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Article: Clinical relevance of the risk factors for coronary artery lesions in Kawasaki disease.

Weng, Ken-Pen / Hsieh, Kai-Sheng / Huang, Shih-Hui / Ou, Shan-F / Ma, Chun-Yen / Ho, Tsyr-Yuh / Lai, Chung-Ren / Ger, Luo-Ping

The Kaohsiung journal of medical sciences

2012 Volume 28, Issue 1, Page(s) 23–29

Abstract: We aimed to investigate which factors are associated with coronary artery lesions (CALs) during the acute and chronic stages in Taiwanese children with Kawasaki disease (KD). A total of 216 children with KD were enrolled. Clinical and laboratory data ... ...

Abstract	We aimed to investigate which factors are associated with coronary artery lesions (CALs) during the acute and chronic stages in Taiwanese children with Kawasaki disease (KD). A total of 216 children with KD were enrolled. Clinical and laboratory data were obtained for each child within 7 days of illness. The patients were classified into KD children without acute CALs (n=135) and those with acute CALs (n=81) according to echocardiography data at Week 2 after treatment. Then, KD children with acute CALs were further divided into those without chronic CALs (n=55) and with chronic CALs (n=26) according to annual echocardiography data. During acute stage of KD, neutrophil count (<54%) [odds ratio (OR)=0.44, p=0.041]; second dose of intravenous immunoglobulin (IVIG) treatment (OR=5.01, p=0.009); and platelet count (≤400,000) (OR=0.42, p=0.006) were correlated with the risk of acute CALs. During chronic stage of KD, age (12-60 months) (OR=0.25, p=0.042); first dose of IVIG treatment (OR=0.12, p=0.005); and band count (≥3%) (OR=3.51, p=0.032) were correlated with the risk of chronic CALs. Our results suggest that the effects of neutrophil count, doses of IVIG treatment, and platelet count on CALs in acute KD are important. Age, doses of IVIG treatment, and band count are related to the persistence of CALs in chronic stage of KD.
MeSH term(s)	Child, Preschool ; Chronic Disease ; Coronary Artery Disease/complications ; Demography ; Disease Susceptibility ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Infant, Newborn ; Male ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Multivariate Analysis ; Odds Ratio ; Risk Factors
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2012-01
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639302-0
ISSN	1607-551X ; 0257-5655
ISSN	1607-551X ; 0257-5655
DOI	10.1016/j.kjms.2011.09.002
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Zs.B 3187: Show issues

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Article: Acquired duodenal obstruction in children.

Chien, Jen-Hung / Ho, Tsyr-Yuh / Shih-Peng, Lin / Lee, Chi-Ling / Ou, Shan-Fu

Pediatrics and neonatology

2008 Volume 49, Issue 5, Page(s) 193–196

Abstract: Traumatic intramural hematoma of the duodenum is a rare cause of acquired duodenal obstruction in children, and a high degree of suspicion is therefore required to make an early and accurate diagnosis. We report a 6-year-old boy whose epigastrium was ... ...

Abstract	Traumatic intramural hematoma of the duodenum is a rare cause of acquired duodenal obstruction in children, and a high degree of suspicion is therefore required to make an early and accurate diagnosis. We report a 6-year-old boy whose epigastrium was impacted by the handlebar of his bicycle during a traffic accident. The boy then experienced epigastralgia. Six days later, progressive bilious vomiting suggestive of gastrointestinal obstruction was noted. Imaging studies revealed a large hematoma extending from the fourth portion of the duodenum to the jejunum. Conservative methods of treatment failed to manage his condition. He underwent laparoscopic surgery to evacuate the hematoma. We also report a case of duodenal obstruction in a previously healthy 2-year-old girl who presented for the first time with acute symptoms of proximal intestinal obstruction. Contrast examinations showed apparent barium retention over the stomach and proximal duodenum. She underwent surgery due to persistent obstruction, and a mushroom-like foreign body was detected embedded in the orifice of the windsock duodenal web. After duodenoduodenostomy and removal of the bezoar, she had a smooth recovery and tolerated feeding well. We conclude that blunt abdominal trauma and incomplete duodenal obstruction, such as that caused by duodenal web, should be considered as possible causes of acquired proximal gastrointestinal obstruction in previously healthy children, despite their rarity.
MeSH term(s)	Accidents, Traffic ; Bezoars/complications ; Child ; Child, Preschool ; Duodenal Diseases/complications ; Duodenal Obstruction/etiology ; Duodenum ; Female ; Hematoma/complications ; Humans ; Male
Language	English
Publishing date	2008-10
Publishing country	Singapore
Document type	Case Reports ; Journal Article
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/S1875-9572(09)60008-5
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Article ; Online: Interleukin-18 and coronary artery lesions in patients with Kawasaki disease.

