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Article ; Online: Editorial for "Added Value of [18F]PSMA-1007 PET/CT and PET/MRI in Patients With Biochemically Recurrent Prostate Cancer: Impact on Detection Rates and Clinical Management".

Moses, Daniel Aaron / Ho Shon, Ivan

Journal of magnetic resonance imaging : JMRI

2024

Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Editorial
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29426
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

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Article ; Online: Clinical Images: Crowned dens syndrome detected on

Lim, Miao Yunn / Ho Shon, Ivan / Sammel, Anthony M

Arthritis & rheumatology (Hoboken, N.J.)

2024 Volume 76, Issue 4, Page(s) 664–665

MeSH term(s)	Humans ; Giant Cell Arteritis ; Positron Emission Tomography Computed Tomography ; Syndrome ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42777
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Zs.A 24: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Imaging of cell death in malignancy: Targeting pathways or phenotypes?

Ho Shon, Ivan / Hogg, Philip J

Nuclear medicine and biology

2023 Volume 124-125, Page(s) 108380

Abstract: Cell death is fundamental in health and disease and resisting cell death is a hallmark of cancer. Treatment of malignancy aims to cause cancer cell death, however current clinical imaging of treatment response does not specifically image cancer cell ... ...

Abstract	Cell death is fundamental in health and disease and resisting cell death is a hallmark of cancer. Treatment of malignancy aims to cause cancer cell death, however current clinical imaging of treatment response does not specifically image cancer cell death but assesses this indirectly either by changes in tumor size (using x-ray computed tomography) or metabolic activity (using 2-[
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Neoplasms/diagnostic imaging ; Positron-Emission Tomography/methods ; Tomography, X-Ray Computed ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-08-13
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2023.108380
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Zs.A 1090: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Incidental finding of tall cell variant papillary thyroid carcinoma on prostate-specific membrane antigen PET CT scan.

Xie, Benjamin / Lehane, Christopher / Paulus, Felik / Ho Shon, Ivan

Journal of medical imaging and radiation oncology

2023 Volume 67, Issue 7, Page(s) 753–755

Abstract: Prostate-specific membrane antigen (PSMA) PET CT is widely used for staging and restaging of prostate cancer. Thyroid and other non-prostatic pathology may be incidentally identified by this imaging modality. Such findings warrant further investigation ... ...

Abstract	Prostate-specific membrane antigen (PSMA) PET CT is widely used for staging and restaging of prostate cancer. Thyroid and other non-prostatic pathology may be incidentally identified by this imaging modality. Such findings warrant further investigation given their malignant potential. We describe the first reported case of PSMA avid T cell-variant papillary thyroid carcinoma incidentally detected on PSMA PET CT.
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Prostate/pathology ; Thyroid Cancer, Papillary/diagnostic imaging ; Thyroid Cancer, Papillary/pathology ; Incidental Findings ; Gallium Radioisotopes ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen ; Thyroid Neoplasms/diagnostic imaging ; Neoplasm Staging
Chemical Substances	Gallium Radioisotopes ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-10-05
Publishing country	Australia
Document type	Letter
ZDB-ID	2389687-5
ISSN	1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
ISSN (online)	1754-9485 ; 1440-1673
ISSN	1754-9477 ; 0004-8461
DOI	10.1111/1754-9485.13595
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Zs.B 66: Show issues

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Clinical Images: Pulmonary Arteritis in Clinically Occult Aneurysmal Giant Cell Arteritis.

Johnson, Victoria L / Ryan, Jon / Ho-Shon, Ivan / Davidson, Trent / Sammel, Anthony

ACR open rheumatology

2021 Volume 3, Issue 5, Page(s) 356

Language	English
Publishing date	2021-05-01
Publishing country	United States
Document type	Journal Article
ISSN	2578-5745
ISSN (online)	2578-5745
DOI	10.1002/acr2.11249
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Article ; Online: A first-in-human study of [<sup>68</sup>Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death.

Ho Shon, Ivan / Hennessy, Thomas / Guille, Jennifer / Gotsbacher, Michael P / Lay, Angelina J / McBride, Bruce / Codd, Rachel / Hogg, Philip J

European journal of nuclear medicine and molecular imaging

2022 Volume 49, Issue 12, Page(s) 4037–4047

Abstract: Purpose: This study assesses human biodistribution, radiation dosimetry, safety and tumour uptake of cell death indicator labelled with ... 68 ... Ga ([ ... 68 ... Ga]Ga-CDI), a novel radiopharmaceutical that can image multiple forms of cell death.!## ...

