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Article ; Online: Imagerie des accidents vasculaires cérébraux à la phase aiguë.

Hmeydia, Ghazi / Benzakoun, Joseph / Hmeydia, Ghazi

2020 Volume 70, Issue 6, Page(s) 621–625

Abstract: Acute stroke imaging. Imaging, within the first 24 hours of stroke, supports its clinical diagnosis and allows a careful patient selection for treatment. It excludes hemorrhage and stroke mimics, provides an estimate of potentially salvageable brain ... ...

Title translation	Acute stroke imaging.
Abstract	Acute stroke imaging. Imaging, within the first 24 hours of stroke, supports its clinical diagnosis and allows a careful patient selection for treatment. It excludes hemorrhage and stroke mimics, provides an estimate of potentially salvageable brain tissue, locates and characterizes the intra-arterial thrombus before treatment decision in acute ischaemic stroke. In cerebral hemorrhage, it plays a pivotal role in establishing the diagnosis and identifying causes and complications. We outline the role of neuroimaging applied to patients presenting with acute stroke within the first 24 hours.
MeSH term(s)	Brain ; Brain Ischemia ; Cerebral Hemorrhage ; Humans ; Stroke/diagnosis ; Stroke/diagnostic imaging ; Thrombolytic Therapy
Language	French
Publishing date	2020-10-15
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Remote Diffusion-Weighted Imaging Lesions and Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.

Posener, Sacha / Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Baron, Jean-Claude / Turc, Guillaume

Stroke

2023 Volume 54, Issue 4, Page(s) e133–e137

Abstract: Background: Remote diffusion-weighted imaging lesions (RDWILs) in the context of spontaneous intracerebral hemorrhage (ICH) are associated with an increased risk of recurrent stroke, worse functional outcome, and death. To update current knowledge on ... ...

Abstract	Background: Remote diffusion-weighted imaging lesions (RDWILs) in the context of spontaneous intracerebral hemorrhage (ICH) are associated with an increased risk of recurrent stroke, worse functional outcome, and death. To update current knowledge on RDWILs, we conducted a systematic review and meta-analysis of the prevalence, associated factors and presumed causes of RDWILs. Methods: We searched Pubmed, Embase, and Cochrane up to June 2022 for studies reporting RDWILs in adults with symptomatic ICH of no-identified-cause, assessed by magnetic resonance imaging, and analyzed associations between baseline variables and RDWILs in random-effects meta-analyses. Results: Eighteen observational studies (7 prospective), reporting 5211 patients were included, of whom 1386 had ≥1 RDWIL (pooled prevalence: 23.5% [19.0-28.6]). RDWIL presence was associated with neuroimaging features of microangiopathy, atrial fibrillation (odds ratio, 3.67 [1.80-7.49]), clinical severity (mean difference in National Institutes of Health Stroke Scale score, 1.58 points [0.50-2.66]), elevated blood pressure (mean difference, 14.02 mmHg [9.44-18.60]), ICH volume (mean difference, 2.78 mL [0.97-4.60]), and subarachnoid (odds ratio, 1.80 [1.00-3.24]) or intraventricular (odds ratio, 1.53 [1.28-1.83]) hemorrhage. RDWIL presence was associated with poor 3-month functional outcome (odds ratio, 1.95 [1.48-2.57]). Conclusions: RDWILs are detected in approximately 1-in-4 patients with acute ICH. Our results suggest that most RDWILs result from disruption of cerebral small vessel disease by ICH-related precipitating factors such as elevated intracranial pressure and cerebral autoregulation impairment. Their presence is associated with worse initial presentation and outcome. However, given the mostly cross-sectional designs and heterogeneity in study quality, further studies are needed to investigate whether specific ICH treatment strategies may reduce the incidence of RDWILs and in turn improve outcome and reduce stroke recurrence.
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Cross-Sectional Studies ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/etiology ; Diffusion Magnetic Resonance Imaging ; Stroke/drug therapy
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.122.040689
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Article: Diagnostic performance of dynamic 3D magnetic resonance angiography in daily practice for the detection of intracranial arteriovenous shunts in patients with non-traumatic intracranial hemorrhage.

