LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 100

Search options

  1. Book: Handbook of immunosenescence / Volume 1

    Fulop, Tamas / Franceschi, Claudio / Hirokawa, Katsuiku / Pawelec, Graham

    Basic understanding and clinical implications

    2019  

    Author's details Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec editors
    Collection Handbook of immunosenescence
    Language English
    Size xlix, 992 Seiten, Illustrationen, Diagramme
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020165472
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1116 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Collection: Handbook of immunosenescence

    Fulop, Tamas / Franceschi, Claudio / Hirokawa, Katsuiku / Pawelec, Graham

    Basic understanding and clinical implications

    2019  

    Author's details Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec editors
    Keywords Age-associated pathologies ; Aging ; Gerontology ; Immunity ; Immunosenescence ; T-cells
    Subject code 610
    Language English
    Dates of publication 2019-9999
    Size 2921 Seiten in 3 Teilen, 23.5 cm x 15.5 cm
    Edition econd edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Collection (display volumes)
    Note 1st. ed. 2009
    HBZ-ID HT020148264
    ISBN 978-3-319-99373-7 ; 3-319-99373-9 ; 9783319993751 ; 9783319993744 ; 3319993755 ; 3319993747
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Handbook of immunosenescence / Volume 2

    Fulop, Tamas / Franceschi, Claudio / Hirokawa, Katsuiku / Pawelec, Graham

    Basic understanding and clinical implications

    2019  

    Author's details Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec editors
    Collection Handbook of immunosenescence
    Language English
    Size xlix Seiten, Seite 995 - 1989, Illustrationen, Diagramme
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020165476
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1117 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: Handbook of immunosenescence / Volume 3

    Fulop, Tamas / Franceschi, Claudio / Hirokawa, Katsuiku / Pawelec, Graham

    Basic understanding and clinical implications

    2019  

    Author's details Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec editors
    Collection Handbook of immunosenescence
    Language English
    Size xlix Seiten, Seite 1993 - 2921, Illustrationen, Diagramme
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020165481
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1118 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Digital mapping of Lewy bodies and neurites in alpha-synuclein stained large cerebral hemispheric sections from three patients with dementia with Lewy bodies showing psychotic manifestations: A pilot study.

    Homma, Taku / Toru, Shuta / Hirokawa, Katsuiku / Uchihara, Toshiki

    Neuroscience letters

    2021  Volume 747, Page(s) 135708

    Abstract: Background: Dementia with Lewy bodies (DLB) is one of the major neurodegenerative diseases and a clinical diagnosis is made based on the fourth consensus report on DLB. However, clinicopathological features of DLB are variable among cases.: Methods: ... ...

    Abstract Background: Dementia with Lewy bodies (DLB) is one of the major neurodegenerative diseases and a clinical diagnosis is made based on the fourth consensus report on DLB. However, clinicopathological features of DLB are variable among cases.
    Methods: We analyzed three autopsy-proven cases of DLB (patients 1-3). Their clinical features were variable in spite of their pathological commonality. The entire hemispheric sections were stained for phosphorylated alpha-synuclein (aS), digitized, and each aS positive lesion was mapped using a virtual slide system.
    Results: The three patients were clinically diagnosed as having DLB. However, patient 1 exhibited amnesia and misrecognition, while patient 3 exhibited abnormal behavior in addition to dementia. Therefore, both patients 1 and 3 did not fulfill the clinical criteria of DLB, in contrast to patient 2. In spite of the clinical heterogeneity, Lewy pathology was similar in patients 1, 2, and 3. Additionally, patient 1 exhibited less frequent Lewy neurites of the amygdala and entorhinal cortex, and less frequent neurofibrillary tangles and senile plaque as compared to patient 2. On the other hand, the Lewy pathology of patient 3 extended far beyond those of patients 1 and 2, wherein the superior to middle frontal cortices, insular cortex, and lentiform nucleus were severely affected by Lewy pathology.
    Conclusions: Clinical features could be variable among autopsy-proven cases of DLB. Furthermore, we show that the accent of Lewy pathology differs according to the variability of the clinical symptoms. This method will provide a comprehensive strategy to analyze wide-spread aS lesions scattered throughout the entire cerebral hemisphere and help determine the corresponding pathological lesions responsible for the clinical variability of neurodegenerative disorders, including DLB.
    MeSH term(s) Aged ; Aged, 80 and over ; Cerebral Cortex/metabolism ; Female ; Humans ; Lewy Bodies/metabolism ; Lewy Body Disease/pathology ; Male ; Neurites/metabolism ; Neurites/pathology ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Pilot Projects
    Language English
    Publishing date 2021-02-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2021.135708
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Parallel gold enhancement of quantum dots 565/655 for double-labelling correlative light and electron microscopy on human autopsied samples.

    Uematsu, Miho / Mikami, Kyohei / Nakamura, Ayako / Takahashi, Ryosuke / Yokota, Takanori / Hirokawa, Katsuiku / Uchihara, Toshiki

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6113

    Abstract: Cadmium selenide quantum dots (QDs) are fluorescent and electron-dense nanoparticles. When used as reporter of immunolabeling, this dual visibility is essential for direct comparison of its fluorescent signals on light microscopy (LM) and their ... ...

