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Article ; Online: The arrowhead appearance of bile ducts in recurrent pyogenic cholangitis.

Lee, Kam-Ho / Ho, Yuen-Chi

2017 Volume 42, Issue 12, Page(s) 2964–2965

MeSH term(s)	Bile Ducts/diagnostic imaging ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Cholangiopancreatography, Magnetic Resonance/methods ; Cholangitis/diagnostic imaging ; Humans ; Recurrence
Language	English
Publishing date	2017-06-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-017-1234-0
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Zs.A 1262: Show issues

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Article ; Online: "Venous cut-off sign" as an adjunct to the "whirl sign" in recognizing acute small bowel volvulus via CT scan.

Ho, Yuen Chi

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2012 Volume 16, Issue 10, Page(s) 2005–2006

Abstract: Introduction: A young adult patient was admitted for signs and symptoms of acute abdomen.: Materials and methods: Urgent CT scan was performed and small bowel volvulus was confirmed. The "whirl sign" diagnostic of small bowel volvulus was present.: ...

Abstract	Introduction: A young adult patient was admitted for signs and symptoms of acute abdomen. Materials and methods: Urgent CT scan was performed and small bowel volvulus was confirmed. The "whirl sign" diagnostic of small bowel volvulus was present. Results: Furthermore, the accompanying superior mesenteric vein was noted to be truncated at the point of torsion. Conclusion: The "venous cut-off sign" can be a useful adjunct sign to the diagnosis.
MeSH term(s)	Abdomen, Acute/etiology ; Acute Disease ; Adolescent ; Humans ; Intestinal Volvulus/complications ; Intestinal Volvulus/diagnostic imaging ; Intestinal Volvulus/pathology ; Intestine, Small/diagnostic imaging ; Intestine, Small/pathology ; Male ; Mesenteric Veins/diagnostic imaging ; Mesenteric Veins/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2012-05-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-012-1910-x
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of empagliflozin on liver fat in patients with metabolic dysfunction-associated steatotic liver disease without diabetes mellitus: A randomized, double-blind, placebo-controlled trial.

Cheung, Ka Shing / Ng, Ho Yu / Hui, Rex Wan Hin / Lam, Lok Ka / Mak, Lung Yi / Ho, Yuen Chi / Tan, Jing Tong / Chan, Esther W / Seto, Wai Kay / Yuen, Man Fung / Leung, Wai K

Hepatology (Baltimore, Md.)

2024

Abstract: Background and aims: We investigated whether empagliflozin reduces hepatic steatosis in patients with metabolic dysfunction-associated steatotic liver disease without diabetes mellitus.: Approach and results: This was an investigator-initiated, ... ...

Abstract	Background and aims: We investigated whether empagliflozin reduces hepatic steatosis in patients with metabolic dysfunction-associated steatotic liver disease without diabetes mellitus. Approach and results: This was an investigator-initiated, double-blind, randomized, placebo-controlled trial recruiting adult subjects from the community. Eligible subjects without diabetes mellitus (fasting plasma glucose < 7 mmol/L and HbA1c < 6.5%) who had magnetic resonance imaging-proton density fat fraction (MRI-PDFF) ≥ 5% were randomly allocated to receive empagliflozin 10 mg daily or placebo (1:1 ratio) for 52 weeks (end of treatment, EOT). MRI-PDFF was conducted at baseline and EOT. The primary outcome was the difference in change of MRI-PDFF between the 2 groups at EOT. Secondary outcomes were hepatic steatosis resolution (MRI-PDFF < 5%), alanine aminotransferase drop ≥ 17 U/L, MRI-PDFF decline ≥ 30%, a combination of both, and changes of anthropometric and laboratory parameters at EOT. All outcomes were based on intention-to-treat analysis. Of 98 recruited subjects (median age: 55.7 y [IQR:49.5-63.4]; male:54 [55.1%]), 97 (empagliflozin:49, placebo:48; median MRI-PDFF:9.7% vs 9.0%) had MRI-PDFF repeated at EOT. The Empagliflozin group had a greater reduction in median MRI-PDFF compared to the placebo group (-2.49% vs. -1.43%; p = 0.025), with a nonsignificant trend of resolution of hepatic steatosis (44.9% vs. 28.6%; p = 0.094). There was no significant difference in alanine aminotransferase drop ≥ 17 U/L (16.3% vs. 12.2%; p = 0.564), MRI-PDFF drop ≥ 30% (49.0% vs. 40.8%; p = 0.417), and composite outcome (8.2% vs. 8.2%; p = 1.000). Empagliflozin group had a greater drop in body weight (-2.7 vs. -0.2 kg), waist circumference (-2.0 vs. 0 cm), fasting glucose (-0.3 vs. 0 mmol/L), and ferritin (-126 vs. -22 pmol/L) (all p < 0.05). Conclusions: Empagliflozin for 52 weeks reduces hepatic fat content in subjects with nondiabetic metabolic dysfunction-associated steatotic liver disease. (ClinicalTrials.gov Identifier: NCT04642261).
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000855
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Zs.A 1660: Show issues

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Article ; Online: Total colorectal and terminal ileal duplication presenting as intussusception and intestinal obstruction.