Roumi, Arnaud / Ben Hassen, Wagih / Hmeydia, Ghazi / Posener, Sacha / Pallud, Johan / Sharshar, Tarek / Calvet, David / Mas, Jean-Louis / Baron, Jean-Claude / Oppenheim, Catherine / Naggara, Olivier / Turc, Guillaume

Frontiers in neurology

2023 Volume 13, Page(s) 1085806

Abstract: Introduction: Identification of treatable causes of intracranial hemorrhage (ICH) such as intracranial arteriovenous shunt is crucial to prevent recurrence. However, diagnostic approaches vary considerably across centers, partly because of limited ... ...

Abstract	Introduction: Identification of treatable causes of intracranial hemorrhage (ICH) such as intracranial arteriovenous shunt is crucial to prevent recurrence. However, diagnostic approaches vary considerably across centers, partly because of limited knowledge of the diagnostic performance of first-line vascular imaging techniques. We assessed the diagnostic performance of dynamic three-dimensional magnetic resonance angiography (dynamic 3D MRA) in daily practice to detect intracranial arteriovenous shunts in ICH patients against subsequent digital subtraction angiography (DSA) as reference standard. Methods: We reviewed all adult patients who underwent first-line dynamic 3D MRA and subsequent DSA for non-traumatic ICH between January 2016 and September 2021 in a tertiary center. Sensitivity, specificity, accuracy, positive and negative predictive values of dynamic 3D MRA for the detection of intracranial arteriovenous shunt were calculated with DSA as reference standard. Results: Among 104 included patients, 29 (27.9%) had a DSA-confirmed arteriovenous shunt [19 pial arteriovenous malformations, 10 dural arteriovenous fistulae; median onset-to-DSA: 17 (IQR: 3-88) days]. The sensitivity and specificity of dynamic 3D MRA [median onset-to-dynamic 3D MRA: 14 (3-101) h] for the detection of intracranial arteriovenous shunt were 66% (95% CI: 48-83) and 91% (95% CI: 84-97), respectively. The corresponding accuracy, positive and negative predictive values were 84% (95% CI: 77-91), 73% (95% CI: 56-90), and 87% (95% CI: 80-95), respectively. Conclusion: This study suggests that although first-line evaluation with dynamic 3D MRA may be helpful for the detection of intracranial arteriovenous shunts in patients with ICH, additional vascular imaging work-up should not be withheld if dynamic 3D MRA is negative. Comparative prospective studies are needed to determine the best imaging strategy to diagnose arteriovenous shunts after non-traumatic ICH.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.1085806
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Article ; Online: Discrepancies in the late auditory potentials of post-anoxic patients: Watch out for focal brain lesions, a pilot retrospective study.

Lévi-Strauss, Julie / Hmeydia, Ghazi / Benzakoun, Joseph / Bouchereau, Eléonore / Hermann, Bertrand / Legouy, Camille / Oppenheim, Catherine / Sharshar, Tarek / Gavaret, Martine / Pruvost-Robieux, Estelle

Resuscitation

2023 Volume 187, Page(s) 109801

Abstract: Aims: Late auditory evoked potentials, and notably mismatch negativity (MMN) and P3 responses, can be used as part of the multimodal prognostic evaluation in post-anoxic disorders of consciousness (DOC). MMN response preferentially stems from the ... ...

