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  1. AU="Hirano, Toru"
  2. AU="Kong, Rebekah"
  3. AU="Karen de Jager"
  4. AU=Peters A
  5. AU="Xiaofang Li"
  6. AU="Campbell, John D"
  7. AU="Emara, Yasmine"
  8. AU="Orbe, Paul"
  9. AU="Karel J van Erpecum"
  10. AU=Oltean Mihai
  11. AU="Relph, Katharine A"
  12. AU=Li Jifen AU=Li Jifen
  13. AU="Diamant, Eran"
  14. AU="Kyoung, Henry" AU="Kyoung, Henry"
  15. AU=al-Gazali L I
  16. AU="Maillet, Jean-Michel"
  17. AU="Enlong Liu"
  18. AU="Afria, Dikshant"
  19. AU="Duggal, M. S."
  20. AU="Narcisa G. Pricope"
  21. AU="Kunisada, Toshiyuki"
  22. AU="Barvkar, Vitthal"

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  1. Artikel ; Online: [Developmental Future of Radiological Technology Research].

    Yanagawa, Noriyuki / Ishida, Takayuki / Hirano, Toru / Isobe, Tomonori / Hayashi, Naoki

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2024  Band 80, Heft 1, Seite(n) 79–86

    Sprache Japanisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2024-2296
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  2. Artikel ; Online: Usefulness of the spectral shaping dual-source computed tomography imaging technique in posterior corrective fusion for adolescent idiopathic scoliosis.

    Noto, Yoshiyuki / Endo, Yuki / Ohashi, Masayuki / Hirano, Toru / Kuramoto, Tatsuya / Chida, Koichi / Watanabe, Kei

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2024  Band 33, Heft 2, Seite(n) 706–712

    Abstract: Purpose: Since childhood exposure to radiation has been demonstrated to increase cancer risk with increase in radiation dose, reduced radiation exposure during computed tomography (CT) evaluation is desired for adolescent idiopathic scoliosis (AIS). ... ...

    Abstract Purpose: Since childhood exposure to radiation has been demonstrated to increase cancer risk with increase in radiation dose, reduced radiation exposure during computed tomography (CT) evaluation is desired for adolescent idiopathic scoliosis (AIS). Therefore, this retrospective study aimed to investigate the radiation dose of dual-source CT using a spectral shaping technique and the accuracy of the thoracic pedicle screw (TPS) placement for posterior spinal fusion (PSF) in patients with AIS.
    Methods: Fifty-nine female patients with thoracic AIS who underwent PSF using CT-guided TPSs were included and divided into two groups comprised of 23 patients who underwent dual-source CT (DSCT) with a tin filter (DSCT group) and 36 who underwent conventional multislice CT (MSCT group). We assessed the CT radiation dose using the CT dose index (CTDI
    Results: The DSCT and MSCT groups differed significantly (p < 0.001) in the mean CTDI
    Conclusion: Spectral shaping DSCT with a tube-based tin filter allowed a 75% radiation dose reduction while achieving TPS insertion accuracy similar to procedures based on conventional CT without spectral shaping.
    Mesh-Begriff(e) Humans ; Adolescent ; Female ; Child ; Retrospective Studies ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Tin ; Tomography, X-Ray Computed ; Dioctyl Sulfosuccinic Acid ; Phenolphthalein
    Chemische Substanzen Tin (7440-31-5) ; Dioctyl Sulfosuccinic Acid (10041-19-7) ; Phenolphthalein (6QK969R2IF)
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-08006-7
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  3. Artikel ; Online: The Onset of IgG4-related Retroperitoneal Fibrosis under Administration of a TNF Inhibitor in a Rheumatoid Arthritis Patient.

    Ogawa, Takao / Tsujimoto, Kohei / Shimagami, Hiroshi / Fukuda, Chiaki / Hirano, Toru

    Internal medicine (Tokyo, Japan)

    2023  Band 62, Heft 21, Seite(n) 3251–3254

    Abstract: An 80-year-old woman with rheumatoid arthritis during treatment with etanercept, a tumor necrosis factor (TNF) inhibitor, showed swelling of the salivary glands and retroperitoneal fibrosis, which was diagnosed as IgG4-related disease. Although some ... ...

