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  1. Article: What's new in dermatopathology 2023: WHO 5th edition updates.

    Ho, Jonathan / Collie, Chico J

    Journal of pathology and translational medicine

    2023  Volume 57, Issue 6, Page(s) 337–340

    Abstract: The 5th edition WHO Classification of Skin Tumors (2022) has introduced changes to nomenclature and diagnostics. Important differences are discussed below. Changes in each category of skin tumor have been detailed, with particular emphasis on meaningful ... ...

    Abstract The 5th edition WHO Classification of Skin Tumors (2022) has introduced changes to nomenclature and diagnostics. Important differences are discussed below. Changes in each category of skin tumor have been detailed, with particular emphasis on meaningful advances in our understanding of the molecular pathogenesis of the skin's diverse tumor landscape.
    Language English
    Publishing date 2023-10-17
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3022395-7
    ISSN 2383-7845 ; 2383-7837
    ISSN (online) 2383-7845
    ISSN 2383-7837
    DOI 10.4132/jptm.2023.09.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectiveness of Vasopressin Against Cardiac Arrest: A Systematic Review of Systematic Reviews.

    Ho, Jonathan Ka-Ming / Tam, Hon-Lon / Leung, Leona Yuen-Ling

    Cardiovascular drugs and therapy

    2024  

    Abstract: Purpose: This systematic review (SR) of SRs evaluates the effectiveness of vasopressin alone or in combination with other drugs in improving the outcomes of cardiac arrest (CA).: Methods: Using a three-step approach, we searched five databases to ... ...

    Abstract Purpose: This systematic review (SR) of SRs evaluates the effectiveness of vasopressin alone or in combination with other drugs in improving the outcomes of cardiac arrest (CA).
    Methods: Using a three-step approach, we searched five databases to identify all relevant SRs. Two reviewers independently selected suitable studies, assessed study quality, and extracted relevant data. If an outcome was reported by multiple SRs, a re-meta-analysis was conducted as needed; otherwise, a narrative analysis was performed.
    Results: Twelve SRs covering 16 original studies were included in this review. The meta-analysis results revealed a significant increase in survival to hospital admission for patients with in-hospital CA (IHCA) or out-of-hospital CA (OHCA) receiving vasopressin alone compared with that for those receiving epinephrine alone. Furthermore, the return of spontaneous circulation (ROSC) was significantly increased in patients with OHCA receiving vasopressin with epinephrine compared with that in those receiving epinephrine alone. Compared with patients with IHCA receiving epinephrine with placebo, those receiving vasopressin, steroids, and epinephrine (VSE) exhibited significant increases in ROSC, survival to hospital discharge, favorable neurological outcomes, mean arterial pressure, renal failure-free days, coagulation failure-free days, and insulin requirement.
    Conclusion: VSE is the most effective drug combination for improving the short- and long-term outcomes of IHCA. It is recommended to use VSE in patients with IHCA. Future studies should investigate the effectiveness of VSE against OHCA and CA of various etiologies, the types and standard dosages of steroids for cardiac resuscitation, and the effectiveness of vasopressin-steroid in improving CA outcomes.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-024-07571-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3057: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Pre-/postbiopsy diagnosis concordance in women from an Afro-Caribbean population: Response to Douglas et al "Scalp biopsy influences diagnostic accuracy and treatment in Black women with alopecia: A retrospective study".

    Ho, Jonathan D / Collie, Chico J / Spencer, Sherri-Ann

    Journal of the American Academy of Dermatology

    2023  Volume 90, Issue 1, Page(s) e25–e26

    MeSH term(s) Humans ; Female ; Retrospective Studies ; Scalp/pathology ; Alopecia/diagnosis ; Alopecia/pathology ; Biopsy ; Caribbean Region
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.08.091
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    Zs.A 1540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Histopathologic Spectrum of Alopecias Seen in a Jamaican Setting.

