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  1. Article ; Online: Recurrence of hypertensive disorder in second pregnancy.

    Hjartardottir, Sigrun / Leifsson, Björn G / Geirsson, Reynir T / Steinthorsdottir, Valgerdur

    American journal of obstetrics and gynecology

    2006  Volume 194, Issue 4, Page(s) 916–920

    Abstract: Objective: The purpose of this study was to investigate the recurrence of hypertensive disorders in pregnancy with regard to the type of disorder, the onset of hypertension, and the modulating effect of overweight and weight gain between pregnancies.: ...

    Abstract Objective: The purpose of this study was to investigate the recurrence of hypertensive disorders in pregnancy with regard to the type of disorder, the onset of hypertension, and the modulating effect of overweight and weight gain between pregnancies.
    Study design: Maternity records from 896 parous women with hypertensive disorders in pregnancy in the first pregnancy were reviewed to reclassify disease status and calculate odds ratios for recurrence.
    Results: Recurrence of hypertensive disorders in pregnancy occurred in 58% to 94% of second pregnancies, depending on first pregnancy disorder. Overweight (odds ratio, 1.82) and weight gain (odds ratio, 2.20) were related to recurrence among women with gestational hypertension. Early hypertension (<or =34 weeks of gestation) increased the recurrence risk for women with gestational hypertension (odds ratio, 1.85) and preeclampsia (odds ratio, 3.42).<br />Conclusion: Recurrence of hypertensive disorders in pregnancy is common, but not specified by type of disorder in first pregnancy. Overweight and weight gain between pregnancies are associated with recurrent hypertensive disorders in pregnancy in women with gestational hypertension. Early onset of hypertension is a risk factor, independent of body weight.
    MeSH term(s) Female ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Parity ; Pregnancy ; Recurrence ; Risk Factors
    Language English
    Publishing date 2006-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2005.10.819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Paternity change and the recurrence risk in familial hypertensive disorder in pregnancy.

    Hjartardottir, Sigrun / Leifsson, Björn G / Geirsson, Reynir T / Steinthorsdottir, Valgerdur

    Hypertension in pregnancy

    2004  Volume 23, Issue 2, Page(s) 219–225

    Abstract: Objective: To investigate if there is an increased risk for recurrence of hypertensive disorder in pregnancy with a new partner and whether this is affected by maternal age and the interbirth interval through use of familial material.: Methods: Data ... ...

    Abstract Objective: To investigate if there is an increased risk for recurrence of hypertensive disorder in pregnancy with a new partner and whether this is affected by maternal age and the interbirth interval through use of familial material.
    Methods: Data on 614 multiparous women, with confirmed de novo hypertensive disorder in a first pregnancy, were used to assess the effect of paternity and interbirth interval on recurrence of hypertensive disorders.
    Results: There were 121 women (19.7%) who had changed partner. Recurrent hypertension occurred in 318 women (64.5%) with the same partner and in 75 women (62%) with a new partner. The odds ratio (OR) for recurrence with the same partner was 1.115 (95% CI 0.739-1.680) and with a new partner 0.897 (95% CI 0.595-1.353). The mean interbirth interval was longer for women with recurrent hypertension (4.9 vs. 4.0 years, p = 0.0002). The OR for developing recurrent hypertensive disorder was 1.154 (95% CI 1.049-1.269) for every interval year with the same partner and 1.145 (95% CI 0.958-1.368) with a new partner after correction for maternal age.
    Conclusion: In women with a positive family history and previous hypertension in pregnancy, change of paternity does not influence the risk of recurrence. Increasing interbirth interval may account for a 15% recurrence risk for each year, independent of maternal age. There was no indication that a change of partner conferred any influence on the recurrence risk that is not explained with birth interval or age.
    MeSH term(s) Female ; Humans ; Hypertension/epidemiology ; Iceland/epidemiology ; Maternal Age ; Maternal Welfare ; Paternity ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Complications, Cardiovascular/epidemiology ; Recurrence ; Risk Factors ; Statistics as Topic
    Language English
    Publishing date 2004
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1151886-8
    ISSN 1525-6065 ; 1064-1955
    ISSN (online) 1525-6065
    ISSN 1064-1955
    DOI 10.1081/PRG-120037889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Follow-up of children diagnosed with pervasive developmental disorders: stability and change during the preschool years.

    Jónsdóttir, Sigrídur Lóa / Saemundsen, Evald / Asmundsdóttir, Gudlaug / Hjartardóttir, Sigrún / Asgeirsdóttir, Bryndís B / Smáradóttir, Hrafnhildur H / Sigurdardóttir, Solveig / Smári, Jakob

    Journal of autism and developmental disorders

    2007  Volume 37, Issue 7, Page(s) 1361–1374

    Abstract: Forty-one children with pervasive developmental disorders (PDDs) receiving eclectic services were assessed twice during their preschool years. Measures were compared over time for the whole group and for diagnostic subgroups: Childhood autism (CA group) ... ...

