LIVIVO - Search results -

Search results

Result 1 - 10 of total 41

Search options

Article ; Online: Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-nitroso-N-pivaloyl-D-penicillamine (SNPiP): Implications for Improved Diastolic Function and Cardiac Performance.

Takenaka, Yasuhiro / Hirasaki, Masataka / Bono, Hidemasa / Nakamura, Shigeo / Kakinuma, Yoshihiko

2024

Abstract: We previously reported a novel compound called S-nitroso-N-pivaloyl-D-penicillamine (SNPiP), which was screened from a group of nitric oxide (NO) donor compounds with a basic chemical structure of S-nitroso-N-acetylpenicillamine (SNAP), to activate the ... ...

Abstract	We previously reported a novel compound called S-nitroso-N-pivaloyl-D-penicillamine (SNPiP), which was screened from a group of nitric oxide (NO) donor compounds with a basic chemical structure of S-nitroso-N-acetylpenicillamine (SNAP), to activate the non-neuronal acetylcholine (NNA) system. SNPiP-treated mice exhibited improved cardiac output and enhanced diastolic function, without an increase in heart rate. The NNA-activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis. Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function. A time-course study (24 and 48 h after SNPiP administration) revealed that SNPiP initially induced Wnt and cGMP-protein kinase G (PKG) signaling pathways, along with upregulation of genes involved in cardiac muscle tissue development and oxytocin signaling pathway. We also observed enrichment of glycolysis-related genes in response to SNPiP treatment, resulting in a metabolic shift from oxidative phosphorylation to glycolysis, which was suggested by reduced cardiac glucose contents while maintaining ATP levels. Additionally, SNPiP significantly upregulated atrial natriuretic peptide (ANP) and sarcolipin (SLN), which play crucial roles in calcium handling and cardiac performance. These findings suggest that SNPiP may have therapeutic potential based on the pleiotropic mechanisms elucidated in this study.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001552
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1471: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Temporal inhibition of the electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts.

Takenaka, Yasuhiro / Inoue, Ikuo / Hirasaki, Masataka / Ikeda, Masaaki / Kakinuma, Yoshihiko

The FEBS journal

2023 Volume 290, Issue 15, Page(s) 3843–3857

Abstract: We previously developed a stress-induced premature senescence (SIPS) model in which normal human fibroblast MRC-5 cells were treated with either the proteasome inhibitor MG132 or the vacuolar-type ATPase inhibitor bafilomycin A1 (BAFA1). To clarify the ... ...

Abstract	We previously developed a stress-induced premature senescence (SIPS) model in which normal human fibroblast MRC-5 cells were treated with either the proteasome inhibitor MG132 or the vacuolar-type ATPase inhibitor bafilomycin A1 (BAFA1). To clarify the involvement of mitochondrial function in our SIPS model, MRC-5 cells were treated with MG132 or BAFA1 along with an inhibitor targeting either the electron transport chain complex I or complex III, or with a mitochondrial uncoupler. SIPS induced by MG132 or BAFA1 was significantly attenuated by short-term co-treatment with the complex III inhibitor, antimycin A (AA), but not the complex I inhibitor, rotenone or the mitochondrial uncoupler, carbonyl cyanide 3-chlorophenylhydrazone. By co-treatment with AA, mitochondrial and intracellular reactive oxygen species levels, accumulation of protein aggregates and mitochondrial unfolded protein responses (UPR
MeSH term(s)	Humans ; Electron Transport ; Proteostasis ; Electron Transport Complex III ; Reactive Oxygen Species/metabolism ; Cellular Senescence ; Fibroblasts/metabolism
Chemical Substances	Electron Transport Complex III (EC 7.1.1.8) ; Reactive Oxygen Species
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16785
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 260: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Temporal inhibition of the electron transport chain attenuates stress‐induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts

Takenaka, Yasuhiro / Inoue, Ikuo / Hirasaki, Masataka / Ikeda, Masaaki / Kakinuma, Yoshihiko

The FEBS Journal. 2023 Aug., v. 290, no. 15 p.3843-3857

2023

Abstract: We previously developed a stress‐induced premature senescence (SIPS) model in which normal human fibroblast MRC‐5 cells were treated with either the proteasome inhibitor MG132 or the vacuolar‐type ATPase inhibitor bafilomycin A1 (BAFA1). To clarify the ... ...