    Abstract An 80-year-old woman with rheumatoid arthritis during treatment with etanercept, a tumor necrosis factor (TNF) inhibitor, showed swelling of the salivary glands and retroperitoneal fibrosis, which was diagnosed as IgG4-related disease. Although some reports have shown the efficacy of TNF inhibitors for IgG4-related disease or retroperitoneal fibrosis, TNF inhibitors sometimes cause paradoxical reactions like psoriasis, and the mechanisms are considered to involve the upregulation of plasmacytoid dendritic cells and IFN-α, which is also common in patients with IgG4-related disease. This is a case report of IgG4-related retroperitoneal fibrosis with the possibility of a rare paradoxical reaction by a TNF inhibitor.
    Mesh-Begriff(e) Female ; Humans ; Aged, 80 and over ; Tumor Necrosis Factor Inhibitors ; Retroperitoneal Fibrosis/chemically induced ; Retroperitoneal Fibrosis/drug therapy ; Retroperitoneal Fibrosis/diagnosis ; Immunoglobulin G/adverse effects ; Immunoglobulin G4-Related Disease ; Arthritis, Rheumatoid/drug therapy
    Chemische Substanzen Tumor Necrosis Factor Inhibitors ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1326-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Evolution of the three-dimensional image and image processing in the cranial nerve systems].

    Hirano, Toru

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2013  Band 69, Heft 11, Seite(n) 1285–1291

    Mesh-Begriff(e) Cerebral Angiography/methods ; Cerebral Angiography/trends ; Cranial Nerves/diagnostic imaging ; Cranial Nerves/pathology ; Humans ; Image Processing, Computer-Assisted/methods ; Image Processing, Computer-Assisted/trends ; Imaging, Three-Dimensional/methods ; Imaging, Three-Dimensional/trends ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/trends ; Perfusion Imaging/methods ; Perfusion Imaging/trends ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, Emission-Computed, Single-Photon/trends ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/trends
    Sprache Japanisch
    Erscheinungsdatum 2013-11-19
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2013_jsrt_69.11.1285
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [About construction and the use of the 3D laboratory].

    Hirano, Toru

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2013  Band 69, Heft 6, Seite(n) 689–692

    Mesh-Begriff(e) Humans ; Imaging, Three-Dimensional ; Laboratories ; Magnetic Resonance Angiography
    Sprache Japanisch
    Erscheinungsdatum 2013-06-20
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2013_jsrt_69.6.689
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  6. Artikel ; Online: Automatic evaluation of atlantoaxial subluxation in rheumatoid arthritis by a deep learning model.

    Okita, Yasutaka / Hirano, Toru / Wang, Bowen / Nakashima, Yuta / Minoda, Saki / Nagahara, Hajime / Kumanogoh, Atsushi

    Arthritis research & therapy

    2023  Band 25, Heft 1, Seite(n) 181

    Abstract: Background: This work aims to develop a deep learning model, assessing atlantoaxial subluxation (AAS) in rheumatoid arthritis (RA), which can often be ambiguous in clinical practice.: Methods: We collected 4691 X-ray images of the cervical spine of ... ...

    Abstract Background: This work aims to develop a deep learning model, assessing atlantoaxial subluxation (AAS) in rheumatoid arthritis (RA), which can often be ambiguous in clinical practice.
    Methods: We collected 4691 X-ray images of the cervical spine of the 906 patients with RA. Among these images, 3480 were used for training the deep learning model, 803 were used for validating the model during the training process, and the remaining 408 were used for testing the performance of the trained model. The two-dimensional key points' detection model of Deep High-Resolution Representation Learning for Human Pose Estimation was adopted as the base convolutional neural network model. The model inferred four coordinates to calculate the atlantodental interval (ADI) and space available for the spinal cord (SAC). Finally, these values were compared with those by clinicians to evaluate the performance of the model.
    Results: Among the 408 cervical images for testing the performance, the trained model correctly identified the four coordinates in 99.5% of the dataset. The values of ADI and SAC were positively correlated among the model and two clinicians. The sensitivity of AAS diagnosis with ADI or SAC by the model was 0.86 and 0.97 respectively. The specificity of that was 0.57 and 0.5 respectively.
    Conclusions: We present the development of a deep learning model for the evaluation of cervical lesions of patients with RA. The model was demonstrably shown to be useful for quantitative evaluation.
    Mesh-Begriff(e) Humans ; Deep Learning ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnostic imaging ; Cervical Vertebrae ; Neural Networks, Computer
    Sprache Englisch
    Erscheinungsdatum 2023-09-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-023-03172-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Neck and shoulder pain in thoracic adolescent idiopathic scoliosis 10 years after posterior spinal fusion.

    Ohashi, Masayuki / Watanabe, Kei / Hirano, Toru / Hasegawa, Kazuhiro / Tashi, Hideki / Makino, Tatsuo / Minato, Keitaro / Sato, Masayuki / Kawashima, Hiroyuki

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2024  

    Abstract: Purpose: We aimed to determine the clinical significance of neck and shoulder pain (NSP) 10 years after posterior spinal fusion (PSF) for thoracic adolescent idiopathic scoliosis (AIS) and the relationship between radiographic parameters and NSP.: ... ...