Abstract	Aims: Late auditory evoked potentials, and notably mismatch negativity (MMN) and P3 responses, can be used as part of the multimodal prognostic evaluation in post-anoxic disorders of consciousness (DOC). MMN response preferentially stems from the temporal cortex and the arcuate fasciculus. Situations with discrepant evaluations, for example MMN absent but P3 present, are frequent and difficult to interpret. We hypothesize that discrepant MMN-/P3+ results could reflect a higher prevalence of lesions in MMN generating regions. This study presents correlations between neurophysiological and neuroradiological results. Methods: This retrospective study was conducted on 38 post-anoxic DOC patients. Brain lesions were analyzed on 3T MRI both anatomically and through computation of the local arcuate fasciculus fractional anisotropy values on Diffusion Tensor Imaging sequences. Neurophysiological data and outcome were also analyzed. Results: Our cohort included 8 MMN-/P3+, 7 MMN+/P3+, 21 MMN-/P3- and 2 MMN-/P3+ patients, assessed at a median delay of 20.5 days since cardiac arrest. Our results show that MMN-/P3+ patients tended to have fewer temporal and basal ganglia lesions than MMN-/P3- patients, and more than MMN+/P3+ patients (p-values for trend: p = 0.02 for temporal and p = 0.02 for basal ganglia lesions). There was a statistical difference across groups for mean fractional anisotropy values in the arcuate fasciculus (p = 0.008). The percentage of patients regaining consciousness at three months in MMN-/P3+ patients was higher than in MMN-/P3- patients and lower than in MMN+/P3+ patients. Conclusion: This study suggests that discrepancies in late auditory evoked potentials may be linked to focal post-anoxic brain lesions, visible on brain MRI.
MeSH term(s)	Humans ; Retrospective Studies ; Diffusion Tensor Imaging ; Evoked Potentials, Auditory/physiology ; Hypoxia, Brain/diagnostic imaging ; Hypoxia, Brain/etiology ; White Matter/diagnostic imaging ; Electroencephalography
Language	English
Publishing date	2023-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2023.109801
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Article ; Online: Synthetic FLAIR as a Substitute for FLAIR Sequence in Acute Ischemic Stroke.

Benzakoun, Joseph / Deslys, Marc-Antoine / Legrand, Laurence / Hmeydia, Ghazi / Turc, Guillaume / Hassen, Wagih Ben / Charron, Sylvain / Debacker, Clément / Naggara, Olivier / Baron, Jean-Claude / Thirion, Bertrand / Oppenheim, Catherine

Radiology

2022 Volume 303, Issue 1, Page(s) 153–159

Abstract: Background In acute ischemic stroke (AIS), fluid-attenuated inversion recovery (FLAIR) is used for treatment decisions when onset time is unknown. Synthetic FLAIR could be generated with deep learning from information embedded in diffusion-weighted ... ...

Abstract	Background In acute ischemic stroke (AIS), fluid-attenuated inversion recovery (FLAIR) is used for treatment decisions when onset time is unknown. Synthetic FLAIR could be generated with deep learning from information embedded in diffusion-weighted imaging (DWI) and could replace acquired FLAIR sequence (real FLAIR) and shorten MRI duration. Purpose To compare performance of synthetic and real FLAIR for DWI-FLAIR mismatch estimation and identification of patients presenting within 4.5 hours from symptom onset. Materials and Methods In this retrospective study, all pretreatment and early follow-up (<48 hours after symptom onset) MRI data sets including DWI (
MeSH term(s)	Aged ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Ischemic Stroke/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Male ; Reproducibility of Results ; Retrospective Studies ; Stroke/therapy ; Time Factors
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.211394
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Article ; Online: Validation of a post-mortem computed tomography method for age estimation based on the 4th rib in a French population.

Richard, Marie-Edith / Delabarde, Tania / Hmeydia, Ghazi / Provost, Corentin / de Jong, Laura / Hamza, Lilia / Meder, Jean-François / Oppenheim, Catherine / Ludes, Bertrand / Benzakoun, Joseph

International journal of legal medicine

2022 Volume 136, Issue 3, Page(s) 833–839

Abstract: Age estimation is a key factor for identification procedure in forensic context. Based on anthropological findings, degenerative changes of the sternal extremity of the 4th rib are currently used for age estimation. These have been adapted to post-mortem ...