Abstract	We previously developed a stress‐induced premature senescence (SIPS) model in which normal human fibroblast MRC‐5 cells were treated with either the proteasome inhibitor MG132 or the vacuolar‐type ATPase inhibitor bafilomycin A1 (BAFA1). To clarify the involvement of mitochondrial function in our SIPS model, MRC‐5 cells were treated with MG132 or BAFA1 along with an inhibitor targeting either the electron transport chain complex I or complex III, or with a mitochondrial uncoupler. SIPS induced by MG132 or BAFA1 was significantly attenuated by short‐term co‐treatment with the complex III inhibitor, antimycin A (AA), but not the complex I inhibitor, rotenone or the mitochondrial uncoupler, carbonyl cyanide 3‐chlorophenylhydrazone. By co‐treatment with AA, mitochondrial and intracellular reactive oxygen species levels, accumulation of protein aggregates and mitochondrial unfolded protein responses (UPRᵐᵗ) were remarkably suppressed. Furthermore, AA co‐treatment suppressed the hyperpolarization of the mitochondrial membrane and the induction of mitophagy observed in MG132‐treated cells and enhanced mitochondrial biogenesis. These findings provide evidence that the temporal inhibition of mitochondrial respiration exerts protective effects against the progression of premature senescence caused by impaired proteostasis.
Keywords	adenosinetriphosphatase ; antimycin A ; biogenesis ; cell senescence ; cyanides ; electron transport chain ; fibroblasts ; humans ; mitochondria ; mitochondrial membrane ; mitophagy ; models ; proteasome inhibitors ; reactive oxygen species ; rotenone
Language	English
Dates of publication	2023-08
Size	p. 3843-3857.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16785
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2006/704: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Complete response to pembrolizumab in a patient with recurrent and metastatic urothelial bladder carcinoma reflecting coexisting sarcomatoid subtype and glandular differentiation: a case report.

Miyama, Yu / Kanao, Kent / Uranishi, Kousuke / Hirasaki, Masataka / Yasuda, Masanori

International cancer conference journal

2022 Volume 12, Issue 1, Page(s) 24–30

Abstract: In advanced urothelial carcinoma (UC), approximately 20% of patients respond to pembrolizumab, an anti-programmed cell death-1 (PD-1) antibody. Herein, we reported a single case of UC showing coexistence of sarcomatoid subtype and glandular ... ...

Abstract	In advanced urothelial carcinoma (UC), approximately 20% of patients respond to pembrolizumab, an anti-programmed cell death-1 (PD-1) antibody. Herein, we reported a single case of UC showing coexistence of sarcomatoid subtype and glandular differentiation. Notably, only glandular differentiation was recurrent, probably progressive, and metastatic, which showed complete response to pembrolizumab. An 80-year-old woman presented with hematuria and dysuria, and an intra-vesical tumor was detected on ultrasound. Transurethral resections (TUR) were performed three times. In the first TUR, a sub-pedunculated tumor and a flat lesion were closely but independently located. Pathologically, the sub-pedunculated tumor was an invasive UC, sarcomatoid subtype. Meanwhile, the flat lesion was invasive UC with glandular differentiation. Despite the second and the additional TUR, the tumor was growing and a lymph node metastasis was detected. The third TUR specimen showed UC with glandular differentiation, and a positive PD-L1 expression as well as high density CD8-positive lymphocytic cells infiltration were observed. Pembrolizumab was administered for four courses after terminating the chemotherapy. The CT scan revealed shrinkage of both primary tumor and metastases. Cystectomy and lymph nodes dissection were performed, and no residual carcinoma was detected. The therapeutic effect was regarded as pathological complete response. Pembrolizumab could be effective for special subtype or divergent differentiation of UC, particularly in an event of an 'immune hot' tumor. Supplementary information: The online version contains supplementary material available at 10.1007/s13691-022-00568-5.
Language	English
Publishing date	2022-08-06
Publishing country	Singapore
Document type	Case Reports
ISSN	2192-3183
ISSN (online)	2192-3183
DOI	10.1007/s13691-022-00568-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane.

Nogi, Takehiro / Uranishi, Kousuke / Suzuki, Ayumu / Hirasaki, Masataka / Nakamura, Tina / Kazama, Tomiei / Nagasaka, Hiroshi / Okuda, Akihiko / Mieda, Tsutomu

PloS one

2024 Volume 19, Issue 3, Page(s) e0298264

Abstract: Although sevoflurane is one of the most commonly used inhalational anesthetic agents, the popularity of desflurane is increasing to a level similar to that of sevoflurane. Inhalational anesthesia generally activates and represses the expression of genes ... ...

