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  1. AU="Ho, Chun-Ming"
  2. AU="Dymond, Ian W"
  3. AU="Álvarez, María Noel"
  4. AU="J. Muñoz i Vidal"
  5. AU="Zeng, Guangming"
  6. AU="Luigi Mazzeo, Pier"
  7. AU="Danilova, Olga V"
  8. AU="Jian, Shang"
  9. AU="Jae-Gyu Jeon"
  10. AU="Andrade, Letícia G."
  11. AU="Hosseinzadeh, Sara Ali"
  12. AU="Lee, Kristen"
  13. AU="Gentile, Giulia"
  14. AU="Shoben, Abigail B."
  15. AU="Rowe, Elizabeth"
  16. AU="Pandemic Response COVID-19 Research Collaboration Platform for HCQ/CQ Pooled Analyses"
  17. AU="Rahali, Anwar"
  18. AU="Zhang, Zhuang-Wei"
  19. AU="Townsend, Elizabeth C"
  20. AU="Lange, Mona V"
  21. AU="Bruner, Brenda G"
  22. AU="Michael Craigen"
  23. AU="Lambard, G."
  24. AU="Dempsey, Connor P"
  25. AU=Li Youxian
  26. AU="Bhosale, Chanakya R"

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  1. Artikel ; Online: Yoga and Pilates compared to pelvic floor muscle training for urinary incontinence in elderly women: A randomised controlled pilot trial.

    Kannan, Priya / Hsu, Wai Hin / Suen, Wai Tung / Chan, Lok Man / Assor, Ayelet / Ho, Chun Ming

    Complementary therapies in clinical practice

    2021  Band 46, Seite(n) 101502

    Abstract: Background: and purpose: There is limited evidence from randomised controlled trials (RCTs) regarding the use of yoga and Pilates for the management of urinary incontinence (UI) in women. This study aims to investigate the preliminary effects of using ... ...

    Abstract Background: and purpose: There is limited evidence from randomised controlled trials (RCTs) regarding the use of yoga and Pilates for the management of urinary incontinence (UI) in women. This study aims to investigate the preliminary effects of using Pilates and yoga to manage UI.
    Materials and methods: An assessor-blinded, prospective, three-arm parallel-group randomised controlled pilot trial was conducted in three elderly care centres in Hong Kong. Thirty women aged 60 years or above were included in the study. Study centres were randomly assigned to each of the three interventions (yoga, Pilates and pelvic floor muscle training [PFMT; standard care control]). Study interventions were provided once a week for four weeks, followed by unsupervised CD-guided home exercises for eight weeks. Outcomes included the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), 1-h pad test, and feasibility measures such as adherence to the intervention programme, recruitment and retention rates and safety. Outcomes were assessed at baseline, 4 and 12 weeks. Statistical analysis was performed using two-way repeated measures analysis of covariance.
    Results: All three interventions demonstrated a statistically significant effect on ICIQ-SF scores from baseline to weeks 4 and 12. Significant effects in UI were reported for yoga compared with Pilates (mean: -2.93, 95% CI -5.35, -0.51; p = 0.02).
    Conclusion: Yoga poses intended to address the pelvic floor and core muscles were found to have superior benefits over Pilates exercises in terms of improved continence measured with the ICIQ-SF.
    Mesh-Begriff(e) Aged ; Exercise Therapy ; Female ; Humans ; Middle Aged ; Pelvic Floor ; Pilot Projects ; Treatment Outcome ; Urinary Incontinence/therapy ; Urinary Incontinence, Stress ; Yoga
    Sprache Englisch
    Erscheinungsdatum 2021-10-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 2182834-9
    ISSN 1873-6947 ; 1744-3881
    ISSN (online) 1873-6947
    ISSN 1744-3881
    DOI 10.1016/j.ctcp.2021.101502
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma.

    Ho, Chun-Ming / Lin, Kuen-Tyng / Shen, Roger / Gu, De-Leung / Lee, Szu-Shuo / Su, Wen-Hui / Jou, Yuh-Shan

    Computational and structural biotechnology journal

    2022  Band 20, Seite(n) 1752–1763

    Abstract: With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innovative targets to improve therapeutic strategies is crucial for prolonging the lives of patients. To identify innovative targets, we conducted a ... ...

