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  1. Article ; Online: Analysis on high-resolution spectrum of the S1-S0 transition of free-base phthalocyanine.

    Miyamoto, Yuki / Hiramoto, Ayami / Iwakuni, Kana / Kuma, Susumu / Enomoto, Katsunari / Nakayama, Naofumi / Baba, Masaaki

    The Journal of chemical physics

    2024  Volume 160, Issue 14

    Abstract: A high-resolution absorption spectrum of the S1-S0 transition of free-base phthalocyanine was observed and analyzed with improved reliability. The spectrum, with a partially resolved rotational structure, was obtained by using the buffer-gas cooling ... ...

    Abstract A high-resolution absorption spectrum of the S1-S0 transition of free-base phthalocyanine was observed and analyzed with improved reliability. The spectrum, with a partially resolved rotational structure, was obtained by using the buffer-gas cooling technique and a single-mode tunable laser. Our new analysis reveals that the S1←S0000 band belongs to the a-type transition, where the electronic transition moment aligns parallel to the NH-HN direction, allowing the assignment of the S1 state to 1B3u. These results agree with a prior study using supersonic expansion and are well supported by theoretical calculations. Interestingly, the rotational constant B in the S1 state, which is often smaller than that in the ground state for typical molecules, was found to be slightly larger than that in the S01Ag state. This suggests a change in the character of π bonds with the electronic excitation.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0191810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Newly observed low-lying Ω = 1 state of PbO.

    Enomoto, Katsunari / Tojo, Taichi / Kobayashi, Kaori / Kuma, Susumu / Hiramoto, Ayami / Miyamoto, Yuki / Baba, Masaaki

    The Journal of chemical physics

    2024  Volume 160, Issue 13

    Abstract: High-resolution spectroscopy of lead monoxide was performed in a range of 22 400-25 300 cm-1. A new Ω = 1 state located between the a1 and A0+ states was observed, and it is labeled c1. Spectroscopic constants, including the hyperfine interaction ... ...

    Abstract High-resolution spectroscopy of lead monoxide was performed in a range of 22 400-25 300 cm-1. A new Ω = 1 state located between the a1 and A0+ states was observed, and it is labeled c1. Spectroscopic constants, including the hyperfine interaction coefficient, were determined for the a1 and c1 states. The vibrational levels of these two electronic states are located closely to each other, and the interaction between them causes gradual exchange of electronic state properties in our observation wave number range. Our observation poses a question for the band assignment for the b0- state, which has some resemblance with this c1 state.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0196184
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  3. Article: Abnormal Behavior Episodes Associated With Zonisamide in Three Dogs: A Case Report.

    Kanazono, Shinichi / Ukai, Masayasu / Hiramoto, Akira

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 763822

    Abstract: Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes. Abnormal behavior episodes ... ...

    Abstract Psychiatric adverse effect associated with anti-seizure drugs has been well-recognized in human medicine. This case report describes three dogs with presumptive idiopathic epilepsy presented for abnormal behavior episodes. Abnormal behavior episodes included sudden rage and aggression to the family members, insomnia, restlessness, and/or constant attention-seeking behavior. MRI study and cerebrospinal fluid analysis in two dogs were unremarkable. The abnormal behavior episodes deteriorated along with gradual dose increment of zonisamide and these episodes almost completely disappeared within 5 days after discontinuation of zonisamide. The exact same episodes relapsed within days after re-administration of zonisamide and disappeared again shortly after discontinuation of zonisamide. Dose adjustments of other anti-seizure medications in case 2 did not result in significant changes in these behavior episodes. Although psychiatric adverse effects including aggressive behavior associated with zonisamide are widely recognized in humans, this is the first report in dogs in the clinical setting.
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.763822
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  4. Article ; Online: Extracellular Leakage Protein Patterns in Two Types of Cancer Cell Death: Necrosis and Apoptosis.

    Sato, Akira / Shimotsuma, Akira / Miyoshi, Tetsuya / Takahashi, Yui / Funayama, Naoki / Ogino, Yoko / Hiramoto, Akiko / Wataya, Yusuke / Kim, Hye-Sook

    ACS omega

    2023  Volume 8, Issue 28, Page(s) 25059–25065

    Abstract: Dead cells release fragments of DNA, RNA, and proteins (including peptides) into the extracellular space. Two major forms of cell death during cancer development have been identified: necrosis and apoptosis. Our group investigated the mechanisms that ... ...

    Abstract Dead cells release fragments of DNA, RNA, and proteins (including peptides) into the extracellular space. Two major forms of cell death during cancer development have been identified: necrosis and apoptosis. Our group investigated the mechanisms that regulate cell death during the treatment of mouse tumor FM3A cells with the anticancer drug floxuridine (FUdR). In the original strain F28-7, FUdR induced necrosis, whereas in the variant F28-7-A, it induced apoptosis. Here, we report that the extracellular leakage proteome (
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c01691
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  5. Article ; Online: Doppler-free Spectroscopy of Buffer-Gas-Cooled Calcium Monohydroxide.