Weng, Ken-Pen / Hsieh, Kai-Sheng / Huang, Shih-Hui / Ou, Shan-F / Lai, Tsung-Jen / Tang, Chia-Wan / Lin, Chu-Chuan / Ho, Tsyr-Yuh / Liou, Huei-Han / Ger, Luo-Ping

Journal of the Chinese Medical Association : JCMA

2013 Volume 76, Issue 8, Page(s) 438–445

Abstract: Background: Interleukin-18 (IL-18) plays an important role in mediating cytokine cascade leading to coronary artery lesions (CALs) in Kawasaki disease (KD). However, our research suggested that the literature regarding IL-18 and KD is limited. ... ...

Abstract	Background: Interleukin-18 (IL-18) plays an important role in mediating cytokine cascade leading to coronary artery lesions (CALs) in Kawasaki disease (KD). However, our research suggested that the literature regarding IL-18 and KD is limited. Consequently, this study aimed to evaluate the correlation between IL-18 and CALs in patients with KD. Methods: In this prospective study of 14 children with KD (seven without and seven with CALs in the acute phase), we obtained patient measurements of a series of serum IL-18 levels in the acute, subacute, and convalescent phases. Serum IL-18 levels were measured with a Bio-Plex cytokine assay. Control samples were obtained from 18 febrile children with viral infection. Results: Compared with febrile controls, patients with acute-stage CALs [postintravenous immunoglobulin (post-IVIG) period] had a significantly higher IL-18 level (88.4 ± 20.7 vs 56.0 ± 35.0 pg/mL, p = 0.006). However, those without acute-stage CALs (post-IVIG period) lacked similarly elevated IL-18 level readings (62.0 ± 40.6 vs 56.0 ± 35.0 pg/mL, p = 0.762). The IL-18 level of patients with acute-stage CALs did not decrease significantly until the convalescent phase (97.4 ± 55.8 vs 38.7 ± 22.6 pg/mL, p = 0.018), but for those without CALs, it decreased significantly in the subacute phase (60.2 ± 37.4 vs 23.6 ± 13.8 pg/mL, p = 0.018). In the subacute stage, there was a significant difference of IL-18 level between patients with and without acute-stage CALs (p = 0.048). Conclusion: Our data show that IL-18 levels were elevated in the acute phase of KD and might be related to the formation of CALs.
MeSH term(s)	C-Reactive Protein/analysis ; Child ; Child, Preschool ; Coronary Artery Disease/etiology ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Infant, Newborn ; Interferon-gamma/biosynthesis ; Interleukin-18/blood ; Interleukin-18/physiology ; Male ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/immunology ; Prospective Studies
Chemical Substances	Immunoglobulins, Intravenous ; Interleukin-18 ; Interferon-gamma (82115-62-6) ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2013-06-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1016/j.jcma.2013.04.005
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Zs.A 2699: Show issues

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Article: Assessment of growth from foot length in Taiwanese neonates.

Ho, Tsyr-Yuh / Ou, Shan-Fu / Huang, Shih-Hui / Lee, Chi-Ning / Ger, Luo-Ping / Hsieh, Kai-Sheng / Huang, Shih-Ming / Weng, Ken-Pen

Pediatrics and neonatology

2009 Volume 50, Issue 6, Page(s) 287–290

Abstract: Background: Previous studies have demonstrated a positive correlation between foot length (FL) and birth body weight (BBW), birth body length (BBL), and head circumference (HC). However, there is no data on birth FL in Taiwan. The aim of this study was ... ...