Abstract	Purpose: This study assesses human biodistribution, radiation dosimetry, safety and tumour uptake of cell death indicator labelled with <sup>68</sup>Ga ([<sup>68</sup>Ga]Ga-CDI), a novel radiopharmaceutical that can image multiple forms of cell death. Methods: Five participants with at least one extracranial site of solid malignancy > 2 cm and no active cancer treatment in the 8 weeks prior to the study were enrolled. Participants were administered 205 ± 4.1 MBq (range, 200-211 MBq) of [<sup>68</sup>Ga]Ga-CDI and 8 serial PET scans acquired: the first commencing immediately and the last 3 h later. Participants were monitored for clinical, laboratory and electrocardiographic side effects and adverse events. Urine and blood radioactivity was measured. Spherical volumes of interest were drawn over tumour, blood pool and organs to determine biodistribution and calculate dosimetry. In one participant, tumour specimens were analysed for cell death using terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) staining. Results: [<sup>68</sup>Ga]Ga-CDI is safe and well-tolerated with no side effects or adverse events. [<sup>68</sup>Ga]Ga-CDI is renally excreted, demonstrates low levels of physiologic uptake in the other organs and has excellent imaging characteristics. The mean effective dose was 2.17E - 02 ± 4.61E - 03 mSv/MBq. It images constitutive tumour cell death and correlates with tumour cell death on histology. Conclusion: [<sup>68</sup>Ga]Ga-CDI is a novel cell death imaging radiopharmaceutical that is safe, has low radiation dosimetry and excellent biodistribution and imaging characteristics. It has potential advantages over previously investigated radiopharmaceuticals for imaging of cell death and has progressed to a proof-of-concept trial. Trial registration: ACTRN12621000641897 (28/5/2021, retrospectively registered).
MeSH term(s)	Cell Death ; DNA Nucleotidylexotransferase/metabolism ; Electrons ; Gallium Radioisotopes ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/adverse effects ; Positron-Emission Tomography/methods ; Radiometry ; Radiopharmaceuticals/adverse effects ; Tissue Distribution
Chemical Substances	Gallium Radioisotopes ; Radiopharmaceuticals ; DNA Nucleotidylexotransferase (EC 2.7.7.31)
Language	English
Publishing date	2022-07-02
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-022-05880-z
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Zs.A 1227: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Concordant PET/CT and ICG positive lymph nodes in endometrial cancer: a case of mistaken identity.

Lee, Hong L / Farrell, Rhonda / Kamath, Vasanth / Ho-Shon, Ivan / Yap, Francis

Journal of surgical case reports

2020 Volume 2020, Issue 1, Page(s) rjz377

Abstract: Endometrial carcinoma is the most common gynecological malignancy in developed countries. In early stage endometrial cancer, routine systemic pelvic lymphadenectomy showed no survival benefits and results in increased morbidity. The role of PET/CT ... ...

Abstract	Endometrial carcinoma is the most common gynecological malignancy in developed countries. In early stage endometrial cancer, routine systemic pelvic lymphadenectomy showed no survival benefits and results in increased morbidity. The role of PET/CT imaging for the pre-operative detection of lymph node metastases in endometrial cancer is unclear. Sentinel lymph node (SLN) mapping may reduce the surgical staging morbidity while maintaining prognostic information of the lymph node status. Recently, indocyanine green (ICG) SLN mapping has been utilized to detect nodal metastasis in endometrial cancer. Endosalpingiosis is defined as the presence of tubal-like epithelium outside of the fallopian tube and can sometimes be misinterpreted as cancer metastasis. Here, we discuss a patient with newly diagnosed endometrial cancer who had pelvic and para-aortic lymph nodes with high glucose avidity on PET/CT, and ICG positivity on SLN mapping, suspected clinically to be metastatic adenocarcinoma, but with the pathological finding of endosalpingiosis only.
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjz377
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Article: Influence of X-ray computed tomography (CT) exposure and reconstruction parameters on positron emission tomography (PET) quantitation.

Ho Shon, Ivan / Reece, Christopher / Hennessy, Thomas / Horsfield, Megan / McBride, Bruce

EJNMMI physics

2020 Volume 7, Issue 1, Page(s) 62

Abstract: Background: The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves image quality with lower exposures ... ...

