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  1. Article ; Online: Macacine alphaherpesvirus 1 (B Virus) Infection in Humans, Japan, 2019

    Souichi Yamada / Harutaka Katano / Yuko Sato / Tadaki Suzuki / Akihiko Uda / Keita Ishijima / Motoi Suzuki / Daigo Yamada / Shizuko Harada / Hitomi Kinoshita / Phu Hoang Anh Nguyen / Hideki Ebihara / Ken Maeda / Masayuki Saijo / Shuetsu Fukushi

    Emerging Infectious Diseases, Vol 30, Iss 1, Pp 177-

    2024  Volume 179

    Abstract: Two human patients with Macacine alphaherpesvirus 1 infection were identified in Japan in 2019. Both patients had worked at the same company, which had a macaque facility. The rhesus-genotype B virus genome was detected in cerebrospinal fluid samples ... ...

    Abstract Two human patients with Macacine alphaherpesvirus 1 infection were identified in Japan in 2019. Both patients had worked at the same company, which had a macaque facility. The rhesus-genotype B virus genome was detected in cerebrospinal fluid samples from both patients.
    Keywords Macacine alphaherpesvirus 1 ; B virus ; viruses ; zoonoses ; Japan ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Non-Omicron breakthrough infection with higher viral load and longer vaccination-infection interval improves SARS-CoV-2 BA.4/5 neutralization

    Sho Miyamoto / Takeshi Arashiro / Akira Ueno / Takayuki Kanno / Shinji Saito / Harutaka Katano / Shun Iida / Akira Ainai / Seiya Ozono / Takuya Hemmi / Yuichiro Hirata / Saya Moriyama / Ryutaro Kotaki / Hitomi Kinoshita / Souichi Yamada / Masaharu Shinkai / Shuetsu Fukushi / Yoshimasa Takahashi / Tadaki Suzuki

    iScience, Vol 26, Iss 2, Pp 105969- (2023)

    2023  

    Abstract: Summary: The immune responses to SARS-CoV-2 variants in COVID-19 cases are influenced by various factors including pre-existing immunity via vaccination and prior infection. Elucidating the drivers for upgrading neutralizing activity to SARS-CoV-2 in ... ...

    Abstract Summary: The immune responses to SARS-CoV-2 variants in COVID-19 cases are influenced by various factors including pre-existing immunity via vaccination and prior infection. Elucidating the drivers for upgrading neutralizing activity to SARS-CoV-2 in COVID-19 cases with pre-existing immunity will aid in improving COVID-19 booster vaccines with enhanced cross-protection against antigenically distinct variants, including the Omicron sub-lineage BA.4/5. This study revealed that the magnitude and breadth of neutralization activity to SARS-CoV-2 variants after breakthrough infections are determined primarily by upper respiratory viral load and vaccination-infection time interval. Extensive neutralizing breadth, covering even the most antigenically distant BA.4/5, was observed in cases with higher viral load and longer time intervals. Antigenic cartography depicted a critical role of the time interval in expanding the breadth of neutralization to SARS-CoV-2 variants. Our results illustrate the importance of dosing interval optimization as well as antigen design in developing variant-proof booster vaccines.
    Keywords Immunology ; Immune response ; Virology ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Dengue Sentinel Traveler Surveillance

    Munehisa Fukusumi / Takeshi Arashiro / Yuzo Arima / Tamano Matsui / Tomoe Shimada / Hitomi Kinoshita / Ashley Arashiro / Tomohiko Takasaki / Tomimasa Sunagawa / Kazunori Oishi

    PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e

    Monthly and Yearly Notification Trends among Japanese Travelers, 2006-2014.

    2016  Volume 0004924

    Abstract: BACKGROUND:Dengue is becoming an increasing threat to non-endemic countries. In Japan, the reported number of imported cases has been rising, and the first domestic dengue outbreak in nearly 70 years was confirmed in 2014, highlighting the need for ... ...