    Abstract Forty-one children with pervasive developmental disorders (PDDs) receiving eclectic services were assessed twice during their preschool years. Measures were compared over time for the whole group and for diagnostic subgroups: Childhood autism (CA group) and Other PDDs group. The mean intelligence quotient/developmental quotient (IQ/DQ) of the whole group was stable (P = 0.209) and scores on the Childhood Autism Rating Scale (CARS) decreased (P = 0.001). At time 2, the CA group was more impaired than the other PDDs group: autistic symptoms were more severe (P = 0.01), adaptive behavior scores were lower (P = 0.014), and a trend for lower IQ/DQs (P = 0.06). Children in this study seemed to fare better than reported in previous follow-up studies on children with autism.
    MeSH term(s) Child ; Child Development Disorders, Pervasive/diagnosis ; Child Development Disorders, Pervasive/epidemiology ; Child, Preschool ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Female ; Follow-Up Studies ; Humans ; International Classification of Diseases ; Language Disorders/diagnosis ; Language Disorders/epidemiology ; Male ; Neuropsychological Tests ; Severity of Illness Index
    Language English
    Publishing date 2007-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-006-0282-z
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  4. Article ; Online: Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

    Steinthorsdottir, Valgerdur / McGinnis, Ralph / Williams, Nicholas O / Stefansdottir, Lilja / Thorleifsson, Gudmar / Shooter, Scott / Fadista, João / Sigurdsson, Jon K / Auro, Kirsi M / Berezina, Galina / Borges, Maria-Carolina / Bumpstead, Suzannah / Bybjerg-Grauholm, Jonas / Colgiu, Irina / Dolby, Vivien A / Dudbridge, Frank / Engel, Stephanie M / Franklin, Christopher S / Frigge, Michael L /
    Frisbaek, Yr / Geirsson, Reynir T / Geller, Frank / Gretarsdottir, Solveig / Gudbjartsson, Daniel F / Harmon, Quaker / Hougaard, David Michael / Hegay, Tatyana / Helgadottir, Anna / Hjartardottir, Sigrun / Jääskeläinen, Tiina / Johannsdottir, Hrefna / Jonsdottir, Ingileif / Juliusdottir, Thorhildur / Kalsheker, Noor / Kasimov, Abdumadjit / Kemp, John P / Kivinen, Katja / Klungsøyr, Kari / Lee, Wai K / Melbye, Mads / Miedzybrodska, Zosia / Moffett, Ashley / Najmutdinova, Dilbar / Nishanova, Firuza / Olafsdottir, Thorunn / Perola, Markus / Pipkin, Fiona Broughton / Poston, Lucilla / Prescott, Gordon / Saevarsdottir, Saedis / Salimbayeva, Damilya / Scaife, Paula Juliet / Skotte, Line / Staines-Urias, Eleonora / Stefansson, Olafur A / Sørensen, Karina Meden / Thomsen, Liv Cecilie Vestrheim / Tragante, Vinicius / Trogstad, Lill / Simpson, Nigel A B / Aripova, Tamara / Casas, Juan P / Dominiczak, Anna F / Walker, James J / Thorsteinsdottir, Unnur / Iversen, Ann-Charlotte / Feenstra, Bjarke / Lawlor, Deborah A / Boyd, Heather Allison / Magnus, Per / Laivuori, Hannele / Zakhidova, Nodira / Svyatova, Gulnara / Stefansson, Kari / Morgan, Linda

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 5976

    Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal ... ...

    Abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adult ; Aged ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Asia, Central/epidemiology ; Blood Pressure/genetics ; Case-Control Studies ; Datasets as Topic ; Europe/epidemiology ; Female ; Fibroblast Growth Factor 5/genetics ; Genetic Loci/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Hypertension, Pregnancy-Induced/genetics ; MDS1 and EVI1 Complex Locus Protein/genetics ; Middle Aged ; Multifactorial Inheritance ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/genetics ; Pregnancy ; Prospective Studies
    Chemical Substances Adaptor Proteins, Signal Transducing ; FGF5 protein, human ; MDS1 and EVI1 Complex Locus Protein ; MECOM protein, human ; SH2B3 protein, human ; Fibroblast Growth Factor 5 (129653-64-1) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-19733-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

    McGinnis, Ralph / Steinthorsdottir, Valgerdur / Williams, Nicholas O / Thorleifsson, Gudmar / Shooter, Scott / Hjartardottir, Sigrun / Bumpstead, Suzannah / Stefansdottir, Lilja / Hildyard, Lucy / Sigurdsson, Jon K / Kemp, John P / Silva, Gabriela B / Thomsen, Liv Cecilie V / Jääskeläinen, Tiina / Kajantie, Eero / Chappell, Sally / Kalsheker, Noor / Moffett, Ashley / Hiby, Susan /
    Lee, Wai Kwong / Padmanabhan, Sandosh / Simpson, Nigel A B / Dolby, Vivien A / Staines-Urias, Eleonora / Engel, Stephanie M / Haugan, Anita / Trogstad, Lill / Svyatova, Gulnara / Zakhidova, Nodira / Najmutdinova, Dilbar / Dominiczak, Anna F / Gjessing, Håkon K / Casas, Juan P / Dudbridge, Frank / Walker, James J / Pipkin, Fiona Broughton / Thorsteinsdottir, Unnur / Geirsson, Reynir T / Lawlor, Debbie A / Iversen, Ann-Charlotte / Magnus, Per / Laivuori, Hannele / Stefansson, Kari / Morgan, Linda

    Nature genetics

    2017  Volume 49, Issue 8, Page(s) 1255–1260

    Abstract: Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have ... ...

    Abstract Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10
    MeSH term(s) Cohort Studies ; Female ; Fetus ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genome, Human ; Genome-Wide Association Study ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Pre-Eclampsia/genetics ; Pregnancy ; Pregnancy Proteins/genetics ; Vascular Endothelial Growth Factor Receptor-1/blood ; Vascular Endothelial Growth Factor Receptor-1/genetics
    Chemical Substances Pregnancy Proteins ; FLT1 protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2017-06-19
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.3895
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