    Abstract Purpose: We aimed to determine the clinical significance of neck and shoulder pain (NSP) 10 years after posterior spinal fusion (PSF) for thoracic adolescent idiopathic scoliosis (AIS) and the relationship between radiographic parameters and NSP.
    Methods: Of 72 patients who underwent PSF for thoracic AIS (Lenke 1 or 2) between 2000 and 2013, we included 52 (46 females; Lenke type 1 in 34 patients and type 2 in 18; mean age, 25.6 years) who underwent NSP evaluation using visual analog scale (VAS, 10 cm) 10 years postoperatively (follow-up rate, 72.2%). Correlation analyses were performed using Spearman's rank correlation coefficient (r).
    Results: The VAS for NSP was 2.6 cm in median and 3.4 cm in mean at 10 years. The VAS had significant negative correlations with several SRS-22 domain scores (rs = - 0.348 for pain, - 0.347 for function,  -  0.308 for mental health, and - 0.372 for total) (p < 0.05). In addition, the VAS score was significantly correlated with cervical lordosis (CL) (rs = 0.296), lumbar lordosis (rs = - 0.299), and sacral slope (rs = 0.362) (p < 0.05). Furthermore, at the 10-year follow-up, CL was significantly negatively correlated with T1 slope (rs = - 0.763) and thoracic kyphosis (TK) (- 0.554 for T1-12 and - 0.344 for T5-12) (p < 0.02).
    Conclusion: NSP was associated with deterioration in SRS-22 scores, indicating that NSP is a clinically significant long-term issue in PSF for thoracic AIS. Restoring or maintaining the TK and T1 slopes, which are controllable factors during PSF, may improve cervical lordosis and alleviate NSP at 10-year follow-up.
    Sprache Englisch
    Erscheinungsdatum 2024-04-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-024-08233-6
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  8. Artikel ; Online: Photosensitized Protein Damage by DiethyleneglycoxyP(V)tetrakis(p-n-butoxyphenyl)porphyrin Through Electron Transfer: Activity Control Through Self-aggregation and Dissociation.

    Hirakawa, Kazutaka / Yoshida, Mami / Hirano, Toru / Nakazaki, Jotaro / Segawa, Hiroshi

    Photochemistry and photobiology

    2021  Band 98, Heft 2, Seite(n) 434–441

    Abstract: DiethyleneglycoxyP(V)tetrakis(p-n-butoxyphenyl)porphyrin (EGP(V)TBPP) forms a self-aggregation in an aqueous solution, and the photoexcited state of this molecule was effectively deactivated. Association with human serum albumin (HSA), a water-soluble ... ...

    Abstract DiethyleneglycoxyP(V)tetrakis(p-n-butoxyphenyl)porphyrin (EGP(V)TBPP) forms a self-aggregation in an aqueous solution, and the photoexcited state of this molecule was effectively deactivated. Association with human serum albumin (HSA), a water-soluble protein, causes dissociation of the self-aggregation, resulting in recovery of the photosensitizer activity of EGP(V)TBPP. Under visible light irradiation, EGP(V)TBPP photosensitized HSA oxidation. The photosensitized singlet oxygen-generating activity of EGP(V)TBPP was confirmed by near-infrared emission measurement. A singlet oxygen quencher, sodium azide, partially inhibited the HSA photodamage; however, the quenching effect was estimated to be 57%. Another 43% of the HSA photodamage could be explained by the electron transfer mechanism. The redox potential of EGP(V)TBPP and the calculated Gibbs energy of electron transfer from tryptophan to photoexcited EGP(V)TBPP demonstrated the possibility of HSA oxidation through electron extraction. Fluorescence lifetime measurements of EGP(V)TBPP verified the electron transfer from HSA. The photosensitizer activity of EGP(V)TBPP can be controlled through an association with biomolecules, such as protein, and the electron transfer-mediated biomolecule photooxidation plays an important role in photodynamic therapy under hypoxia.
    Mesh-Begriff(e) Electron Transport ; Electrons ; Humans ; Photosensitizing Agents/metabolism ; Photosensitizing Agents/pharmacology ; Porphyrins/pharmacology ; Singlet Oxygen/metabolism
    Chemische Substanzen Photosensitizing Agents ; Porphyrins ; Singlet Oxygen (17778-80-2)
    Sprache Englisch
    Erscheinungsdatum 2021-09-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13517
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Axial Neck-Shoulder Pain After Posterior Correction and Fusion for Adolescent Idiopathic Scoliosis With Structural Thoracic Curve: Does Cranial Fusion Level Affect Neck Symptoms?

    Watanabe, Kei / Ohashi, Masayuki / Tashi, Hideki / Shibuya, Yohei / Makino, Tatsuo / Hasegawa, Kazuhiro / Hirano, Toru

    Clinical spine surgery

    2022  Band 36, Heft 7, Seite(n) E311–E316

    Abstract: Study design: A retrospective cohort study using prospectively collected data.: Objectives: To investigate the incidence and impact of fusion to the upper thoracic spine on neck-shoulder symptoms after posterior spinal fusion (PSF) for adolescent ... ...

