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Article ; Online: A new association between Harpellales, insect-gut inhabiting fungi, and Chironomidae in Japan with an updated list of Harpellales documented from Chironomidae

Hiroki Sato

CHIRONOMUS Journal of Chironomidae Research, Iss

2023 Volume 37

Abstract: Harpellales (Zoopagomycotina) is a fungal order of which species inhabit the intestine of aquatic arthropods by attaching their thalli to the host’s gut lining. Harpellales consists of 270 species with over half found in Chironomidae larvae. The aim of ... ...

Abstract	Harpellales (Zoopagomycotina) is a fungal order of which species inhabit the intestine of aquatic arthropods by attaching their thalli to the host’s gut lining. Harpellales consists of 270 species with over half found in Chironomidae larvae. The aim of this research is to document a species, S. pedifer, new to Japan with a chironomid host association and to list all Chironomidae-commensal species of Harpellales with host and country information.
Keywords	Aquatic insect ; Diptera ; Gut fungi ; Symbiosis ; Trichomycetes ; Science ; Q ; Zoology ; QL1-991
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	NTNU University Museum Norwegian University of Science and Technology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Significance of seed dispersal by the largest frugivore for large-diaspore trees

Hiroki Sato

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 14

Abstract: Abstract How do large-bodied frugivores contribute to seed dispersal of large-diaspore plants? This study examined seed dispersal effectiveness for two large-diaspore tree species, Astrotrichilia asterotricha (AA) and Abrahamia deflexa (AD), in a ... ...

Abstract	Abstract How do large-bodied frugivores contribute to seed dispersal of large-diaspore plants? This study examined seed dispersal effectiveness for two large-diaspore tree species, Astrotrichilia asterotricha (AA) and Abrahamia deflexa (AD), in a Madagascan forest. I evaluated fruit removal rates through focal tree observations and factors affecting seedling recruitment up to the 2-year-old seedling stage. I confirmed brown lemur (Eulemur fulvus) as the sole disperser, removing 58.8% and 26.0% of fruits produced by AA and AD. Brown lemurs frequently visited large-crowned AA trees with high density of fallen fruits and more adjacent fruiting trees during seasons with low fruit diversity. Most AA seedlings were removed by predators, although canopy openness slightly improved seedling establishment. Although AD seeds were severely attacked by predators under mother trees, the seedlings survived under dispersal conditions distant from the mother trees, and with low density of diaspores. AD had a higher cumulative probability from fruit removal to seedling recruitment (6.5%) than AA (1.5%) in the first rainy season. This study clarifies the significance of seed dispersal to tree recruitment strategies, which vary among different combinations of tree species and large frugivores, i.e. quantitative dispersal to reach suitable microhabitats, and qualitative dispersal to escape from dangerous zones near mother trees.
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Situation of type specimens of Cordyceps and allies described by Dr Kobayasi

Hiroki Sato

Mycology, Vol 8, Iss 4, Pp 303-

2017 Volume 307

Abstract: Information about authentic specimens of Cordyceps spp. that were described by Dr Kobayasi were summarised. Dr Kobayasi, National Museum of Nature and Science, has described/proposed about 28% of the scientific names for the major two genera of ... ...

Abstract	Information about authentic specimens of Cordyceps spp. that were described by Dr Kobayasi were summarised. Dr Kobayasi, National Museum of Nature and Science, has described/proposed about 28% of the scientific names for the major two genera of entomopathogenic fungi (Cordyceps s. l. and Torrubiella s. l.) with Mr Shimizu before 2007. In total 44 authentic specimens were discovered at present: 19 in Torrubiella, 6 in Cordyceps spp. on Elaphomyces, 19 in Cordyceps spp. on cicada. Although the colour iconography books published by Dr Kobayasi and Mr Shimizu did not explain the information about the illustrated specimens, 22 among the discovered specimens have been illustrated in colour showing their fresh condition in the books.
Keywords	Authentic specimen ; cicada ; colour illustration ; Elaphomyces ; holotype ; lectotype ; paratype ; Torrubiella ; Biology (General) ; QH301-705.5 ; Microbiology ; QR1-502
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Single-center prospective study on the efficacy of nivolumab against platinum-sensitive recurrent or metastatic head and neck squamous cell carcinoma

Isaku Okamoto / Kiyoaki Tsukahara / Hiroki Sato

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 10

Abstract: Abstract Nivolumab, an immune checkpoint inhibitor, is beneficial to patients with platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). However, platinum-sensitive R/M-HNSCC has not yet been studied. Hence, in ... ...

