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  1. Article ; Online: Non-linear predictor outcome associations.

    Ho, Frederick K / Cole, Tim J

    BMJ medicine

    2023  Volume 2, Issue 1, Page(s) e000396

    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ISSN 2754-0413
    ISSN (online) 2754-0413
    DOI 10.1136/bmjmed-2022-000396
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  2. Article ; Online: Thromboembolism and bleeding after covid-19.

    Ho, Frederick K / Pell, Jill P

    BMJ (Clinical research ed.)

    2022  Volume 377, Page(s) o817

    MeSH term(s) COVID-19 ; Hemorrhage/etiology ; Humans ; Thromboembolism/etiology
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o817
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  3. Article ; Online: Schizophrenia and Types of Stroke: A Mendelian Randomization Study.

    Nakada, Shinya / Ho, Frederick K / Celis-Morales, Carlos / Pell, Jill P

    Journal of the American Heart Association

    2024  Volume 13, Issue 5, Page(s) e032011

    Abstract: Background: Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and ... ...

    Abstract Background: Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes.
    Methods and results: Two-sample Mendelian randomization analyses were conducted. The summary-level data (restricted to European ancestry) were obtained for schizophrenia and stroke: ischemic stroke, large-artery stroke, small-vessel stroke, cardioembolic stroke, and intracerebral hemorrhage. The associations between schizophrenia and each outcome were analyzed by an inverse variance weighting method primarily and Mendelian randomization Egger, weighted median, and weighted mode subsequently. The presence of pleiotropy was also tested by Cochran
    Conclusions: We have provided evidence of a potentially causal association between schizophrenia and cardioembolic stroke. Our findings suggest that cardiac evaluation should be considered for those with schizophrenia.
    MeSH term(s) Humans ; Embolic Stroke ; Mendelian Randomization Analysis ; Schizophrenia/epidemiology ; Schizophrenia/genetics ; Stroke/epidemiology ; Stroke/genetics ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/genetics ; Genome-Wide Association Study
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032011
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  4. Article ; Online: Vegetarians: Past, Present, and Future Regarding Their Diet Quality and Nutritional Status.

    Petermann-Rocha, Fanny / Ho, Frederick K

    Nutrients

    2023  Volume 15, Issue 16

    Abstract: The term "vegetarian" usually refers to individuals who exclude meat, fish, poultry and/or their derived products from their diet [ ... ]. ...

    Abstract The term "vegetarian" usually refers to individuals who exclude meat, fish, poultry and/or their derived products from their diet [...].
    MeSH term(s) Animals ; Humans ; Nutritional Status ; Diet ; Meat ; Vegetarians
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15163587
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  5. Article ; Online: Psychosocial predictors of COVID-19 infection in UK biobank (N = 104 201).

    Wauye, Victor M / Ho, Frederick K / Lyall, Donald M

    Journal of public health (Oxford, England)

    2023  Volume 45, Issue 3, Page(s) 560–568

    Abstract: Background: Since the outbreak of COVID-19, data on its psychosocial predictors are limited. We therefore aimed to explore psychosocial predictors of COVID-19 infection at the UK Biobank (UKB).: Methods: This was a prospective cohort study conducted ... ...

    Abstract Background: Since the outbreak of COVID-19, data on its psychosocial predictors are limited. We therefore aimed to explore psychosocial predictors of COVID-19 infection at the UK Biobank (UKB).
    Methods: This was a prospective cohort study conducted among UKB participants.
    Results: The sample size was N = 104 201, out of which 14 852 (14.3%) had a positive COVID-19 test. The whole sample analysis showed significant interactions between sex and several predictor variables. Among females, absence of college/university degree [odds ratio (OR) 1.55, 95% confidence interval (CI) 1.45-1.66] and socioeconomic deprivation (OR 1.16 95% CI 1.11-1.21) were associated with higher odds of COVID-19 infection, while history of psychiatric consultation (OR 0.85 95% CI 0.77-0.94) with lower odds. Among males, absence of college/university degree (OR 1.56, 95% CI 1.45-1.68) and socioeconomic deprivation (OR 1.12, 95% CI 1.07-1.16) were associated with higher odds, while loneliness (OR 0.87, 95% CI 0.78-0.97), irritability (OR 0.91, 95% CI 0.83-0.99) and history of psychiatric consultation (OR 0.85, 95% CI 0.75-0.97) were associated with lower odds.
    Conclusion: Sociodemographic factors predicted the odds of COVID-19 infection equally among male and female participants, while psychological factors had differential impacts.
    MeSH term(s) Humans ; Male ; Female ; COVID-19/epidemiology ; SARS-CoV-2 ; Prospective Studies ; Biological Specimen Banks ; United Kingdom/epidemiology
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdad009
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    Zs.B 2186: Show issues Location:
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  6. Article ; Online: Reply to: "Defining severe NAFLD based on ICD codes in large cohorts: Balancing feasibility and limitations".