Ho, Yuen Chi

World journal of gastroenterology

2011 Volume 18, Issue 43, Page(s) 6338–6340

Abstract: Colonic intussusception and gastrointestinal duplication are diseases that arise in young children. The clinical presentation of adult cases of intussusception and enteric duplication is non-specific and thus poses a diagnostic challenge. A computed ... ...

Abstract	Colonic intussusception and gastrointestinal duplication are diseases that arise in young children. The clinical presentation of adult cases of intussusception and enteric duplication is non-specific and thus poses a diagnostic challenge. A computed tomography (CT) scan is recommended in adult cases as the most sensitive diagnostic tool and the pathognomonic finding of outer intussuscepiens and central intussusceptum is diagnostic. A septum of a duplicated colon in a non-intussuscepted segment has been rarely reported in the literature. With advancements in radiological imaging technology and the increased availability of CT scanners, the capacity for a correct pre-operative diagnosis has been significantly enhanced. Our current case report illustrates the importance of considering an uncommon etiology for enteric intussusception and duplication as a differential diagnosis of acute abdomen in an adult patient. Our analyses of this patient also highlight the successful use of CT scanning to make this diagnosis.
MeSH term(s)	Abdomen, Acute/etiology ; Adult ; Colon/diagnostic imaging ; Colon/pathology ; Colon/surgery ; Humans ; Ileum/diagnostic imaging ; Ileum/pathology ; Ileum/surgery ; Intestinal Diseases/complications ; Intestinal Diseases/diagnosis ; Intestinal Diseases/surgery ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intussusception/diagnosis ; Intussusception/etiology ; Intussusception/surgery ; Male ; Predictive Value of Tests ; Rectum/diagnostic imaging ; Rectum/pathology ; Rectum/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2011-05-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v18.i43.6338
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Zs.A 6039: Show issues

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Article ; Online: Predicting the level of difficulty of the double-stapling technique in laparoscopic total mesorectal excision.

Foo, Chi Chung / Hung, Hing Tsun / Ho, Yuen Chi / Lam, Wendy Wai Man / Law, Wai Lun

Surgical endoscopy

2019 Volume 34, Issue 8, Page(s) 3382–3387

Abstract: Background: The transection of rectum and fashioning of anastomosis is a crucial step in laparoscopic total mesorectal excision (TME) and the double-stapling technique (DST) is often employed. This study aimed to evaluate the factors that were ... ...

Abstract	Background: The transection of rectum and fashioning of anastomosis is a crucial step in laparoscopic total mesorectal excision (TME) and the double-stapling technique (DST) is often employed. This study aimed to evaluate the factors that were associated with difficult DST. Method: Cases of laparoscopic TME were retrospectively reviewed. The clinico-anatomical parameters were retrieved from a prospectively maintained database. In addition, pelvic dimensions were taken by reviewing the magnetic resonance imaging scan. The number of stapler cartridges used for intracorporeal transection of rectum was used as a surrogate for the level of difficulty of DST and its relationship with various parameters were evaluated. Results: There were a total of 121 consecutive cases analyzed. The mean number of stapler cartridges used was 2.1 ± 0.7. Pelvic inlet (p = 0.002) and tumor height (p = 0.015) were predictors of the number of cartridges used, R Conclusion: The difficulty of DST was associated with patient's clinico-anatomical factors. Surgeons can consider other feasible alternatives, like transanal anastomosis, when a technically challenging DST is anticipated.
MeSH term(s)	Anastomosis, Surgical/methods ; Anastomosis, Surgical/statistics & numerical data ; Humans ; Laparoscopy/methods ; Laparoscopy/statistics & numerical data ; Operative Time ; Rectal Neoplasms/surgery ; Rectum/surgery ; Retrospective Studies ; Surgical Stapling/adverse effects ; Surgical Stapling/classification ; Surgical Stapling/methods ; Surgical Stapling/statistics & numerical data
Language	English
Publishing date	2019-09-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-019-07112-2
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Zs.A 2214: Show issues

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Article ; Online: Late stenosis after repair of anomalous pulmonary venous drainage and the value of cardiovascular magnetic resonance for assessment of this important complication.