Abstract	Although sevoflurane is one of the most commonly used inhalational anesthetic agents, the popularity of desflurane is increasing to a level similar to that of sevoflurane. Inhalational anesthesia generally activates and represses the expression of genes related to xenobiotic metabolism and immune response, respectively. However, there has been no comprehensive comparison of the effects of sevoflurane and desflurane on the expression of these genes. Thus, we used a next-generation sequencing method to compare alterations in the global gene expression profiles in the livers of rats subjected to inhalational anesthesia by sevoflurane or desflurane. Our bioinformatics analyses revealed that sevoflurane and, to a greater extent, desflurane significantly activated genes related to xenobiotic metabolism. Our analyses also revealed that both anesthetic agents, especially sevoflurane, downregulated many genes related to immune response.
MeSH term(s)	Animals ; Rats ; Sevoflurane/pharmacology ; Desflurane ; Isoflurane/pharmacology ; Methyl Ethers/pharmacology ; Transcriptome ; Xenobiotics ; Anesthetics, Inhalation/pharmacology ; Anesthesia, Inhalation
Chemical Substances	Sevoflurane (38LVP0K73A) ; Desflurane (CRS35BZ94Q) ; Isoflurane (CYS9AKD70P) ; Methyl Ethers ; Xenobiotics ; Anesthetics, Inhalation
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298264
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification of novel oncogenes in oral cancer among elderly nonsmokers.

Inoue, Hitoshi / Hirasaki, Masataka / Kogashiwa, Yasunao / Nakachi, Yutaka / Kuba, Kiyomi / Ebihara, Yasuhiro / Nakahira, Mitsuhiko / Yasuda, Masanori / Okuda, Akihiko / Sugasawa, Masashi

Clinical and experimental dental research

2023 Volume 9, Issue 4, Page(s) 711–720

Abstract: Objectives: In recent years, an increase in oral cancer among elderly nonsmokers has been noted. The aim of this study was to identify novel oncogenes in oral cancer in older nonsmokers.: Material and methods: Whole-exome sequencing (WES) data from ... ...

Abstract	Objectives: In recent years, an increase in oral cancer among elderly nonsmokers has been noted. The aim of this study was to identify novel oncogenes in oral cancer in older nonsmokers. Material and methods: Whole-exome sequencing (WES) data from 324 oral cancer patients were obtained from The Cancer Genome Atlas. Single nucleotide variants (SNVs) and insertions/deletions (INDELs) were extracted from the WES data of older patients. Fisher's exact test was performed to determine the specificity of variants in these genes. Finally, SNVs and INDELs were identified by target enrichment sequencing. Results: Gene ontology analysis of 112 genes with significant SNVs or INDELs in nonsmokers revealed that nonsynonymous SNVs in HECTD4 were significantly more frequent in nonsmokers than in smokers by target enrichment sequencing (p = .02). Conclusions: Further investigation of the function of HECTD4 variants as oncogenes in older nonsmokers is warranted.
MeSH term(s)	Humans ; Aged ; Exome ; Non-Smokers ; Polymorphism, Single Nucleotide ; Oncogenes/genetics ; Mouth Neoplasms/genetics
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2829558-4
ISSN	2057-4347 ; 2057-4347
ISSN (online)	2057-4347
ISSN	2057-4347
DOI	10.1002/cre2.739
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Correction: PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study.

Mihara, Yoshiaki / Hirasaki, Masataka / Horita, Yosuke / Fujino, Takashi / Fukushima, Hisayo / Kamakura, Yasuo / Uranishi, Kousuke / Hirano, Yasumitsu / Ryozawa, Shomei / Yasuda, Masanori / Makino, Yoshinori / Shibazaki, Satomi / Hamaguchi, Tetsuya

BMC gastroenterology

2024 Volume 24, Issue 1, Page(s) 67

Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03154-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Long noncoding RNA

Yoneda, Ryoma / Ueda, Naomi / Uranishi, Kousuke / Hirasaki, Masataka / Kurokawa, Riki

The Journal of biological chemistry

2020 Volume 295, Issue 17, Page(s) 5626–5639

Abstract: ... pncRNA- ... ...

