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  1. Article ; Online: Exploring the Kinh Vietnamese genomic database for the polymorphisms of the P450 genes towards precision public health

    Diep Thi Hoang / Tran Van Hiep / Thao Thi Phuong Nguyen / Hoang Thi My Nhung / Kien Trung Tran / Le Sy Vinh

    Annals of Human Biology, Vol 49, Iss 2, Pp 152-

    2022  Volume 155

    Abstract: Background Human cytochrome P450 (CYPs) genes are essential in metabolising drugs. Due to their high polymorphism, population-specific studies are of great interest. Aim This research examined the six CYP genes, including CYP2B6, CYP2C9, CYP2C19, CYP2D6, ...

    Abstract Background Human cytochrome P450 (CYPs) genes are essential in metabolising drugs. Due to their high polymorphism, population-specific studies are of great interest. Aim This research examined the six CYP genes, including CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A5, and CYP4F2 in the Kinh Vietnamese (KHV) for population-scale precision medicine. Subjects and methods We processed data from a genomics database of 206 healthy and unrelated KHV individuals to calculate CYP allele frequencies. First, we compared the CYP genes of the KHV to six other populations retrieved from the 1000 Genomes Project. Second, we searched the PharmGBK database for drug-CYP interaction data to compile a drug dosage recommendation for the KHV. Results We observed the diverging trends in genetic variations of CYP2B6, CYP2D6, and CYP3A5 in the KHV. Regarding phenotypic drug responses in the KHV, CYP2C19 exhibited all metabolic phenotypes at a non-trivial frequency. In addition, CYP3A5 metabolised drugs at a lower rate compared to the other five CYPs. Conclusion This is the first large-scale study to investigate multiple CYP genes in the KHV for precision medicine from a public health perspective. Differences found in the distributions of metabolizers for the KHV suggest careful prescriptions for CYP2C19 and CYP3A5-metabolised drugs.
    Keywords cyp450 ; pharmacogenetics ; khv ; drug dosing ; next-generation sequencing ; Biology (General) ; QH301-705.5 ; Human anatomy ; QM1-695 ; Physiology ; QP1-981
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Initial characterisation of exosomes released by umbilical cord-derived mesenchymal stem cells and mature dendritic cells, under ‘Good Manufacturing Practice’ conditions

    Hoang Huong Diem / Bui Thi Van Khanh / Hoang Thi My Nhung / Nguyen Thanh Liem / Than Thi Trang Uyen

    Vietnam Journal of Science, Technology and Engineering, Vol 61, Iss

    2022  Volume 3

    Abstract: Exosomes represent an important mode of intercellular communication and play key roles in many physiological and pathological processes. Exosomes have hitherto exhibited their capacity to modulate biological activities through their carrying of ... ...

    Abstract Exosomes represent an important mode of intercellular communication and play key roles in many physiological and pathological processes. Exosomes have hitherto exhibited their capacity to modulate biological activities through their carrying of functional molecules such as proteins, lipids, and genetic materials. In the current study, we investigated exosomes released by mature dendritic cells (mDCs) and umbilical cord-derived mesenchymal stem cells (UCMSCs) under Good Manufacturing Practice (GMP) conditions. Ultracentrifugation was used to isolate and purify the exosomes. Additionally, a transmission electron microscope (TEM) and immunoblotting were used to characterise exosomal morphology and markers. The preliminary results showed that both mDCs and UCMSCs secreted exosomes into GMP culture media. Exosomes exhibited a cup-shaped morphology and showed positive for CD63. Additionally, no difference was observed between mDC-derived exosomes and UCMSC-derived exosomes regarding marker expression or morphology. This data indicates the potential for further development of GMP exosomes for clinical application.
    Keywords dendritic cells ; exosomes ; mesenchymal stem cells ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Vietnam Ministry of Science and Technology
    Document type Article ; Online
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  3. Article: Detection of sFas, sCD137, and IL-27 Cytokines as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis.

    Do, Xuan-Hai / Le, Mai Thi / Nguyen, Thu Huyen / Le, Thanh Thien / Nguyen, Xuan-Hung / Mai, Thanh Binh / Hoang, Thi My Nhung / Than, Uyen Thi Trang

    Journal of hepatocellular carcinoma

    2023  Volume 10, Page(s) 783–793

    Abstract: Purpose: Hepatocellular carcinoma (HCC), a prevalent type of liver cancer, is mainly diagnosed in the advanced stage, leading to a high mortality rate. Recent advances have identified peripheral cytokines as a potential tool to predict disease outcomes ... ...