    Abstract With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innovative targets to improve therapeutic strategies is crucial for prolonging the lives of patients. To identify innovative targets, we conducted a comprehensive comparative transcriptome analysis of 5,410 human HCCs and 974 mouse liver cancers to identify concordantly expressed genes associated with patient survival. Among the 664 identified prognostic comparative HCC (pcHCC) genes, upregulated pcHCC genes were associated with prognostic clinical features, including large tumor size, vascular invasion and late HCC stages. Interestingly, after validating HCC patient prognoses in multiple independent datasets, we matched the 664 aberrant pcHCC genes with the sorafenib-altered genes in TCGA_LIHC patients and found these 664 pcHCC genes were enriched in sorafenib-related functions, such as downregulated xenobiotic and lipid metabolism and upregulated cell proliferation. Therapeutic agents targeting aberrant pcHCC genes presented divergent molecular mechanisms, including suppression of sorafenib-unrelated oncogenic pathways, induction of sorafenib-unrelated ferroptosis, and modulation of sorafenib transportation and metabolism, to potentiate sorafenib therapeutic effects in HCC combination therapy. Moreover, the pcHCC genes NCAPG and CENPW, which have not been targeted in combination with sorafenib treatment, were knocked down and combined with sorafenib treatment, which reduced HCC cell viability based on disruption to the p38/STAT3 axis, thereby hypersensitizing HCC cells. Together, our results provide important resources and reveal that 664 pcHCC genes represent innovative targets suitable for developing therapeutic strategies in combination with sorafenib based on the divergent synergistic mechanisms for HCC tumor suppression.
    Sprache Englisch
    Erscheinungsdatum 2022-04-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.04.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma

    Ho, Chun-Ming / Lin, Kuen-Tyng / Shen, Roger / Gu, De-Leung / Lee, Szu-Shuo / Su, Wen-Hui / Jou, Yuh-Shan

    Computational and Structural Biotechnology Journal. 2022, v. 20

    2022  

    Abstract: With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innovative targets to improve therapeutic strategies is crucial for prolonging the lives of patients. To identify innovative targets, we conducted a ... ...

    Abstract With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innovative targets to improve therapeutic strategies is crucial for prolonging the lives of patients. To identify innovative targets, we conducted a comprehensive comparative transcriptome analysis of 5,410 human HCCs and 974 mouse liver cancers to identify concordantly expressed genes associated with patient survival. Among the 664 identified prognostic comparative HCC (pcHCC) genes, upregulated pcHCC genes were associated with prognostic clinical features, including large tumor size, vascular invasion and late HCC stages. Interestingly, after validating HCC patient prognoses in multiple independent datasets, we matched the 664 aberrant pcHCC genes with the sorafenib-altered genes in TCGA_LIHC patients and found these 664 pcHCC genes were enriched in sorafenib-related functions, such as downregulated xenobiotic and lipid metabolism and upregulated cell proliferation. Therapeutic agents targeting aberrant pcHCC genes presented divergent molecular mechanisms, including suppression of sorafenib-unrelated oncogenic pathways, induction of sorafenib-unrelated ferroptosis, and modulation of sorafenib transportation and metabolism, to potentiate sorafenib therapeutic effects in HCC combination therapy. Moreover, the pcHCC genes NCAPG and CENPW, which have not been targeted in combination with sorafenib treatment, were knocked down and combined with sorafenib treatment, which reduced HCC cell viability based on disruption to the p38/STAT3 axis, thereby hypersensitizing HCC cells. Together, our results provide important resources and reveal that 664 pcHCC genes represent innovative targets suitable for developing therapeutic strategies in combination with sorafenib based on the divergent synergistic mechanisms for HCC tumor suppression.
    Schlagwörter biotechnology ; cell proliferation ; cell viability ; data collection ; ferroptosis ; hepatoma ; humans ; lipid metabolism ; liver ; mice ; mortality ; patients ; therapeutics ; transcriptomics ; xenobiotics
    Sprache Englisch
    Umfang p. 1752-1763.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.04.008
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel: Mutations in

    Su, Wen-Hui / Jou, Yuh-Shan / Zhang, Jia-Hao / Ho, Chun-Ming / Tai, Dar-In

    Journal of Cancer

    2018  Band 9, Heft 15, Seite(n) 2678–2686

    Abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related mortality because of its poor prognosis. Therefore, identifying targetable genetic mutations and mutational signatures associated with prognosis ...

    Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related mortality because of its poor prognosis. Therefore, identifying targetable genetic mutations and mutational signatures associated with prognosis and treatment strategies are needed. Ultra-deep sequencing of 409 cancer genes using formalin-fixed paraffin-embedded tissue from 33 male patients with hepatitis B virus-associated HCC was performed to identify mutational signatures associated with the prognosis of HCC. A total of 47 genes were found to be mutated in more than 10% of patients. Chromatin remodeling genes were overrepresented in the mutation profile. We found patient survival was associated with mutations in
    Sprache Englisch
    Erscheinungsdatum 2018-06-23
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.25438
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Population study on diagnosis, treatment and outcomes of critically ill patients with tuberculosis (2008-2018).