Abstract	Abstract Nivolumab, an immune checkpoint inhibitor, is beneficial to patients with platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). However, platinum-sensitive R/M-HNSCC has not yet been studied. Hence, in this prospective study, we evaluated the efficacy and safety of nivolumab in patients with platinum-sensitive R/M-HNSCC. This prospective single-arm study was conducted in a single institution in Japan. Patients with platinum-sensitive R/M-HNSCC (defined as head and neck cancer that recurred or metastasized at least 6 months after platinum-based chemotherapy or chemoradiotherapy) were enrolled. The primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS), overall response rate (ORR), immune-related adverse events (irAEs), and quality of life (QOL). This study was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN000031324). Twenty-two patients with platinum-sensitive R/M-HNSCC were enrolled. The median OS was 17.4 months, and the 1-year OS rate was 73%. The median PFS was 9.6 months, 1-year PFS rate was 48%, and ORR was 36%. Sixteen irAEs were recorded in 12 patients; however, no grade 4 or 5 irAEs were observed. The QOL assessments revealed that nivolumab did not decrease the QOL of patients. Nivolumab is effective against platinum-sensitive R/M-HNSCC with acceptable safety.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation of Metarhizium spp. from rhizosphere soils of wild plants reflects fungal diversity in soil but not plant specificity

Oumi Nishi / Hiroki Sato

Mycology, Vol 10, Iss 1, Pp 22-

2019 Volume 31

Abstract: Understanding the abundance and diversity of fungal entomopathogens associated with plant species is critical for improving their field efficacy as microbial insecticides. Metarhizium is a cosmopolitan entomopathogenic fungus, with some species in this ... ...

Abstract	Understanding the abundance and diversity of fungal entomopathogens associated with plant species is critical for improving their field efficacy as microbial insecticides. Metarhizium is a cosmopolitan entomopathogenic fungus, with some species in this genus showing rhizosphere competencies. This study sought to determine the abundance and diversity of Metarhizium spp. in rhizosphere soils of wild plants in a field in Japan. Metarhizium spp. were detected in 76.2% of 151 rhizosphere soil samples collected from 41 plant species using a plating method. The mean density of Metarhizium spp. in rhizosphere soils was 1.2 × 104 colony forming units/g soil [base 10 logarithm of the mean = 4.06 (S.D. = 0.88)]. There was no significant difference in the densities and detection rates between Asteraceae and Poaceae as well as among two aster and one grass species. The fungal isolates were identified as five species, of which M. pingshaense was the most frequently detected and abundant species. No significant specific associations were recognised between the isolated Metarhizium spp. and the examined aster and grass species. Our findings demonstrated the high occurrence and abundance of M. pingshaense in rhizosphere soils of wild plants at the sampling site irrespective of host plant taxa.
Keywords	Metarhizium ; entomopathogens ; rhizosphere competency ; host specificity ; PCR-RFLP ; Hypocreales ; Biology (General) ; QH301-705.5 ; Microbiology ; QR1-502
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction

Hiroaki Konishi / Hiroki Sato / Kenji Takahashi / Mikihiro Fujiya

International Journal of Molecular Sciences, Vol 22, Iss 12303, p

2021 Volume 12303

Abstract: MicroRNAs (miRNAs) are single-stranded short-chain RNAs that are endogenously expressed in vertebrates; they are considered the fine-tuners of cellular protein expression that act by modifying mRNA translation. miRNAs control tissue development and ... ...

