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Article ; Online: Neural responses to syllable-induced P1m and social impairment in children with autism spectrum disorder and typically developing Peers.

Sano, Masuhiko / Hirosawa, Tetsu / Yoshimura, Yuko / Hasegawa, Chiaki / An, Kyung-Min / Tanaka, Sanae / Yaoi, Ken / Naitou, Nobushige / Kikuchi, Mitsuru

PloS one

2024 Volume 19, Issue 3, Page(s) e0298020

Abstract: In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness ... ...

Abstract	In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40-92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits.
MeSH term(s)	Child ; Humans ; Autism Spectrum Disorder/diagnosis ; Magnetoencephalography ; Intelligence/physiology ; Intelligence Tests ; Peer Group
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298020
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Article ; Online: Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease.

Naito, Nobushige / Hirosawa, Tetsu / Tsubomoto, Makoto / Miyagishi, Yoshiaki / Kikuchi, Mitsuru

PloS one

2022 Volume 17, Issue 4, Page(s) e0266693

Abstract: Introduction: Alzheimer's disease (AD) affects multiple neural pathways and regions, resulting in various visual impairments such as motion perception. Generally, gamma-band activities during visual motion perception have been thought to reflect ongoing ...

Abstract	Introduction: Alzheimer's disease (AD) affects multiple neural pathways and regions, resulting in various visual impairments such as motion perception. Generally, gamma-band activities during visual motion perception have been thought to reflect ongoing cognitive processes. Nevertheless, few studies have specifically examined induced gamma band activity during visual motion perception in AD patients. Therefore, after performing magnetoencephalography (MEG) recording during apparent motion (AM) stimulation for the left hemi-visual field in patients diagnosed as having AD in the early stage, we compared the results with findings of cognitive performance. Methods: Seventeen AD patients in the early stage and 17 controls matched for age, sex, and educational attainment participated in this study. For each participant, memory performance was assessed with the Mini-Mental State Examination (MMSE) and the Wechsler Memory Scale-Revised (WMS-R). For MEG analysis, we examined power changes induced in a higher frequency range (20-100 Hz) after AM stimuli. Results: The power of induced gamma band activities was significantly higher in AD patients. The power of induced gamma band activities was associated with higher performance on both MMSE and WMS-R tests for attention and concentration in AD patients. Conclusions: Given that neuronal dysfunction in AD is associated with excitotoxic neurodegeneration, and given that subsequent development of compensatory inhibitory mechanisms also contributes to pathology in AD patients, elevated gamma band oscillations might reflect an imbalance of inhibitory and excitatory activity in AD patients. Moreover, positive correlation between induced gamma activity and cognitive performance might signify a compensating mechanism of inhibitory neurons which preserve the pyramidal neuron from excitotoxicity in a posterior association area.
MeSH term(s)	Alzheimer Disease/diagnosis ; Humans ; Magnetoencephalography ; Motion Perception ; Neural Pathways ; Visual Perception
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266693
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Article ; Online: Autism Detection in Children using Common Spatial Patterns of MEG Signals.

Barik, Kasturi / Watanabe, Katsumi / Hirosawa, Tetsu / Yoshimura, Yuko / Kikuchi, Mitsuru / Bhattacharya, Joydeep / Saha, Goutam

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–4

Abstract: Autism exhibits a wide range of developmental disabilities and is associated with aberrant anatomical and functional neural patterns. To detect autism in young children (4-7 years) in an automatic and non-invasive fashion, we have recorded ... ...