    Abstract BACKGROUND:Dengue is becoming an increasing threat to non-endemic countries. In Japan, the reported number of imported cases has been rising, and the first domestic dengue outbreak in nearly 70 years was confirmed in 2014, highlighting the need for greater situational awareness and better-informed risk assessment. METHODS:Using national disease surveillance data and publically available traveler statistics, we compared monthly and yearly trends in the destination country-specific dengue notification rate per 100,000 Japanese travelers with those of domestic dengue cases in the respective country visited during 2006-2014. Comparisons were made for countries accounting for the majority of importations; yearly comparisons were restricted to countries where respective national surveillance data were publicly available. RESULTS:There were 1007 imported Japanese dengue cases (Bali, Indonesia (n = 202), the Philippines (n = 230), Thailand (n = 160), and India (n = 152)). Consistent with historic local dengue seasonality, monthly notification rate among travelers peaked in August in Thailand, September in the Philippines, and in Bali during April with a smaller peak in August. While the number of travelers to Bali was greatest in August, the notification rate was highest in April. Annually, trends in the notification rate among travelers to the Philippines and Thailand also closely reflected local notification trends. CONCLUSION:Travelers to dengue-endemic countries appear to serve as reliable "sentinels", with the trends in estimated risk of dengue infection among Japanese travelers closely reflecting local dengue trends, both seasonally and annually. Sentinel traveler surveillance can contribute to evidence-based pretravel advice, and help inform risk assessments and decision-making for importation and potentially for subsequent secondary transmission. As our approach takes advantage of traveler data that are readily available as a proxy denominator, sentinel traveler surveillance can be a practical surveillance tool ...
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Ongoing local transmission of dengue in Japan, August to September 2014

    Yuzo Arima / Tamano Matsui / Tomoe Shimada / Masahiro Ishikane / Kunio Kawabata / Tomimasa Sunagawa / Hitomi Kinoshita / Tomohiko Takasaki / Yoshio Tsuda / Kyoko Sawabe / Kazunori Oishi

    Western Pacific Surveillance and Response, Vol 5, Iss 4, Pp 27-

    2014  Volume 29

    Abstract: ... No ... ...

    Abstract No abstract
    Keywords dengue ; Japan ; local transmission ; autochthonous dengue ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher World Health Organization Regional Office for the Western Pacific
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Epidemiological and genetic analysis of a 2014 outbreak of hepatitis A in Japan

    Ishii, Koji / Atsuhiro Kanayama / Hitomi Kinoshita / Kazunori Oishi / Kunio Kawabata / Mamoru Noda / Masashi Uema / Sayaka Yoshizaki / Takaji Wakita / Takehito Saitou / Takuri Takahashi / Tomimasa Sunagawa / Tomoko Kiyohara / Yuichiro Yahata

    Vaccine. 2015 Nov. 09, v. 33, no. 45

    2015  

    Abstract: Hepatitis A virus (HAV) is one of the most common causes of feces-transmitted acute hepatitis worldwide. In Japan, most of HAV infections have been sporadic cases and a relatively low number of cases (approximately 100–150) of acute hepatitis A were ... ...

    Abstract Hepatitis A virus (HAV) is one of the most common causes of feces-transmitted acute hepatitis worldwide. In Japan, most of HAV infections have been sporadic cases and a relatively low number of cases (approximately 100–150) of acute hepatitis A were reported in 2012 and 2013. However, in 2014, 342 cases were reported as of week 22. In order to characterize the viral agents causing this outbreak, we collected stool or sera (and both for three case) from patients with hepatitis A from many regions throughout Japan and performed genotyping of the VP1/P2A regions of HAV. We then used a multiple-alignment algorithm to compare the nucleotide sequences with those of reference strains. Phylogenetic tree analyses revealed that the 159 HAV isolates were divided into three subgenotypes: IA (137 cases), IB (4 cases), and IIIA (18 cases). The most unique feature of this outbreak was that for most subgenotype IA cases (103 out of 137 IA cases) the sequences analyzed shared 100% homology. Interestingly, the peak week for these IA infections was almost the same nationwide, suggesting that the epidemic of hepatitis A caused by this subgenotype IA strain may have expanded from a single source possibly because of one food-borne or waterborne source that was distributed nationwide at once.
    Keywords algorithms ; disease incidence ; disease outbreaks ; genotyping ; hepatitis A ; Hepatitis A virus ; nucleotide sequences ; patients ; phylogeny ; vaccines ; Japan
    Language English
    Dates of publication 2015-1109
    Size p. 6029-6036.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2015.04.061
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Assessment of SARS-CoV-2 infectivity of upper respiratory specimens from COVID-19 patients by virus isolation using VeroE6/TMPRSS2 cells