Abstract	Background: Previous studies have demonstrated a positive correlation between foot length (FL) and birth body weight (BBW), birth body length (BBL), and head circumference (HC). However, there is no data on birth FL in Taiwan. The aim of this study was to evaluate FL measurement in Taiwanese neonates as a method of estimating other anthropometric indices. Methods: In this retrospective study, we enrolled 256 babies born at our hospital and Kaohsiung Veterans General Hospital from 2003-2005. Medical records were reviewed for sex, BBW, BBL, HC, gestational age, and birth FL. Ill newborns, small-for-gestational-age babies, or those with poor birth footprints were excluded. FL at birth was measured from the center of the back of the heel to the tip of the big toe. Linear regression analysis was used to investigate the relation of FL to BBW and BBL. The intraclass correlation coefficient was used to assess inter-rater reliability. Results: A total of 256 babies were reviewed. There were 136 male and 120 female neonates. The gestational age was 38.5+/-1.3 (mean+/-standard deviation) weeks, ranging from 35-42 weeks. The BBW was 3137+/-396g. The BBL was 51.1+/-2.1 cm. The HC was 33.5+/-1.7 cm. The FL was 7.4+/-0.46 cm. The regression equation for BBW (y) on FL (x) was as follows: y=486.2+360.4x (p<0.001, r=0.421). The regression equation for BBL (y) on FL (x) was as follows: y=40.1+1.45x (p<0.001, r= 0.305). The regression equation for HC (y) on FL (x) was as follows: y=14.8+2.53x (p<0.001, r=0.423). FL showed excellent reliability, with an intraclass correlation coefficient of 0.965 (p<0.001). Conclusion: Our study demonstrated a significant degree of correlation between FL and BBW, BBL and HC. However, it did not reliably estimate BBW, BBL, or HC-the three anthropometric indices were weakly correlated (r<0.5) with FL.
MeSH term(s)	Birth Weight ; Body Height ; Female ; Fetal Development ; Foot/anatomy & histology ; Humans ; Infant, Newborn ; Male ; Regression Analysis ; Retrospective Studies
Language	English
Publishing date	2009-12
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/S1875-9572(09)60079-6
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Article: Effects of a classroom-based weight-control intervention on cardiovascular disease in elementary-school obese children.

Huang, Shi-Hui / Weng, Ken-Pen / Hsieh, Kai-Sheng / Ou, Shan-Fu / Lin, Chu-Chuan / Chien, Kuang-Jen / Liu, Po-Yen / Ho, Tsyr-Yuh

Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi

2007 Volume 48, Issue 4, Page(s) 201–206

Abstract: Background: Childhood obesity has become a growing public health issue in Taiwan. Obese children have risk factors for type 2 diabetes and cardiovascular disease. In this prospective study, we investigated the effect of a twelve-week heart health ... ...

Abstract	Background: Childhood obesity has become a growing public health issue in Taiwan. Obese children have risk factors for type 2 diabetes and cardiovascular disease. In this prospective study, we investigated the effect of a twelve-week heart health education and physical activity program on body weight and risk factors for type 2 diabetes and cardiovascular disease. Methods: Subjects were 120 obese fifth graders (65 boys and 55 girls, aged 10-13 years (mean 10.6 yrs), body mass index (BMI) at the 95th percentile or more) and were randomly assigned to an intervention group (n=60) or control group (n=60). The intervention group received a twelve-week heart health education and physical activity program, while the control group did not. In both groups, a series of examinations were done at baseline and post-test, including height, weight, BMI, body fat, blood pressure (BP), physical fitness (800-meter running test), heart health knowledge, and serum biochemistry. Differences for baseline and post-test data were compared between both groups. Results: Mean changes in the intervention group versus control group were significant for weight (P = 0.024), BMI (P = 0.047), percentage body fat (P = 0.008), physical fitness (800-meter running test) (P = 0.025), heart health knowledge (P = 0.006), total cholesterol (P = 0.027), triglycerides (P = 0.018), high-density lipoprotein cholesterol (HDL-C) (P = 0.009), low-density lipoprotein cholesterol (LDL-C) (P = 0.041), sugar (P = 0.035), insulin (P = 0.007), and insulin resistance (HOMA-IR) (P = 0.028). At post-test, weight, BMI, body fat, total cholesterol, triglycerides, LDL-C, sugar, insulin and HOMA-IR had decreased, but HDL-C had increased in the intervention group. Conclusions: A classroom-based weight-control intervention provides educational programs to promote cardiovascular health in children. This intervention is simple, practical, and beneficial for elementary school children.
MeSH term(s)	Adolescent ; Cardiovascular Diseases/prevention & control ; Child ; Diabetes Mellitus, Type 2/prevention & control ; Exercise ; Female ; Health Education ; Humans ; Male ; Obesity/complications ; Prospective Studies ; Weight Loss
Language	English
Publishing date	2007-07
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1501489-7
ISSN	1608-8115 ; 0001-6578
ISSN	1608-8115 ; 0001-6578
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Article ; Online: IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan.

