Article ; Online: Histopathologic Spectrum of Alopecias Seen in a Jamaican Setting.
The American Journal of dermatopathology
2023 Volume 45, Issue 8, Page(s) 532–538
Abstract: Abstract: Alopecia is common in Jamaican, primarily Afro-Caribbean patients. We performed a retrospective review examining the histopathologic alopecia diagnoses over ∼5 years. Requisition forms and pathology reports were assessed. Demographic/clinical/ ... ...
| Abstract | Abstract: Alopecia is common in Jamaican, primarily Afro-Caribbean patients. We performed a retrospective review examining the histopathologic alopecia diagnoses over ∼5 years. Requisition forms and pathology reports were assessed. Demographic/clinical/technical/diagnostic and pathologic findings of chronicity/severity data were recorded. Three hundred thirty-eight biopsies were included. The majority were 4 mm punches, grossed horizontally. The F:M ratio was 4.8:1, mean age = 42.7 years, and mean duration of alopecia = 5.1 years. Cicatricial alopecias (CAs) predominated over non-CAs (NCAs). The top 10 diagnoses were central centrifugal CA (21.9%), folliculitis decalvans (10.9%), multifactorial alopecias (10.1%), pattern hair loss (8%), lichen planopilaris (7.1%), alopecia areata (6.2%), discoid lupus erythematosus (6.2%), nonclassifiable lymphocytic scarring alopecias (5.6%), frontal fibrosing alopecia (5.3%), and nonspecific NCAs (5%). This contrasted with other richly pigmented populations where discoid lupus erythematosus predominates. Other interesting findings included relatively frequent folliculitis decalvans and lichen planus pigmentosus in 40.9% of frontal fibrosing alopecia cases. Scarring/nonscarring clinicopathologic congruence occurred in 83.4%.Regarding histopathologic features of severity/chronicity, CAs had markedly decreased hair counts. Perifollicular fibrosis affecting retained hairs occurred in 75% of CAs, moderate to severe in >50% of these. Approximately 50% of NCA samples demonstrated advanced miniaturization (T:V ratio <2:1). In our study, relatively young women with chronic hair loss and CA are most frequently biopsied. Central centrifugal CA is the most common diagnosis. Local features of chronic/severe disease are seen microscopically. Clinical impression of scarring/nonscarring correlates well with histopathology. |
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| MeSH term(s) | Humans ; Female ; Adult ; Cicatrix/pathology ; Jamaica/epidemiology ; Alopecia/pathology ; Lupus Erythematosus, Discoid/pathology ; Alopecia Areata ; Lichen Planus/pathology ; Folliculitis/pathology |
| Language | English |
| Publishing date | 2023-06-28 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 448469-1 |
| ISSN | 1533-0311 ; 0193-1091 |
| ISSN (online) | 1533-0311 |
| ISSN | 0193-1091 |
| DOI | 10.1097/DAD.0000000000002487 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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