LIVIVO - Search results -

Search results

Result 1 - 10 of total 15

Search options

Article ; Online: Spinal microglia-neuron interactions in chronic pain.

Ho, Idy H T / Chan, Matthew T V / Wu, William K K / Liu, Xiaodong

2020 Volume 108, Issue 5, Page(s) 1575–1592

Abstract: Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle for developing effective treatments against chronic pain. Whereas neurocentric mechanisms alone are insufficient to provide satisfactory explanation for such ... ...

Abstract	Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle for developing effective treatments against chronic pain. Whereas neurocentric mechanisms alone are insufficient to provide satisfactory explanation for such transition, neuro-immune crosstalk has attracted attention in recent pain research. In contrast to brain microglia, spinal microglia are activated immediately in various pain states. The fast-responsive enrichment and activation of spinal microglia among different pain conditions have highlighted the crucial role of neuroinflammation caused by microglia-neuron crosstalk in pain initiation. Recent studies have revealed spinal microglia-neuron interactions are also involved in chronic pain maintenance, albeit, with different anatomic distribution, cellular and molecular mechanisms, and biologic functions. Delineating the exact temporal discrepancies of spinal microglia distribution and functions along acute-to-chronic pain transition may provide additional mechanistic insights for drug development to prevent deterioration of acute pain into the chronic state. This narrative review summerizes the longitudinal alterations of spinal microglia-neuron interactions in the initiation of pain hypersensitivity, acute-to-chronic pain progression, and chronic pain maintenance, followed by an overview of current clinical translation of preclinical studies on spinal microglia. This review highlights the crucial role of the interaction between spinal microglia and neighboring neurons in the initiation and maintenance of pain hypersensitivity, in relation to the release of cytokines, chemokines, and neuroactive substances, as well as the modulation of synaptic plasticity. Further exploration of the uncharted functions of spinal microglia-neuron crosstalk may lead to the design of novel drugs for preventing acute-to-chronic pain transition.
MeSH term(s)	Animals ; Chronic Pain/immunology ; Chronic Pain/pathology ; Cytokines/immunology ; Humans ; Microglia/immunology ; Microglia/pathology ; Neurons/immunology ; Neurons/pathology ; Signal Transduction/immunology ; Spinal Cord/immunology ; Spinal Cord/pathology
Chemical Substances	Cytokines
Language	English
Publishing date	2020-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.3MR0520-695R
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: Genetic Deletion of

Liu, Yun / Zhu, Zeyao / Ho, Idy H T / Shi, Yujian / Li, Jianzhen / Wang, Xia / Chan, Matthew T V / Cheng, Christopher H K

Frontiers in genetics

2020 Volume 11, Page(s) 853

Abstract: ... MiR- ... ...

Abstract	MiR-430
Language	English
Publishing date	2020-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2020.00853
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Long non-coding RNAs in the spinal cord injury: Novel spotlight.

Li, Zheng / Ho, Idy H T / Li, Xingye / Xu, Derong / Wu, William K K / Chan, Matthew T V / Li, Shugang / Liu, Xiaodong

Journal of cellular and molecular medicine

2019 Volume 23, Issue 8, Page(s) 4883–4890

Abstract: Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic ... ...

Abstract	Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic interventions are still far from satisfaction as the secondary damages resulting from the complex and progressive molecular alterations after SCI are not properly addressed. Recent studies revealed that long non-coding RNAs (lncRNAs) are abundant in the brain and might play critical roles in several nervous system disorders. At the cellular level, lncRNAs have been shown to regulate the expression of protein-coding RNAs and hence participate in neuronal death, demyelination and glia activation. Notably, SCI is characterized by these biological processes, suggesting that lncRNAs could be novel modulators in the pathogenesis of SCI. This review describes recent progresses in the lncRNA transcriptome analyses and their molecular functions in regulating SCI progression.
MeSH term(s)	Animals ; Apoptosis/genetics ; Gene Expression Profiling ; Humans ; Neuroglia/cytology ; Neuroglia/metabolism ; Neurons/metabolism ; Neurons/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Spinal Cord/metabolism ; Spinal Cord/pathology ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/pathology ; Transcriptome
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2019-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.14422
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5752: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization.