Hsieh, Kai-Sheng / Lai, Tsung-Jen / Hwang, Yu-Tung / Lin, Ming-Wei / Weng, Ken-Pen / Chiu, Yi-Ten / Ho, Tsyr-Yuh / Chen, Chi-Shan / Shiue, Yow-Ling / Hsiao, Michael / Tsai, Shih-Feng / Ger, Luo-Ping

Disease markers

2011 Volume 30, Issue 1, Page(s) 51–59

Abstract: Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the ... ...

Abstract	Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (-1082, -819, and -592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci -819 T > C and -592 A > C for KD cases was observed (P permutation = 0.029 and P permutation = 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p = 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090-2.443; P permutation = 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. The haplotype CC (-819, -592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987-1.797; p = 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant, p =0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and -592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.
MeSH term(s)	Case-Control Studies ; Child, Preschool ; Female ; Genetic Association Studies ; Haplotypes ; Heredity ; Humans ; Infant ; Interleukin-10/genetics ; Male ; Mucocutaneous Lymph Node Syndrome/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Taiwan
Chemical Substances	IL10 protein, human ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2011-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.3233/DMA-2011-0765
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Effects of flow rate on delivery of bubble continuous positive airway pressure in an in vitro model.

Ho, Tsyr-Yuh / Ou, Shan-Fu / Huang, Shih-Hui / Lee, Chi-Ning / Ger, Luo-Ping / Hsieh, Kai-Sheng / Cheng, Hui-Ying / Lee, Wei Yang / Weng, Ken-Pen

Pediatrics and neonatology

2010 Volume 51, Issue 4, Page(s) 214–218

Abstract: Background: There has been concern over the effect of vigorous bubbling on the delivery pressure during the operation of the bubble nasal continuous positive airway pressure (CPAP) system. We investigated the relationship between intra-tubing pressure ... ...

Abstract	Background: There has been concern over the effect of vigorous bubbling on the delivery pressure during the operation of the bubble nasal continuous positive airway pressure (CPAP) system. We investigated the relationship between intra-tubing pressure changes and flow rates in a closed bubble CPAP system in vitro. Methods: Using an experimental (in vitro) model, the distal connecting tube of the CPAP system was immersed under the water seal to a depth of 5 cm. Sixteen different flow rates, ranging from 2 L/min to 20 L/min, were tested. The procedure was repeated 10 times at each flow rate, and the intra-tubing pressure was recorded. Results: The intra-tubing pressure within the model increased as the air flow rates were adjusted from 2 L/min to 20 L/min. The relationship was represented by the following equation, pressure (cmH(2)O) = 5.37 + 0.15 x flow rate (L/min) (R(2) = 0.826, p < 0.001). Conclusion: These results demonstrated that the intra-tubing pressure in a bubble CPAP system was highly correlated with flow rate in vitro.
MeSH term(s)	Air Pressure ; Airway Resistance/physiology ; Continuous Positive Airway Pressure/instrumentation ; Humans ; Infant, Newborn ; Infant, Premature ; Intubation/instrumentation ; Models, Biological ; Respiratory Distress Syndrome, Newborn/therapy ; Rheology
Language	English
Publishing date	2010-06-01
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/S1875-9572(10)60041-1
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Article ; Online: Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children.