    Tadaki Suzuki / Souichi Yamada / Shuetsu Fukushi / Hitomi Kinoshita / Makoto Ohnishi / Tsuguto Fujimoto / Masayuki Saijo / Ken Maeda / Nozomu Hanaoka / Naomi Nojiri / Ai Kawana-Tachikawa / Shigeru Kusagawa / Koichi Ishikawa / Shigeyoshi Harada / Saori Matsuoka / Tadashi Kikuchi / Sayuri Seki / Midori Nakamura-Hoshi / Shoji Miki /
    Lucky Ronald Runtuwene / Nobuo Koizumi / Sunao Iyoda / Hideyuki Takahashi / Hidemasa Izumiya / Jiro Mitobe / Shouji Yamamoto / Masatomo Morita / Ken-ichi Lee / Ken Shimuta / Kyoko Saito / Masayoshi Fukasawa / Yasutaka Hoshino / Ken Miyazawa / Minoru Nagi / Chikako Shimokawa / Yasuyuki Morishima / Takashi Sakudoh / Yoshihiro Kaku / Chang Kweng Lim / Shigeru Tajima / Takahiro Maeki / Eri Nakayama / Satoshi Taniguchi / Motohiko Ogawa / Takanobu Kato / Hussein Hassan Aly / Kousho Wakae / Kento Fukano

    BMJ Open Respiratory Research, Vol 8, Iss

    2021  Volume 1

    Abstract: Background An outbreak of novel coronavirus (SARS-CoV-2)-associated respiratory infectious diseases (COVID-19) emerged in 2019 and has spread rapidly in humans around the world. The demonstration of in vitro infectiousness of respiratory specimens is an ... ...

    Abstract Background An outbreak of novel coronavirus (SARS-CoV-2)-associated respiratory infectious diseases (COVID-19) emerged in 2019 and has spread rapidly in humans around the world. The demonstration of in vitro infectiousness of respiratory specimens is an informative surrogate for SARS-CoV-2 transmission from patients with COVID-19; accordingly, viral isolation assays in cell culture are an important aspect of laboratory diagnostics for COVID-19.Methods We developed a simple and rapid protocol for isolating SARS-CoV-2 from respiratory specimens using VeroE6/TMPRSS2 cells, a cell line that is highly susceptible to the virus. We also investigated a correlation between isolation of SARS-CoV-2 and viral load detected by real-time RT-PCR (rRT-PCR) using N2 primer/probe set that has been developed for testing of COVID-19 in Japan.Results The SARS-CoV-2 isolation protocol did not require blind passage of inoculated cells and yielded the results of viral isolation within 7 days after inoculation. Specimens with cycle threshold (Ct) values of <20.2, determined by rRT-PCR, were predicted to be isolation-positive. On the other hand, 6.9% of specimens with Ct values >35 were virus isolation-positive, indicating that low viral loads (high Ct values) in upper respiratory specimens do not always indicate no risk of containing transmissible virus.Conclusion In combination with rRT-PCR, the SARS-CoV-2 isolation protocol provides a means for assessing the potential risk of transmissible virus in upper respiratory specimens.
    Keywords Medicine ; R ; Diseases of the respiratory system ; RC705-779
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Exposure to H1 genotype measles virus at an international airport in Japan on 31 July 2016 results in a measles outbreak

    Aika Watanabe / Yusuke Kobayashi / Tomoe Shimada / Yuichiro Yahata / Ayako Kobayashi / Mizue Kanai / Yushi Hachisu / Munehisa Fukusumi / Hajime Kamiya / Takuri Takahashi / Yuzo Arima / Hitomi Kinoshita / Kazuhiko Kanou / Takehito Saitoh / Satoru Arai / Hiroshi Satoh / Hideo Okuno / Saeko Morino / Tamano Matsui /
    Tomimasa Sunagawa / Keiko Tanaka-Taya / Makoto Takeda / Katsuhiro Komase / Kazunori Oishi

    Western Pacific Surveillance and Response, Vol 8, Iss 1, Pp 37-

    2017  Volume 39

    Keywords measles ; elimination ; outbreaks ; surveillance ; genotyping ; sequence analysis ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2017-02-01T00:00:00Z
    Publisher World Health Organization Regional Office for the Western Pacific
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Ongoing increase in measles cases following importations, Japan, March 2014

    Takuri Takahashi / Yuzo Arima / Hitomi Kinoshita / Kazuhiko Kanou / Takehito Saitoh / Tomimasa Sunagawa / Hiroaki Ito / Atsuhiro Kanayama / Ayako Tabuchi / Kazutoshi Nakashima / Yuichiro Yahata / Takuya Yamagishi / Tamie Sugawara / Yasushi Ohkusa / Tamano Matsui / Satoru Arai / Hiroshi Satoh / Keiko Tanaka-Taya / Katsuhiro Komase /
    Makoto Takeda / Kazunori Oishi

    Western Pacific Surveillance and Response, Vol 5, Iss 2, Pp 31-

    times of challenge and opportunity

    2014  Volume 33

    Keywords imported measles cases ; Japan ; measles cases 2014 ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2014-05-01T00:00:00Z
    Publisher World Health Organization Regional Office for the Western Pacific
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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