    So, Christina / Ling, Lowell / Wong, Wai Tat / Zhang, Jack Zhenhe / Ho, Chun Ming / Ng, Pauline Yeung / Shum, Hoi Ping / Yeung, Alwin Wai Tak / Sin, Kai Cheuk / Chan, Jacky / Au, Ka Fai / Liong, Ting / Ho, Eunise / Chow, Fu Loi / Ho, Laptin / Chan, Kai Man / Joynt, Gavin Matthew

    Thorax

    2022  Band 78, Heft 7, Seite(n) 674–681

    Abstract: Background: Tuberculosis (TB) is a preventable and curable disease, but mortality remains high among those who develop sepsis and critical illness from TB.: Methods: This was a population-based, multicentre retrospective cohort study of patients ... ...

    Abstract Background: Tuberculosis (TB) is a preventable and curable disease, but mortality remains high among those who develop sepsis and critical illness from TB.
    Methods: This was a population-based, multicentre retrospective cohort study of patients admitted to all 15 publicly funded Hong Kong adult intensive care units (ICUs) between 1 April 2008 and 31 March 2019. 940 adult critically ill patients with at least one positive
    Results: ICU and hospital mortality were 24.7% (232/940) and 41.1% (386/940), respectively. Of those who died in the ICU, 22.8% (53/232) never received antituberculosis drugs. SMR for ICU patients with TB remained unchanged over the study period (Kendall's τb=0.37, p=0.876). After adjustment for age, Charlson comorbidity index, APACHE IV, albumin, vasopressors, mechanical ventilation and renal replacement therapy, delayed TB treatment was directly associated with hospital mortality. In 302/940 (32.1%) of patients, TB could only be established from MTB cultures alone as Ziehl-Neelsen staining or PCR was either not performed or negative. Among this group, only 31.1% (94/302) had concurrent MTB PCR performed.
    Conclusions: Survival of ICU patients with TB has not improved over the last decade and mortality remains high. Delay in TB treatment was associated with higher hospital mortality. Use of MTB PCR may improve diagnostic yield and facilitate early treatment.
    Mesh-Begriff(e) Adult ; Humans ; Critical Illness/therapy ; Retrospective Studies ; Tuberculosis ; Intensive Care Units ; Hospital Mortality ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-08-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-218868
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma.

    Chen, Kuan-Ju / Huang, Jing-Hsiang / Shih, Jou-Ho / Gu, De-Leung / Lee, Szu-Shuo / Shen, Roger / Hsu, Yu-Hsuan / Kung, Ying-Chih / Wu, Cheng-Yen / Ho, Chun-Ming / Jen, Hsin-Wei / Lee, Hsin-Yi / Lang, Yaw-Dong / Hsiao, Chen-Hao / Jou, Yuh-Shan

    Molecular carcinogenesis

    2022  Band 62, Heft 3, Seite(n) 348–359

    Abstract: Adenosine-to-inosine (A-to-I) RNA editing is the most common posttranscriptional editing to create somatic mutations and increase proteomic diversity. However, the functions of the edited mutations are largely underexplored. To identify novel targets in ... ...