Weng, Ken-Pen / Ho, Tsyr-Yuh / Chiao, Ya-Hui / Cheng, Jiin-Tsuey / Hsieh, Kai-Sheng / Huang, Shih-Hui / Ou, Shan-F / Liu, Kai-His / Hsu, Ching-Ju / Lu, Pei-Jung / Hsiao, Michael / Ger, Luo-Ping

Circulation journal : official journal of the Japanese Circulation Society

2010 Volume 74, Issue 12, Page(s) 2726–2733

Abstract: Background: The relationship between cytokine gene polymorphisms and susceptibility to Kawasaki diseases (KD) is still controversial, so the aim of the present study was to investigate the association of 14 various polymorphisms of 9 cytokine genes ( ... ...

Abstract	Background: The relationship between cytokine gene polymorphisms and susceptibility to Kawasaki diseases (KD) is still controversial, so the aim of the present study was to investigate the association of 14 various polymorphisms of 9 cytokine genes (interleukin (IL)-1A, IL-1B, IL-1RN, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-A and transforming growth factor-B) with KD risk. Methods and results: A total of 211 KD children and 221 adult controls were recruited. All controls were frequency matched to KD patients on sex and ethnicity. PCR and TaqMan assays were used for genotyping. There were no significant differences between KD children and adult controls in the genotype or allelic type frequencies of the 14 polymorphisms. No significant associations were found between haplotypes, constructed by IL-1B, IL-4, IL-8, and IL-10 cytokine genes, and risk of KD. Additionally, a linear trend was observed when these single nucleotide polymorphisms were combined, as evidenced by an increasing risk of KD as the number of at-risk genotypes increased (P(linear trend)=0.002). In the stratification analysis of age and sex, there was a linear trend of KD risk as the number of at-risk genotypes increased among those aged >12 months (P=0.014) or female (P=0.001), respectively. Conclusions: No associations between individual cytokine genetic polymorphisms and susceptibility of KD were observed, but a gene-dosage effect on the risk of KD was found, especially for older or female subjects.
MeSH term(s)	Adult ; Age Factors ; Asian Continental Ancestry Group ; Child, Preschool ; Cytokines/genetics ; Female ; Gene Dosage ; Genetic Predisposition to Disease ; Humans ; Infant ; Male ; Middle Aged ; Mucocutaneous Lymph Node Syndrome/genetics ; Polymorphism, Genetic ; Retrospective Studies ; Risk Factors ; Sex Factors ; Taiwan
Chemical Substances	Cytokines
Language	English
Publishing date	2010-10-30
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.cj-10-0542
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Article ; Online: IL-1B polymorphism in association with initial intravenous immunoglobulin treatment failure in Taiwanese children with Kawasaki disease.

Weng, Ken-Pen / Hsieh, Kai-Sheng / Ho, Tsyr-Yuh / Huang, Shih-Hui / Lai, Chung-Ren / Chiu, Yi-Ten / Huang, Shih-Chen / Lin, Chu-Chuan / Hwang, Yu-Tung / Ger, Luo-Ping

Circulation journal : official journal of the Japanese Circulation Society

2010 Volume 74, Issue 3, Page(s) 544–551

Abstract: Background: Approximately 8-38% of children with Kawasaki disease (KD) will have persistent or recrudescent fever after initial intravenous immunoglobulin (IVIG) treatment and are at increased risk for development of coronary artery abnormalities. Using ...

