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  1. Book ; Thesis: Akut rupturierte, intrakranielle Aneurysmen

    Ho, Michael

    klinische und angiografische Ergebnisse im Langzeit-Verlauf nach stent-assistierten Coiling mit Neuroform-Stent

    2017  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Michael Ho
    Language German
    Size 97 Blätter, Diagramme
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2018
    HBZ-ID HT019844294
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 1570 order for loan Magazin

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  2. Article ; Online: Perspectives on the development of neutralizing antibodies against SARS-CoV-2.

    Ho, Mitchell

    Antibody therapeutics

    2020  Volume 3, Issue 2, Page(s) 109–114

    Abstract: SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-converting enzyme 2 (ACE2). Therefore, the receptor binding domain (RBD) of the S protein is the primary target for neutralizing antibodies. Selection of broad- ... ...

    Abstract SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-converting enzyme 2 (ACE2). Therefore, the receptor binding domain (RBD) of the S protein is the primary target for neutralizing antibodies. Selection of broad-neutralizing antibodies against SARS-CoV-2 and SARS-CoV is attractive and might be useful for treating not only COVID-19 but also future SARS-related CoV infections. Broad-neutralizing antibodies, such as 47D11, S309, and VHH-72, have been reported to target a conserved region in the RBD of the S1 subunit. The S2 subunit required for viral membrane fusion might be another target. Due to their small size and high stability, single-domain antibodies might have the ability to be administered by an inhaler making them potentially attractive therapeutics for respiratory infections. A cocktail strategy combining two (or more) antibodies that recognize different parts of the viral surface that interact with human cells might be the most effective.
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2516-4236
    ISSN (online) 2516-4236
    DOI 10.1093/abt/tbaa009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deep Learning for Synthetic CT from Bone MRI in the Head and Neck.

    Bambach, S / Ho, M-L

    AJNR. American journal of neuroradiology

    2023  Volume 43, Issue 8, Page(s) 1172–1179

    Abstract: Background and purpose: Bone MR imaging techniques enable visualization of cortical bone without the need for ionizing radiation. Automated conversion of bone MR imaging to synthetic CT is highly desirable for downstream image processing and eventual ... ...

    Abstract Background and purpose: Bone MR imaging techniques enable visualization of cortical bone without the need for ionizing radiation. Automated conversion of bone MR imaging to synthetic CT is highly desirable for downstream image processing and eventual clinical adoption. Given the complex anatomy and pathology of the head and neck, deep learning models are ideally suited for learning such mapping.
    Materials and methods: This was a retrospective study of 39 pediatric and adult patients with bone MR imaging and CT examinations of the head and neck. For each patient, MR imaging and CT data sets were spatially coregistered using multiple-point affine transformation. Paired MR imaging and CT slices were generated for model training, using 4-fold cross-validation. We trained 3 different encoder-decoder models: Light_U-Net (2 million parameters) and VGG-16 U-Net (29 million parameters) without and with transfer learning. Loss functions included mean absolute error, mean squared error, and a weighted average. Performance metrics included Pearson
    Results: The Light_U-Net architecture quantitatively outperformed VGG-16 models. Mean absolute error loss resulted in higher bone precision, while mean squared error yielded higher bone recall. Performance metrics decreased when using training data captured only in a different environment but increased when local training data were augmented with those from different hospitals, vendors, or MR imaging techniques.
    Conclusions: We have optimized a robust deep learning model for conversion of bone MR imaging to synthetic CT, which shows good performance and generalizability when trained on different hospitals, vendors, and MR imaging techniques. This approach shows promise for facilitating downstream image processing and adoption into clinical practice.
    MeSH term(s) Adult ; Humans ; Child ; Deep Learning ; Retrospective Studies ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging/methods ; Head/diagnostic imaging ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A7588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1580: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Vaccine adjuvants: current status, research and development, licensing, and future opportunities.

    Cui, Ying / Ho, Megan / Hu, Yongjie / Shi, Yuan

    Journal of materials chemistry. B

    2024  

    Abstract: Vaccines represent one of the most significant inventions in human history and have revolutionized global health. Generally, a vaccine functions by triggering the innate immune response and stimulating antigen-presenting cells, leading to a defensive ... ...

    Abstract Vaccines represent one of the most significant inventions in human history and have revolutionized global health. Generally, a vaccine functions by triggering the innate immune response and stimulating antigen-presenting cells, leading to a defensive adaptive immune response against a specific pathogen's antigen. As a key element, adjuvants are chemical materials often employed as additives to increase a vaccine's efficacy and immunogenicity. For over 90 years, adjuvants have been essential components in many human vaccines, improving their efficacy by enhancing, modulating, and prolonging the immune response. Here, we provide a timely and comprehensive review of the historical development and the current status of adjuvants, covering their classification, mechanisms of action, and roles in different vaccines. Additionally, we perform systematic analysis of the current licensing processes and highlights notable examples from clinical trials involving vaccine adjuvants. Looking ahead, we anticipate future trends in the field, including the development of new adjuvant formulations, the creation of innovative adjuvants, and their integration into the broader scope of systems vaccinology and vaccine delivery. The article posits that a deeper understanding of biochemistry, materials science, and vaccine immunology is crucial for advancing vaccine technology. Such advancements are expected to lead to the future development of more effective vaccines, capable of combating emerging infectious diseases and enhancing public health.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02861e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Strengthening primary care in Hong Kong: fostering continuity of care from a health system perspective.

    Ho, M K

    Hong Kong medical journal = Xianggang yi xue za zhi

    2020  Volume 26, Issue 6, Page(s) 543–545

    MeSH term(s) Community Health Planning/methods ; Community Health Planning/organization & administration ; Continuity of Patient Care/organization & administration ; Delivery of Health Care, Integrated/methods ; Delivery of Health Care, Integrated/organization & administration ; Electronic Health Records ; Hong Kong ; Humans ; Information Dissemination ; Primary Health Care/methods ; Primary Health Care/organization & administration
    Language English
    Publishing date 2020-12-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj198368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Inaugural Editorial: Searching for Magic Bullets.

    Ho, Mitchell

    Antibody therapeutics

    2018  Volume 1, Issue 1, Page(s) 1–5

    Abstract: Single domain antibodies have emerged as a new class of therapeutic molecules in antibody engineering. A single domain antibody (shark ... ...

    Abstract Single domain antibodies have emerged as a new class of therapeutic molecules in antibody engineering. A single domain antibody (shark V
    Language English
    Publishing date 2018-06-20
    Publishing country United States
    Document type Journal Article
    ISSN 2516-4236
    ISSN (online) 2516-4236
    DOI 10.1093/abt/tby001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The burden of myeloma: novel approaches to disease assessment.

    Ho, Matthew / Kourelis, Taxiarchis

    Hematology. American Society of Hematology. Education Program

    2022  Volume 2022, Issue 1, Page(s) 356–362

    Abstract: Novel therapies in multiple myeloma (MM) have increased the rates of conventional complete remission (CR) in patients. However, patients in CR can have highly heterogeneous outcomes. Novel and more sensitive methods of assessing residual disease burden ... ...

    Abstract Novel therapies in multiple myeloma (MM) have increased the rates of conventional complete remission (CR) in patients. However, patients in CR can have highly heterogeneous outcomes. Novel and more sensitive methods of assessing residual disease burden after therapy will help prognosticate this group better and, ideally, allow individualized therapy adjustments based on response depth in the future. Here, we review novel bone marrow, peripheral blood, and imaging methods for assessing myeloma burden and discuss the opportunities and limitations of incorporating these in everyday clinical practice.
    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Remission Induction ; Bone Marrow ; Neoplasm, Residual
    Language English
    Publishing date 2022-12-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2022000348
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  8. Article ; Online: Development of Glypican-2 Targeting Single-Domain Antibody CAR T Cells for Neuroblastoma.