Ho, Yuen Chi / Chen, Sylvia S M / Mohiaddin, Raad H

Pediatric cardiology

2012 Volume 34, Issue 2, Page(s) 480–482

MeSH term(s)	Adult ; Aged ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/etiology ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging, Cine/methods ; Postoperative Complications/diagnosis ; Pulmonary Veins/pathology ; Pulmonary Veno-Occlusive Disease/diagnosis ; Pulmonary Veno-Occlusive Disease/surgery ; Time Factors
Language	English
Publishing date	2012-10-18
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-012-0518-y
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Zs.A 1528: Show issues

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Article ; Online: Development and validation of an imaging and clinical scoring system to predict early mortality in spontaneous ruptured hepatocellular carcinoma treated with transarterial embolization.

Lee, Kam-Ho / Tse, Man-Lap Donald / Law, Martin / Cheng, Andrew Kai-Chun / Wong, Ho-Yuen Frank / Yu, Man-Leung / Li, Yan-Lin / Ho, Yuen-Chi / Chu, Ferdinand / Lam, Wendy Wai-Man

Abdominal radiology (New York)

2019 Volume 44, Issue 3, Page(s) 903–911

Abstract: Purpose: To develop and validate a scoring system using a combination of imaging and clinical parameters to predict 30-day mortality in ruptured HCC (rHCC) patients after transarterial embolization (TAE).: Methods: 98 consecutive patients with rHCC ... ...

Abstract	Purpose: To develop and validate a scoring system using a combination of imaging and clinical parameters to predict 30-day mortality in ruptured HCC (rHCC) patients after transarterial embolization (TAE). Methods: 98 consecutive patients with rHCC who underwent abdominal CT and subsequent TAE between January 2007 and December 2016 were retrospectively reviewed. The CT scans were reviewed by two radiologists blinded to the patient outcome. Clinical parameters including serum bilirubin, albumin, INR, creatinine, and hemoglobin were recorded. Independent risk factors for 30-day mortality after TAE were identified using multivariate binary logistic regression, for development of a scoring system. The scoring system was then validated in 20 patients between January 2017 and May 2018. Results: In the development cohort, bilobar tumor distribution (OR = 29.6), clinical parameters of bilirubin > 2.5 mg/dL (OR = 5.9), and albumin < 30 g/L (OR = 4.1) were independent predictors for 30-day mortality. A 6-point score was derived and yielded area-under-the-receiver-operating-characteristic-curve (AUC) of 0.904. A score ≥ 4 resulted in sensitivity of 80.5% and specificity of 91.2% for 30-day mortality. In the validation cohort, AUC for 30-day mortality was 0.939. A score ≥ 4 resulted in sensitivity of 81.2% and specificity of 88.9%. In both development and validation cohorts, the proposed scoring system was better than biochemical components of Child-Pugh score and serum bilirubin to predict 30-day mortality. Conclusion: Imaging and clinical parameters can be combined into a scoring system to accurately predict 30-day mortality after TAE in rHCC patients. The score may help identify and counsel high-risk patients.
MeSH term(s)	Aged ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Cohort Studies ; Embolization, Therapeutic/methods ; Female ; Humans ; Liver/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Risk Assessment ; Rupture, Spontaneous ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Language	English
Publishing date	2019-01-10
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-019-01895-7
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Zs.A 1262: Show issues

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Article ; Online: Case report: Completely unroofed coronary sinus with a left superior vena cava draining into the left atrium studied by cardiovascular magnetic resonance.

Raj, Vimal / Joshi, Sanjiv / Ho, Yuen Chi / Kilner, Philip J

The Indian journal of radiology & imaging

2010 Volume 20, Issue 3, Page(s) 215–217

Abstract: A persistent left superior vena cava (LSVC) draining through a dilated coronary sinus into the right atrium is a relatively common congenital cardiovascular anomaly. It is readily identified by cardiovascular magnetic resonance (CMR). However, a LSVC ... ...

Abstract	A persistent left superior vena cava (LSVC) draining through a dilated coronary sinus into the right atrium is a relatively common congenital cardiovascular anomaly. It is readily identified by cardiovascular magnetic resonance (CMR). However, a LSVC draining into the left atrium (LA) and associated with unroofing of the coronary sinus, with resulting interatrial communication, is rare and may have important clinical consequences. As with any large atrial septal defect, it can be associated with a higher than expected incidence of pulmonary arterial hypertension, systemic embolization, and brain abscesses. In this report, we present a case of a completely unroofed coronary sinus with a persistent LSVC draining directly into the LA and illustrate the role of CMR in the diagnosis and evaluation of such anomalies.
Language	English
Publishing date	2010-10-29
Publishing country	Germany
Document type	Case Reports
ZDB-ID	605869-3
ISSN	1998-3808 ; 0971-3026 ; 0970-2016
ISSN (online)	1998-3808
ISSN	0971-3026 ; 0970-2016
DOI	10.4103/0971-3026.69359
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Zs.A 430: Show issues

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Article ; Online: Depiction of celiac ganglia on positron emission tomography and computed tomography in patients with lung cancer.