Abstract	Age estimation is a key factor for identification procedure in forensic context. Based on anthropological findings, degenerative changes of the sternal extremity of the 4th rib are currently used for age estimation. These have been adapted to post-mortem computed tomography (PMCT). The aim of this study was to validate a post-mortem computed tomography method based on a revision of the Iscan's method on a French sample. A total of 250 PMCT (aged from 18-98 years (IQR 36-68 years, median 51 years); 68 (27%) females) from the Medicolegal Institute of Paris (MLIP) were analyzed by two radiologists. The sternal extremity of 4th right rib was scored using method adapted from Iscan et al. Weighted κ was used to evaluate intra- and inter-observer reliability and Spearman correlation was performed to evaluate relationship between age and score. Confidence intervals for individual prediction of age based on 4th rib score and sex were computed with bootstrapping. The intra-observer reliability and inter-observer reliability were almost perfect (weighted κ = 0.85 [95%CI: 0.78-0.93] and 0.82 [95%CI 0.70-0.96] respectively). We confirmed a high correlation between the 4th rib score and subject age (rho = 0.72, p < 0.001), although the confidence intervals for individual age prediction were large, spanning over several decades. This study confirms the high reliability of Iscan method applied to PMCT for age estimation, although future multimodal age prediction techniques may help reducing the span of confidence intervals for individual age estimation.Trial registration: INDS 0,509,211,020, October 2020, retrospectively registered.
MeSH term(s)	Age Determination by Skeleton/methods ; Female ; Humans ; Reproducibility of Results ; Ribs/diagnostic imaging ; Tomography
Language	English
Publishing date	2022-03-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1055109-8
ISSN	1437-1596 ; 0937-9827
ISSN (online)	1437-1596
ISSN	0937-9827
DOI	10.1007/s00414-022-02798-x
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Article ; Online: Excess out-of-hospital deaths during the COVID-19 outbreak: evidence of pulmonary embolism as a main determinant.

Benzakoun, Joseph / Hmeydia, Ghazi / Delabarde, Tania / Hamza, Lilia / Meder, Jean-François / Ludes, Bertrand / Mebazaa, Alexandre

European journal of heart failure

2020 Volume 22, Issue 6, Page(s) 1046–1047

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Disease Outbreaks ; Global Health ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pulmonary Embolism/etiology ; Pulmonary Embolism/mortality ; SARS-CoV-2 ; Survival Rate/trends
Keywords	covid19
Language	English
Publishing date	2020-06-29
Publishing country	England
Document type	Letter
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.1916
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Article ; Online: Experience with postmortem computed tomography in the forensic analysis of the November 2015 Paris attacks.

de Jong, Laura W / Legrand, Laurence / Delabarde, Tania / Hmeydia, Ghazi / Edjlali, Myriam / Hamza, Lilia / Benzakoun, Joseph / Oppenheim, Catherine / Ludes, Bertrand / Meder, Jean-François

Forensic sciences research

2020 Volume 5, Issue 3, Page(s) 242–247

Language	English
Publishing date	2020-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2885963-7
ISSN	2471-1411 ; 2096-1790
ISSN (online)	2471-1411
ISSN	2096-1790
DOI	10.1080/20961790.2020.1802686
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Article: Excess out-of-hospital deaths during the COVID-19 outbreak: evidence of pulmonary embolism as a main determinant

Benzakoun, Joseph / Hmeydia, Ghazi / Delabarde, Tania / Hamza, Lilia / Meder, Jean-François / Ludes, Bertrand / Mebazaa, Alexandre

Eur J Heart Fail

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #401594
Database	COVID19

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Article ; Online: Excess out‐of‐hospital deaths during the COVID ‐19 outbreak

Benzakoun, Joseph / Hmeydia, Ghazi / Delabarde, Tania / Hamza, Lilia / Meder, Jean‐François / Ludes, Bertrand / Mebazaa, Alexandre

European Journal of Heart Failure

evidence of pulmonary embolism as a main determinant

2020 Volume 22, Issue 6, Page(s) 1046–1047

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.1916
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