Abstract	MicroRNAs (miRNAs) are single-stranded short-chain RNAs that are endogenously expressed in vertebrates; they are considered the fine-tuners of cellular protein expression that act by modifying mRNA translation. miRNAs control tissue development and differentiation, cell growth, and apoptosis in cancer and non-cancer cells. Aberrant regulation of miRNAs is involved in the pathogenesis of various diseases including cancer. Numerous investigations have shown that the changes in cellular miRNA expression in cancerous tissues and extracellular miRNAs enclosed in exosomes are correlated with cancer prognosis. Therefore, miRNAs can be used as cancer biomarkers and therapeutic targets for cancer in clinical applications. In the previous decade, miRNAs have been shown to regulate cellular functions by directly binding to proteins and mRNAs, thereby controlling cancer progression. This regulatory system implies that cancer-associated miRNAs can be applied as molecular-targeted therapy. This review discusses the roles of miRNA–protein systems in cancer progression and its future applications in cancer treatment.
Keywords	microRNA ; RNA-binding protein ; cancer therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Genetic Relatedness between Gastric and Oral Helicobacter pylori in Patients with Early Gastric Cancer Using Multilocus Sequence Typing

Ryoko Nagata / Hiroki Sato / Shoji Takenaka / Junji Yokoyama / Shuji Terai / Hitomi Mimuro / Yuichiro Noiri

International Journal of Molecular Sciences, Vol 24, Iss 2211, p

2023 Volume 2211

Abstract: The oral cavity is the second most colonized site of Helicobacter pylori after the stomach. This study aimed to compare the genetic relatedness between gastric and oral H. pylori in Japanese patients with early gastric cancer through multilocus sequence ... ...

Abstract	The oral cavity is the second most colonized site of Helicobacter pylori after the stomach. This study aimed to compare the genetic relatedness between gastric and oral H. pylori in Japanese patients with early gastric cancer through multilocus sequence typing (MLST) analysis using eight housekeeping genes. Gastric biopsy specimens and oral samples were collected from 21 patients with a fecal antigen test positive for H. pylori . The number of H. pylori allelic profiles ranged from zero to eight since the yield of DNA was small even when the nested PCR was performed. MLST analysis revealed that only one patient had a matching oral and gastric H. pylori genotype, suggesting that different genotypes of H. pylori inhabit the oral cavity and gastric mucosa. The phylogenetic analysis showed that oral H. pylori in six patients was similar to gastric H. pylori , implying that the two strains are related but not of the same origin, and those strains may be infected on separate occasions. It is necessary to establish a culture method for oral H. pylori to elucidate whether the oral cavity acts as the source of gastric infection, as our analysis was based on a limited number of allele sequences.
Keywords	Helicobacter pylori ; genotypes ; allele sequences ; gastric mucosa ; multilocus sequence typing ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A case of subdural hemorrhage due to ruptured cerebral aneurysm presenting with atypical imaging features

Eisuke Tsukagoshi, MD / Hiroki Sato, MD / Shinya Kohyama, MD, PhD

Radiology Case Reports, Vol 16, Iss 12, Pp 3911-

2021 Volume 3914

Abstract: Acute subdural hemorrhage caused by ruptured cerebral aneurysms is rare. Herein, we report an atypical case of subdural hemorrhage caused by ruptured anterior communicating artery aneurysm in a 49-year-old woman. Computed tomography revealed subarachnoid, ...

Abstract	Acute subdural hemorrhage caused by ruptured cerebral aneurysms is rare. Herein, we report an atypical case of subdural hemorrhage caused by ruptured anterior communicating artery aneurysm in a 49-year-old woman. Computed tomography revealed subarachnoid, intracerebral, and subdural hemorrhages. After the treatment with endovascular coiling significantly decreased the patient's subdural hemorrhage. However, the subdural hemorrhage revealed and became iso-attenuation compared with the white matter on the 11th day, and hypo-attenuation on the 19th day. On the 33rd day, this subdural hemorrhage completely resolved after discontinuation of dual antiplatelet therapy. Due to rapid changes in the radiologic features of SDH, frequent computed tomography scans at least once a week may be needed especially in patients who receive antiplatelet therapy during the vasospasm phase.
Keywords	Cerebral angiography ; Endovascular coiling ; Cerebral vasospasm ; Subdural hemorrhage ; Ruptured aneurysm ; Vasospasm ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dimer Interface in Natural Variant NK1 Is Dispensable for HGF-Dependent Met Receptor Activation

Yumiko Tahira / Katsuya Sakai / Hiroki Sato / Ryu Imamura / Kunio Matsumoto

International Journal of Molecular Sciences, Vol 22, Iss 9240, p

2021 Volume 9240

Abstract: NK1, a splicing variant of hepatocyte growth factor (HGF), binds to and activates Met receptor by forming an NK1 dimer and 2:2 complex with Met. Although the structural mechanism underlying Met activation by HGF remains incompletely resolved, it has been ...

