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  1. Article ; Online: Why We Explain.

    Ho, Dien

    Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

    2023  , Page(s) 1–5

    Abstract: Since its initial publication in 2018, Professor Anya Plutynski' ... ...

    Abstract Since its initial publication in 2018, Professor Anya Plutynski's
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146581-5
    ISSN 1469-2147 ; 0963-1801
    ISSN (online) 1469-2147
    ISSN 0963-1801
    DOI 10.1017/S0963180123000427
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  2. Article ; Online: A Call to Revise

    Ho, Dien

    Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

    2023  Volume 33, Issue 1, Page(s) 141–142

    Abstract: Since its introduction in 1964, the World Medical Association' ... ...

    Abstract Since its introduction in 1964, the World Medical Association's
    MeSH term(s) Humans ; Helsinki Declaration ; Biomedical Research
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146581-5
    ISSN 1469-2147 ; 0963-1801
    ISSN (online) 1469-2147
    ISSN 0963-1801
    DOI 10.1017/S0963180123000397
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  3. Article ; Online: Disability and uncertainty: How to proceed when we do not know.

    Ho, Dien

    Surgery

    2022  Volume 171, Issue 4, Page(s) 1119–1120

    MeSH term(s) Humans ; Uncertainty
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2022.01.009
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  4. Article ; Online: The Pandemic Dilemma: When Philosophy Conflicts with Public Health.

    Ho, Dien

    Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

    2022  Volume 31, Issue 1, Page(s) 1–3

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Philosophy ; Public Health
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 1146581-5
    ISSN 1469-2147 ; 0963-1801
    ISSN (online) 1469-2147
    ISSN 0963-1801
    DOI 10.1017/S0963180121000414
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  5. Article ; Online: Addressing COVID-19 Drug Development with Artificial Intelligence.

    Ho, Dean

    Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)

    2020  Volume 2, Issue 5, Page(s) 2000070

    Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that led to the COVID-19 (Coronavirus Disease 2019) pandemic, has resulted in substantial overburdening of healthcare systems as well as an economic crisis on a ... ...

    Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that led to the COVID-19 (Coronavirus Disease 2019) pandemic, has resulted in substantial overburdening of healthcare systems as well as an economic crisis on a global scale. This has in turn resulted in widespread efforts to identify suitable therapies to address this aggressive pathogen. Therapeutic antibody and vaccine development are being actively explored, and a phase I clinical trial of mRNA-1273 which is developed in collaboration between the National Institute of Allergy and Infectious Diseases and Moderna, Inc. is currently underway. Timelines for the broad deployment of a vaccine and antibody therapies have been estimated to be 12-18 months or longer. These are promising approaches that may lead to sustained efficacy in treating COVID-19. However, its emergence has also led to a large number of clinical trials evaluating drug combinations composed of repurposed therapies. As study results of these combinations continue to be evaluated, there is a need to move beyond traditional drug screening and repurposing by harnessing artificial intelligence (AI) to optimize combination therapy design. This may lead to the rapid identification of regimens that mediate unexpected and markedly enhanced treatment outcomes.
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country Germany
    Document type Journal Article
    ISSN 2640-4567
    ISSN (online) 2640-4567
    DOI 10.1002/aisy.202000070
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  6. Article ; Online: Artificial intelligence in cancer therapy.

    Ho, Dean

    Science (New York, N.Y.)

    2020  Volume 367, Issue 6481, Page(s) 982–983

    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Artificial Intelligence ; Drug Design ; Drug Discovery ; Humans ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaz3023
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  7. Article ; Online: Commentary: Harm, Truth, and the Nocebo Effect.

    Ho, Dien

    Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

    2020  Volume 29, Issue 2, Page(s) 236–245

    Abstract: Nocebo effects occur when an individual experiences undesirable physiological reactions caused by doxastic states that are not a treatment's core or characteristic features.1 As Scott Gelfand2 points out, there are numerous studies that have shown that ... ...

    Abstract Nocebo effects occur when an individual experiences undesirable physiological reactions caused by doxastic states that are not a treatment's core or characteristic features.1 As Scott Gelfand2 points out, there are numerous studies that have shown that the disclosure of a treatment's side effects to a patient increases the risk of the side effects. From an ethical point of view, nocebo effects caused by the disclosures of side effects present a challenging problem. On the one hand, clinicians' duty to inform patients of the consequences (including possible side effects) of their treatments is critical in ensuring that patients' autonomy is respected. Patients cannot act autonomously if relevant information is withheld from them (without their consent, perhaps). On the other hand, clinicians also ought to minimize harm to patients.
    MeSH term(s) Disclosure ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Informed Consent ; Nocebo Effect
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1146581-5
    ISSN 1469-2147 ; 0963-1801
    ISSN (online) 1469-2147
    ISSN 0963-1801
    DOI 10.1017/S0963180119001038
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  8. Article ; Online: Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients.

    Tayyar, Ralph / Ho, Dora

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Herpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infections that can ... ...

    Abstract Herpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infections that can have significant impact on patients' quality of life. HSV commonly causes oral and genital mucocutaneous infections whereas VZV is responsible for varicella/chickenpox and herpes zoster/shingles, but cancer patients are at particularly higher risk of complications including disseminated and visceral infections due to impaired cell-mediated immunity. While diagnosis of more common HSV and/or VZV infections is frequently clinically based, immunocompromised hosts may have atypical skin presentation or visceral involvement. Thus, diagnostic confirmation using virus-specific tests such as polymerase chain reaction or immunohistochemical staining is crucial in some cases. Oral acyclovir, valacyclovir and famciclovir are usually used for mild to moderate infections and intravenous acyclovir is the drug of choice for severe or disseminated infections. Foscarnet can be used when acyclovir-resistance is confirmed or suspected. Pharmaceutical prophylaxis against HSV and/or VZV should be considered in high-risk cancers patients. Currently, there is no commercially available vaccine against HSV, but VZV vaccines are available to prevent varicella and zoster.
    MeSH term(s) Humans ; Chickenpox ; Herpesvirus 3, Human ; Simplexvirus ; Quality of Life ; Herpes Zoster/drug therapy ; Varicella Zoster Virus Infection/complications ; Varicella Zoster Virus Infection/drug therapy ; Acyclovir ; Neoplasms/complications
    Chemical Substances Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2023-02-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020439
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  9. Article: Deep Learning and Drug Discovery for Healthy Aging.

    Wang, Peter / Ho, Dean

    ACS central science

    2023  Volume 9, Issue 10, Page(s) 1860–1863

    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type News
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.3c01212
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  10. Article ; Online: Preoperative Medical Consultation-Questioning a Long-Standing Practice.

    Sareen, Vasu / Ho, Daniel

    JAMA internal medicine

    2023  Volume 183, Issue 9, Page(s) 1033–1034

    MeSH term(s) Humans ; Preoperative Care ; Referral and Consultation ; Sexual Behavior
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.2917
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