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  1. Article ; Online: Diagnosing atrial fibrillation: Can we do better than the ECG?

    Ho, Kevin S / Keefe, Joshua A / Wehrens, Xander H T

    Heart rhythm

    2022  Volume 19, Issue 9, Page(s) 1459–1460

    MeSH term(s) Atrial Fibrillation/diagnosis ; Electrocardiography ; Electrocardiography, Ambulatory ; Humans
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2022.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Role of Ca²⁺ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia

    Keefe, Joshua A. / Moore, Oliver M. / Ho, Kevin S. / Wehrens, Xander H. T.

    Arch Toxicol. 2023 Jan., v. 97, no. 1, p. 73-92

    2023  , Page(s) 73–92

    Abstract: Calcium (Ca²⁺) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca²⁺-handling proteins is required for healthy cardiac function, whereas disruption in any of ... ...

    Abstract Calcium (Ca²⁺) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca²⁺-handling proteins is required for healthy cardiac function, whereas disruption in any of these can cause cardiac arrhythmias. This comprehensive review provides a broad overview of the roles of Ca²⁺-handling proteins and their regulators in healthy cardiac function and the mechanisms by which mutations in these proteins contribute to inherited arrhythmias. Major Ca²⁺ channels and Ca²⁺-sensitive regulatory proteins involved in cardiac excitation–contraction coupling are discussed, with special emphasis on the function of the RyR2 macromolecular complex. Inherited arrhythmia disorders including catecholaminergic polymorphic ventricular tachycardia, long QT syndrome, Brugada syndrome, short QT syndrome, and arrhythmogenic right-ventricular cardiomyopathy are discussed with particular emphasis on subtypes caused by mutations in Ca²⁺-handling proteins.
    Keywords calcium ; cardiac output ; cardiomyocytes ; cardiomyopathy ; tachycardia
    Language English
    Dates of publication 2023-01
    Size p. 73-92
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    Note Review
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-022-03385-0
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 63/164: Show issues

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  3. Article ; Online: Genome Editing and Cardiac Arrhythmias.

    Moore, Oliver M / Ho, Kevin S / Copeland, Juwan S / Parthasarathy, Vaidya / Wehrens, Xander H T

    Cells

    2023  Volume 12, Issue 10

    Abstract: This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in ... ...

    Abstract This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in vivo genome editing in preclinical models of heritable and acquired arrhythmias. Third, we discuss recent advancements in cardiac gene transfer, including delivery methods, gene expression optimization, and potential adverse effects associated with therapeutic somatic genome editing. While genome editing for cardiac arrhythmias is still in its infancy, this approach holds great promise, especially for inherited arrhythmia syndromes with a defined genetic defect.
    MeSH term(s) Humans ; Gene Editing ; Tachycardia, Ventricular/genetics ; Tachycardia, Ventricular/metabolism ; Tachycardia, Ventricular/therapy ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/therapy ; Arrhythmias, Cardiac/metabolism ; Myocytes, Cardiac/metabolism
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12101363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of Ca

    Keefe, Joshua A / Moore, Oliver M / Ho, Kevin S / Wehrens, Xander H T

    Archives of toxicology

    2022  Volume 97, Issue 1, Page(s) 73–92

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    MeSH term(s) Humans ; Arrhythmias, Cardiac/metabolism ; Myocytes, Cardiac/metabolism ; Tachycardia, Ventricular/genetics ; Tachycardia, Ventricular/pathology ; Mutation ; Calcium Signaling ; Calcium/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism
    Chemical Substances Calcium (SY7Q814VUP) ; Ryanodine Receptor Calcium Release Channel
    Language English
    Publishing date 2022-10-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-022-03385-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Limitations of alignment-free tools in total RNA-seq quantification.

    Wu, Douglas C / Yao, Jun / Ho, Kevin S / Lambowitz, Alan M / Wilke, Claus O

    BMC genomics

    2018  Volume 19, Issue 1, Page(s) 510

    Abstract: Background: Alignment-free RNA quantification tools have significantly increased the speed of RNA-seq analysis. However, it is unclear whether these state-of-the-art RNA-seq analysis pipelines can quantify small RNAs as accurately as they do with long ... ...

    Abstract Background: Alignment-free RNA quantification tools have significantly increased the speed of RNA-seq analysis. However, it is unclear whether these state-of-the-art RNA-seq analysis pipelines can quantify small RNAs as accurately as they do with long RNAs in the context of total RNA quantification.
    Result: We comprehensively tested and compared four RNA-seq pipelines for accuracy of gene quantification and fold-change estimation. We used a novel total RNA benchmarking dataset in which small non-coding RNAs are highly represented along with other long RNAs. The four RNA-seq pipelines consisted of two commonly-used alignment-free pipelines and two variants of alignment-based pipelines. We found that all pipelines showed high accuracy for quantifying the expression of long and highly-abundant genes. However, alignment-free pipelines showed systematically poorer performance in quantifying lowly-abundant and small RNAs.
    Conclusion: We have shown that alignment-free and traditional alignment-based quantification methods perform similarly for common gene targets, such as protein-coding genes. However, we have identified a potential pitfall in analyzing and quantifying lowly-expressed genes and small RNAs with alignment-free pipelines, especially when these small RNAs contain biological variations.
    MeSH term(s) Algorithms ; Area Under Curve ; High-Throughput Nucleotide Sequencing ; RNA/chemistry ; RNA/metabolism ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; ROC Curve ; Sequence Analysis, RNA/methods
    Chemical Substances RNA, Ribosomal ; RNA (63231-63-0) ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2018-07-03
    Publishing country England
    Document type Journal Article
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/s12864-018-4869-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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