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Article ; Online: Percutaneous transfistulous interventions for intractable pancreatic fistula.

Hirota, Masahiko

2011 Volume 2011, Page(s) 109259

Abstract: THREE TECHNIQUES FOR THE TREATMENT OF INTRACTABLE PANCREATIC FISTULA: percutaneous transfistulous pancreatic duct drainage (PTPD), percutaneous transfistulous pancreatojejunostomy (PTPJ), and percutaneous transfistulous pancreatic duct embolization (PTPE) ...

Abstract	THREE TECHNIQUES FOR THE TREATMENT OF INTRACTABLE PANCREATIC FISTULA: percutaneous transfistulous pancreatic duct drainage (PTPD), percutaneous transfistulous pancreatojejunostomy (PTPJ), and percutaneous transfistulous pancreatic duct embolization (PTPE) are presented as treatment options for intractable pancreatic fistula. PTPD is effective for most cases of intractable fistula that communicate with the main pancreatic duct. However, PTPD itself is not enough in some specific cases. PTPJ and PTPE are applicable in such cases.
Language	English
Publishing date	2011-03-30
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2594649-3
ISSN	2090-195X ; 2090-1941
ISSN (online)	2090-195X
ISSN	2090-1941
DOI	10.1155/2011/109259
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Article: [Acute pancreatitis. 2. Etiology and physiopathology].

Hirota, Masahiko

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2010 Volume 99, Issue 1, Page(s) 9–14

MeSH term(s)	Acute Disease ; Female ; Humans ; Male ; Pancreatitis/etiology ; Pancreatitis/physiopathology
Language	Japanese
Publishing date	2010-01-13
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.99.9
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Article ; Online: A case of accessory hepatic duct entering cystic duct successfully treated by laparoscopic cholecystectomy for cholecystolithiasis.

Tomita, Masahiro / Okabe, Hirohisa / Masuda, Toshiro / Ono, Asuka / Kuroda, Daisuke / Kuroki, Hideyuki / Hirota, Masahiko / Hibi, Taizo / Baba, Hideo / Sugita, Hiroki

Asian journal of endoscopic surgery

2023 Volume 16, Issue 3, Page(s) 546–549

Abstract: Although laparoscopic cholecystectomy is a well-established surgical procedure, an accessory hepatic duct (AcHD) entering the cystic duct is poorly understood. A 77-year-old woman with symptomatic cholecystlithiasis was referred to our hospital. ... ...

Abstract	Although laparoscopic cholecystectomy is a well-established surgical procedure, an accessory hepatic duct (AcHD) entering the cystic duct is poorly understood. A 77-year-old woman with symptomatic cholecystlithiasis was referred to our hospital. Abdominal ultrasonography indicated several small stones in the gall bladder. Magnetic resonance cholangiopancreatography (MRCP) did not reveal an anomalous cystic duct. Dissecting the gall bladder bed at operation, AcHD entering the cystic duct was suspected. Intraoperative cholangiography revealed that B5 branch entered the cystic duct. We ligated the AcHD, and divided it. Laparoscopic cholecystectomy was completed, and the patient was discharged without any complication. A week after the operation, MRCP showed that ventral branch of B5 was dilated. The patient showed no symptom for more than a year. The present case exhibited extremely rare AcHD entering the cystic duct, which was hardly recognized before surgery. It is possible to recognize such anomalous variants with standard laparoscopic approach based on 2018 Tokyo Guidelines and with attention to the possibilities of AcHD entering the cystic duct.
MeSH term(s)	Female ; Humans ; Aged ; Cystic Duct/surgery ; Cholecystectomy, Laparoscopic/methods ; Cholecystolithiasis/complications ; Cholecystolithiasis/surgery ; Hepatic Duct, Common/surgery ; Cholangiography
Language	English
Publishing date	2023-03-21
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.13175
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Article ; Online: Combined Neutrophil-to-Lymphocyte Ratio Score Is Associated With Chemotherapeutic Response and Predicts Prognosis in Patients With Advanced Pancreatic Cancer.

Okabe, Hirohisa / Masuda, Toshiro / Tomita, Masahiro / Ono, Asuka / Ogawa, Daisuke / Kuroda, Daisuke / Kuroki, Hideyuki / Hirota, Masahiko / Hibi, Taizo / Baba, Hideo / Sugita, Hiroki

Anticancer research

2024 Volume 44, Issue 4, Page(s) 1575–1582

Abstract: Background/aim: Neutrophil-to-lymphocyte ratio (NLR) is a prognostic indicator for several malignancies, including pancreatic cancer. We developed a novel combined NLR score (cNLRS) based on baseline NLR and change in NLR after chemotherapy (ΔNLR), and ... ...

Abstract	Background/aim: Neutrophil-to-lymphocyte ratio (NLR) is a prognostic indicator for several malignancies, including pancreatic cancer. We developed a novel combined NLR score (cNLRS) based on baseline NLR and change in NLR after chemotherapy (ΔNLR), and examined its prognostic value and role in chemotherapeutic response in patients with advanced pancreatic cancer. Patients and methods: This study retrospectively assessed 210 advanced pancreatic cancer patients receiving chemotherapy between 2010 and 2021. The cNLRS was developed and its association with chemotherapeutic response and prognosis was investigated. Results: The cNLRS consisted of baseline NLR ≥2.5 and ΔNLR ≥0, both of which were remained as independent poor predictors of prognosis adjusting for other traditional clinicopathological features. A high cNLRS served as an independent prognostic factor of reduced overall survival. Of note, the cNLRS was significantly associated with disease control rate and treatment duration not only in 1st line treatment but also in 2nd line treatment. Conclusion: The cNLRS established as a useful prognostic biomarker might be associated with chemotherapeutic response and could predict survival in advanced patients with pancreatic ductal adenocarcinoma treated with chemotherapy.
MeSH term(s)	Humans ; Neutrophils/pathology ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Prognosis ; Lymphocytes/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology
Language	English
Publishing date	2024-03-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16955
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Article ; Online: Preoperative serum CA19-9 predicts postoperative pancreatic fistula in PDAC patients: retrospective analysis at a single institution.

Sugita, Hiroki / Okabe, Hirohisa / Ogawa, Daisuke / Hirao, Hiroki / Kuroda, Daisuke / Taki, Katsunobu / Tomiyasu, Shinjiro / Hirota, Masahiko

BMC surgery

2022 Volume 22, Issue 1, Page(s) 367

Abstract: Background: Postoperative pancreatic fistula (POPF) is a critical complication of pancreatectomy in patients with pancreatic ductal adenocarcinoma (PDAC). Recent papers reported that serum carbohydrate antigen (CA)19-9 levels predicted long-term ... ...

Abstract	Background: Postoperative pancreatic fistula (POPF) is a critical complication of pancreatectomy in patients with pancreatic ductal adenocarcinoma (PDAC). Recent papers reported that serum carbohydrate antigen (CA)19-9 levels predicted long-term prognosis. We investigated whether preoperative serum CA19-9 levels were associated with POPF in PDAC patients. Methods: This cohort study was conducted at a single institution retrospectively. Clinicopathologic features were determined using medical records. Results: Among of 196 consecutive patients who underwent pancreatectomy against PDAC, 180 patients whose CA19-9 levels were above the measurement sensitivity, were registered in this study. The patients consisted of 122 patients who underwent pancreaticoduodenectomy and 58 patients who underwent distal pancreatectomy. Several clinicopathological factors, including CA 19-9 level, as well as surgical factors were determined retrospectively based on the medical records. Patients with high CA19-9 levels had a significantly higher incidence of POPF than those with low levels (43.9 vs. 13.0%, P < 0.0001). The receiver operating characteristic curves calculated that the cutoff CA19-9 value to predict POPF was 428 U/mL. CA19-9, BMI, curability, and histology were statistically significant risk factors for POPF by univariate analysis. Multivariate analysis showed that CA19-9 and BMI levels were statistically significant independent risk factors for POPF. CA19-9 levels were correlated with both histology and curability. Disease free survival and overall survival of patients with higher levels of CA19-9 were significantly shorter than that of patients with lower levels of preoperative serum CA19-9. Conclusions: In patients undergoing pancreatectomy for PDAC, higher preoperative CA19-9 levels are a significant predictor for POPF.
MeSH term(s)	Humans ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/etiology ; Pancreatic Fistula/surgery ; CA-19-9 Antigen ; Retrospective Studies ; Cohort Studies ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatic Neoplasms/pathology ; Pancreaticoduodenectomy/adverse effects ; Pancreatectomy/adverse effects ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Risk Factors ; Pancreatic Neoplasms
Chemical Substances	CA-19-9 Antigen
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-022-01825-3
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Article ; Online: No-touch pancreatectomy for invasive ductal carcinoma of the pancreas.

Hirota, Masahiko / Ogawa, Michio

JOP : Journal of the pancreas

2014 Volume 15, Issue 3, Page(s) 243–249

Abstract: Background: Pancreatectomy is the only effective treatment for cancers of the pancreas. Surgeons usually grasp tumors during pancreatectomy; however, this procedure may increase the risk of squeezing and shedding of the cancer cells into the portal vein, ...

Abstract	Background: Pancreatectomy is the only effective treatment for cancers of the pancreas. Surgeons usually grasp tumors during pancreatectomy; however, this procedure may increase the risk of squeezing and shedding of the cancer cells into the portal vein, retroperitoneum, and/or peritoneal cavity. In an effort to overcome these problems, we have developed surgical techniques for no-touch pancreatectomy. Methods: From April 2008 through September 2013, 52 patients have been operated on no-touch pancreatectomy for invasive ductal carcinoma of the pancreas by a single operator (M.H.). Among them, 40 received pancreatoduodenectomy (PD), and 12 did distal pancreatectomy (DP). Twenty two cases (42%) required SMV-PV resection. This is a study to see if pancreatectomy can be technically done using a no-touch surgical technique without deteriorating the post-operative prognosis. During the procedure, the pancreatic tumor is neither grasped nor squeezed by the surgeon. Furthermore, for improved dissection of the retroperitoneal tissue (leftward and posterior margins for PD and rightward and posterior margins for DP), we use a hanging and clamping maneuver and dissection behind Gerota fascia. Results: Overall 2- and 5-year survival rates were 64 and 42% with mean follow-up periods of 34.4 months (range: 6-68 months). Recurrence free 2- and 5-year survival rates were 49 and 31%, respectively. The 5-year survival rates of patients with JPS-stage III and those with JPS-stage IV were 57 and 20%, respectively. The 5-year survival rates of patients with UICC-stage IIA and those with UICC- stage IIB were 49 and 39%, respectively. Patients with UICC-stage III or IV did not survive for more than 2 years. Conclusions: No-touch pancreatectomy has many theoretic advantages that merit further investigation in future randomized controlled trials.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/secondary ; Carcinoma, Pancreatic Ductal/surgery ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Invasiveness/prevention & control ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Neoplastic Cells, Circulating/pathology ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreatectomy/mortality ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Prognosis ; Retroperitoneal Space/surgery ; Surgical Instruments ; Touch
Language	English
Publishing date	2014-05-27
Publishing country	Italy
Document type	Clinical Trial ; Journal Article
ZDB-ID	2039637-5
ISSN	1590-8577 ; 1590-8577
ISSN (online)	1590-8577
ISSN	1590-8577
DOI	10.6092/1590-8577/2502
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Article ; Online: Roles of Autophagy and Pancreatic Secretory Trypsin Inhibitor in Trypsinogen Activation in Acute Pancreatitis.

Hirota, Masahiko / Ohmuraya, Masaki / Hashimoto, Daisuke / Suyama, Koichi / Sugita, Hiroki / Ogawa, Michio

Pancreas

2020 Volume 49, Issue 4, Page(s) 493–497

Abstract: The focus of the review is on roles of autophagy and pancreatic secretory trypsin inhibitor (PSTI), an endogenous trypsin inhibitor, in trypsinogen activation in acute pancreatitis. Acute pancreatitis is a disease in which tissues in and around the ... ...

Abstract	The focus of the review is on roles of autophagy and pancreatic secretory trypsin inhibitor (PSTI), an endogenous trypsin inhibitor, in trypsinogen activation in acute pancreatitis. Acute pancreatitis is a disease in which tissues in and around the pancreas are autodigested by pancreatic digestive enzymes. This reaction is triggered by the intrapancreatic activation of trypsinogen. Autophagy causes trypsinogen and cathepsin B, a trypsinogen activator, to colocalize within the autolysosomes. Consequently, if the resultant trypsin activity exceeds the inhibitory activity of PSTI, the pancreatic digestive enzymes are activated, and they cause autodigestion of the acinar cells. Thus, autophagy and PSTI play important roles in the development and suppression of acute pancreatitis, respectively.
MeSH term(s)	Acinar Cells/pathology ; Animals ; Autophagy/physiology ; Cathepsin B/metabolism ; Disease Models, Animal ; Endoplasmic Reticulum Stress ; Enzyme Activation ; Glycoproteins/deficiency ; Humans ; Lysosomes/enzymology ; Mice ; Mice, Knockout ; Molecular Chaperones/physiology ; Pancreatitis/enzymology ; Pancreatitis/metabolism ; Pancreatitis/pathology ; Prostatic Secretory Proteins ; Protein Folding ; Proteolysis ; Secretory Vesicles/enzymology ; Transcription Factor CHOP/deficiency ; Trypsin Inhibitor, Kazal Pancreatic/deficiency ; Trypsin Inhibitor, Kazal Pancreatic/physiology ; Trypsinogen/metabolism
Chemical Substances	Ddit3 protein, mouse ; Glycoproteins ; Molecular Chaperones ; Prostatic Secretory Proteins ; SPINK1 protein, human ; Spink1 protein, mouse ; Transcription Factor CHOP (147336-12-7) ; Trypsin Inhibitor, Kazal Pancreatic (50936-63-5) ; Trypsinogen (9002-08-8) ; CTSB protein, human (EC 3.4.22.1) ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001519
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Article: [Various mediators of acute pancreatitis and the mechanism of their activation].