    Abstract Purpose: Hepatocellular carcinoma (HCC), a prevalent type of liver cancer, is mainly diagnosed in the advanced stage, leading to a high mortality rate. Recent advances have identified peripheral cytokines as a potential tool to predict disease outcomes and inform therapeutic decisions. Hence, in this study, we aim to build a predictive model for HCC based on serum levels of different cytokines.
    Patients and methods: We used immunoassay to quantify the concentrations of IL-27, MIP-1β, Perforin, sCD137, sFas, and TNF-α in the serum of 38 HCC patients and 15 healthy controls. Logistic regression was then used to construct classification models detecting HCC based on these cytokines. A nomogram of the best-performing model was generated to visualize HCC prediction.
    Results: sFas and MIP-1β were found to be significantly higher in HCC patients compared to controls. Predictive models based on cytokine levels combining sFas, sCD137, and IL-27 performed the best in distinguishing HCC patients from healthy controls. This model has a bias-corrected area under the receiver operating characteristic (ROC) curve (AUC) of 0.948, a sensitivity of 92.11%, a specificity of 93.33%, and an accuracy of 0.925.
    Conclusion: Our findings suggest that serum cytokines have the potential to be utilized in HCC screening to improve detection rates.
    Language English
    Publishing date 2023-05-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S409649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe

    Do, Xuan-Hai / Nguyen, Tu Dac / Le, Thi Thu Huong / To, Thuy Thanh / Bui, Thi Van Khanh / Pham, Nam Hong / Lam, Khanh / Hoang, Thi My Nhung / Ha, Phuong Thu

    Pharmaceutics

    2023  Volume 15, Issue 5

    Abstract: 1) Background: Magnetite ( ... ...

    Abstract (1) Background: Magnetite (Fe
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15051523
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  5. Article ; Online: High biocompatible FITC-conjugated silica nanoparticles for cell labeling in both in vitro and in vivo models.

    Nguyen, Thi Thuy / Nguyen, Hoang Nam / Nghiem, Thi Ha Lien / Do, Xuan-Hai / To, Thanh Thuy / Do, Thi Xuan Phuong / Do, Dieu Linh / Nguyen, Huong Giang / Nguyen, Huy Manh / Nguyen, Ngoc Dinh / Luu, Manh Quynh / Nguyen, Trong Nghia / Nguyen, Thi Bich Ngoc / Nguyen, Van Toan / Pham, Van Thanh / Than, Uyen Thi Trang / Hoang, Thi My Nhung

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6969

    Abstract: Fluorescence nanosilica-based cell tracker has been explored and applied in cell biological research. However, the aggregation of these nanoparticles at physiological pH is still the main limitation. In this research, we introduced a novel fluorescence ... ...

    Abstract Fluorescence nanosilica-based cell tracker has been explored and applied in cell biological research. However, the aggregation of these nanoparticles at physiological pH is still the main limitation. In this research, we introduced a novel fluorescence nano-based cell tracker suitable for application in live cells. The silica-coated fluorescein isothiocyanate isomer (FITC-SiO
    MeSH term(s) Animals ; Humans ; HeLa Cells ; Fluorescein-5-isothiocyanate ; Silicon Dioxide/chemistry ; Endothelial Cells ; Nanoparticles/toxicity ; Nanoparticles/chemistry
    Chemical Substances Fluorescein-5-isothiocyanate (I223NX31W9) ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55600-w
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  6. Article ; Online: Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy

    Nghiem Thi Ha Lien / Anh D. Phan / Bui Thi Van Khanh / Nguyen Thi Thuy / Nguyen Trong Nghia / Hoang Thi My Nhung / Tran Hong Nhung / Do Quang Hoa / Vu Duong / Nguyen Minh Hue

    ACS Omega, Vol 5, Iss 32, Pp 20231-

    2020  Volume 20237

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Phase I Clinical Trial Using Autologous Ex Vivo Expanded NK Cells and Cytotoxic T Lymphocytes for Cancer Treatment in Vietnam

    Nguyen Thanh Liem / Nguyen Van Phong / Nguyen Trung Kien / Bui Viet Anh / Truong Linh Huyen / Chu Thi Thao / Nguyen Dac Tu / Doan Trung Hiep / Do Thi Hoai Thu / Hoang Thi My Nhung

    International Journal of Molecular Sciences, Vol 20, Iss 13, p

    2019  Volume 3166

    Abstract: 1) Background: Immune cell therapy recently attracted enormous attention among scientists as a cancer treatment, but, so far, it has been poorly studied and applied in Vietnam. The aim of this study was to assess the safety of autologous immune cell ... ...