    Abstract Adenosine-to-inosine (A-to-I) RNA editing is the most common posttranscriptional editing to create somatic mutations and increase proteomic diversity. However, the functions of the edited mutations are largely underexplored. To identify novel targets in lung adenocarcinoma (LUAD), we conducted a genome-wide somatic A-to-I RNA editing analysis of 23 paired adjacent normal and LUAD transcriptomes and identified 26,280 events, including known nonsynonymous AZIN1-S367G and novel RHOAiso2 (RHOA isoform 2)-R176G, tubulin gamma complex associated protein 2 (TUBGCP2)-N211S, and RBMXL1-I40 M mutations. We validated the edited mutations in silico in multiple databases and in newly collected LUAD tissue pairs with the SEQUENOM MassARRAY® and TaqMan PCR Systems. We selected RHOAiso2-R176G due to its significant level, isoform-specificity, and being the most common somatic edited nonsynonymous mutation of RHOAiso2 to investigate its roles in LUAD tumorigenesis. RHOAiso2 is a ubiquitous but low-expression alternative spliced isoform received a unique Alu-rich exon at the 3' RHOA mRNA to become an editing RNA target, leading to somatic hypermutation and protein diversity. Interestingly, LUAD patients harboring the RHOAiso2-R176G mutation were associated with aberrant RHOA functions, cancer cell proliferation and migration, and poor clinical outcomes in transcriptome analysis. Mechanistically, RHOAiso2-R176G mutation-expressing LUAD cells potentiate RHOA-guanosine triphosphate (GTP) activity to phosphorylate ROCK1/2 effectors and enhance cell proliferation and migration in vitro and increase tumor growth in xenograft and systemic metastasis models in vivo. Taken together, the RHOAiso2-R176G mutation is a common somatic A-to-I edited mutation of the hypermutated RHOA isoform 2. It is an oncogenic and isoform-specific theranostic target that activates RHOA-GTP/p-ROCK1/2 signaling to promote tumor progression.
    Mesh-Begriff(e) Humans ; RNA ; Proteomics ; Adenosine ; Adenocarcinoma of Lung/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Lung Neoplasms/genetics ; Guanosine Triphosphate ; Inosine ; Mutation ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
    Chemische Substanzen RNA (63231-63-0) ; Adenosine (K72T3FS567) ; Protein Isoforms ; Guanosine Triphosphate (86-01-1) ; Inosine (5A614L51CT) ; RHOA protein, human (124671-05-2) ; rhoA GTP-Binding Protein (EC 3.6.5.2) ; ROCK1 protein, human (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2022-12-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004029-8
    ISSN 1098-2744 ; 0899-1987
    ISSN (online) 1098-2744
    ISSN 0899-1987
    DOI 10.1002/mc.23490
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma.

    Lee, Hsin-Yi / Chen, Chi-Kuan / Ho, Chun-Ming / Lee, Szu-Shuo / Chang, Chieh-Yu / Chen, Kuan-Ju / Jou, Yuh-Shan

    Oncotarget

    2018  Band 9, Heft 17, Seite(n) 13193–13205

    Abstract: Targeting tumor angiogenesis is a common strategy against human hepatocellular carcinoma (HCC). However, identification of molecular targets as biomarker for elevating therapeutic efficacy is critical to prolong HCC patient survival. Here, we showed that ...

    Abstract Targeting tumor angiogenesis is a common strategy against human hepatocellular carcinoma (HCC). However, identification of molecular targets as biomarker for elevating therapeutic efficacy is critical to prolong HCC patient survival. Here, we showed that EIF3C (eukaryotic translation initiation factor 3 subunit C) is upregulated during HCC tumor progression and associated with poor patient survival. Expression of EIF3C did not alter proliferation and expression of other tumor progressive genes such as HIF1A, TGFβ1 and VEGF, but reduced cell migration in HCC cells. Nevertheless, expression of EIF3C in HCC cells significantly increase secretion of extracellular exosomes confirmed by increased exosomes labelling by PKH26 fluorescent dye, vesicles in exosome size detected by electronic microscopy and nanoparticle tracking analysis, and expression of divergent exosome markers. The EIF3C-increased exosomes were oncogenic to potentiate tumor angiogenesis via tube formation of HUVEC cells and growth of vessels by plugs assays on nude mice. Subcutaneous inoculation of EIF3C-exosomes mixed with Huh7 HCC cells not only promoted growth of vessels but also increased expression of EIF3C in tumors. Conversely, treatment of exosome inhibitor GW4869 reversed aforementioned oncogenic assays. We identified EIF3C activated expression of S100A11 involved in EIF3C-exosome increased tube formation in angiogenesis. Simultaneous high expression of EIF3C and S100A11 in human HCC tumors for RNA level in TCGA and protein level by IHC are associated with poor survival of HCC patients. Collectively, our results demonstrated that EIF3C overexpression is a potential target of angiogenesis for treatment with exosome inhibitor or S100A11 reduction to suppress HCC angiogenesis and tumorigenesis.
    Sprache Englisch
    Erscheinungsdatum 2018-03-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.24149
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: 64 Gb/s PAM4 VCSEL-based FSO link.

    Lu, Hai-Han / Li, Chung-Yi / Ho, Chun-Ming / Cheng, Ming-Te / Lin, Xin-Yao / Yang, Zih-Yi / Chen, Hwan-Wei

    Optics express

    2017  Band 25, Heft 5, Seite(n) 5749–5757

    Abstract: A 64 Gb/s four-level pulse amplitude modulation (PAM4) vertical-cavity surface-emitting laser (VCSEL)-based free-space optical (FSO) link with an external light injection scheme is proposed and successfully demonstrated. Experimental results show that ... ...

    Abstract A 64 Gb/s four-level pulse amplitude modulation (PAM4) vertical-cavity surface-emitting laser (VCSEL)-based free-space optical (FSO) link with an external light injection scheme is proposed and successfully demonstrated. Experimental results show that the 11.2 GHz VCSEL with an external light injection scheme is sufficiently powerful for 64 Gb/s PAM4 FSO links. This study is the first one that adopts a 1550-nm VCSEL transmitter with an external light injection scheme in a 64 Gb/s PAM4 FSO link. The link performances of the proposed PAM4 VCSEL-based FSO links have been analyzed in real-time in terms of eye diagrams and offline processed by Matlab in terms of bit error rate (BER) performances. Good BER performance and clear eye diagrams are acquired over a 100-m free-space link. Such a proposed 64 Gb/s PAM4 VCSEL-based FSO link with an external light injection scheme is a promising one for providing high transmission rate and long transmission distance.
    Sprache Englisch
    Erscheinungsdatum 2017-03-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.25.005749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: 16 Gb/s PAM4 UWOC system based on 488-nm LD with light injection and optoelectronic feedback techniques.

    Li, Chung-Yi / Lu, Hai-Han / Tsai, Wen-Shing / Cheng, Ming-Te / Ho, Chun-Ming / Wang, Yun-Chieh / Yang, Zih-Yi / Chen, De-Yu

    Optics express

    2017  Band 25, Heft 10, Seite(n) 11598–11605

    Abstract: A 16 Gb/s four-level pulse amplitude modulation (PAM4) underwater wireless optical communication (UWOC) system based on 488-nm laser diode (LD) with light injection and optoelectronic feedback techniques is proposed and successfully demonstrated. ... ...

    Abstract A 16 Gb/s four-level pulse amplitude modulation (PAM4) underwater wireless optical communication (UWOC) system based on 488-nm laser diode (LD) with light injection and optoelectronic feedback techniques is proposed and successfully demonstrated. Experimental results show that such a 1.8-GHz 488-nm blue light LD with light injection and optoelectronic feedback techniques is enough forceful for a 16 Gb/s PAM4 signal underwater link. To the authors' knowledge, this study is the first to successfully adopt a 488-nm LD transmitter with light injection and optoelectronic feedback techniques in a PAM4 UWOC system. By adopting a 488-nm LD transmitter with light injection and optoelectronic feedback techniques, good bit error rate performance (offline processed by Matlab) and clear eye diagrams (measured in real-time) are achieved over a 10-m underwater link. The proposed system has the potential to play a vital role in the future UWOC infrastructure by effectively providing high transmission rate (16 Gb/s) and long underwater transmission distance (10 m).
    Sprache Englisch
    Erscheinungsdatum 2017-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.25.011598
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Bidirectional fiber-IVLLC and fiber-wireless convergence system with two orthogonally polarized optical sidebands.

    Lu, Hai-Han / Wu, Hsiao-Wen / Li, Chung-Yi / Ho, Chun-Ming / Yang, Zih-Yi / Cheng, Ming-Te / Lu, Chang-Kai

    Optics express

    2017  Band 25, Heft 9, Seite(n) 9743–9754

    Abstract: A bidirectional fiber-invisible laser light communication (IVLLC) and fiber-wireless convergence system with two orthogonally polarized optical sidebands for hybrid cable television (CATV)/millimeter-wave (MMW)/baseband (BB) signal transmission is ... ...

    Abstract A bidirectional fiber-invisible laser light communication (IVLLC) and fiber-wireless convergence system with two orthogonally polarized optical sidebands for hybrid cable television (CATV)/millimeter-wave (MMW)/baseband (BB) signal transmission is proposed and experimentally demonstrated. Two optical sidebands generated by a 60-GHz MMW signal are orthogonally polarized and separated into different polarizations. These orthogonally polarized optical sidebands are delivered over a 40-km single-mode fiber (SMF) transport to effectually reduce the fiber dispersion induced by a 40-km SMF transmission and the distortion caused by the parallel polarized optical sidebands. To the best of our knowledge, this work is the first to adopt two orthogonally polarized optical sidebands in a bidirectional fiber-IVLLC and fiber-wireless convergence system to reduce fiber dispersion and distortion effectually. Good carrier-to-noise ratio, composite second order, composite triple beat, and bit error rate (BER) are achieved for downlink transmission at a 40-km SMF operation and a 100-m free-space optical (FSO) link/3-m RF wireless transmission. For up-link transmission, good BER performance is acquired over a 40-km SMF transport and a 100-m FSO link. The approach presented in this work signifies the advancements in the convergence of SMF-based backbone and optical/RF wireless-based feeder.
    Sprache Englisch
    Erscheinungsdatum 2017-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.25.009743
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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