    Abstract Study design: A retrospective cohort study using prospectively collected data.
    Objectives: To investigate the incidence and impact of fusion to the upper thoracic spine on neck-shoulder symptoms after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS).
    Summary of background data: Axial neck-shoulder pain is established as a sequela of posterior cervical spine surgery and is mainly caused by the dissection of extensor muscles in the cervical and upper thoracic spine.
    Materials and methods: Sixty-three female patients with AIS who underwent PSF using segmental pedicle screw constructs for structural main thoracic curve with a minimum 2-year follow-up were included. Axial neck-shoulder pain was assessed using the visual analog scale and cervical spine function domain score of the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire. The patients were divided into 2 groups, a higher group (underwent fusion up to T3 or above, n=27) and a lower group (underwent fusion up to T4 or below, n=36), and radiologic and clinical outcomes were compared.
    Results: The incidence of axial neck-shoulder pain (visual analog scale ≥30) preoperatively and at the 2-year follow-up was 29 and 40%, respectively. The pain and mental health domains of the Scoliosis Research Society-22 and cervical spine function domain of the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire were correlated with the severity of axial neck pain. In the comparison of clinical outcomes between the 2 groups, the pain domain score of the Scoliosis Research Society-22 in the lower group was significantly better than that in the higher group at the 2-year follow-up ( P <0.05). Other parameters showed no significant differences preoperatively or at the 2-year follow-up.
    Conclusion: Female patients with AIS had a relatively high incidence of axial neck-shoulder pain after PSF, which affected their health-related quality of life. Both groups showed similar clinical outcomes, and the cranial fusion level did not affect axial neck-shoulder pain and cervical spine function.
    Level of evidence: Level 3.
    Mesh-Begriff(e) Humans ; Adolescent ; Female ; Scoliosis/surgery ; Retrospective Studies ; Quality of Life ; Shoulder Pain ; Thoracic Vertebrae/surgery ; Kyphosis ; Spinal Cord Diseases ; Spinal Fusion/adverse effects ; Treatment Outcome ; Follow-Up Studies
    Sprache Englisch
    Erscheinungsdatum 2022-08-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001370
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Association of success of brace treatment and various aspects of in-brace correction in patients with adolescent idiopathic scoliosis.

    Sato, Masayuki / Ohashi, Masayuki / Tashi, Hideki / Makino, Tatsuo / Shibuya, Yohei / Hirano, Toru / Watanabe, Kei

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2022  Band 28, Heft 6, Seite(n) 1221–1226

    Abstract: Background: Although skeletal maturity and brace wear time contribute to the success of brace treatment in adolescent idiopathic scoliosis (AIS), the extent of initial in-brace correction for ensuring successful outcomes remains unclear. We hypothesized ...

    Abstract Background: Although skeletal maturity and brace wear time contribute to the success of brace treatment in adolescent idiopathic scoliosis (AIS), the extent of initial in-brace correction for ensuring successful outcomes remains unclear. We hypothesized that the degree of initial in-brace correction correlates with brace success in patients with AIS.
    Method: The study included 135 AIS patients with a major Cobb angle of 20°-40° treated with a thoracic lumbosacral orthosis for at least one year and followed up for skeletal maturity. The subjects were divided into two groups: the skeletally immature group (group I, n = 72), who met the Bracing in Adolescent Idiopathic Scoliosis Trial study protocol at the start of brace treatment, and the skeletally mature group (group M, n = 63). Treatment success was defined as not needing surgical treatment and a major Cobb angle <40° at the end of brace treatment.
    Results: In both groups, the mean major Cobb angles before treatment, while wearing the brace, and at the end of brace treatment were 30.6°/31.7°, 22.9°/24.2°, and 38.8°/33.9° (p < 0.05), respectively, and the treatment success rate was 56.9% and 77.8%, respectively (p < 0.05). Univariate regression analysis revealed the following risk factors: Risser grade 0 in group I, major Cobb angles before treatment, initial in-brace major Cobb angle, and in-brace correction rate in both groups. Cutoff values of in-brace major Cobb angle for treatment success calculated by ROC curve in groups I and M were 24° and 29°, respectively.
    Conclusions: In-brace major scoliosis correction of <25° in patients with immature skeletal status and <30° in patients with mature skeletal structure should be aimed at to achieve significant brace treatment success.
    Mesh-Begriff(e) Humans ; Adolescent ; Scoliosis/diagnostic imaging ; Scoliosis/therapy ; Retrospective Studies ; Braces ; Kyphosis ; Orthotic Devices ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-11-10
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1016/j.jos.2022.10.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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