Abstract	Background: Approximately 8-38% of children with Kawasaki disease (KD) will have persistent or recrudescent fever after initial intravenous immunoglobulin (IVIG) treatment and are at increased risk for development of coronary artery abnormalities. Using genetic markers may be helpful to identify the high-risk group of IVIG-resistant patients for aggressive treatment. The aim of this study was to evaluate the associations between 4 potential polymorphisms in the interleukin (IL)-1 family of genes and initial IVIG treatment failure in KD children. Methods and results: A total of 156 KD children (136 with and 20 without a response to IVIG treatment) who were treated with high-dose IVIG (2 g/kg) within 10 days of fever onset were recruited. Polymerase chain reaction and Taqman assays were used for genotyping. A significant increase in IVIG resistance risk was observed for IL-1B -511 TT and IL-1B -31 CC genotypes (adjusted odds ratio (AOR) 5.27, 95% confidence interval (CI) 1.69-16.38, P=0.004; AOR 3.95, 95%CI 1.26-12.41, P=0.019, separately). The diplotype TC/TC (at IL-1B -511 and -31) also showed a significantly increased risk of IVIG resistance (AOR 4.32, 95%CI 1.36-13.71, P=0.013). Conclusions: The IL-1B -511 TT and IL-1B -31 CC genotypes or the TC/TC diplotype may be associated with initial IVIG treatment failure in Taiwanese children with KD.
MeSH term(s)	Child, Preschool ; Female ; Gene Frequency ; Genotype ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Incidence ; Infant ; Interleukin-1beta/genetics ; Male ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Mucocutaneous Lymph Node Syndrome/immunology ; Mucocutaneous Lymph Node Syndrome/therapy ; Retrospective Studies ; Risk Factors ; Taiwan/epidemiology ; Treatment Failure
Chemical Substances	Immunoglobulins, Intravenous ; Immunologic Factors ; Interleukin-1beta
Language	English
Publishing date	2010-01-18
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.cj-09-0664
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Article: Risk factors of prolonged postoperative pleural effusion after repair of tetralogy of Fallot.

Liang, Chi-Ming / Hwang, Betau / Lu, Jen-Her / Lee, Pi-Chang / Weng, Zeng-Chung / Ho, Tsyr-Yuh / Meng, C C Laura

Journal of the Chinese Medical Association : JCMA

2005 Volume 68, Issue 9, Page(s) 406–410

Abstract: Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, and total correction is the definitive treatment. Chest tube drainage of pleural effusion (PE) is essential after surgery. Prolonged PE (> 7 days) is one of the ... ...

Abstract	Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, and total correction is the definitive treatment. Chest tube drainage of pleural effusion (PE) is essential after surgery. Prolonged PE (> 7 days) is one of the complications; it may increase hospital stay and the risks of morbidity and mortality. The aim of this study was to investigate and analyze the possible risk factors for prolonged PE after total correction of TOF. Methods: Thirty-seven patients who received total correction of TOF between July 1999 and April 2001 were included in this study. They were divided into 2 groups according to the duration of chest tube drainage for postoperative PE: Group I had postoperative PE < or = 7 days; Group II had postoperative PE > 7 days. Detailed records were taken on patients' demographic characteristics, blood parameters, surgery, electrocardiographic and radiologic data, and angiographic and echocardiographic findings. The data of the 2 groups were compared using the Wilcoxon rank-sum test and Fisher's exact test. Risk factors were analyzed by logistic regression and model selection. Results: Of the 37 patients, 16 were male and 21 were female. There were 32 patients (86.5%) in Group I and 5 (13.5%) in Group II. Mean patient age at repair was 1.82 +/- 1.29 years (range, 0.53-3.11 years). Significant differences (p < 0.05) between the 2 groups were noted for gender, age at repair, body weight, presence of wound infection, duration on heart-lung machine (bypass time), oxygen saturation before surgery, duration of endotracheal intubation, length of hospital stay, and Nakata index. These risk factors were analyzed by logistic regression and model selection. Two models were set up: Model 1--oxygen saturation before surgery, presence of wound infection, age at repair; Model 2--oxygen saturation before surgery, presence of wound infection. Conclusion: Prolonged PE is a significant morbidity after TOF repair. The risk factors for prolonged PE are gender, age at repair, body weight, bypass time, low oxygen saturation before surgery, wound infection after surgery, duration of endotracheal intubation, length of hospital stay, and Nakata index. Oxygen saturation before surgery and wound infection were major risk factors while age at repair was a confounder.
MeSH term(s)	Age Factors ; Child, Preschool ; Female ; Humans ; Infant ; Length of Stay ; Logistic Models ; Male ; Pleural Effusion/etiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors ; Sex Factors ; Surgical Wound Infection/complications ; Tetralogy of Fallot/surgery
Language	English
Publishing date	2005-09-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1016/s1726-4901(09)70155-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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