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  1. Article ; Online: Hydrodynamic Analysis of a Breakwater-Integrated Heaving-Buoy-Type Wave Energy Converter with an Optimal Artificial Damping Scheme

    Ho-Jin Jeong / Sung-Jae Kim / WeonCheol Koo

    Applied Sciences, Vol 12, Iss 3401, p

    2022  Volume 3401

    Abstract: A three-dimensional frequency-domain numerical wave tank (FR-NWT) based on the Rankine panel method was developed. An optimal artificial damping zone (ADZ) scheme was first applied to the FR-NWT to prevent reflection waves from the end walls. Parametric ... ...

    Abstract A three-dimensional frequency-domain numerical wave tank (FR-NWT) based on the Rankine panel method was developed. An optimal artificial damping zone (ADZ) scheme was first applied to the FR-NWT to prevent reflection waves from the end walls. Parametric studies of ramp function shape with artificial damping coefficients and damping zone length were conducted to find a proper damping scheme for the frequency domain program. Applying both the Sommerfeld radiation condition and the ADZ scheme to the frequency domain program can reduce the length of the ADZ to less than one wavelength. The FR-NWT developed by the authors was used to calculate the hydrodynamic response of a hemispherical-heaving buoy wave energy converter (WEC) integrated with a seawall-type breakwater of infinite length. A linear power take-off system was used to calculate power generation of the WEC. The global motion of the WEC combined with the breakwater was up to 1.85 times greater than that of the WEC without the breakwater. Moreover, the capture width ratio of the WEC increased approximately 3.67 times more than that of the WEC without the breakwater.
    Keywords numerical wave tank ; artificial damping scheme ; motion amplification ; wave energy converter ; frequency domain ; breakwater-integrated ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 535
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Sex and Economic Disparity Related to Reperfusion Therapies for Patients with Acute Ischemic Stroke in South Korea across a 10-Year Period

    Jusun Moon / Jinyoung Shin / Jeehye Lee / Ho Jin Jeong / Hyeongsu Kim / Jaehyeong An / Sung Hyun Jo / Kwang-Pil Ko / Jeoungbin Choi

    International Journal of Environmental Research and Public Health, Vol 19, Iss 3050, p

    A Nationwide Population-Based Study Using the National Health Insurance Database

    2022  Volume 3050

    Abstract: A complete enumeration study was conducted to evaluate trends related to reperfusion therapies (intravenous thrombolysis (IVT) and endovascular treatment (EVT)) in acute ischemic stroke (AIS) in South Korea, according to sex, economic status, and age, ... ...

    Abstract A complete enumeration study was conducted to evaluate trends related to reperfusion therapies (intravenous thrombolysis (IVT) and endovascular treatment (EVT)) in acute ischemic stroke (AIS) in South Korea, according to sex, economic status, and age, over a 10-year period retrospectively, using the National Health Information Database (NHIS-2020-1-481). This study included AIS patients aged ≥20 years who were hospitalized in a general hospital or tertiary hospital for ≥4 days and underwent brain imaging during the same period. Study participants were classified by sex, economic status (Medical Aid beneficiaries and National Health Insurance beneficiaries) and age (20–44, 45–64, 65–79, and ≥80 years). Women showed a significantly lower OR (Odds ratio) than men in IVT (OR: 0.75; 95% CI: 0.73–0.77), EVT (OR: 0.96; 95% CI: 0.93–0.99), and any therapy (OR: 0.82; 95% CI: 0.80–0.84). The Medical Aid beneficiaries showed significantly lower OR in IVT (OR 0.91, 95% CI 0.88–0.95), EVT (OR 0.93, 95% CI 0.89–0.98), and either therapy (OR 0.92, 95% CI 0.90–0.95) than the National Health Insurance beneficiaries. This study showed sex and economic disparity related to reperfusion therapies in patients with AIS in Korea.
    Keywords acute stroke ; healthcare disparities ; thrombolytic therapy ; Medicine ; R
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Abscopal Effect of Radiotherapy Enhanced with Immune Checkpoint Inhibitors of Triple Negative Breast Cancer in 4T1 Mammary Carcinoma Model

    Haa-Na Song / Hana Jin / Jung-Hoon Kim / In-Bong Ha / Ki-Mun Kang / Hoon-Sik Choi / Ho-Jin Jeong / Min-Young Kim / Hye-Jung Kim / Bae-Kwon Jeong

    International Journal of Molecular Sciences, Vol 22, Iss 10476, p

    2021  Volume 10476

    Abstract: Local radiotherapy (RT) is important to manage metastatic triple-negative breast cancer (TNBC). Although RT primarily reduces cancer cells locally, this control can be enhanced by triggering the immune system via immunotherapy. RT and immunotherapy may ... ...

    Abstract Local radiotherapy (RT) is important to manage metastatic triple-negative breast cancer (TNBC). Although RT primarily reduces cancer cells locally, this control can be enhanced by triggering the immune system via immunotherapy. RT and immunotherapy may lead to an improved systemic effect, known as the abscopal effect. Here, we analyzed the antitumor effect of combination therapy using RT with an anti-programmed cell death-1 (PD-1) antibody in primary tumors, using poorly immunogenic metastatic mouse mammary carcinoma 4T1 model. Mice were injected subcutaneously into both flanks with 4T1 cells, and treatment was initiated 12 days later. Mice were randomly assigned to three treatment groups: (1) control (no treatment with RT or immune checkpoint inhibitor (ICI)), (2) RT alone, and (3) RT+ICI. The same RT dose was prescribed in both RT-alone and RT+ICI groups as 10Gy/fx in two fractions and delivered to only one of the two tumor burdens injected at both sides of flanks. In the RT+ICI group, 200 µg fixed dose of PD-1 antibody was intraperitoneally administered concurrently with RT. The RT and ICI combination markedly reduced tumor cell growth not only in the irradiated site but also in non-irradiated sites, a typical characteristic of the abscopal effect. This was observed only in radiation-sensitive cancer cells. Lung metastasis development was lower in RT-irradiated groups (RT-only and RT+ICI groups) than in the non-irradiated group, regardless of the radiation sensitivity of tumor cells. However, there was no additive effect of ICI on RT to control lung metastasis, as was already known regarding the abscopal effect. The combination of local RT with anti-PD-1 blockade could be a promising treatment strategy against metastatic TNBC. Further research is required to integrate our results into a clinical setting.
    Keywords abscopal effect ; radiotherapy ; immune checkpoint inhibitor ; triple-negative breast cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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