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  1. Article ; Online: Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection.

    Fishbane, Steven / Hirsch, Jamie S / Nair, Vinay

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Volume 79, Issue 4, Page(s) 480–482

    MeSH term(s) COVID-19 ; Drug Combinations ; Humans ; Kidney Transplantation ; Lactams ; Leucine ; Nitriles ; Proline ; Ritonavir ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances Drug Combinations ; Lactams ; Nitriles ; nirmatrelvir and ritonavir drug combination ; Proline (9DLQ4CIU6V) ; Leucine (GMW67QNF9C) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.01.001
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  2. Article ; Online: Erythropoiesis-Stimulating Agent Treatment in Patients With COVID-19.

    Fishbane, Steven / Hirsch, Jamie S

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2020  Volume 76, Issue 3, Page(s) 303–305

    MeSH term(s) Acute Kidney Injury/blood ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/epidemiology ; Anemia/blood ; Anemia/drug therapy ; Anemia/epidemiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Erythropoiesis/drug effects ; Erythropoiesis/physiology ; Erythropoietin/blood ; Hematinics/pharmacology ; Hematinics/therapeutic use ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Hematinics ; Erythropoietin (11096-26-7)
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.05.002
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  3. Article: Wide intra- and inter-racial variation of end-stage kidney disease risk and transplant rate in pre-emptively listed kidney transplant candidates.

    Hirsch, Jamie S / Jhaveri, Kenar D / Abate, Mersema / Molmenti, Ernesto / Coppa, Kevin / Nair, Vinay

    Clinical nephrology

    2023  Volume 100, Issue 3, Page(s) 140–142

    MeSH term(s) Humans ; Kidney Transplantation ; Kidney Failure, Chronic/surgery ; Tissue Donors ; Racial Groups ; Waiting Lists
    Language English
    Publishing date 2023-06-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN111136
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  4. Article: The Demystification of Secondary Hypertension: Diagnostic Strategies and Treatment Algorithms.

    Hirsch, Jamie S / Hong, Susana

    Current treatment options in cardiovascular medicine

    2019  Volume 21, Issue 12, Page(s) 90

    Abstract: Purpose of review: Hypertension is one of the most common conditions encountered in the primary care setting, affecting 32-46% of people. While essential or primary hypertension is the most common form of the disease, secondary hypertension is quite ... ...

    Abstract Purpose of review: Hypertension is one of the most common conditions encountered in the primary care setting, affecting 32-46% of people. While essential or primary hypertension is the most common form of the disease, secondary hypertension is quite prevalent, occurring in 10-20% of patients with hypertension. Accurately diagnosing secondary hypertension is a challenging and often time-consuming process that requires considerable expertise and effort. However, once the secondary etiology is identified, the patient benefits profoundly from a potentially curative treatment that may lead to significant improvements in quality of life, morbidity, and mortality.
    Recent findings: Common causes of secondary hypertension include medication-induced hypertension, renal parenchymal disease, renovascular hypertension, obstructive sleep apnea, and primary aldosteronism. Other rarer forms include mineralocorticoid-driven hypertension or its mimics, as well as hypercortisolism and pheochromocytoma. Although complex, standard protocols have emerged for investigation, diagnosis, and treatment of these conditions. The current review aims to elucidate the many causes of secondary hypertension and describe their respective prevalence, clinical presentation, screening, diagnosis, treatment, and follow-up. By demystifying secondary hypertension, it is hoped that this disease will be more easily identified and treated so that the associated cardiovascular morbidity and end-organ damage may be mitigated.
    Language English
    Publishing date 2019-12-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057337-6
    ISSN 1534-3189 ; 1092-8464
    ISSN (online) 1534-3189
    ISSN 1092-8464
    DOI 10.1007/s11936-019-0790-8
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  5. Article: Optimizing Care Delivery in Patients with Chronic Kidney Disease in the United States: Proceedings of a Multidisciplinary Roundtable Discussion and Literature Review.

    Hirsch, Jamie S / Danna, Samuel Colby / Desai, Nihar / Gluckman, Ty J / Jhamb, Manisha / Newlin, Kim / Pellechio, Bob / Elbedewe, Ahlam / Norfolk, Evan

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: Background: Approximately 37 million individuals in the United States (US) have chronic kidney disease (CKD). Patients with CKD have a substantial morbidity and mortality, which contributes to a huge economic burden to the healthcare system. A limited ... ...

    Abstract Background: Approximately 37 million individuals in the United States (US) have chronic kidney disease (CKD). Patients with CKD have a substantial morbidity and mortality, which contributes to a huge economic burden to the healthcare system. A limited number of clinical pathways or defined workflows exist for CKD care delivery in the US, primarily due to a lower prioritization of CKD care within health systems compared with other areas (e.g., cardiovascular disease [CVD], cancer screening). CKD is a public health crisis and by the year 2040, CKD will become the fifth leading cause of years of life lost. It is therefore critical to address these challenges to improve outcomes in patients with CKD.
    Methods: The CKD Leaders Network conducted a virtual, 3 h, multidisciplinary roundtable discussion with eight subject-matter experts to better understand key factors impacting CKD care delivery and barriers across the US. A premeeting survey identified topics for discussion covering the screening, diagnosis, risk stratification, and management of CKD across the care continuum. Findings from this roundtable are summarized and presented herein.
    Results: Universal challenges exist across health systems, including a lack of awareness amongst providers and patients, constrained care team bandwidth, inadequate financial incentives for early CKD identification, non-standardized diagnostic classification and triage processes, and non-centralized patient information. Proposed solutions include highlighting immediate and long-term financial implications linked with failure to identify and address at-risk individuals, identifying and managing early-stage CKD, enhancing efforts to support guideline-based education for providers and patients, and capitalizing on next-generation solutions.
    Conclusions: Payers and other industry stakeholders have opportunities to contribute to optimal CKD care delivery. Beyond addressing the inadequacies that currently exist, actionable tactics can be implemented into clinical practice to improve clinical outcomes in patients at risk for or diagnosed with CKD in the US.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051206
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  7. Article ; Online: Erythropoiesis-Stimulating Agent Treatment in Patients With COVID-19

    Fishbane, Steven / Hirsch, Jamie S.

    American Journal of Kidney Diseases

    2020  Volume 76, Issue 3, Page(s) 303–305

    Keywords Nephrology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.05.002
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  8. Article ; Online: Acute Kidney Injury and Advanced Kidney Disease in the COVID-19 Pandemic: Proceedings From a National Kidney Foundation Symposium.

    Hirsch, Jamie S / Ikizler, Talat Alp / Sharma, Shuchita / Mohammed, Azeem

    Kidney medicine

    2021  Volume 3, Issue 3, Page(s) 426–432

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented and historic public health crisis that continues to expand and evolve. The National Kidney Foundation held a 2-part continuing medical education live virtual symposium on July 16 and ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented and historic public health crisis that continues to expand and evolve. The National Kidney Foundation held a 2-part continuing medical education live virtual symposium on July 16 and July 24, 2020, to address the multiple challenges of COVID-19 in the context of advanced chronic kidney disease. Faculty addressed the pathophysiology, impact, risks, and management of COVID-19 as it relates to advanced kidney disease. Testing, risk mitigation, and inpatient and outpatient management were also addressed. This concise review addresses major findings of the symposium along with certain updates regarding vaccinations since then. These findings include: (1) severe COVID-19 infection has been associated with acute kidney injury, (2) it is essential to prevent and actively manage acute kidney injury to decrease mortality in these critically ill patients, (3) management of patients with advanced kidney disease should be geared toward minimizing their risk for exposure while making sure they are receiving adequate treatments, and (4) patients with kidney disease, especially ones in advanced stages, should be prioritized for vaccination.
    Language English
    Publishing date 2021-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2021.03.003
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  9. Article ; Online: Application of a Machine Learning Algorithm to Develop and Validate a Prediction Model for Ambulatory Non-Arrivals.

    Coppa, Kevin / Kim, Eun Ji / Oppenheim, Michael I / Bock, Kevin R / Zanos, Theodoros P / Hirsch, Jamie S

    Journal of general internal medicine

    2023  Volume 38, Issue 10, Page(s) 2298–2307

    Abstract: Background: Non-arrivals to scheduled ambulatory visits are common and lead to a discontinuity of care, poor health outcomes, and increased subsequent healthcare utilization. Reducing non-arrivals is important given their association with poorer health ... ...

    Abstract Background: Non-arrivals to scheduled ambulatory visits are common and lead to a discontinuity of care, poor health outcomes, and increased subsequent healthcare utilization. Reducing non-arrivals is important given their association with poorer health outcomes and cost to health systems.
    Objective: To develop and validate a prediction model for ambulatory non-arrivals.
    Design: Retrospective cohort study.
    Patients or subjects: Patients at an integrated health system who had an outpatient visit scheduled from January 1, 2020, to February 28, 2022.
    Main measures: Non-arrivals to scheduled appointments.
    Key results: There were over 4.3 million ambulatory appointments from 1.2 million adult patients. Patients with appointment non-arrivals were more likely to be single, racial/ethnic minorities, and not having an established primary care provider compared to those who arrived at their appointments. A prediction model using the XGBoost machine learning algorithm had the highest AUC value (0.768 [0.767-0.770]). Using SHAP values, the most impactful features in the model include rescheduled appointments, lead time (number of days from scheduled to appointment date), appointment provider, number of days since last appointment with the same department, and a patient's prior appointment status within the same department. Scheduling visits close to an appointment date is predicted to be less likely to result in a non-arrival. Overall, the prediction model calibrated well for each department, especially over the operationally relevant probability range of 0 to 40%. Departments with fewer observations and lower non-arrival rates generally had a worse calibration.
    Conclusions: Using a machine learning algorithm, we developed a prediction model for non-arrivals to scheduled ambulatory appointments usable for all medical specialties. The proposed prediction model can be deployed within an electronic health system or integrated into other dashboards to reduce non-arrivals. Future work will focus on the implementation and application of the model to reduce non-arrivals.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Appointments and Schedules ; Algorithms ; Time Factors ; Machine Learning
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08065-y
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  10. Article ; Online: The authors reply.

    Ng, Jia H / Hirsch, Jamie S / Jhaveri, Kenar D / Fishbane, Steven

    Kidney international

    2020  Volume 98, Issue 5, Page(s) 1348–1349

    MeSH term(s) Acute Kidney Injury ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.07.048
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