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  1. Article ; Online: Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study.

    Ohara, Masahiro / Hattori, Takaaki / Chen, Qingmeng / Shimano, Kaoru / Hirata, Kosei / Matsui, Mie / Yokota, Takanori

    Journal of neurology

    2024  

    Abstract: Objective: Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease, and sometimes shows idiopathic normal pressure hydrocephalus (iNPH)-like presentations. We aimed to evaluate spinal tap responsiveness in patients with PSP, ... ...

    Abstract Objective: Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease, and sometimes shows idiopathic normal pressure hydrocephalus (iNPH)-like presentations. We aimed to evaluate spinal tap responsiveness in patients with PSP, including the effect of sham spinal tap.
    Methods: Eleven patients with PSP, ten with probable/definite iNPH, and eight control patients were prospectively enrolled. All participants underwent sham spinal tap and spinal tap procedures. Gait was evaluated using wearable inertial sensors. We defined "tap responders" as individuals with a 10% or more improvement from baseline in any of the gait parameters (timed up-and-go test total time, stride length, and velocity during straight walking under single-task and cognitive dual-task conditions). We compared the ratio of responders in patients with PSP to patients with iNPH and controls.
    Results: The ratio of tap responders and the ratio of sham tap responders in patients with PSP were significantly higher than those in control patients, and not different from those in patients with iNPH. PSP patients with iNPH-like MRI features tended to respond to the spinal tap compared to those without such imaging features. Notably, one patient with PSP, who responded to the spinal tap beyond the effect of sham spinal tap, was treated by the shunt operation.
    Conclusion: This is the first prospective study to demonstrate tap and shunt responsiveness in patients with PSP while highlighting the placebo effects of the spinal tap in patients with PSP or iNPH. Our findings suggest that some PSP patients have impaired cerebrospinal fluid circulation, contributing to a distinct component of the clinical spectrum.
    Language English
    Publishing date 2024-05-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12391-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Teaching NeuroImages: Parkinsonism Secondary to a Metastatic Lesion Involving the Substantia Nigra.

    Hirata, Kosei / Yokota, Takanori / Miura, Yoshiharu

    Neurology

    2020  Volume 96, Issue 13, Page(s) e1800–e1801

    MeSH term(s) Aged ; Brain Stem Neoplasms/complications ; Brain Stem Neoplasms/diagnostic imaging ; Brain Stem Neoplasms/secondary ; Humans ; Lung Neoplasms/pathology ; Male ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/etiology ; Parkinsonian Disorders/physiopathology ; Small Cell Lung Carcinoma/complications ; Small Cell Lung Carcinoma/diagnostic imaging ; Small Cell Lung Carcinoma/secondary ; Substantia Nigra/diagnostic imaging
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Turning and multitask gait unmask gait disturbance in mild-to-moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage.

    Chen, Qingmeng / Hattori, Takaaki / Tomisato, Hiroshi / Ohara, Masahiro / Hirata, Kosei / Yokota, Takanori

    Human brain mapping

    2022  Volume 44, Issue 3, Page(s) 1193–1208

    Abstract: Multiple sclerosis (MS) causes gait and cognitive impairments that are partially normalized by compensatory mechanisms. We aimed to identify the gait tasks that unmask gait disturbance and the underlying neural correlates in MS. We included 25 patients ... ...

    Abstract Multiple sclerosis (MS) causes gait and cognitive impairments that are partially normalized by compensatory mechanisms. We aimed to identify the gait tasks that unmask gait disturbance and the underlying neural correlates in MS. We included 25 patients with MS (Expanded Disability Status Scale score: median 2.0, interquartile range 1.0-2.5) and 19 healthy controls. Fast-paced gait examinations with inertial measurement units were conducted, including straight or circular walking with or without cognitive/motor tasks, and the timed up and go test (TUG). Receiver operating characteristic curve analysis was performed to distinguish both groups by the gait parameters. The correlation between gait parameters and cortical thickness or fractional anisotropy values was examined by using three-dimensional T1-weighted imaging and diffusion tensor imaging, respectively (corrected p < .05). Total TUG duration (>6.0 s, sensitivity 88.0%, specificity 84.2%) and stride velocity during cognitive dual-task circular walking (<1.12 m/s, 84.0%, 84.2%) had the highest discriminative power of the two groups. Deterioration of these gait parameters was correlated with thinner cortical thickness in regional areas, including the left precuneus and left temporoparietal junction, overlapped with parts of the default mode network, ventral attention network, and frontoparietal network. Total TUG duration was negatively correlated with fractional anisotropy values in the deep cerebral white matter areas. Turning and multitask gait may be optimal to unveil partially compensated gait disturbance in patients with mild-to-moderate MS through dynamic balance control and multitask processing, based on the structural damage in functional networks.
    MeSH term(s) Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnostic imaging ; Diffusion Tensor Imaging ; Postural Balance ; Cerebral Cortical Thinning ; Time and Motion Studies ; Gait ; Walking
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.26151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients.

