph nodes was observed. This is the first report to confirm Mycobacterium avium subspecies hominissuis infection in cats through gene analysis and to completely cure it with combination antibiotics.
MeSH term(s)	Animals ; Anti-Bacterial Agents/therapeutic use ; Cat Diseases/microbiology ; Cats ; Drug Therapy, Combination ; Isoniazid/adverse effects ; Isoniazid/therapeutic use ; Liver/microbiology ; Lung Diseases/drug therapy ; Lung Diseases/microbiology ; Lung Diseases/veterinary ; Male ; Mycobacterium avium/genetics ; Mycobacterium avium/isolation & purification ; Polymorphism, Single Nucleotide ; Pyridoxal Phosphate/therapeutic use ; Seizures/chemically induced ; Seizures/veterinary ; Tuberculosis/drug therapy ; Tuberculosis/microbiology ; Tuberculosis/veterinary
Chemical Substances	Anti-Bacterial Agents ; Pyridoxal Phosphate (5V5IOJ8338) ; Isoniazid (V83O1VOZ8L)
Keywords	covid19
Language	English
Publishing date	2019-10-31
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.19-0492
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Zs.B 579: Show issues

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Article: [Unilateral adrenal tuberculosis: a case report].

Mochizuki, Taku / Sanjo, Hiroyuki / Hirai, Kotaro / Horita, Ayako / Saito, Ikuo

Hinyokika kiyo. Acta urologica Japonica

2014 Volume 60, Issue 12, Page(s) 611–614

Abstract: Computed tomography (CT) performed for a 75-year-old man as a follow-up examination for deep vein thrombosis in October 2010 revealed a left adrenal mass (diameter, 8 mm). In December 2012, the adrenal mass increased to 28 mm in diameter, and he was ... ...

Abstract	Computed tomography (CT) performed for a 75-year-old man as a follow-up examination for deep vein thrombosis in October 2010 revealed a left adrenal mass (diameter, 8 mm). In December 2012, the adrenal mass increased to 28 mm in diameter, and he was referred to our department. Several blood examinations revealed that the adrenal mass was non-functioning, and only peripheral lesions were observed to be enhanced by using CT in the arterial phase. Malignancy was suspected due to the irregular shape and growth of the mass, and left adrenalectomy was performed in February 2013. The histopathological diagnosis was adrenal mycobacteriosis, and clinical diagnosis was adrenal tuberculosis. No other tuberculosis infection-related lesion was detected, and the patient was treated with multidrug antituberculous chemotherapy.
MeSH term(s)	Adrenal Gland Diseases/drug therapy ; Adrenal Gland Diseases/pathology ; Aged ; Humans ; Male ; Tuberculosis, Endocrine/drug therapy ; Tuberculosis, Endocrine/pathology
Language	Japanese
Publishing date	2014-12
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604331-8
ISSN	0018-1994
ISSN	0018-1994
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Zs.A 411: Show issues

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Article ; Online: Clinical application of neutrophil CD64 quantification for differential diagnosis of acute scrotum.

Hayashi, Hirofumi / Mochizuki, Taku / Sanjo, Hiroyuki / Komiya, Akiko / Matsui, Toshihiro / Tohma, Shigeto / Hirai, Kotaro

International journal of urology : official journal of the Japanese Urological Association

2016 Volume 23, Issue 3, Page(s) 266–269

Abstract: The management of acute scrotum can be challenging, especially in infants or patients with a neurological or neurodevelopmental disorder in whom presentation, diagnosis and definitive management tends to be delayed. This leads to poor outcomes, such as ... ...

Abstract	The management of acute scrotum can be challenging, especially in infants or patients with a neurological or neurodevelopmental disorder in whom presentation, diagnosis and definitive management tends to be delayed. This leads to poor outcomes, such as loss of the affected testis. Here we present two cases of testicular torsion in patients with neurodevelopmental disorders, and a further two cases of epidydimo-orchitis in whom measurement of CD64 expression on neutrophils was helpful for differential diagnosis. These data suggest that the levels of expression of CD64 by neutrophils, known as a marker of infection, could also be useful for differentiating between testicular torsion and infection in acute scrotum.
MeSH term(s)	Abdominal Pain/blood ; Abdominal Pain/etiology ; Acute Pain/blood ; Acute Pain/etiology ; Adolescent ; Adult ; Aged ; Attention Deficit Disorder with Hyperactivity/complications ; Cerebral Palsy/complications ; Diagnosis, Differential ; Epididymitis/blood ; Epididymitis/complications ; Epididymitis/diagnosis ; Flow Cytometry ; Humans ; Male ; Middle Aged ; Neutrophils/metabolism ; Orchitis/blood ; Orchitis/complications ; Orchitis/diagnosis ; Receptors, IgG/metabolism ; Retrospective Studies ; Scrotum/diagnostic imaging ; Scrotum/pathology ; Spermatic Cord Torsion/blood ; Spermatic Cord Torsion/complications ; Spermatic Cord Torsion/diagnosis ; Testis/diagnostic imaging ; Testis/pathology ; Tomography, X-Ray Computed ; Ultrasonography, Doppler, Color
Chemical Substances	Receptors, IgG
Language	English
Publishing date	2016-03
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.13036
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat

KANEGI, Ryoji / YASUGI, Mayo / NABETANI, Tomoyo / TANAKA, Toshiyuki / WADA, Yusuke / HIRAI, Kotaro / SUGIURA, Kikuya / HATOYA, Shingo

The Journal of Veterinary Medical Science 81(12) 1842--1849

2019

Abstract	A cat was referred because of diffuse parenchymal lung disease. Close examinations revealed a swollen abdominal lymph node and multiple nodules of the liver. Mycobacterium avium subspecies hominissuis infection was confirmed by culture and single nucleotide polymorphism analysis of samples recovered from the liver and bronchoalveolar lavage. After administration of combination antibiotics for 6 months, culture results were negative. Though atonic seizures were observed during the treatment, it disappeared after isoniazid discontinuation and pyridoxal phosphate administration. On day 771 of illness, no clinical signs, lung diseases, or obvious swelling of lymph nodes was observed. This is the first report to confirm Mycobacterium avium subspecies hominissuis infection in cats through gene analysis and to completely cure it with combination antibiotics.
Keywords	Coronaviridae ; Viridae ; corona viruses ; biotic associations ; CETAF-taskforce ; covid ; covid-19 ; pathogens ; biotic interaction ; virus-host ; biotic relations ; pathogen-host ; covid19
Language	English
Publishing date	2019-12-31
Publishing country	eu
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [A case of dedifferentiated liposarcoma of the spermatic cord].

Funahashi, Makoto / Murayama, Tetsuo / Hirai, Kotaro

Hinyokika kiyo. Acta urologica Japonica

2008 Volume 54, Issue 2, Page(s) 151–153

Abstract: We report a case of dedifferentiated liposarcoma of the spermatic cord. A 79-year-old man was referred to our hospital with the chief complaint of a painless right scrotal swelling. A hard mass was palpable beside the soft mass which was suspected of ... ...

Abstract	We report a case of dedifferentiated liposarcoma of the spermatic cord. A 79-year-old man was referred to our hospital with the chief complaint of a painless right scrotal swelling. A hard mass was palpable beside the soft mass which was suspected of lipoma or liposarcoma, and under this mass there was right testis. Therefore, we performed a right radical orciectomy. Histopathological diagnosis was dedifferentiated liposarcoma of the spermatic cord. Dedifferentiated liposarcoma of the spermatic cord was rare, and preoperative diagnosis was difficult.
MeSH term(s)	Aged ; Genital Neoplasms, Male/pathology ; Genital Neoplasms, Male/surgery ; Humans ; Liposarcoma/pathology ; Liposarcoma/surgery ; Male ; Orchiectomy ; Spermatic Cord
Language	Japanese
Publishing date	2008-02
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604331-8
ISSN	0018-1994
ISSN	0018-1994
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Article ; Online: A case of squamous cell carcinoma arising from a suprapubic cystostomy tract

Horita Ayako / Ohshima Noboru / Ishigaki Hanako / Arao Masayuki / Ito Hiroki / Saito Ikuo / Hirai Kotaro

BMC Urology, Vol 11, Iss 1, p

2011 Volume 20

Abstract: Abstract Background Patients with spinal cord injury and a chronic indwelling urinary catheter are known to have an increased risk of bladder malignancy. However, squamous cell carcinoma (SCC) of the epidermis around a suprapubic cystostomy is relatively ...

Abstract	Abstract Background Patients with spinal cord injury and a chronic indwelling urinary catheter are known to have an increased risk of bladder malignancy. However, squamous cell carcinoma (SCC) of the epidermis around a suprapubic cystostomy is relatively rare. Here, we report a case of lower abdominal SCC arising from the suprapubic cystostomy tract. Case presentation A 58-year-old man with a complete spinal cord injury was referred to our hospital with a chief complaint of an abdominal mass. Abdominal enhanced computed tomography (CT) showed a 7-cm mass surrounding the suprapubic cystostomy and bilateral inguinal and para-aortic lymph nodes metastasis. Histopathological examination of percutaneous biopsy specimens was performed. The diagnosis was stage IV (cT4N1M1) epidermal SCC, which was treated with palliative external radiation therapy. Conclusion The SCC in this case was thought to arise from mechanical stimulus of the suprapubic cystostomy. Physicians and patients should pay careful attention to any signs of neoplasms with long-term indwelling catheters, such as skin changes around the suprapubic cystostomy site. This case presentation is only the fourth report of SCC arising from the suprapubic cystostomy tract in the literature. In cases of unresectable tumors and contraindications to chemotherapy, palliative radiotherapy may lead to disease remission and symptom relief.
Keywords	Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616 ; 610
Language	English
Publishing date	2011-10-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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