Abstract	pncRNA-D
MeSH term(s)	Cell Cycle Checkpoints ; Cyclin D1/genetics ; Down-Regulation ; Epigenesis, Genetic ; Genes, bcl-1 ; HeLa Cells ; Humans ; Methylation ; Promoter Regions, Genetic ; RNA, Long Noncoding/genetics
Chemical Substances	CCND1 protein, human ; RNA, Long Noncoding ; Cyclin D1 (136601-57-5)
Language	English
Publishing date	2020-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.011556
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.

Kitamura, Yuka / Uranishi, Kousuke / Hirasaki, Masataka / Nishimoto, Masazumi / Suzuki, Ayumu / Okuda, Akihiko

Scientific reports

2021 Volume 11, Issue 1, Page(s) 9737

Abstract: A non-canonical PRC1 (PRC1.6) prevents precocious meiotic onset. Germ cells alleviate its negative effect by reducing their amount of MAX, a component of PRC1.6, as a prerequisite for their bona fide meiosis. Here, we found that germ cells produced Mga ... ...

Abstract	A non-canonical PRC1 (PRC1.6) prevents precocious meiotic onset. Germ cells alleviate its negative effect by reducing their amount of MAX, a component of PRC1.6, as a prerequisite for their bona fide meiosis. Here, we found that germ cells produced Mga variant mRNA bearing a premature termination codon (PTC) during meiosis as an additional mechanism to impede the function of PRC1.6. The variant mRNA encodes an anomalous MGA protein that lacks the bHLHZ domain and thus functions as a dominant negative regulator of PRC1.6. Notwithstanding the presence of PTC, the Mga variant mRNA are rather stably present in spermatocytes and spermatids due to their intrinsic inefficient background of nonsense-mediated mRNA decay. Thus, our data indicate that meiosis is controlled in a multi-layered manner in which both MAX and MGA, which constitute the core of PRC1.6, are at least used as targets to deteriorate the integrity of the complex to ensure progression of meiosis.
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Female ; Genetic Variation ; Germ Cells/cytology ; Germ Cells/metabolism ; HEK293 Cells ; Humans ; Male ; Meiosis ; Mice, Inbred C57BL ; Polycomb Repressive Complex 1/genetics ; RNA, Messenger/genetics ; Spermatogenesis ; Spermatozoa/cytology ; Spermatozoa/metabolism ; Mice
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Mga protein, mouse ; RNA, Messenger ; Polycomb Repressive Complex 1 (EC 2.3.2.27)
Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89123-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells.

Uranishi, Kousuke / Hirasaki, Masataka / Kitamura, Yuka / Mizuno, Yosuke / Nishimoto, Masazumi / Suzuki, Ayumu / Okuda, Akihiko

Stem cells (Dayton, Ohio)

2021 Volume 39, Issue 11, Page(s) 1435–1446

Abstract: Although the physiological meaning of the high potential of mouse embryonic stem cells (ESCs) for meiotic entry is not understood, a rigid safeguarding system is required to prevent ectopic onset of meiosis. PRC1.6, a non-canonical PRC1, is known for its ...

Abstract	Although the physiological meaning of the high potential of mouse embryonic stem cells (ESCs) for meiotic entry is not understood, a rigid safeguarding system is required to prevent ectopic onset of meiosis. PRC1.6, a non-canonical PRC1, is known for its suppression of precocious and ectopic meiotic onset in germ cells and ESCs, respectively. MGA, a scaffolding component of PRC1.6, bears two distinct DNA-binding domains termed bHLHZ and T-box. However, it is unclear how this feature contributes to the functions of PRC1.6. Here, we demonstrated that both domains repress distinct sets of genes in murine ESCs, but substantial numbers of meiosis-related genes are included in both gene sets. In addition, our data demonstrated that bHLHZ is crucially involved in repressing the expression of Meiosin, which plays essential roles in meiotic entry with Stra8, revealing at least part of the molecular mechanisms that link negative and positive regulation of meiotic onset.
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; DNA/metabolism ; Embryonic Stem Cells/metabolism ; Germ Cells ; Meiosis/genetics ; Mice ; Mouse Embryonic Stem Cells
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Mga protein, mouse ; DNA (9007-49-2)
Language	English
Publishing date	2021-07-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1002/stem.3433
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1894: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito