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  1. Article ; Online: Androgen effects cause sex-biased impairment of CD8

    Bevilacqua, Alessio / Ho, Ping-Chih

    Science immunology

    2022  Volume 7, Issue 73, Page(s) eabq6783

    Abstract: Androgen signaling compromises ... ...

    Abstract Androgen signaling compromises CD8
    MeSH term(s) Androgens ; CD8-Positive T-Lymphocytes ; Humans ; Neoplasms ; Signal Transduction
    Chemical Substances Androgens
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abq6783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunosurveillance encounters cancer metabolism.

    Chuang, Yu-Ming / Tzeng, Sheue-Fen / Ho, Ping-Chih / Tsai, Chin-Hsien

    EMBO reports

    2024  Volume 25, Issue 2, Page(s) 471–488

    Abstract: Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic, biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support host immunity against cancer and determine differentiation and fate of ... ...

    Abstract Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic, biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support host immunity against cancer and determine differentiation and fate of leukocytes. Thus, metabolic deregulation and imbalance in immune cells within the tumor microenvironment have been reported to drive immune evasion and to compromise therapeutic outcomes. Interestingly, emerging evidence indicates that anti-tumor immunity could modulate tumor heterogeneity, aggressiveness, and metabolic reprogramming, suggesting that immunosurveillance can instruct cancer progression in multiple dimensions. This review summarizes our current understanding of how metabolic crosstalk within tumors affects immunogenicity of tumor cells and promotes cancer progression. Furthermore, we explain how defects in the metabolic cascade can contribute to developing dysfunctional immune responses against cancers and discuss the contribution of immunosurveillance to these defects as a feedback mechanism. Finally, we highlight ongoing clinical trials and new therapeutic strategies targeting cellular metabolism in cancer.
    MeSH term(s) Humans ; Monitoring, Immunologic ; Neoplasms/pathology ; Energy Metabolism ; Metabolic Networks and Pathways ; Tumor Microenvironment
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-023-00038-w
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    Zs.A 5433: Show issues Location:
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  3. Article ; Online: cDC1 craves glutamine for its glory.

    Vilbois, Stefania / Park, Jaeoh / Ho, Ping-Chih

    Nature immunology

    2023  Volume 24, Issue 9, Page(s) 1405–1406

    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01598-8
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  4. Article ; Online: Re-"Formate" T-cell Antitumor Responses.

    Lin, Mei-Chun / Moller, Sofie Hedlund / Ho, Ping-Chih

    Cancer discovery

    2023  Volume 13, Issue 12, Page(s) 2507–2509

    Abstract: Summary: Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells ... ...

    Abstract Summary: Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti-PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade. See related article by Rowe et al., p. 2566 (8).
    MeSH term(s) Humans ; Programmed Cell Death 1 Receptor ; CD8-Positive T-Lymphocytes ; Neoplasms ; Lymphocyte Activation ; Formates ; Tumor Microenvironment
    Chemical Substances Programmed Cell Death 1 Receptor ; Formates
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-1059
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    Zs.A 6916: Show issues Location:
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  5. Article ; Online: Metabolic interplay: tumor macrophages and regulatory T cells.

    Vilbois, Stefania / Xu, Yingxi / Ho, Ping-Chih

    Trends in cancer

    2023  Volume 10, Issue 3, Page(s) 242–255

    Abstract: The tumor microenvironment (TME) contains a complex cellular ecosystem where cancer, stromal, vascular, and immune cells interact. Macrophages and regulatory T cells (Tregs) are critical not only for maintaining immunological homeostasis and tumor growth ...

    Abstract The tumor microenvironment (TME) contains a complex cellular ecosystem where cancer, stromal, vascular, and immune cells interact. Macrophages and regulatory T cells (Tregs) are critical not only for maintaining immunological homeostasis and tumor growth but also for monitoring the functional states of other immune cells. Emerging evidence reveals that metabolic changes in macrophages and Tregs significantly influence their pro-/antitumor functions through the regulation of signaling cascades and epigenetic reprogramming. Hence, they are increasingly recognized as therapeutic targets in cancer immunotherapy. Specific metabolites in the TME may also affect their pro-/antitumor functions by intervening with the metabolic machinery. We discuss how metabolites influence the immunosuppressive phenotypes of tumor-associated macrophages (TAMs) and Tregs. We then describe how TAMs and Tregs, independently or collaboratively, utilize metabolic mechanisms to suppress the activity of CD8
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; CD8-Positive T-Lymphocytes ; Ecosystem ; Macrophages ; Neoplasms/therapy ; Tumor Microenvironment
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.11.007
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  6. Article ; Online: Mitochondria Dictate Function and Fate of HSCs and T Cells.

    Xu, Yingxi / Chiang, Yi-Hsuan / Ho, Ping-Chih / Vannini, Nicola

    Cancer immunology research

    2023  Volume 11, Issue 10, Page(s) 1303–1313

    Abstract: Hematopoietic stem cells (HSC) and T cells are intimately related, lineage-dependent cell populations that are extensively used as therapeutic products for the treatment of hematologic malignancies and certain types of solid tumors. These cellular ... ...

    Abstract Hematopoietic stem cells (HSC) and T cells are intimately related, lineage-dependent cell populations that are extensively used as therapeutic products for the treatment of hematologic malignancies and certain types of solid tumors. These cellular therapies can be life-saving treatments; however, their efficacies are often limited by factors influencing their activity and cellular properties. Among these factors is mitochondrial metabolism, which influences the function and fate commitment of both HSCs and T cells. Mitochondria, besides being the "cellular powerhouse," provide metabolic intermediates that are used as substrates for epigenetic modifications and chromatin remodeling, thus, driving cell fate decisions during differentiation. Moreover, mitochondrial fitness and mitochondrial quality control mechanisms are closely related to cellular function, and impairment of these mitochondrial properties associates with cellular dysfunction due to factors such as T-cell exhaustion and aging. Here, we give an overview of the role of mitochondria in shaping the behavior of these lineage-related cell populations. Moreover, we discuss the potential of novel mitochondria-targeting strategies for enhancing HSC- and T cell-based cancer immunotherapies and highlight how design and application of such approaches requires consideration of the metabolic similarities and differences between HSCs and T cells. See related article on p. 1302.
    MeSH term(s) T-Lymphocytes/metabolism ; Hematopoietic Stem Cells ; Cell Differentiation ; Mitochondria/metabolism
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-22-0685
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    Zs.A 7022: Show issues Location:
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  7. Article: Metabolic guidance and stress in tumors modulate antigen-presenting cells.

    Park, Jaeoh / Wang, Limei / Ho, Ping-Chih

    Oncogenesis

    2022  Volume 11, Issue 1, Page(s) 62

    Abstract: Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting cells (APCs); however, the capacity of APCs is found to be defective in many cancers. Metabolically reprogrammed cancer cells support the energetic and ... ...

    Abstract Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting cells (APCs); however, the capacity of APCs is found to be defective in many cancers. Metabolically reprogrammed cancer cells support the energetic and biosynthetic demands of their high proliferation rates by exploiting nutrients available in the tumor microenvironment (TME), which in turn limits proper metabolic reprogramming of APCs during recruitment, differentiation, activation and antigen presentation. Furthermore, some metabolites generated by the TME are unfavorable to antitumor immunity. This review summarizes recent studies on the metabolic features of APCs and their functionality in the TME. Particularly, we will describe how APCs respond to altered TME and how metabolic byproducts from cancer and immunomodulatory cells affect APCs. Finally, we introduce the current status of APC-oriented research and clinical trials targeting metabolic features to boost efficient immunotherapy.
    Language English
    Publishing date 2022-10-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2674437-5
    ISSN 2157-9024
    ISSN 2157-9024
    DOI 10.1038/s41389-022-00438-y
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  8. Article ; Online: IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk.

    Kao, Kung-Chi / Jaccard, Alison / Ho, Ping-Chih

    Cancer discovery

    2022  Volume 12, Issue 7, Page(s) 1615–1616

    Abstract: Summary: In this issue, Hu and colleagues unveil that IFNα administration combined with anti-PD-1 therapy can potentiate murine and human CD8+ T-cell antitumor response in hepatocellular carcinoma, highlighting a novel therapeutic strategy for ... ...

    Abstract Summary: In this issue, Hu and colleagues unveil that IFNα administration combined with anti-PD-1 therapy can potentiate murine and human CD8+ T-cell antitumor response in hepatocellular carcinoma, highlighting a novel therapeutic strategy for hepatocellular carcinoma. See related article by Hu et al., p. 1718 (6) .
    MeSH term(s) Animals ; Carcinoma, Hepatocellular/drug therapy ; Glucose ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Liver Neoplasms/drug therapy ; Mice ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-0472
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  9. Article ; Online: Metabolic dynamics instruct CD8

    Bevilacqua, Alessio / Li, Zhiyu / Ho, Ping-Chih

    European journal of immunology

    2022  Volume 52, Issue 4, Page(s) 541–549

    Abstract: Cytotoxic ... ...

    Abstract Cytotoxic CD8
    MeSH term(s) CD8-Positive T-Lymphocytes ; Cell Differentiation ; Lymphocyte Activation ; Lymphocyte Count ; T-Lymphocytes, Cytotoxic
    Language English
    Publishing date 2022-03-16
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149486
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  10. Article ; Online: The hidden side of PD-L1.

    Jaccard, Alison / Ho, Ping-Chih

    Nature cell biology

    2020  Volume 22, Issue 9, Page(s) 1031–1032

    MeSH term(s) Acetylation ; Antibodies, Monoclonal ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Immunotherapy
    Chemical Substances Antibodies, Monoclonal ; B7-H1 Antigen
    Language English
    Publishing date 2020-08-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-020-0568-y
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    Zs.MG 12: Show issues

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