    Miyamoto, Yuki / Tobaru, Reo / Takahashi, Yuiki / Hiramoto, Ayami / Iwakuni, Kana / Kuma, Susumu / Enomoto, Katsunari / Baba, Masaaki

    The journal of physical chemistry. A

    2023  Volume 127, Issue 21, Page(s) 4758–4763

    Abstract: In this study, we report the Doppler-free spectra of buffer-gas-cooled CaOH. We observed five Doppler-free spectra containing low- ...

    Abstract In this study, we report the Doppler-free spectra of buffer-gas-cooled CaOH. We observed five Doppler-free spectra containing low-
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c08565
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  6. Article ; Online: Anticancer Strategy Targeting Cell Death Regulators: Switching the Mechanism of Anticancer Floxuridine-Induced Cell Death from Necrosis to Apoptosis.

    Sato, Akira / Hiramoto, Akiko / Kim, Hye-Sook / Wataya, Yusuke

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: Cell death can be broadly characterized as either necrosis or apoptosis, depending on the morphological and biochemical features of the cell itself. We have previously reported that the treatment of mouse mammary carcinoma FM3A cells with the anticancer ... ...

    Abstract Cell death can be broadly characterized as either necrosis or apoptosis, depending on the morphological and biochemical features of the cell itself. We have previously reported that the treatment of mouse mammary carcinoma FM3A cells with the anticancer drug floxuridine (FUdR) induces necrosis in the original clone F28-7 but apoptosis in the variant F28-7-A. We have identified regulators, including heat shock protein 90, lamin-B1, cytokeratin-19, and activating transcription factor 3, of cell death mechanisms by using comprehensive gene and protein expression analyses and a phenotype-screening approach. We also observed that the individual inhibition or knockdown of the identified regulators in F28-7 results in a shift from necrotic to apoptotic morphology. Furthermore, we investigated microRNA (miRNA, miR) expression profiles in sister cell strains F28-7 and F28-7-A using miRNA microarray analyses. We found that several unique miRNAs, miR-351-5p and miR-743a-3p, were expressed at higher levels in F28-7-A than in F28-7. Higher expression of these miRNAs in F28-7 induced by transfecting miR mimics resulted in a switch in the mode of cell death from necrosis to apoptosis. Our findings suggest that the identified cell death regulators may play key roles in the decision of cell death mechanism: necrosis or apoptosis.
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Apoptosis/drug effects ; Floxuridine/pharmacology ; Floxuridine/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism
    Chemical Substances Antimetabolites, Antineoplastic ; MicroRNAs ; Floxuridine (039LU44I5M)
    Language English
    Publishing date 2020-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165876
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  7. Article ; Online: Diagnosis of severe fever with thrombocytopenia syndrome (SFTS) in a cat with clinical findings resembling lymphoma.

    Irie, Mitsuhiro / Miyoshi, Takuma / Hiramoto, Akira / Hirata, Masahiko / Takanosu, Masamine / Park, Eun-Sil / Maeda, Ken

    The Journal of veterinary medical science

    2022  Volume 84, Issue 5, Page(s) 675–679

    Abstract: A two-year-old male domestic cat showed lethargy, tonic-clonic convulsion, and mucosal jaundice. Upon admission, blood examination indicated severe neutropenia and thrombocytopenia, and ultrasonography revealed diffuse splenomegaly with a honeycomb ... ...

    Abstract A two-year-old male domestic cat showed lethargy, tonic-clonic convulsion, and mucosal jaundice. Upon admission, blood examination indicated severe neutropenia and thrombocytopenia, and ultrasonography revealed diffuse splenomegaly with a honeycomb appearance and abdominal lymph nodes enlargement in addition to a decrease in cardiac blood flow indicating a shock condition. Cytology of the spleen showed a cell population composed of immature large lymphoid cells with distinct nucleoli, suggesting lymphoma. The cat received symptomatic treatments but died four hours later. Reverse transcriptase polymerase chain reaction assay of the spleen sample indicated the presence of severe fever with thrombocytopenia syndrome (SFTS) virus S gene segment. Clinical features of this case that was diagnose as SFTS were similar to lymphoma. Therefore, pet owners and veterinary workers should be protected against infection of SFTS.
    MeSH term(s) Animals ; Cat Diseases/diagnosis ; Cats ; Lymphoma/veterinary ; Male ; Phlebovirus/genetics ; Severe Fever with Thrombocytopenia Syndrome/veterinary
    Language English
    Publishing date 2022-04-11
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.21-0519
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  8. Article ; Online: High-resolution spectroscopy of buffer-gas-cooled phthalocyanine.

    Miyamoto, Yuki / Tobaru, Reo / Takahashi, Yuiki / Hiramoto, Ayami / Iwakuni, Kana / Kuma, Susumu / Enomoto, Katsunari / Baba, Masaaki

    Communications chemistry

    2022  Volume 5, Issue 1, Page(s) 161

    Abstract: For over five decades, studies in the field of chemical physics and physical chemistry have primarily aimed to understand the quantum properties of molecules. However, high-resolution rovibronic spectroscopy has been limited to relatively small and ... ...

    Abstract For over five decades, studies in the field of chemical physics and physical chemistry have primarily aimed to understand the quantum properties of molecules. However, high-resolution rovibronic spectroscopy has been limited to relatively small and simple systems because translationally and rotationally cold samples have not been prepared in sufficiently large quantities for large and complex systems. In this study, we present high-resolution rovibronic spectroscopy results for large gas-phase molecules, namely, free-base phthalocya-nine (FBPc). The findings suggest that buffer-gas cooling may be effective for large molecules introduced via laser ablation. High-resolution electronic spectroscopy, combined with other experimental and theoretical studies, will be useful in understanding the quantum properties of molecules. These findings also serve as a guide for quantum chemical calculations of large molecules.
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-022-00783-4
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  9. Book ; Online: Multi-Fingered In-Hand Manipulation with Various Object Properties Using Graph Convolutional Networks and Distributed Tactile Sensors

    Funabashi, Satoshi / Isobe, Tomoki / Hongyi, Fei / Hiramoto, Atsumu / Schmitz, Alexander / Sugano, Shigeki / Ogata, Tetsuya

    2022  

    Abstract: Multi-fingered hands could be used to achieve many dexterous manipulation tasks, similarly to humans, and tactile sensing could enhance the manipulation stability for a variety of objects. However, tactile sensors on multi-fingered hands have a variety ... ...

    Abstract Multi-fingered hands could be used to achieve many dexterous manipulation tasks, similarly to humans, and tactile sensing could enhance the manipulation stability for a variety of objects. However, tactile sensors on multi-fingered hands have a variety of sizes and shapes. Convolutional neural networks (CNN) can be useful for processing tactile information, but the information from multi-fingered hands needs an arbitrary pre-processing, as CNNs require a rectangularly shaped input, which may lead to unstable results. Therefore, how to process such complex shaped tactile information and utilize it for achieving manipulation skills is still an open issue. This paper presents a control method based on a graph convolutional network (GCN) which extracts geodesical features from the tactile data with complicated sensor alignments. Moreover, object property labels are provided to the GCN to adjust in-hand manipulation motions. Distributed tri-axial tactile sensors are mounted on the fingertips, finger phalanges and palm of an Allegro hand, resulting in 1152 tactile measurements. Training data is collected with a data-glove to transfer human dexterous manipulation directly to the robot hand. The GCN achieved high success rates for in-hand manipulation. We also confirmed that fragile objects were deformed less when correct object labels were provided to the GCN. When visualizing the activation of the GCN with a PCA, we verified that the network acquired geodesical features. Our method achieved stable manipulation even when an experimenter pulled a grasped object and for untrained objects.

    Comment: Accepted at ICRA 2022 and RA-Letter
    Keywords Computer Science - Robotics
    Subject code 629
    Publishing date 2022-05-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Direct interaction analysis of microRNA-351-5p and nuclear scaffold lamin B1 mRNA by the cell-free in vitro mRNA/miRNA binding evaluation system.

    Sato, Akira / Ogino, Yoko / Shimotsuma, Akira / Hiramoto, Akiko / Kim, Hye-Sook / Wataya, Yusuke

    Nucleosides, nucleotides & nucleic acids

    2020  Volume 39, Issue 6, Page(s) 799–805

    Abstract: We previously demonstrated that miR-351-5p regulates nuclear scaffold lamin B1 expression and mediates the anticancer floxuridine-induced necrosis shift to apoptosis in mammalian tumor cells. Notably, it is unknown whether lamin B1 mRNA is a direct ... ...

    Abstract We previously demonstrated that miR-351-5p regulates nuclear scaffold lamin B1 expression and mediates the anticancer floxuridine-induced necrosis shift to apoptosis in mammalian tumor cells. Notably, it is unknown whether lamin B1 mRNA is a direct target of miR-351-5p. Here, we show that miR-351-5p interacts with a lamin B1 mRNA partial sequence by using the cell-free
    MeSH term(s) Base Sequence ; Binding Sites ; Fluorescein-5-isothiocyanate/chemistry ; Fluorescent Dyes/chemistry ; Gene Expression Regulation, Neoplastic ; Lamin Type B/genetics ; MicroRNAs/metabolism ; Nuclear Matrix/metabolism ; Optical Imaging ; RNA Interference ; RNA, Messenger/metabolism ; Signal Transduction
    Chemical Substances Fluorescent Dyes ; Lamin Type B ; MicroRNAs ; RNA, Messenger ; Fluorescein-5-isothiocyanate (I223NX31W9)
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2019.1702675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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