Abstract	Autism exhibits a wide range of developmental disabilities and is associated with aberrant anatomical and functional neural patterns. To detect autism in young children (4-7 years) in an automatic and non-invasive fashion, we have recorded magnetoencephalogram (MEG) signals from 30 autistic and 30 age-matched typically developing (TD) children. We have used a machine learning classification framework with common spatial pattern (CSP)-based logarithmic band power (LBP) features. When comparing the LBP feature to the conventional logarithmic variance (LV) spatial pattern, CSP + LBP (92.77%) has performed better than CSP + LV (90.66%) in the 1-100 Hz frequency range for distinguishing autistic children from TD children. In frequency band-wise analysis using our proposed method, the high gamma frequency band (50-100 Hz) has shown the highest classification accuracy (97.14%). Our findings reveal that the occipital lobe exhibits the most distinct spatial pattern in autistic children over the whole frequency range. This study shows that spatial brain activation patterns can be utilized as potential biomarkers of autism in young children. The improved performance signifies the clinical relevance of the work for autism detection using MEG signals.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Magnetoencephalography ; Autistic Disorder/diagnosis ; Brain ; Occipital Lobe ; Head
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340449
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Article ; Online: Relation between acquisition of lexical concept and joint attention in children with autism spectrum disorder without severe intellectual disability.

Sano, Masuhiko / Hirosawa, Tetsu / Kikuchi, Mitsuru / Hasegawa, Chiaki / Tanaka, Sanae / Yoshimura, Yuko

PloS one

2022 Volume 17, Issue 4, Page(s) e0266953

Abstract: In children with autism spectrum disorder (ASD), impairment of joint attention and language function are observed frequently from early childhood. Earlier reports have described these two phenomena as mutually related. For this study, developing past ... ...

Abstract	In children with autism spectrum disorder (ASD), impairment of joint attention and language function are observed frequently from early childhood. Earlier reports have described these two phenomena as mutually related. For this study, developing past research, the relation between joint attention and the ability of conceptual inference is examined in 113 Japanese children (67.9 months mean age, 75% male) with ASD. We calculated Pearson's correlation coefficients between their Joint attention abnormality evaluated by ADOS-2 and "Riddle" subscale in K-ABC, then they are negatively correlated: r (104) = -.285. A larger abnormality of joint attention is associated with a lower ability of conceptual inference. New findings were obtained indicating that, in children of this age group with ASD, the degree of joint attention impairment is correlated negatively with conceptual inference ability, but not with expressive and receptive language abilities. Consideration of the mechanism of this relation is presented in this report.
MeSH term(s)	Attention ; Autism Spectrum Disorder ; Child ; Child, Preschool ; Female ; Humans ; Intellectual Disability/complications ; Language Development ; Language Development Disorders/complications ; Male
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266953
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Article: Eyes-state-dependent alterations of magnetoencephalographic connectivity associated with delayed recall in Alzheimer's disease via graph theory approach.

Yuasa, Keigo / Hirosawa, Tetsu / Soma, Daiki / Furutani, Naoki / Kameya, Masafumi / Sano, Masuhiko / Kitamura, Koji / Ueda, Minehisa / Kikuchi, Mitsuru

Frontiers in psychiatry

2023 Volume 14, Page(s) 1272120

Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1272120
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Article: Effect of transcranial direct current stimulation on the functionality of 40 Hz auditory steady state response brain network: graph theory approach.

Hirosawa, Tetsu / Soma, Daiki / Miyagishi, Yoshiaki / Furutani, Naoki / Yoshimura, Yuko / Kameya, Masafumi / Yamaguchi, Yohei / Yaoi, Ken / Sano, Masuhiko / Kitamura, Koji / Takahashi, Tetsuya / Kikuchi, Mitsuru

Frontiers in psychiatry

2023 Volume 14, Page(s) 1156617

Abstract: Introduction: Measuring whole-brain networks of the 40 Hz auditory steady state response (ASSR) is a promising approach to describe the after-effects of transcranial direct current stimulation (tDCS). The main objective of this study was to evaluate the ...