Abtahi, Seyed Mahdi / Elmi, Azadeh / Hedgire, Sandeep S / Ho, Yuen Chi / Pourjabbar, Sarvenaz / Singh, Sarabjeet / Kalra, Mannudeep / Harisinghani, Mukesh

Clinical imaging

2014 Volume 38, Issue 3, Page(s) 292–295

Abstract: Objective: To differentiate imaging characteristics of celiac ganglia from metastatic lesion on positron emission tomography-computed tomography (PET-CT) in patients with lung cancer and correlate these findings to postmortem multidetector row computed ... ...

Abstract	Objective: To differentiate imaging characteristics of celiac ganglia from metastatic lesion on positron emission tomography-computed tomography (PET-CT) in patients with lung cancer and correlate these findings to postmortem multidetector row computed tomography (MDCT). Methods: One hundred twenty-nine patients were included. Imaging characteristics and fluorodeoxyglucose (FDG) avidity of the celiac ganglia were recorded. Postmortem MDCT of 20 subjects were reviewed. Results: Celiac ganglia were identified unilaterally in 127 and bilaterally in 108 patients without abnormal FDG uptake. Postmortem images showed celiac ganglia in all cases with no significant difference compared to our patients. Conclusions: Familiarity with CT characteristics and FDG-avidity of celiac ganglia enable us to distinguish them from metastatic lesions in their vicinity.
MeSH term(s)	Adult ; Aged ; Female ; Fluorodeoxyglucose F18 ; Ganglia, Sympathetic/diagnostic imaging ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Retrospective Studies
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2014-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2013.12.017
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Zs.A 1469: Show issues

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Article ; Online: Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation.

Chen, Mei-Pian / Li, Shu-Na / Lam, Wendy W M / Ho, Yuen-Chi / Ha, Shau-Yin / Chan, Godfrey C F / Cheung, Yiu-Fai

BMC cardiovascular disorders

2014 Volume 14, Page(s) 49

Abstract: Background: Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse ... ...

Abstract	Background: Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron load on proteolysis of the giant sarcomeric protein titin. Methods and results: In 44 thalassaemia patients aged 25 ± 7 years and 38 healthy subjects, LV torsion and twisting velocities were determined at rest using speckle tracking echocardiography. Changes in LV torsional parameters during submaximal exercise testing were further assessed in 32 patients and 17 controls. Compared with controls, patients had significantly reduced LV apical rotation, torsion, systolic twisting velocity, and diastolic untwisting velocity. T2* cardiac magnetic resonance findings correlated with resting diastolic untwisting velocity. The increments from baseline and resultant LV torsion and systolic and diastolic untwisting velocities during exercise were significantly lower in patients than controls. Significant correlations existed between LV systolic torsion and diastolic untwisting velocities in patients and controls, both at rest and during exercise. In HL-1 cells and ventricular myocardium of B6D2F1 mice overloaded with iron, the titin-stained pattern of sarcomeric structure became disrupted. Gel electrophoresis of iron-overloaded mouse myocardial tissue further showed significant decrease in the amount of titin isoforms and increase in titin degradation products. Conclusions: Resting and dynamic LV torsional mechanics is impaired in patients with beta-thalassaemia major. Cell and animal models suggest a potential role of titin degradation in iron overload-induced alteration of LV torsional mechanics.
MeSH term(s)	Adolescent ; Adult ; Animals ; Biomechanical Phenomena ; Case-Control Studies ; Cell Line ; Female ; Humans ; Iron/metabolism ; Magnetic Resonance Imaging ; Male ; Mice ; Myocardial Contraction ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Prospective Studies ; Protein Kinases/metabolism ; Proteolysis ; Thalassemia/complications ; Thalassemia/diagnostic imaging ; Thalassemia/metabolism ; Thalassemia/physiopathology ; Torsion, Mechanical ; Ultrasonography ; Ventricular Function, Left ; Young Adult
Chemical Substances	Iron (E1UOL152H7) ; Protein Kinases (EC 2.7.-) ; titin protein, mouse (EC 2.7.11.1)
Language	English
Publishing date	2014-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/1471-2261-14-49
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