    Petermann-Rocha, Fanny / Ho, Frederick K / Pell, Jill P

    Journal of hepatology

    2023  Volume 79, Issue 6, Page(s) e233–e234

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/epidemiology ; International Classification of Diseases ; Feasibility Studies
    Language English
    Publishing date 2023-08-20
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.08.014
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  7. Article ; Online: Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants.

    Nakada, Shinya / Ho, Frederick K / Celis-Morales, Carlos / Pell, Jill P

    Journal of public health (Oxford, England)

    2023  Volume 45, Issue 3, Page(s) 569–576

    Abstract: Background: Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically ...

    Abstract Background: Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically insufficient statistical power and residual confounding, to determine if such association exists.
    Methods: This is a population-based retrospective cohort study of 320 249 men and women aged 40-69 years. Breastfeeding status was self-reported. CVD and myocardial infarction (MI) events and deaths based via linkage to hospitalization and death records.
    Results: Overall, 28 469 (8.4%) participants experienced a CVD event and 5174 (1.6%) experienced an MI. Following adjustment for sociodemographic, lifestyle and early life confounders, breastfeeding was associated with a reduced risk of CVD events (HR 0.97, 95% CI 0.94-1.00, P = 0.041), CVD deaths (HR 0.91, 95% CI 0.84-0.98, P = 0.017), MI events (HR 0.93, 95% CI 0.87-0.99, P = 0.033) and MI deaths (HR 0.81, 95% CI 0.67-0.98, P = 0.026).
    Conclusions: Child health benefits of breastfeeding are well established. However, the benefits of breastfeeding may extend into later life reinforcing the need to encourage and support breastfeeding.
    MeSH term(s) Male ; Child ; Humans ; Female ; Cardiovascular Diseases/epidemiology ; Cohort Studies ; Breast Feeding ; Retrospective Studies ; Risk Factors ; Myocardial Infarction/epidemiology
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdad016
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  8. Article ; Online: Reply to: "Associations of muscle mass and grip strength with severe NAFLD: A prospective study of 333,295 UK Biobank participants".

    Petermann-Rocha, Fanny / Ho, Frederick K / Pell, Jill P

    Journal of hepatology

    2022  Volume 77, Issue 5, Page(s) 1454–1455

    MeSH term(s) Biological Specimen Banks ; Hand Strength/physiology ; Humans ; Muscles ; Non-alcoholic Fatty Liver Disease ; Prospective Studies ; United Kingdom
    Language English
    Publishing date 2022-08-17
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.07.023
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  9. Article: Editorial: Digital media use and mental health.

    Wong, Rosa S / Tung, Keith T S / Ho, Frederick K W / Man, Kenneth K C

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1253846

    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1253846
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  10. Article ; Online: Association between birth weight and insulin resistance in US adolescents: A retrospective cohort study exploring the role of concurrent body mass index.

    Zhuo, Yubo / He, Jieli / Wang, Liangbing / Chow, Chun Bong / Ho, Frederick K

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2023  Volume 34, Issue 4, Page(s) 1061–1068

    Abstract: Background and aims: This study aimed to investigate the association between birth weight (BW) and abnormal HOMA-IR in US adolescents aged 12-15 years. The role of concurrent body mass index (BMI) in adolescence was also examined.: Methods and results! ...

    Abstract Background and aims: This study aimed to investigate the association between birth weight (BW) and abnormal HOMA-IR in US adolescents aged 12-15 years. The role of concurrent body mass index (BMI) in adolescence was also examined.
    Methods and results: This retrospective cohort study included 3429 participants from NHANES with data in 1999-2020. HOMA-IR ≥2.3 was considered abnormal. Participants were classified as low (LBW; <2.5 kg), normal (NBW; 2.5-4.0 kg), or high (HBW; >4.0 kg) BW. Logistic regression was used to explore the association between BW and HOMA-IR. Mediation analysis was used to examine whether BMI z-score in adolescence mediated the association between BW and HOMA-IR. Compared with those in NBW, the odds ratios (95 % CI) of abnormal HOMA-IR in LBW and HBW groups were 1.26 (0.99-1.60), and 0.62 (0.47-0.83) respectively. The association between BW and abnormal HOMA-IR was consistent in all subgroups with no significant interactions. Mediation analysis showed that BW is associated with lower risk of HOMA-IR directly, but with higher risk indirectly via BMI in adolescence.
    Conclusion: There was a negative linear relationship between BW and the prevalence of abnormal HOMA-IR in adolescents aged 12-15 independent of concurrent BMI. Children who were born with LBW but had high BMI in adolescence were of particularly higher risk of insulin resistance.
    MeSH term(s) Child ; Humans ; Adolescent ; Insulin Resistance ; Body Mass Index ; Birth Weight ; Retrospective Studies ; Nutrition Surveys
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.11.016
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