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  1. AU="Hoang, Oi Pui"
  2. AU="Saradha Baskaran"
  3. AU="Culotta, Lorenza"
  4. AU=Cleaver Ondine
  5. AU="Jordan A. Kreidberg"
  6. AU="Al-Marshoud, Majida"
  7. AU="David S Hui"
  8. AU="Manjappa, Shivaprasad"
  9. AU="Balkan, S"
  10. AU="Chen, Emma"
  11. AU="Delean, Ada"
  12. AU="Gurao, Ankita"
  13. AU="Lang, Zhen"
  14. AU="Mahnaz Mohammadpour"
  15. AU="Britta Grillitsch"
  16. AU=Hoeffner Ellen G
  17. AU="Al Harbi, Shmeylan"
  18. AU=Polevoda Bogdan
  19. AU="Raffaele Galiero"
  20. AU=Hruskova Z
  21. AU="Ayers, J"
  22. AU="Cohen, A D"
  23. AU="Brunetti, Gian Luca"
  24. AU=Andrade Daniel
  25. AU=Hay William W Jr

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  1. Artikel: Local tissue interactions govern pLL patterning in medaka

    Seleit, Ali / Gross, Karen / Onistschenko, Jasmin / Hoang, Oi Pui / Theelke, Jonas / Centanin, Lázaro

    Developmental biology. 2022 Jan., v. 481

    2022  

    Abstract: Vertebrate organs are arranged in a stereotypic, species-specific position along the animal body plan. Substantial morphological variation exists between related species, especially so in the vastly diversified teleost clade. It is still unclear how ... ...

    Abstract Vertebrate organs are arranged in a stereotypic, species-specific position along the animal body plan. Substantial morphological variation exists between related species, especially so in the vastly diversified teleost clade. It is still unclear how tissues, organs and systems can accommodate such diverse scaffolds. Here, we use the distinctive arrangement of neuromasts in the posterior lateral line (pLL) system of medaka fish to address the tissue-interactions defining a pattern. We show that patterning in this peripheral nervous system is established by autonomous organ precursors independent of neuronal wiring. In addition, we target the keratin 15 gene to generate stuck-in-the-midline (siml) mutants, which display epithelial lesions and a disrupted pLL patterning. By using siml/wt chimeras, we determine that the aberrant siml pLL pattern depends on the mutant epithelium, since a wild type epithelium can rescue the siml phenotype. Inducing epithelial lesions by 2-photon laser ablation during pLL morphogenesis phenocopies siml genetic mutants and reveals that epithelial integrity defines the final position of the embryonic pLL neuromasts. Our results using the medaka pLL disentangle intrinsic from extrinsic properties during the establishment of a sensory system. We speculate that intrinsic programs guarantee proper organ morphogenesis, while instructive interactions from surrounding tissues facilitates the accommodation of sensory organs to the diverse body plans found among teleosts.
    Schlagwörter Oryzias latipes ; epithelium ; genes ; keratin ; morphogenesis ; mutants ; neuromasts ; neurons ; peripheral nervous system ; phenotype ; vertebrates
    Sprache Englisch
    Erscheinungsverlauf 2022-01
    Umfang p. 1-13.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2021.09.002
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 76/715: Hefte anzeigen

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  2. Artikel ; Online: Local tissue interactions govern pLL patterning in medaka.

    Seleit, Ali / Gross, Karen / Onistschenko, Jasmin / Hoang, Oi Pui / Theelke, Jonas / Centanin, Lázaro

    Developmental biology

    2021  Band 481, Seite(n) 1–13

    Abstract: Vertebrate organs are arranged in a stereotypic, species-specific position along the animal body plan. Substantial morphological variation exists between related species, especially so in the vastly diversified teleost clade. It is still unclear how ... ...

    Abstract Vertebrate organs are arranged in a stereotypic, species-specific position along the animal body plan. Substantial morphological variation exists between related species, especially so in the vastly diversified teleost clade. It is still unclear how tissues, organs and systems can accommodate such diverse scaffolds. Here, we use the distinctive arrangement of neuromasts in the posterior lateral line (pLL) system of medaka fish to address the tissue-interactions defining a pattern. We show that patterning in this peripheral nervous system is established by autonomous organ precursors independent of neuronal wiring. In addition, we target the keratin 15 gene to generate stuck-in-the-midline (siml) mutants, which display epithelial lesions and a disrupted pLL patterning. By using siml/wt chimeras, we determine that the aberrant siml pLL pattern depends on the mutant epithelium, since a wild type epithelium can rescue the siml phenotype. Inducing epithelial lesions by 2-photon laser ablation during pLL morphogenesis phenocopies siml genetic mutants and reveals that epithelial integrity defines the final position of the embryonic pLL neuromasts. Our results using the medaka pLL disentangle intrinsic from extrinsic properties during the establishment of a sensory system. We speculate that intrinsic programs guarantee proper organ morphogenesis, while instructive interactions from surrounding tissues facilitates the accommodation of sensory organs to the diverse body plans found among teleosts.
    Mesh-Begriff(e) Animals ; Body Patterning ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Keratin-15/genetics ; Keratin-15/metabolism ; Lateral Line System/embryology ; Mutation ; Oryzias/embryology ; Oryzias/genetics
    Chemische Substanzen Fish Proteins ; Keratin-15
    Sprache Englisch
    Erscheinungsdatum 2021-09-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2021.09.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 508: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization.

    Schmidbaur, Hannah / Kawaguchi, Akane / Clarence, Tereza / Fu, Xiao / Hoang, Oi Pui / Zimmermann, Bob / Ritschard, Elena A / Weissenbacher, Anton / Foster, Jamie S / Nyholm, Spencer V / Bates, Paul A / Albertin, Caroline B / Tanaka, Elly / Simakov, Oleg

    Nature communications

    2022  Band 13, Heft 1, Seite(n) 2172

    Abstract: Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. ... ...

    Abstract Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. Using comparative and functional genomics in the model squid Euprymna scolopes, we reveal the unique genomic, topological, and regulatory organization of cephalopod genomes. We show that coleoid cephalopod genomes have been extensively restructured compared to other animals, leading to the emergence of hundreds of tightly linked and evolutionary unique gene clusters (microsyntenies). Such novel microsyntenies correspond to topological compartments with a distinct regulatory structure and contribute to complex expression patterns. In particular, we identify a set of microsyntenies associated with cephalopod innovations (MACIs) broadly enriched in cephalopod nervous system expression. We posit that the emergence of MACIs was instrumental to cephalopod nervous system evolution and propose that microsyntenic profiling will be central to understanding cephalopod innovations.
    Mesh-Begriff(e) Animals ; Cephalopoda/genetics ; Decapodiformes/genetics ; Genome/genetics ; Genomics ; Invertebrates/genetics
    Sprache Englisch
    Erscheinungsdatum 2022-04-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29694-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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