    Ohara, Masahiro / Hirata, Kosei / Hallett, Mark / Matsubayashi, Taiki / Chen, Qingmeng / Kina, Satoko / Shimano, Kaoru / Hirakawa, Akihiro / Yokota, Takanori / Hattori, Takaaki

    Parkinsonism & related disorders

    2023  Volume 108, Page(s) 105322

    Abstract: Background: The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa ... ...

    Abstract Background: The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown.
    Objective: We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.
    Methods: Nineteen drug-naïve PD patients and 21 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors in the following conditions:1) straight walking, 2) circular walking: walking a circle of 1 m diameter in a clock-wise direction for 3 laps, 3) straight or circular walking under cognitive-motor dual-task (serial 7s subtractions). PD patients were evaluated at baseline, within 1 h after intravenous administration of levodopa, and after one, three, and six months treatment with levodopa. The SE was measured by a linear regression slope by plotting consecutive stride lengths over steps. Patients were also separately analyzed depending on laterality of symptoms.
    Results: Long-term levodopa treatment ameliorated the SE only during single-task straight walking. The SE during circular walking was exacerbated after long-term levodopa treatment for right-side dominant patients. During dual-task straight walking, the SE at baseline was greater in right-side dominant PD patients.
    Conclusions: The SE only during single-task straight walking can be ameliorated by long-term levodopa treatment. However, the SE may be exaggerated by cognitive motor interference or by asymmetrical stride length with/without long-term levodopa treatment, depending on the laterality of symptoms.
    MeSH term(s) Humans ; Levodopa/pharmacology ; Parkinson Disease ; Gait Disorders, Neurologic ; Walking/physiology ; Gait/physiology
    Chemical Substances Levodopa (46627O600J)
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2023.105322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Steroid-responsive myositis in a patient with Sjögren's syndrome and refractory peripheral neuropathy.

    Hirata, Kosei / Kobayashi, Masaki / Miyashita, Akiko / Yokota, Takanori

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2019  Volume 41, Issue 5, Page(s) 1303–1305

    MeSH term(s) Humans ; Myositis/complications ; Myositis/drug therapy ; Peripheral Nervous System Diseases/complications ; Peripheral Nervous System Diseases/drug therapy ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/drug therapy ; Steroids/therapeutic use
    Chemical Substances Steroids
    Language English
    Publishing date 2019-12-11
    Publishing country Italy
    Document type Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-019-04170-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury.

    Miyata, Mari / Takahata, Keisuke / Sano, Yasunori / Yamamoto, Yasuharu / Kurose, Shin / Kubota, Manabu / Endo, Hironobu / Matsuoka, Kiwamu / Tagai, Kenji / Oya, Masaki / Hirata, Kosei / Saito, Fumie / Mimura, Masaru / Kamagata, Koji / Aoki, Shigeki / Higuchi, Makoto

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7129

    Abstract: Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and ... ...

    Abstract Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and cognitive impairments in retired athletes with a long history of rmTBI. Overall, 27 retired athletes with a history of rmTBI (18 boxers, 3 kickboxers, 2 wrestlers, and 4 others; rmTBI group) and 23 age/sex-matched healthy participants (control group) were enrolled. MPRAGE on 3 T MRI was acquired and segmented. The TBV and TBV-adjusted regional brain volumes were compared between groups, and the relationship between the neuropsychological test scores and the regional brain volumes were evaluated. Total brain volume (TBV) and regional brain volumes of the mammillary bodies (MBs), hippocampi, amygdalae, thalami, caudate nuclei, and corpus callosum (CC) were estimated using the SPM12 and ITK-SNAP tools. In the rmTBI group, the regional brain volume/TBV ratio (rmTBI vs. control group, Mann-Whitney U test, p < 0.05) underwent partial correlation analysis, adjusting for age and sex, to assess its connection with neuropsychological test results. Compared with the control group, the rmTBI group showed significantly lower the MBs volume/TBV ratio (0.13 ± 0.05 vs. 0.19 ± 0.03 × 10
    MeSH term(s) Humans ; Brain Concussion ; Mammillary Bodies ; Brain ; Memory Disorders/etiology ; Athletes/psychology ; Brain Injuries, Traumatic/complications
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57383-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Relationship between the temporal course of astrogliosis and symptom improvement in cerebral infarction: report of a case monitored using

    Ishibashi, Kenji / Miura, Yoshiharu / Hirata, Kosei / Toyohara, Jun / Ishii, Kenji

    BMC medical imaging

    2020  Volume 20, Issue 1, Page(s) 81

    Abstract: Background: 18: Case presentation: A 72-year-old man, complaining of total loss of sensation in the left index finger, was diagnosed with acute cerebral infarction, and underwent : Conclusions: ... ...