Abstract	Introduction: Measuring whole-brain networks of the 40 Hz auditory steady state response (ASSR) is a promising approach to describe the after-effects of transcranial direct current stimulation (tDCS). The main objective of this study was to evaluate the effect of tDCS on the brain network of 40 Hz ASSR in healthy adult males using graph theory. The second objective was to identify a population in which tDCS effectively modulates the brain network of 40 Hz ASSR. Methods: This study used a randomized, sham-controlled, double-blinded crossover approach. Twenty-five adult males (20-24 years old) completed two sessions at least 1 month apart. The participants underwent cathodal or sham tDCS of the dorsolateral prefrontal cortex, after which 40 Hz ASSR was measured using magnetoencephalography. After the signal sources were mapped onto the Desikan-Killiany brain atlas, the statistical relationships between localized activities were evaluated in terms of the debiased weighted phase lag index (dbWPLI). Weighted and undirected graphs were constructed for the tDCS and sham conditions based on the dbWPLI. Weighted characteristic path lengths and clustering coefficients were then measured and compared between the tDCS and sham conditions using mixed linear models. Results: The characteristic path length was significantly lower post-tDCS simulation ( Discussion: Given that the healthy brain is functionally integrated, we conclude that tDCS could effectively normalize less functionally integrated brain networks rather than enhance functional integration.
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1156617
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Article ; Online: Influence of oxytocin administration on somatosensory evoked magnetic fields induced by median nerve stimulation during hand action observation in healthy male volunteers.

Ono, Yasuki / Hirosawa, Tetsu / Hasegawa, Chiaki / Ikeda, Takashi / Kudo, Kiwamu / Naito, Nobushige / Yoshimura, Yuko / Kikuchi, Mitsuru

PloS one

2021 Volume 16, Issue 3, Page(s) e0249167

Abstract: Watching another person's hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, ... ...

Abstract	Watching another person's hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalography (MEG) to investigate SEFs following electrical stimulation of the right median nerve in 20 healthy male participants during hand movement observation, which were initially presented as static images followed by moving images. The participants were randomly assigned to receive either oxytocin or saline during the first trial, with the treatment being reversed during a second trial. Log-transformed ratios of the N20 and N30 amplitudes were calculated and compared between moving and static images observations. Phase locking (calculated using intertrial phase coherence) of brain oscillations was also analyzed to evaluate alpha, beta and gamma rhythm changes after oxytocin administration. Log N30 ratios showed no significant changes after placebo administration but showed a decreasing tendency (albeit not significant) after placebo administration, which may suggest mirror neuron system involvement. In contrast, log N20 ratios were increased after placebo administration, but showed no significant change after oxytocin administration. Interestingly, the gamma band activity around N20 increased after placebo administration, suggesting that oxytocin exerted an analgesic effect on median nerve stimulation, and inhibited the gamma band increase. Oxytocin might therefore modulate not only the mirror neuron system, but also the sensory processing associated with median nerve stimulation.
MeSH term(s)	Adult ; Brain/physiology ; Cross-Over Studies ; Evoked Potentials, Somatosensory/drug effects ; Evoked Potentials, Somatosensory/physiology ; Hand/physiology ; Healthy Volunteers ; Humans ; Magnetoencephalography ; Male ; Middle Aged ; Oxytocin/administration & dosage ; Oxytocin/pharmacology ; Placebo Effect ; Single-Blind Method ; Young Adult
Chemical Substances	Oxytocin (50-56-6)
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0249167
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Article ; Online: Complexity of Body Movements during Sleep in Children with Autism Spectrum Disorder.

Furutani, Naoki / Takahashi, Tetsuya / Naito, Nobushige / Maruishi, Takafumi / Yoshimura, Yuko / Hasegawa, Chiaki / Hirosawa, Tetsu / Kikuchi, Mitsuru

Entropy (Basel, Switzerland)

2021 Volume 23, Issue 4

Abstract: Recently, measuring the complexity of body movements during sleep has been proven as an objective biomarker of various psychiatric disorders. Although sleep problems are common in children with autism spectrum disorder (ASD) and might exacerbate ASD ... ...

Abstract	Recently, measuring the complexity of body movements during sleep has been proven as an objective biomarker of various psychiatric disorders. Although sleep problems are common in children with autism spectrum disorder (ASD) and might exacerbate ASD symptoms, their objectivity as a biomarker remains to be established. Therefore, details of body movement complexity during sleep as estimated by actigraphy were investigated in typically developing (TD) children and in children with ASD. Several complexity analyses were applied to raw and thresholded data of actigraphy from 17 TD children and 17 children with ASD. Determinism, irregularity and unpredictability, and long-range temporal correlation were examined respectively using the false nearest neighbor (FNN) algorithm, information-theoretic analyses, and detrended fluctuation analysis (DFA). Although the FNN algorithm did not reveal determinism in body movements, surrogate analyses identified the influence of nonlinear processes on the irregularity and long-range temporal correlation of body movements. Additionally, the irregularity and unpredictability of body movements measured by expanded sample entropy were significantly lower in ASD than in TD children up to two hours after sleep onset and at approximately six hours after sleep onset. This difference was found especially for the high-irregularity period. Through this study, we characterized details of the complexity of body movements during sleep and demonstrated the group difference of body movement complexity across TD children and children with ASD. Complexity analyses of body movements during sleep have provided valuable insights into sleep profiles. Body movement complexity might be useful as a biomarker for ASD.
Language	English
Publishing date	2021-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e23040418
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Article ; Online: Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype.

An, Kyung-Min / Ikeda, Takashi / Hirosawa, Tetsu / Yaoi, Ken / Yoshimura, Yuko / Hasegawa, Chiaki / Tanaka, Sanae / Saito, Daisuke N / Kikuchi, Mitsuru

Scientific reports

2021 Volume 11, Issue 1, Page(s) 10001

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in ... ...

Abstract	Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in the parents of individuals with ASD, suggesting that it has heritable factors. Although previous studies have demonstrated brain morphometry differences in ASD, they are poorly understood in parents of individuals with ASD. Here, we estimated grey matter volume in 45 mothers of children with ASD (mASD) and 46 age-, sex-, and handedness-matched controls using whole-brain voxel-based morphometry analysis. The mASD group had smaller grey matter volume in the right middle temporal gyrus, temporoparietal junction, cerebellum, and parahippocampal gyrus compared with the control group. Furthermore, we analysed the correlations of these brain volumes with ASD behavioural characteristics using autism spectrum quotient (AQ) and systemizing quotient (SQ) scores, which measure general autistic traits and the drive to systemize. Smaller volumes in the middle temporal gyrus and temporoparietal junction correlated with higher SQ scores, and smaller volumes in the cerebellum and parahippocampal gyrus correlated with higher AQ scores. Our findings suggest that atypical grey matter volumes in mASD may represent one of the neurostructural endophenotypes of ASD.
MeSH term(s)	Adult ; Autism Spectrum Disorder/diagnostic imaging ; Autism Spectrum Disorder/genetics ; Case-Control Studies ; Endophenotypes ; Female ; Gray Matter/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Mothers
Language	English
Publishing date	2021-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89393-z
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Article ; Online: Japanese local government management of compulsory hospitalization for patients with mental disorders and comorbid COVID-19.

Naito, Nobushige / Hirosawa, Tetsu / Tsubomoto, Makoto / Sano, Masuhiko / Miyagishi, Yoshiaki / Kameya, Masafumi / Okuda, Takeshi / Kikuchi, Mitsuru

Asian journal of psychiatry

2021 Volume 65, Page(s) 102859

Abstract: Administering medical treatment or managing quarantine for a patient is particularly difficult when a patient harming others or causing self-harm because of severe depression, a manic state, or psychomotor agitation is also infected with COVID-19. ... ...

Abstract	Administering medical treatment or managing quarantine for a patient is particularly difficult when a patient harming others or causing self-harm because of severe depression, a manic state, or psychomotor agitation is also infected with COVID-19. Kanazawa University Hospital is the only facility able to manage such difficult cases occurring in Ishikawa prefecture, a local administrative area in Japan. The hospital has arranged a negative pressure apparatus in a psychiatric ward with two protection rooms. This report describes an urgently established but viable system in one prefecture of Japan for treating COVID-19-infected patients with severe psychiatric symptoms during the COVID-19 pandemic.
MeSH term(s)	COVID-19 ; Hospitalization ; Humans ; Japan ; Local Government ; Mental Disorders/complications ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-09-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2021.102859
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