    Ho, Jonathan D / Collie, Chico J / Spencer, Sherri-Ann

    The American Journal of dermatopathology

    2023  Volume 45, Issue 8, Page(s) 532–538

    Abstract: Abstract: Alopecia is common in Jamaican, primarily Afro-Caribbean patients. We performed a retrospective review examining the histopathologic alopecia diagnoses over ∼5 years. Requisition forms and pathology reports were assessed. Demographic/clinical/ ... ...

    Abstract Abstract: Alopecia is common in Jamaican, primarily Afro-Caribbean patients. We performed a retrospective review examining the histopathologic alopecia diagnoses over ∼5 years. Requisition forms and pathology reports were assessed. Demographic/clinical/technical/diagnostic and pathologic findings of chronicity/severity data were recorded. Three hundred thirty-eight biopsies were included. The majority were 4 mm punches, grossed horizontally. The F:M ratio was 4.8:1, mean age = 42.7 years, and mean duration of alopecia = 5.1 years. Cicatricial alopecias (CAs) predominated over non-CAs (NCAs). The top 10 diagnoses were central centrifugal CA (21.9%), folliculitis decalvans (10.9%), multifactorial alopecias (10.1%), pattern hair loss (8%), lichen planopilaris (7.1%), alopecia areata (6.2%), discoid lupus erythematosus (6.2%), nonclassifiable lymphocytic scarring alopecias (5.6%), frontal fibrosing alopecia (5.3%), and nonspecific NCAs (5%). This contrasted with other richly pigmented populations where discoid lupus erythematosus predominates. Other interesting findings included relatively frequent folliculitis decalvans and lichen planus pigmentosus in 40.9% of frontal fibrosing alopecia cases. Scarring/nonscarring clinicopathologic congruence occurred in 83.4%.Regarding histopathologic features of severity/chronicity, CAs had markedly decreased hair counts. Perifollicular fibrosis affecting retained hairs occurred in 75% of CAs, moderate to severe in >50% of these. Approximately 50% of NCA samples demonstrated advanced miniaturization (T:V ratio <2:1). In our study, relatively young women with chronic hair loss and CA are most frequently biopsied. Central centrifugal CA is the most common diagnosis. Local features of chronic/severe disease are seen microscopically. Clinical impression of scarring/nonscarring correlates well with histopathology.
    MeSH term(s) Humans ; Female ; Adult ; Cicatrix/pathology ; Jamaica/epidemiology ; Alopecia/pathology ; Lupus Erythematosus, Discoid/pathology ; Alopecia Areata ; Lichen Planus/pathology ; Folliculitis/pathology
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002487
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1518: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A 32-Year-Old Afro-Caribbean Female With a Slow-Growing Nodule on the Left Buttock: Challenge.

    Neblett, Carlos / Collie, Chico J / Ho, Jonathan D

    The American Journal of dermatopathology

    2023  Volume 45, Issue 12, Page(s) e99–e100

    MeSH term(s) Adult ; Female ; Humans ; Buttocks/pathology
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002539
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    Zs.A 1518: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A 32-Year-Old Afro-Caribbean Female With a Slow-Growing Nodule on the Left Buttock: Answer.

    Neblett, Carlos / Collie, Chico J / Ho, Jonathan D

    The American Journal of dermatopathology

    2023  Volume 45, Issue 12, Page(s) 855–856

    MeSH term(s) Female ; Humans ; Adult ; Buttocks ; Caribbean Region
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1518: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Severe cutaneous adverse reactions in a tertiary care center in Jamaica.

    McNish, Alicia J S / Ho, Jonathan D / East-Innis, Althea D C

    JAAD international

    2024  Volume 15, Page(s) 139–146

    Abstract: Background: Severe cutaneous adverse reactions (SCARs) are associated with morbidity and mortality.: Objective: The aim was to determine the different types of SCARs, their morphology, common offending drugs, interventions, and outcomes.: Methods: ...

    Abstract Background: Severe cutaneous adverse reactions (SCARs) are associated with morbidity and mortality.
    Objective: The aim was to determine the different types of SCARs, their morphology, common offending drugs, interventions, and outcomes.
    Methods: A retrospective cohort study was conducted of all patients admitted to the dermatology service at the University Hospital of the West Indies with Stevens-Johnson syndrome (SJS), SJS/toxic epidermal necrolysis overlap (TEN), TEN, drug reaction with eosinophilia and systemic symptoms and acute generalized exanthematous pustulosis between January 1, 2012 to June 1, 2022.
    Results: Fifty-one cases (51) met the inclusion criteria for SCAR. SJS, SJS/TEN overlap and TEN together accounted for 71.2% of cases. SCARs were most frequent in the fourth, fifth and 6th decades of life and there was a female preponderance. Antibiotics (31%) and anticonvulsants (29%) were the most common causative agents for SCARs. Most patients had at least 1 complication. The liver was the most common extracutaneous organ affected. Mortality was 7.8%. The main cause of death was sepsis.
    Limitations: Results were not generalizable. There were missing data and loss to follow-up.
    Conclusion: Judicious use of antimicrobials and corticosteroids may be beneficial in treatment of severe cutaneous drug reactions.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2024.02.007
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  8. Article ; Online: Characterization of thylakoid division using chloroplast dividing mutants in Arabidopsis.

    Ho, Jonathan / Kwan, Warren / Li, Vivian / Theg, Steven M

    Photosynthesis research

    2023  Volume 157, Issue 1, Page(s) 1–11

    Abstract: Chloroplasts are double membrane bound organelles that are found in plants and algae. Their division requires a number of proteins to assemble into rings along the center of the organelle and to constrict in synchrony. Chloroplasts possess a third ... ...

    Abstract Chloroplasts are double membrane bound organelles that are found in plants and algae. Their division requires a number of proteins to assemble into rings along the center of the organelle and to constrict in synchrony. Chloroplasts possess a third membrane system, the thylakoids, which house the majority of proteins responsible for the light-dependent reactions. The mechanism that allows chloroplasts to sort out and separate the intricate thylakoid membrane structures during organelle division remain unknown. By characterizing the sizes of thylakoids found in a number of different chloroplast division mutants in Arabidopsis, we show that thylakoids do not divide independently of the chloroplast division cycle. More specifically, we show that thylakoid division requires the formation of both the inner and the outer contractile rings of the chloroplast.
    MeSH term(s) Thylakoids/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Chloroplasts/metabolism ; Organelles/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Plants/metabolism
    Chemical Substances Arabidopsis Proteins
    Language English
    Publishing date 2023-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1475688-2
    ISSN 1573-5079 ; 0166-8595
    ISSN (online) 1573-5079
    ISSN 0166-8595
    DOI 10.1007/s11120-023-01002-4
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  9. Article: Longstanding itchy axillae in a young woman.

    Ho, Jonathan Dale / Smith-Matthews, Stephanie

    JAAD case reports

    2022  Volume 24, Page(s) 45–47

    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Classifier-Free Diffusion Guidance

    Ho, Jonathan / Salimans, Tim

    2022  

    Abstract: Classifier guidance is a recently introduced method to trade off mode coverage and sample fidelity in conditional diffusion models post training, in the same spirit as low temperature sampling or truncation in other types of generative models. Classifier ...

    Abstract Classifier guidance is a recently introduced method to trade off mode coverage and sample fidelity in conditional diffusion models post training, in the same spirit as low temperature sampling or truncation in other types of generative models. Classifier guidance combines the score estimate of a diffusion model with the gradient of an image classifier and thereby requires training an image classifier separate from the diffusion model. It also raises the question of whether guidance can be performed without a classifier. We show that guidance can be indeed performed by a pure generative model without such a classifier: in what we call classifier-free guidance, we jointly train a conditional and an unconditional diffusion model, and we combine the resulting conditional and unconditional score estimates to attain a trade-off between sample quality and diversity similar to that obtained using classifier guidance.

    Comment: A short version of this paper appeared in the NeurIPS 2021 Workshop on Deep Generative Models and Downstream Applications: https://openreview.net/pdf?id=qw8AKxfYbI
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2022-07-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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