    Abstract (1) Background: Immune cell therapy recently attracted enormous attention among scientists as a cancer treatment, but, so far, it has been poorly studied and applied in Vietnam. The aim of this study was to assess the safety of autologous immune cell therapy for treating lung, liver, and colon cancers—three prevalent cancers in Vietnam. (2) Method: This was an open-label, single-group clinical trial that included 10 patients with confirmed diagnosis of colon, liver, or lung cancer, conducted between March 2016 and December 2017. (3) Results: After 20−21 days of culture, the average number of cytotoxic T lymphocytes (CTLs) increased 488.5-fold and the average cell viability was 96.3%. The average number of natural killer cells (NKs) increased 542.5-fold, with an average viability of 95%. Most patients exhibited improved quality of life, with the majority of patients presenting a score of 1 to 2 in the Eastern Cooperative Oncology Group (ECOG) performance status (ECOG/PS) scale, a decrease in symptoms on fatigue scales, and an increase in the mean survival time to 18.7 months at the end of the study. (4) Conclusion: This method of immune cell expansion met the requirements for clinical applications in cancer treatment and demonstrated the safety of this therapy for the cancer patients in Vietnam.
    Keywords immune cell therapy ; natural killer cells ; cytotoxic T lymphocytes ; peripheral blood mononuclear cells ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: In vitro high throughput screening, what next? Lessons from the screening for aurora kinase inhibitors.

    Hoang, Thi-My-Nhung / Vu, Hong-Lien / Le, Ly-Thuy-Tram / Nguyen, Chi-Hung / Molla, Annie

    Biology

    2014  Volume 3, Issue 1, Page(s) 167–175

    Abstract: Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls ...

    Abstract Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls encountered in the development of active molecules. We propose a decision tree that could be adapted to most in vitro HTS.
    Language English
    Publishing date 2014-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology3010167
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  9. Article: Survivine, la petite reine du complexe passager : chek-up pour son dixième anniversaire.

    Delacour-Larose, Marlène / Hoang, Thi My Nhung / Molla, Annie

    Medecine sciences : M/S

    2008  Volume 24, Issue 10, Page(s) 828–832

    Abstract: Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by ... ...

    Title translation Survivin, the starlet of the passenger-protein complex : check-up for its tenth anniversary.
    Abstract Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported crystallographic data.
    MeSH term(s) Aurora Kinase B ; Aurora Kinases ; Cell Cycle Proteins/physiology ; Cell Survival ; Centromere/physiology ; Chromosomal Proteins, Non-Histone/physiology ; Cytoskeleton/physiology ; Cytoskeleton/ultrastructure ; Humans ; Inhibitor of Apoptosis Proteins ; Microtubule-Associated Proteins/physiology ; Microtubules/physiology ; Microtubules/ultrastructure ; Mitosis/physiology ; Phosphorylation ; Protein Processing, Post-Translational ; Protein-Serine-Threonine Kinases/physiology ; Spindle Apparatus/physiology ; Ubiquitination
    Chemical Substances BIRC5 protein, human ; CDCA8 protein, human ; Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; INCENP protein, human ; Inhibitor of Apoptosis Proteins ; Microtubule-Associated Proteins ; AURKB protein, human (EC 2.7.11.1) ; Aurora Kinase B (EC 2.7.11.1) ; Aurora Kinases (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language French
    Publishing date 2008-10
    Publishing country France
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20082410828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors

    Hoang, Thi-My-Nhung / Vu, Hong-Lien / Le, Ly-Thuy-Tram / Nguyen, Chi-Hung / Molla, Annie

    Biology. 2014 Feb. 27, v. 3, no. 1

    2014  

    Abstract: Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls ...

    Abstract Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls encountered in the development of active molecules. We propose a decision tree that could be adapted to most in vitro HTS.
    Keywords chemical compounds ; decision support systems ; enzyme inhibitors ; high-throughput screening methods ; in vitro studies ; non-specific serine/threonine protein kinase ; screening
    Language English
    Dates of publication 2014-0227
    Size p. 167-175.
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology3010167
    Database NAL-Catalogue (AGRICOLA)

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