Abstract	Background: The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves image quality with lower exposures however there is little data on very low dose IR CT for AC of PET. This work assesses the impact of CT exposure and reconstruction algorithm on PET voxel values. Method: An anthropomorphic torso phantom was filled with physiologically typical [18]F concentrations in heart, liver and background compartments. A 17-mm-diameter right lung "tumour" filled with [18]F was included (surrounding lung contained no 18[F]). PET was acquired followed by 24 CT acquisitions with varying CT exposures (15-50 mAs, 80-120 kVp, pitch 0.671 or 0.828). Each CT was reconstructed twice using filtered back projection (FBP) or IR and these used for AC of PET. The reference PET reconstruction (RR) used CT acquired at 50 mAs, 120 kVp, pitch 0.828, IR, all others were test PET reconstructions (TR). Regions of interest (ROIs) were drawn in the liver, soft tissue and over "tumour" on each TR and compared with the RR. Voxel values in each TR were compared to the RR using a paired t test and by calculating which and what proportion of voxels in each TR differed by a quantitatively significant difference (QSD) from the RR. Results: TRs reconstructed using lower dose CTs underestimated mean and maximum ROI activity relative to the RR; greater with IR than FBP. Once CT dose index (CTDI) increased to 1 mGy, differences were less than QSD. On voxel analysis, all TRs were significantly different to the RR (p < 0.0001). TRs reconstructed at the lowest CT exposure with IR had 6% of voxels that differed by greater than QSD. Differences were reduced with increasing CTDI and FBP reconstruction. Voxels which exceeded the QSD were spatially localised to regions of high activity, interfaces between different attenuation and areas of CT beam hardening. Conclusions: Very low dose CT exposures are feasible for accurate PET AC. Scanner- and reconstruction-specific validation should be employed prior very low dose CT AC for PET.
Language	English
Publishing date	2020-10-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-020-00331-w
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Article ; Online: Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death.

Ho Shon, Ivan / Gotsbacher, Michael P / Guille, Jennifer / Kumar, Divesh / Codd, Rachel / Hogg, Philip

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1967, Page(s) 295–304

Abstract: Conjugates of 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid (GSAO) with optical or radionuclide probes are able to image cell death in vivo. GSAO conjugates are retained in the cytosol of dying and dead cells via the formation of covalent bonds ... ...

Abstract	Conjugates of 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid (GSAO) with optical or radionuclide probes are able to image cell death in vivo. GSAO conjugates are retained in the cytosol of dying and dead cells via the formation of covalent bonds between the As(III) ion and the thiol groups of proximal cysteine residues. Here we describe the method for preparing a NODAGA-GSAO conjugate and its radiolabeling with gallium-68 (
MeSH term(s)	Acetates/chemistry ; Acetates/therapeutic use ; Animals ; Arsenicals/chemistry ; Arsenicals/therapeutic use ; Cell Death/genetics ; Gallium Radioisotopes/chemistry ; Gallium Radioisotopes/therapeutic use ; Glutathione/analogs & derivatives ; Glutathione/chemistry ; Glutathione/therapeutic use ; Heterocyclic Compounds, 1-Ring/chemistry ; Heterocyclic Compounds, 1-Ring/therapeutic use ; Humans ; Positron-Emission Tomography/methods ; Radioisotopes/administration & dosage ; Radioisotopes/chemistry ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/therapeutic use ; Toluene/analogs & derivatives ; Toluene/chemistry
Chemical Substances	1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane ; 4-(N-(S-glutathionylacetyl)amino)phenylarsenoxide ; Acetates ; Arsenicals ; Gallium Radioisotopes ; Heterocyclic Compounds, 1-Ring ; Radioisotopes ; Radiopharmaceuticals ; Toluene (3FPU23BG52) ; Gallium-68 (98B30EPP5S) ; Glutathione (GAN16C9B8O) ; dithiol (U89B11P7SC)
Language	English
Publishing date	2019-05-09
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-9187-7_19
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Article: Biodistribution and imaging of an hsp90 ligand labelled with

Ho Shon, Ivan / Kumar, Divesh / Sathiakumar, Chithradevi / Berghofer, Paula / Van, Khang / Chicco, Andrew / Hogg, Philip J

EJNMMI research

2020 Volume 10, Issue 1, Page(s) 4

Abstract: Background: 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the γ-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding to intracellular 90-kDa heat ... ...

Abstract	Background: 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the γ-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding to intracellular 90-kDa heat shock proteins (hsp90) when cell membrane integrity is compromised. The ability to image cell death has potential clinical impact especially for early treatment response assessment in oncology. This work aims to assess the biodistribution and tumour uptake of diethylene triamine pentaacetic acid GSAO labelled with Results: There was good tumour uptake of both [ Conclusions: [
Language	English
Publishing date	2020-01-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-020-0590-x
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