Abstract	NK1, a splicing variant of hepatocyte growth factor (HGF), binds to and activates Met receptor by forming an NK1 dimer and 2:2 complex with Met. Although the structural mechanism underlying Met activation by HGF remains incompletely resolved, it has been proposed that the NK1 dimer structure participates in this activation. We investigated the NK1 dimer interface’s role in Met activation by HGF. Because N127, V140, and K144 are closely involved in the head-to-tail NK1 dimer formation, mutant NK1 proteins with replacement of these residues by alanine were prepared. In Met tyrosine phosphorylation assays, N127-NK1, V140-NK1, and K144-NK1 showed 8.3%, 23.8%, and 52.2% activity, respectively, compared with wild-type NK1. Although wild-type NK1 promoted cell migration and scattering, N127-NK1, V140-NK1, and K144-NK1 hardly or marginally promoted them, indicating loss of activity of these mutant NK1 proteins to activate Met. In contrast, mutant HGFs (N127-HGF, V140-HGF, and K144-HGF) with the same amino acid replacements as in NK1 induced Met tyrosine phosphorylation and biological responses at levels comparable to those of wild-type HGF. These results indicate that the structural basis responsible for NK1-dependent Met dimer formation and activation differs from, or is at least distinguishable from, the structural basis responsible for HGF-dependent Met activation.
Keywords	growth factor ; HGF ; Met ; receptor tyrosine kinase ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-tumor activity of a recombinant measles virus against canine lung cancer cells

Kei Tamura / Tomoko Fujiyuki / Kanako Moritoh / Hayato Akimoto / Keigo Iizuka / Hiroki Sato / Kazushi Asano / Misako Yoneda / Chieko Kai

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Canine primary lung cancer with metastasis has a poor prognosis with no effective treatment. We previously generated a recombinant measles virus (MV) that lost binding affinity to a principal receptor, SLAM, to eliminate its virulence as a new ... ...

Abstract	Abstract Canine primary lung cancer with metastasis has a poor prognosis with no effective treatment. We previously generated a recombinant measles virus (MV) that lost binding affinity to a principal receptor, SLAM, to eliminate its virulence as a new cancer treatment strategy. The virus, rMV-SLAMblind, targets nectin-4, recently listed as a tumor marker, and exerts antitumor activity against nectin-4-positive canine mammary cancer and urinary bladder transitional cell carcinoma cells. However, the effectivity of rMV-SLAMblind for other types of canine cancers is still unknown. Here we evaluated the antitumor effect of rMV-SLAMblind to canine lung cancer. Nectin-4 is expressed on three canine lung cancer cell lines (CLAC, AZACL1, AZACL2) and rMV-SLAMblind was able to infect these cell lines. CLAC cells showed reduced cell viability after virus infection. In the CLAC xenograft nude mouse model, intratumoral administration of rMV-SLAMblind significantly suppressed tumor growth. In rMV-SLAMblind-treated mice, natural killer cells were activated, and Cxcl10 and Il12a levels were significantly increased in comparison with levels in the control group. In addition, the depletion of NK cells reduced the anti-tumor effect. To understand difference in efficacy among canine lung cancer cell lines, we compared virus growth and gene expression pattern after virus treatment in the three canine lung cancer cell lines; virus growth was highest in CLAC cells compared with the other cell lines and the induction of interferon (IFN)-beta and IFN-stimulated genes was at lower levels in CLAC cells. These results suggested that rMV-SLAMblind exhibits oncolytic effect against some canine lung cancer cells and the cellular response after the virus infection may influence its efficacy.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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