    Abstract Background: 18
    Case presentation: A 72-year-old man, complaining of total loss of sensation in the left index finger, was diagnosed with acute cerebral infarction, and underwent
    Conclusions: 18
    MeSH term(s) Aged ; Aminopyridines/administration & dosage ; Cerebral Infarction/diagnostic imaging ; Cerebral Infarction/etiology ; Cerebral Infarction/metabolism ; Frontal Lobe/diagnostic imaging ; Gliosis/complications ; Gliosis/diagnostic imaging ; Gliosis/metabolism ; Humans ; Male ; Monoamine Oxidase/metabolism ; Positron-Emission Tomography ; Quinolines/administration & dosage ; Somatosensory Cortex/diagnostic imaging
    Chemical Substances Aminopyridines ; Quinolines ; THK5351 ; Monoamine Oxidase (EC 1.4.3.4)
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-020-00481-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bilateral Optic Tract Hyperintensity due to Pituitary Apoplexy.

    Hirata, Kosei / Numasawa, Yoshiyuki / Kobayashi, Zen / Yokota, Takanori

    Internal medicine (Tokyo, Japan)

    2018  Volume 58, Issue 8, Page(s) 1185–1186

    Language English
    Publishing date 2018-10-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1515-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: 18F-THK5351 PET Can Identify Astrogliosis in Multiple Sclerosis Plaques.

    Ishibashi, Kenji / Miura, Yoshiharu / Hirata, Kosei / Toyohara, Jun / Ishii, Kenji

    Clinical nuclear medicine

    2019  Volume 45, Issue 2, Page(s) e98–e100

    Abstract: A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent F-THK5351 PET during a remission period. PET imaging showed that small regions with elevated uptake of F-THK5351 were scattered in the brain and that the foci of F-THK5351 ... ...

    Abstract A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent F-THK5351 PET during a remission period. PET imaging showed that small regions with elevated uptake of F-THK5351 were scattered in the brain and that the foci of F-THK5351 accumulations corresponded anatomically to MS plaques identified by MRI. Because F-THK5351 binds to monoamine oxidase B highly expressed in astrocytes, F-THK5351 accumulates in lesions undergoing astrogliosis. Hence, elevated uptake of F-THK5351 in the present case can represent ongoing astrogliosis in inactive MS lesions (plaques).
    MeSH term(s) Adult ; Aminopyridines ; Female ; Gliosis/diagnostic imaging ; Humans ; Multiple Sclerosis/diagnostic imaging ; Positron-Emission Tomography ; Quinolines ; Radiopharmaceuticals
    Chemical Substances Aminopyridines ; Quinolines ; Radiopharmaceuticals ; THK5351
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000002751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Striatal Dopamine Denervation Impairs Gait Automaticity in Drug-Naïve Parkinson's Disease Patients.

    Hirata, Kosei / Hattori, Takaaki / Kina, Satoko / Chen, Qingmeng / Ohara, Masahiro / Yokota, Takanori

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 35, Issue 6, Page(s) 1037–1045

    Abstract: Background: Gait automaticity, which is impaired in patients with Parkinson's disease (PD), can be quantified by gait variability analysis. Among the 3 regions of the striatum (sensorimotor, executive, and limbic), the sensorimotor region may play a ... ...

    Abstract Background: Gait automaticity, which is impaired in patients with Parkinson's disease (PD), can be quantified by gait variability analysis. Among the 3 regions of the striatum (sensorimotor, executive, and limbic), the sensorimotor region may play a crucial role in motor automaticity in healthy individuals. However, neural correlates of impaired gait automaticity are poorly investigated in PD.
    Objective: We aimed to examine the relationship between gait automaticity and striatal dopaminergic depletion in drug-naïve PD patients.
    Methods: A total of 21 drug-naïve PD patients and 12 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors under fast-paced gait or cognitive dual-task conditions, and their respective coefficient of variation (CV) and dual-task cost were calculated. The extent of striatal dopaminergic depletion was evaluated by dopamine transporter (DAT) imaging with single-photon emission computed tomography using N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[
    Results: PD had higher mean bilateral CV and dual-task cost of stride length than healthy controls. The mean bilateral CV of stride length was negatively correlated with DAT uptake in the bilateral executive regions of the striatum. Voxel-based analysis revealed a negative correlation between the mean bilateral CV of stride length and DAT uptake in the anteromedial striatum.
    Conclusions: Dopaminergic denervation in the anteromedial striatum, a part of the executive region, is associated with impaired gait automaticity in drug-naïve PD patients. This region may compensate for the posterior sensorimotor striatum, maintaining gait automaticity. © 2020 International Parkinson and Movement Disorder Society.
    MeSH term(s) Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Denervation ; Dopamine ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Gait ; Humans ; Parkinson Disease/diagnostic imaging ; Pharmaceutical Preparations ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Dopamine Plasma Membrane Transport Proteins ; Pharmaceutical Preparations ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28024
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