    Li, Nan / Ho, Mitchell

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2446, Page(s) 451–468

    Abstract: Chimeric antigen receptors (CARs) are engineered fusion proteins constructed from antigen-recognition, signaling, and costimulatory domains. CARs can be expressed in T cells with the purpose of reprogramming the T cells to specifically target tumor cells. ...

    Abstract Chimeric antigen receptors (CARs) are engineered fusion proteins constructed from antigen-recognition, signaling, and costimulatory domains. CARs can be expressed in T cells with the purpose of reprogramming the T cells to specifically target tumor cells. This strategy thereby avoids the requirement for antigen processing and presentation by the target cell. Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan with highly tumor-specific expression in neuroblastoma compared with nonmalignant cells. Therefore, GPC2 is an attractive target candidate for CAR T-cell therapy. Single-domain antibodies (sdAbs) can access epitopes different from those targeted by single-chain variable fragments and, because of their stability and modularity, could serve as ideal antigen-recognition domains in CAR T cells. Here, we describe a protocol for generating GPC2-targeted sdAb CAR T cells. We also present a methodology for assessing the efficiency of CAR expression on human T cells and their ability to kill GPC2-positive neuroblastoma cells in vitro and in vivo. The method described here is applicable to the production of CAR T cells derived from all types of sdAbs including VHHs and VNARs.
    MeSH term(s) Cell Line, Tumor ; Glypicans/metabolism ; Humans ; Immunotherapy, Adoptive/methods ; Neuroblastoma/pathology ; Receptors, Antigen, T-Cell/metabolism ; Single-Domain Antibodies/metabolism ; T-Lymphocytes ; Xenograft Model Antitumor Assays
    Chemical Substances Glypicans ; Receptors, Antigen, T-Cell ; Single-Domain Antibodies
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2075-5_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Generation of Single-Domain Antibody-Based Recombinant Immunotoxins.

    Fleming, Bryan D / Ho, Mitchell

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2446, Page(s) 489–512

    Abstract: The discovery of single-domain antibodies has opened new avenues for drug development. Single-domain antibodies, also known as nanobodies, can access buried epitopes that are inaccessible to conventional antibodies. These antigen-binding domains have a ... ...

    Abstract The discovery of single-domain antibodies has opened new avenues for drug development. Single-domain antibodies, also known as nanobodies, can access buried epitopes that are inaccessible to conventional antibodies. These antigen-binding domains have a high level of solubility and stability, which makes them well suited for therapeutic development. This chapter will discuss the design, production, and testing of single-domain antibody-based recombinant immunotoxins. Recombinant immunotoxins are chimeric proteins that combine the specificity of an antibody with the ribosomal-inhibitory domain of a bacterial toxin. Immunotoxins using the Pseudomonas exotoxin domain have been well studied in clinical trials. Recently, an anti-CD22 immunotoxin was granted marketing approval for use in patients with relapsed or refractory hairy cell leukemia. This supports the idea that treatment with recombinant immunotoxins can be explored for cancers that have not responded to standard therapies.
    MeSH term(s) ADP Ribose Transferases/genetics ; ADP Ribose Transferases/metabolism ; Bacterial Toxins/metabolism ; Exotoxins/metabolism ; Humans ; Immunotoxins/therapeutic use ; Neoplasms/drug therapy ; Recombinant Fusion Proteins/genetics ; Single-Domain Antibodies ; Virulence Factors/metabolism
    Chemical Substances Bacterial Toxins ; Exotoxins ; Immunotoxins ; Recombinant Fusion Proteins ; Single-Domain Antibodies ; Virulence Factors ; ADP Ribose Transferases (EC 2.4.2.-)
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2075-5_25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Chinese version Weight-Related Eating Questionnaire to assess psychological aspects of eating behaviours in Chinese adults: abridged secondary publication.

    Ho, M / Smith, R / Chau, P H / Chung, C Y / Fong, D Y T

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29 Suppl 2, Issue 1, Page(s) 29–32

    MeSH term(s) Humans ; Adult ; Feeding Behavior ; Obesity ; Surveys and Questionnaires
    Language English
    Publishing date 2023-03-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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