Ho, Idy H T / Ng, Lhotse H L / Cheng, Xiaojie / Gin, Tony / Chan, Chee Sam / Sun, Wuping / Xiao, Lizu / Zhang, Lin / Chan, Matthew T V / Wu, William K K / Liu, Xiaodong

Neurobiology of pain (Cambridge, Mass.)

2021 Volume 10, Page(s) 100071

Abstract: ANXA2 is a novel MOR1-interacting protein regulating MOR1 sub-cellular localization.•ANXA2 retains MOR1 in late recycling endosomes after remifentanil exposure. ...

Abstract	•ANXA2 is a novel MOR1-interacting protein regulating MOR1 sub-cellular localization.•ANXA2 retains MOR1 in late recycling endosomes after remifentanil exposure.
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article
ISSN	2452-073X
ISSN (online)	2452-073X
DOI	10.1016/j.ynpai.2021.100071
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Emerging roles of long non-coding RNAs in neuropathic pain.

Li, Zheng / Li, Xingye / Chen, Xin / Li, Shugang / Ho, Idy H T / Liu, Xiaodong / Chan, Matthew T V / Wu, William K K

Cell proliferation

2018 Volume 52, Issue 1, Page(s) e12528

Abstract: Neuropathic pain, a type of chronic and potentially disabling pain resulting from primary injury/dysfunction of the somatosensory nervous system and spinal cord injury, is one of the most intense types of chronic pain, which incurs a significant economic ...

Abstract	Neuropathic pain, a type of chronic and potentially disabling pain resulting from primary injury/dysfunction of the somatosensory nervous system and spinal cord injury, is one of the most intense types of chronic pain, which incurs a significant economic and public health burden. However, our understanding of its cellular and molecular pathogenesis is still far from complete. Long non-coding RNAs (lncRNAs) are important regulators of gene expression and have recently been characterized as key modulators of neuronal functions. Emerging evidence suggested that lncRNAs are deregulated and play pivotal roles in the development of neuropathic pain. This review summarizes the current knowledge about the roles of deregulated lncRNAs (eg, KCNA2-AS, uc.48+, NONRATT021972, MRAK009713, XIST, CCAT1) in the development of neuropathic pain. These studies suggested that specific regulation of lncRNAs or their downstream targets might provide novel therapeutic avenues for this refractory disease.
MeSH term(s)	Animals ; Gene Expression Regulation/genetics ; Humans ; Ion Channels/physiology ; MicroRNAs/genetics ; Neuralgia/genetics ; RNA, Long Noncoding/genetics ; Rats ; Sensory Receptor Cells/pathology ; Spinal Cord Injuries/pathology
Chemical Substances	Ion Channels ; MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2018-10-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.12528
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 532: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance.

Huang, Dan / Wang, Xiansong / Liu, Yingzhi / Huang, Ziheng / Hu, Xiaoxu / Hu, Wei / Li, Qing / Chan, Hung / Zou, Yidan / Ho, Idy H T / Wang, Yan / Cheng, Alfred S L / Kang, Wei / To, Ka F / Wang, Maggie H T / Wong, Sunny H / Yu, Jun / Gin, Tony / Zhang, Qingpeng /

Li, Zheng / Shen, Jianxiong / Zhang, Lin / Chan, Matthew T V / Liu, Xiaodong / Wu, William K K

Briefings in bioinformatics

2021 Volume 22, Issue 5

Abstract: Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that TSG promoters could have evolved specific features that facilitate their tumor-suppressing functions. We found that the promoter CpG dinucleotide frequencies of TSGs ...

Abstract	Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that TSG promoters could have evolved specific features that facilitate their tumor-suppressing functions. We found that the promoter CpG dinucleotide frequencies of TSGs are significantly higher than that of non-cancer genes across vertebrate genomes, and positively correlated with gene expression across tissue types. The promoter CpG dinucleotide frequencies of all genes gradually increase with gene age, for which young TSGs have been subject to a stronger evolutionary pressure. Transcription-related features, namely chromatin accessibility, methylation and ZNF263-, SP1-, E2F4- and SP2-binding elements, are associated with gene expression. Moreover, higher promoter CpG dinucleotide frequencies and chromatin accessibility are positively associated with the ability of TSGs to resist downregulation during tumorigenesis. These results were successfully validated with independent datasets. In conclusion, TSGs evolved specific promoter features that optimized cancer resistance through achieving high expression in normal tissues and resistance to downregulation during tumorigenesis.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Chromatin/metabolism ; Chromatin/ultrastructure ; Computational Biology/methods ; CpG Islands ; DNA Methylation ; Datasets as Topic ; Drug Resistance, Neoplasm/genetics ; Evolution, Molecular ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Genes, Tumor Suppressor ; Humans ; Molecular Sequence Annotation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Promoter Regions, Genetic ; Protein Interaction Domains and Motifs ; Transcription, Genetic
Chemical Substances	Antineoplastic Agents ; Chromatin
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbab040
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6262: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain.

Ho, Idy H T / Liu, Xiaodong / Zou, Yidan / Liu, Taian / Hu, Wei / Chan, Hung / Tian, Yuanyuan / Zhang, Yuchen / Li, Qing / Kou, Shanglong / Chan, Chee Sam / Gin, Tony / Cheng, Christopher H K / Wong, Sunny H / Yu, Jun / Zhang, Lin / Wu, William K K / Chan, Matthew T V

Theranostics

2019 Volume 9, Issue 6, Page(s) 1651–1665

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adaptor Proteins, Vesicular Transport/antagonists & inhibitors ; Analgesics/administration & dosage ; Analgesics/pharmacology ; Animals ; Brain-Derived Neurotrophic Factor/antagonists & inhibitors ; Chronic Pain/drug therapy ; Disease Models, Animal ; Ganglia, Spinal/drug effects ; Gene Knockdown Techniques ; Inflammation/complications ; Peptides/administration & dosage ; Peptides/pharmacology ; Rats ; Treatment Outcome
Chemical Substances	Adaptor Proteins, Vesicular Transport ; Analgesics ; Bdnf protein, rat ; Brain-Derived Neurotrophic Factor ; Peptides ; sortilin (Z020Y8WIJ4)
Language	English
Publishing date	2019-02-28
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.29703
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux.

Chen, Xiaoting / Chan, Hung / Zhang, Lin / Liu, Xiaodong / Ho, Idy H T / Zhang, Xiang / Ho, Jeffery / Hu, Wei / Tian, Yuanyuan / Kou, Shanglong / Chan, Chee Sam / Yu, Jun / Wong, Sunny H / Gin, Tony / Chan, Matthew T V / Sun, Xuegang / Wu, William K K

Journal of cellular and molecular medicine

2019 Volume 23, Issue 6, Page(s) 4290–4300

Abstract: Impaired autophagic degradation of intracellular lipids is causally linked to the development of non-alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this ... ...

Abstract	Impaired autophagic degradation of intracellular lipids is causally linked to the development of non-alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein, we investigated the effects of polydatin, a natural precursor of resveratrol, in a murine nutritional model of NASH and a cell line model of steatosis. Results showed that oral administration of polydatin protected against hepatic lipid accumulation and alleviated inflammation and hepatocyte damage in db/db mice fed methionine-choline deficient diet. Polydatin also alleviated palmitic acid-induced lipid accumulation in cultured hepatocytes. In both models, polydatin restored lysosomal function and autophagic flux that were impaired by NASH or steatosis. Mechanistically, polydatin inhibited mTOR signalling and up-regulated the expression and activity of TFEB, a known master regulator of lysosomal function. In conclusion, polydatin ameliorated NASH through restoring autophagic flux. The polydatin-regulated autophagy was associated with inhibition of mTOR pathway and restoration of lysosomal function by TFEB. Our study provided affirmative preclinical evidence to inform future clinical trials for examining the potential anti-NASH effect of polydatin in humans.
MeSH term(s)	Animals ; Autophagy ; Disease Models, Animal ; Glucosides/pharmacology ; Humans ; Lysosomes/drug effects ; Lysosomes/physiology ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/prevention & control ; Protective Agents/pharmacology ; Signal Transduction ; Stilbenes/pharmacology
Chemical Substances	Glucosides ; Protective Agents ; Stilbenes ; polydatin (XM261C37CQ)
Language	English
Publishing date	2019-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.14320
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5752: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.

Critical care (London, England)

2020 Volume 24, Issue 1, Page(s) 47

Abstract: Objectives: The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported ... ...

Abstract	Objectives: The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that cathelicidin is differentially expressed in various tissues in sepsis. However, its role in sepsis-induced intestinal barrier dysfunction has not been investigated. Design: To examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-(Cnlp Results: The ileal expression of cathelicidin was increased by three-fold after CLP, peaking at 4 h. Knockout of Cnlp significantly increased 7-day mortality and was associated with a higher murine sepsis score. Alcian-blue staining revealed a reduced number of mucin-positive goblet cells, accompanied by reduced mucin expression. Increased number of apoptotic cells and cleavage of caspase-3 were observed. Cnlp deletion increased intestinal permeability to 4kD fluorescein-labeled dextran and reduced the expression of tight junction proteins claudin-1 and occludin. Notably, circulating bacterial DNA load increased more than two-fold. Transcriptome analysis revealed upregulation of cytokine/inflammatory pathway. Depletion of Cnlp induced more M1 macrophages and neutrophils compared with the wild-type mice after CLP. Mice pre-treated with cholecalciferol (an inactive form of vitamin D3) or treated with 1alpha, 25-dihydroxyvitamin D3 (an active form of VD3) had decreased 7-day mortality and significantly less severe symptoms. Intriguingly, the administration of cholecalciferol after CLP led to worsened 7-day mortality and the associated symptoms. Conclusions: Endogenous cathelicidin promotes intestinal barrier integrity accompanied by modulating the infiltration of neutrophils and macrophages in polymicrobial sepsis. Our data suggested that 1alpha, 25-dihydroxyvitamin D3 but not cholecalciferol is a potential therapeutic agent for treating sepsis.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/physiology ; Intestinal Mucosa/metabolism ; Macrophages ; Male ; Mice ; Mice, Knockout ; Neutrophils ; Sepsis/physiopathology ; Vitamin D/analogs & derivatives ; Vitamin D/pharmacology
Chemical Substances	Antimicrobial Cationic Peptides ; Vitamin D (1406-16-2) ; ropocamptide (3DD771JO2H) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2020-02-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-020-2754-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5517: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Germline-specific dgcr8 knockout in zebrafish using a BACK approach.

Liu, Yun / Zhu, Zeyao / Ho, Idy H T / Shi, Yujian / Xie, Yuxin / Li, Jianzhen / Zhang, Yong / Chan, Matthew T V / Cheng, Christopher H K

Cellular and molecular life sciences : CMLS

2017 Volume 74, Issue 13, Page(s) 2503–2511

Abstract: Zebrafish is an important model to study developmental biology and human diseases. However, an effective approach to achieve spatial and temporal gene knockout in zebrafish has not been well established. In this study, we have developed a new approach, ... ...

Abstract	Zebrafish is an important model to study developmental biology and human diseases. However, an effective approach to achieve spatial and temporal gene knockout in zebrafish has not been well established. In this study, we have developed a new approach, namely bacterial artificial chromosome-rescue-based knockout (BACK), to achieve conditional gene knockout in zebrafish using the Cre/loxP system. We have successfully deleted the DiGeorge syndrome critical region gene 8 (dgcr8) in zebrafish germ line and demonstrated that the maternal-zygotic dgcr8 (MZdgcr8) embryos exhibit MZdicer-like phenotypes with morphological defects which could be rescued by miR-430, indicating that canonical microRNAs play critical role in early development. Our findings establish that Cre/loxP-mediated tissue-specific gene knockout could be achieved using this BACK strategy and that canonical microRNAs play important roles in early embryonic development in zebrafish.
MeSH term(s)	Animals ; Base Sequence ; Chromosomes, Artificial, Bacterial/genetics ; Embryonic Development/genetics ; Exons/genetics ; Gene Deletion ; Gene Expression Regulation, Developmental ; Gene Knockout Techniques/methods ; Gene Targeting ; Germ Cells/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mutation/genetics ; RNA Processing, Post-Transcriptional/genetics ; Transcription Activator-Like Effector Nucleases/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	MicroRNAs ; Zebrafish Proteins ; dgcr8 protein, zebrafish ; Transcription Activator-Like Effector Nucleases (EC 3.1.-)
Language	English
Publishing date	2017-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-017-2471-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 195: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito