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  1. Article: Influence of fixation systems on complications after tibial plateau leveling osteotomy in dogs greater than 45.4 kilograms (100 lb)

    Chiu, King Wa / Amsellem, Pierre M / Yu, Jenny / Ho, Pui Shan / Radasch, Robert

    Veterinary surgery. 2019 May, v. 48, no. 4

    2019  

    Abstract: OBJECTIVE: To determine the influence of 3 fixation systems on complications rate after tibial plateau leveling osteotomy (TPLO) in dogs >45.4 kg. STUDY DESIGN: Retrospective case series. SAMPLE POPULATION: Dogs (N = 287, 342 stifles) >45.4 kg with ... ...

    Abstract OBJECTIVE: To determine the influence of 3 fixation systems on complications rate after tibial plateau leveling osteotomy (TPLO) in dogs >45.4 kg. STUDY DESIGN: Retrospective case series. SAMPLE POPULATION: Dogs (N = 287, 342 stifles) >45.4 kg with cranial cruciate ligament tear treated with TPLO. METHODS: The medical records of dogs treated with TPLO were reviewed for fixation and postoperative complications, with a follow‐up of at least 6 weeks. A random effects logistic regression model was used to evaluate the association between the type of TPLO fixation system and complications. RESULTS: The fixation systems included a 3.5‐mm broad TPLO plate alone (8P; 78.4%), a 3.5‐mm broad TPLO plate with SOP (String of Pearls) plate (8AP; 14.9%), and a 3.5‐mm standard TPLO plate (6P; 6.7%). Among the included stifles, 214 (62.6%) fixation systems were classified as locking, and 128 (37.4%) were classified as nonlocking. The fixation system was predictive of complications. The 8P had the lowest odds ratio for complication among the 3 fixation systems. Odds of developing complications were higher with the 8AP fixation system than with the 8P fixation system. Locking fixation eliminated the association between weight and complication rate. CONCLUSION: Fixation of a TPLO with the 8AP increased the risk of complications compared with the 8P in this population of large dogs. CLINICAL SIGNIFICANCE: Locking fixation of TPLO with a 3.5‐mm broad TPLO plate alone should be considered in large dogs because it may reduce complications.
    Keywords cranial cruciate ligament ; dogs ; medical records ; odds ratio ; osteotomy ; postoperative complications ; regression analysis ; risk ; stifle
    Language English
    Dates of publication 2019-05
    Size p. 505-512.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1491071-8
    ISSN 1532-950X ; 0161-3499
    ISSN (online) 1532-950X
    ISSN 0161-3499
    DOI 10.1111/vsu.13151
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Influence of fixation systems on complications after tibial plateau leveling osteotomy in dogs greater than 45.4 kilograms (100 lb).

    Chiu, King Wa / Amsellem, Pierre M / Yu, Jenny / Ho, Pui Shan / Radasch, Robert

    Veterinary surgery : VS

    2019  Volume 48, Issue 4, Page(s) 505–512

    Abstract: Objective: To determine the influence of 3 fixation systems on complications rate after tibial plateau leveling osteotomy (TPLO) in dogs >45.4 kg.: Study design: Retrospective case series.: Sample population: Dogs (N = 287, 342 stifles) >45.4 kg ... ...

    Abstract Objective: To determine the influence of 3 fixation systems on complications rate after tibial plateau leveling osteotomy (TPLO) in dogs >45.4 kg.
    Study design: Retrospective case series.
    Sample population: Dogs (N = 287, 342 stifles) >45.4 kg with cranial cruciate ligament tear treated with TPLO.
    Methods: The medical records of dogs treated with TPLO were reviewed for fixation and postoperative complications, with a follow-up of at least 6 weeks. A random effects logistic regression model was used to evaluate the association between the type of TPLO fixation system and complications.
    Results: The fixation systems included a 3.5-mm broad TPLO plate alone (8P; 78.4%), a 3.5-mm broad TPLO plate with SOP (String of Pearls) plate (8AP; 14.9%), and a 3.5-mm standard TPLO plate (6P; 6.7%). Among the included stifles, 214 (62.6%) fixation systems were classified as locking, and 128 (37.4%) were classified as nonlocking. The fixation system was predictive of complications. The 8P had the lowest odds ratio for complication among the 3 fixation systems. Odds of developing complications were higher with the 8AP fixation system than with the 8P fixation system. Locking fixation eliminated the association between weight and complication rate.
    Conclusion: Fixation of a TPLO with the 8AP increased the risk of complications compared with the 8P in this population of large dogs.
    Clinical significance: Locking fixation of TPLO with a 3.5-mm broad TPLO plate alone should be considered in large dogs because it may reduce complications.
    MeSH term(s) Animals ; Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Injuries/veterinary ; Bone Plates/adverse effects ; Bone Plates/veterinary ; Dog Diseases/surgery ; Dogs ; Female ; Logistic Models ; Male ; Osteotomy/instrumentation ; Osteotomy/methods ; Osteotomy/veterinary ; Postoperative Complications/veterinary ; Retrospective Studies ; Stifle/surgery ; Tibia/surgery
    Language English
    Publishing date 2019-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491071-8
    ISSN 1532-950X ; 0161-3499
    ISSN (online) 1532-950X
    ISSN 0161-3499
    DOI 10.1111/vsu.13151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Financial well-being as a mediator of the relationship between multimorbidity and health-related quality of life in people with cancer.

    So, Winnie K W / Au, Doreen W H / Chan, Dorothy N S / Ng, Marques S N / Choi, Kai Chow / Xing, Weijie / Chan, Mandy / Mak, Suzanne S S / Ho, Pui Shan / Tong, Man / Au, Cecilia / Ling, Wai Man / Chan, Maggie / Chan, Raymond J

    Cancer medicine

    2023  Volume 12, Issue 14, Page(s) 15579–15587

    Abstract: Background: It is unknown whether financial well-being mediates the impact of multimorbidity on the health-related quality of life (HRQoL) of cancer patients.: Methods: Participants were recruited from three outpatient oncology clinics of Hong Kong ... ...

    Abstract Background: It is unknown whether financial well-being mediates the impact of multimorbidity on the health-related quality of life (HRQoL) of cancer patients.
    Methods: Participants were recruited from three outpatient oncology clinics of Hong Kong public hospitals. Multimorbidity was assessed using the Charlson Comorbidity Index. Financial well-being, the mediator of the association between multimorbidity and HRQoL outcomes, was assessed using the Comprehensive Score for Financial Toxicity Functional Assessment of Chronic Illness Therapy. The HRQoL outcomes were assessed using the Functional Assessment of Cancer Therapy - General (FACT-G) and its four sub-dimensions. Mediation analyses were conducted using SPSS PROCESS v4.1.
    Results: Six-hundred and forty cancer patients participated in the study. Multimorbidity had a direct effect on FACT-G scores independent of financial well-being (β for path c' = -0.752, p < 0.001). In addition, multimorbidity had an indirect effect on FACT-G scores through its effect on financial well-being (β for path a = -0.517, p < 0.05; β for path b = 0.785, p < 0.001). Even after adjustments were made for the covariates, the indirect effect of multimorbidity on FACT-G via financial well-being remained significant, accounting for 38.0% of the overall effect, indicating partial mediation. Although there were no statistically significant associations between multimorbidity, social well-being, and emotional well-being, the indirect effects of multimorbidity on physical and functional well-being through financial well-being remained significant.
    Conclusions: Poor financial well-being attributable to multimorbidity partially mediates the direct impact of chronic conditions on HRQoL in Chinese cancer patients, particularly their physical and functional well-being.
    MeSH term(s) Humans ; Multimorbidity ; Quality of Life/psychology ; Chronic Disease ; Neoplasms/epidemiology ; Mediation Analysis
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6204
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  4. Article ; Online: Translation and validation of the Traditional Chinese version of the COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy (Version 2).

    Chan, Dorothy N S / Choi, Kai Chow / Ng, Marques S N / Xing, Weijie / Law, Bernard M H / Ho, Pui Shan / Au, Cecilia / Chan, Mandy / Tong, Man / Ling, Wai Man / Chan, Maggie / Mak, Suzanne S S / Chan, Raymond J / So, Winnie K W

    Health and quality of life outcomes

    2021  Volume 19, Issue 1, Page(s) 17

    Abstract: Background: Cancer patients often experience severe financial distress due to the high cost of their treatment, and strategies are needed to objectively measure this financial distress. The COmprehensive Score for financial Toxicity-Functional ... ...

    Abstract Background: Cancer patients often experience severe financial distress due to the high cost of their treatment, and strategies are needed to objectively measure this financial distress. The COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT) is one instrument used to measure such financial distress. This study aimed to translate the COST-FACIT (Version 2) [COST-FACIT-v2] instrument into traditional Chinese (COST-FACIT-v2 [TC]) and evaluate its psychometric properties.
    Methods: The Functional Assessment of Chronic Illness Therapy (FACIT) translation method was adopted. The translated version was reviewed by an expert panel and by 20 cancer patients for content validity and face validity, respectively, and 640 cancer patients, recruited from three oncology departments, completed the translated scale. Its reliability was evaluated in terms of internal consistency and test-retest reliability. Confirmatory factor analysis has been used to evaluate the one- and two-factor structures of the instrument reported in the literature. The convergent validity was examined by the correlation with health-related quality of life (HRQoL) and psychological distress. Known-group validity was examined by the difference in the COST-FACIT-v2 (TC) total mean score between groups with different income levels and frequency of health care service use.
    Results: The COST-FACIT-v2 (TC) showed good content and face validity and demonstrated high internal consistency (Cronbach's alpha, 0.86) and acceptable test-retest reliability (intraclass correlation coefficient, 0.71). Confirmatory factor analysis showed that the one- and two-factor structures of the instrument that have been reported in the literature could not be satisfactorily fitted to the data. Psychological distress correlated significantly with the COST-FACIT-v2 (TC) score (r = 0.47; p < 0.001). HRQOL showed a weak to moderate negative correlation with the COST-FACIT-v2 (TC) score (r = - 0.23 to - 0.46; p < 0.001). Significant differences were seen among the COST-FACIT-v2 (TC) scores obtained in groups of different income level and frequency of health care service use.
    Conclusions: The COST-FACIT-v2 (TC) showed some desirable psychometric properties to support its validity and reliability for assessing cancer patients' level of financial toxicity.
    MeSH term(s) Adult ; Aged ; Asian Continental Ancestry Group ; Chronic Disease/economics ; Chronic Disease/therapy ; Cost of Illness ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/economics ; Psychometrics/instrumentation ; Reproducibility of Results ; Socioeconomic Factors ; Surveys and Questionnaires ; Translations
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Journal Article
    ISSN 1477-7525
    ISSN (online) 1477-7525
    DOI 10.1186/s12955-020-01646-z
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  5. Article ; Online: Identifying a cut-off score for the COST measure to indicate high financial toxicity and low quality of life among cancer patients.

    Ng, Marques S N / Choi, Kai Chow / Chan, Dorothy N S / Wong, Cho Lee / Xing, Weijie / Ho, Pui Shan / Au, Cecilia / Chan, Mandy / Tong, Man / Ling, Wai Man / Chan, Maggie / Mak, Suzanne S S / Chan, Raymond J / So, Winnie K W

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2021  Volume 29, Issue 10, Page(s) 6109–6117

    Abstract: Purpose: To identify a cut-off score for the COmprehensive Score for financial Toxicity (COST) to predict a clinical implication of a high level of financial toxicity (FT).: Methods: A total of 640 cancer patients were recruited from three regional ... ...

    Abstract Purpose: To identify a cut-off score for the COmprehensive Score for financial Toxicity (COST) to predict a clinical implication of a high level of financial toxicity (FT).
    Methods: A total of 640 cancer patients were recruited from three regional hospitals in Hong Kong. They completed a questionnaire comprising the COST measure and the Functional Assessment of Cancer Therapy - General (FACT-G) instrument. The cut-off score for the COST that predicts the lowest quartile of the FACT-G total score was identified by receiver operating characteristic (ROC) analysis. The sample was then stratified by this cut-off score, and characteristics were compared using Fisher's exact, chi-squared or independent sample t-test.
    Results: The mean scores were 20.1 ± 8.8 for the COST and 71.6 ± 15.5 for the FACT-G. The ROC analysis suggested that the cut-off of 17.5 yielded an acceptable sensitivity and specificity. Characteristics of patients with a higher level of FT included being younger, having a monthly household income of < 10,000 HKD (approximately 1290 USD), being more likely not employed, having stage IV cancer and receiving targeted and/or immunotherapy. In terms of financial support, a higher proportion of these patients had discussed financial issues with health care professionals and had received financial assistance. In addition, fewer of them were covered by private health insurance.
    Conclusion: Our findings suggest a cut-off for the COST that can be used to screen for FT in clinical settings. In addition, while a considerable proportion of high-FT patients received targeted therapy, they often received financial assistance. There is a gap between financial hardship and assistance that warrants attention.
    MeSH term(s) Cost of Illness ; Health Expenditures ; Humans ; Insurance, Health ; Neoplasms/therapy ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2021-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-020-05962-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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