    Abstract Cadmium selenide quantum dots (QDs) are fluorescent and electron-dense nanoparticles. When used as reporter of immunolabeling, this dual visibility is essential for direct comparison of its fluorescent signals on light microscopy (LM) and their ultrastructrual counterparts on electron microscopy (EM) as correlative light and electron microscopy (CLEM). To facilitate EM recognition, QDs on EM grid were gold enhanced, which increased their size and electron density. On histological sections as well, gold-enhanced QDs, used as a reporter of immunolabeling, were easily recognized on EM. Because target structures are visible on bright field microscopy, gold enhancement facilitated trimming the target structures into final EM sections. Furthermore, gold enhancement of rod-shaped QD655 on EM grid was accentuated on their tips while spherical QD565 was gold-enhanced as sphere in contrast. This EM distinction was evident on histological sections where QD565 (green fluorescence) and QD655 (red fluorescence) were used as a reporter pair for double immunolabeling. Double-labeled immuno-fluorescent images, initially captured before EM processing, are now compared with their respective immuno EM counterparts. Specific labeling of each epitope was corroborated by mutual comparison between LM and EM. Although fluoronanogold may be a candidate reporter partner with QDs for gold-enhanced, double-labeling CLEM, its limited penetration into fixed tissue hampers universal use for thick histological sections. Gold-enhancement of QD immunolabeling, now expanded to double-labeling CLEM for human brain samples, will pave the way to translate molecular events into ultrastructural morphopathogenesis in situ.
    MeSH term(s) Electrons ; Gold/chemistry ; Humans ; Microscopy, Electron ; Microscopy, Fluorescence/methods ; Quantum Dots
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09849-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Assessment of Age-Related Decline of Immunological Function and Possible Methods for Immunological Restoration in Elderly

    Hirokawa, Katsuiku / Utsuyama, Masanori

    Handbook of Immunosenescence

    Abstract: The immune system plays an important role in protection against infection and cancer, and in the maintenance of the internal environment of the body. However, such important immune functions are known to decline with age in many mammals, including humans. ...

    Abstract The immune system plays an important role in protection against infection and cancer, and in the maintenance of the internal environment of the body. However, such important immune functions are known to decline with age in many mammals, including humans. It is a matter of clinical importance that the incidence of various age-associated diseases such as infections, cancer, and vascular disorders increases with a decrease in immunological vigor. The extent of immunologic decline is variable and exhibits wide interindividual variations. Thus, it is important to assess the extent of immunologic decline in both patients suffering from various diseases and in healthy people in order to maintain healthy conditions. To this end, we have developed a scoring system that analyzes immune parameters according to a database of known age-associated immune changes obtained from a healthy population. Using this scoring system, we can combine several different immunological parameters and express the immune status of individuals as a simple numeral. Several methods of immunological restoration were introduced and the magnitude of restoration was evaluated by the quantitative assessment of immunological level.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-3-319-99375-1_73
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: [Ⅳ. Dendritic Cell Immunotherapy as Pancreatic Cancer Treatment].

    Shimabuku, Masamori / Taguchi, Junichi / Zay Yar Myint, Khin / Kaneda, Munehisa / Kashihara, Kenichi / Kusano, Toshiomi / Horio, Ruriko / Shimizu, Yoko / Hirokawa, Katsuiku

    Gan to kagaku ryoho. Cancer & chemotherapy

    2022  Volume 49, Issue 10, Page(s) 1070–1075

    MeSH term(s) Humans ; Immunotherapy ; Pancreatic Neoplasms/therapy ; Dendritic Cells ; Pancreatic Neoplasms
    Language Japanese
    Publishing date 2022-10-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Aging is something like an opera which can be constructed by many players: an interview with Katsuiku Hirokawa.

    Hirokawa, Katsuiku / Fulop, Tamas

    Biogerontology

    2014  Volume 15, Issue 5, Page(s) 535–542

    MeSH term(s) Aging/immunology ; Animals ; History, 20th Century ; History, 21st Century ; Humans ; Japan ; Research/history
    Language English
    Publishing date 2014
    Publishing country Netherlands
    Document type Historical Article ; Interview ; Portraits
    ZDB-ID 2047160-9
    ISSN 1573-6768 ; 1389-5729
    ISSN (online) 1573-6768
    ISSN 1389-5729
    DOI 10.1007/s10522-014-9518-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5706: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Comorbid argyrophilic grain disease in an 87-year-old male with spinocerebellar ataxia type 31 with dementia: a case report.

    Toru, Shuta / Ishida, Shoko / Uchihara, Toshiki / Hirokawa, Katsuiku / Kitagawa, Masanobu / Ishikawa, Kinya

    BMC neurology

    2020  Volume 20, Issue 1, Page(s) 136

    Abstract: Background: Spinocerebellar ataxia type 31 (SCA31) is not usually associated with dementia, and autopsy in a patient with both conditions is very rare.: Case presentation: An 87-year-old male patient presented with ataxia and progressive dementia. ... ...

    Abstract Background: Spinocerebellar ataxia type 31 (SCA31) is not usually associated with dementia, and autopsy in a patient with both conditions is very rare.
    Case presentation: An 87-year-old male patient presented with ataxia and progressive dementia. Genetic testing led to a diagnosis of SCA31. Fifteen years after his initial symptoms of hearing loss and difficulty walking, he died of aspiration pneumonia. A pathological analysis showed cerebellar degeneration consistent with SCA31 and abundant argyrophilic grains in the hippocampal formation and amygdala that could explain his dementia.
    Conclusions: This is the first autopsy report on comorbid argyrophilic grain disease with SCA31.
    MeSH term(s) Aged, 80 and over ; Amygdala/pathology ; Autopsy ; Brain/pathology ; Dementia/etiology ; Humans ; Male ; Spinocerebellar Ataxias/diagnosis
    Language English
    Publishing date 2020-04-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-020-01723-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top