Hirota, Masahiko

Nihon rinsho. Japanese journal of clinical medicine

2004 Volume 62, Issue 11, Page(s) 1966–1970

MeSH term(s)	Acute Disease ; Animals ; Cytokines/metabolism ; Disease Progression ; Endotoxemia ; Humans ; Inflammation Mediators/metabolism ; Leukocyte Elastase/physiology ; Multiple Organ Failure/etiology ; Pancreatitis/etiology ; Receptor, PAR-2/physiology ; Severity of Illness Index ; Trypsin/metabolism ; Trypsinogen/metabolism
Chemical Substances	Cytokines ; Inflammation Mediators ; Receptor, PAR-2 ; Trypsinogen (9002-08-8) ; Leukocyte Elastase (EC 3.4.21.37) ; Trypsin (EC 3.4.21.4)
Language	Japanese
Publishing date	2004-11
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article ; Online: Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE). A case control study.

Ishikawa, Shinji / Sawayama, Hiroshi / Matsuo, Akinobu / Uchino, Ryojin / Honda, Shinobu / Hirota, Masahiko / Baba, Hideo

Japanese journal of clinical oncology

2019 Volume 49, Issue 3, Page(s) 238–244

Abstract: Background: Stage III colorectal cancer is an indication for adjuvant chemotherapy; however, there is no definite view on the selection of regimen. If the recurrence can be predicted, it can serve as the indicator of regimen selection. The present study ...

Abstract	Background: Stage III colorectal cancer is an indication for adjuvant chemotherapy; however, there is no definite view on the selection of regimen. If the recurrence can be predicted, it can serve as the indicator of regimen selection. The present study aimed to predict the recurrence of stage III colorectal cancer by constructing a simple scoring system. Methods: The information of stage III cases that underwent curative surgery was obtained from two facilities and analyzed. A scoring system was constructed from the analysis results and evaluated based on the cases from a different facility. Results: Five factors were extracted by multivariate analysis: age > 65, male, rectum, ≥pN2 and CA19-9 > 37. When these parameters were scored as 1 point each, the score was correlated with the cumulative recurrence rate. Additionally, when cases were divided into three groups (≤1 point, 2 points, ≥3 points), the 5-year recurrence rate was as follows:, ≤1 point: 33.3%, 2 points: 42.1%, ≥3 points: 78.6%. The cumulative recurrence rate of ≥3 points was significantly higher than that of ≤1 point (P < 0.001). Similar results were obtained by evaluating that cases at a different facility (P = 0.032). Both cases with 2 points were located between ≤1 point and ≥3 points, reflecting the average recurrence rate of each institution. Conclusion: As the SiS-SCORE presented the same result in the facility that was different from the base facility, it can be used widely. However, a prospective study is required to prove the usefulness of the SiS-SCORE.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Colorectal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prospective Studies
Language	English
Publishing date	2019-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyy192
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Article ; Online: Innovations in pancreatic surgery.

Hirota, Masahiko / Sand, Juhani / Segersvärd, Ralf / Cirocchi, Roberto

BioMed research international

2014 Volume 2014, Page(s) 963416

MeSH term(s)	Digestive System Surgical Procedures/instrumentation ; Digestive System Surgical Procedures/methods ; Digestive System Surgical Procedures/trends ; Humans ; Pancreas/surgery
Language	English
Publishing date	2014-07-21
Publishing country	United States
Document type	Editorial
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2014/963416
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