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  1. Article ; Online: Reply to the Editor-Omissions and misconceptions on vein of Marshall ethanol infusion.

    Krisai, Philipp / Hocini, Mélèze

    Heart rhythm

    2021  Volume 18, Issue 7, Page(s) 1251–1252

    MeSH term(s) Atrial Fibrillation/surgery ; Catheter Ablation ; Ethanol ; Humans ; Veins
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2021.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
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  2. Article ; Online: Atrial Periodic Source Spectrum From Preoperative Body Surface Potentials Predicts Long-Term Recurrence of Atrial Fibrillation.

    Feng, Yingjing / Dubois, Remi / Hocini, Meleze / Vigmond, Edward J

    IEEE transactions on bio-medical engineering

    2023  Volume 70, Issue 7, Page(s) 2131–2138

    Abstract: Objective: About half of patients experience recurrence of atrial fibrillation (AF) within three to five years after a single catheter ablation procedure. The suboptimality of the long-term outcomes likely results from the inter-patient variability of ... ...

    Abstract Objective: About half of patients experience recurrence of atrial fibrillation (AF) within three to five years after a single catheter ablation procedure. The suboptimality of the long-term outcomes likely results from the inter-patient variability of AF mechanisms, which can be remedied by improved patient screening. We aim to improve the interpretation of body surface potentials (BSPs), such as 12-lead electrocardiograms and 252-lead BSP maps, to aid preoperative patient screening.
    Methods: We developed the Atrial Periodic Source Spectrum (APSS), a novel patient-specific representation based on atrial periodic content, computed on the f-wave segments of patient BSPs, using a second-order blind source separation and a Gaussian Process for regression. With follow-up data, Cox's proportional hazard model was used to select the most relevant feature from preoperative APSSs responsible for AF recurrence.
    Results: Over 138 persistent AF patients, the presence of highly periodic content with cycle lengths between 220-230 ms or 350-400 ms indicates higher risks of 4-year post-ablation AF recurrence (log-rank test, p-value ).
    Conclusion and significance: Preoperative BSPs demonstrate effective prediction in the long-term outcomes, highlighting their potential for patient screening in AF ablation therapy.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Treatment Outcome ; Recurrence ; Time Factors ; Heart Atria ; Catheter Ablation/methods
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2023.3236893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Burden of Purkinje ectopies associated with sex hormone levels.

    Surget, Elodie / Faye, Ndeye Rokhaya / Marchant, James / Cheniti, Ghassen / Hocini, Mélèze / Haissaguerre, Michel

    HeartRhythm case reports

    2023  Volume 9, Issue 6, Page(s) 410–413

    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.03.018
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  4. Article ; Online: A case of anomalous aortic origin of coronary artery associated with a coved-type electrocardiogram.

    Kamakura, Tsukasa / Cetran, Laura / Sacher, Frédéric / Hocini, Mélèze / Duchateau, Josselin

    Journal of cardiovascular electrophysiology

    2021  Volume 32, Issue 2, Page(s) 554–557

    Abstract: Brugada syndrome (BrS) is a sudden cardiac death syndrome characterized by a coved-type electrocardiogram (ECG). Different disorders, such as ischemia, can emulate a Brugada-pattern ECG (Brugada phenocopy). We report herein, the first case of surgical ... ...

    Abstract Brugada syndrome (BrS) is a sudden cardiac death syndrome characterized by a coved-type electrocardiogram (ECG). Different disorders, such as ischemia, can emulate a Brugada-pattern ECG (Brugada phenocopy). We report herein, the first case of surgical epicardial electrophysiological mapping in a successfully resuscitated patient with an anomalous aortic origin of the coronary artery (AAOCA) associated with a coved-type ECG. It was debatable whether the coved-type ECG and the abnormal arrhythmogenic substrate in the epicardial right ventricular outflow tract were derived from BrS or from repetitive ischemia due to AAOCA; however, the epicardial electrophysiological mapping helped in deciding the treatment strategy.
    MeSH term(s) Brugada Syndrome/complications ; Brugada Syndrome/diagnosis ; Coronary Vessels ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Epicardial Mapping ; Humans
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.14872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2863: Show issues Location:
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  5. Article: Cardioneuroablation: Don't underestimate the posteromedial left atrial ganglionated plexus.

    Ascione, Ciro / Benabou, Léa / Hocini, Mélèze / Jaïs, Pierre / Haïssaguerre, Michel / Duchateau, Josselin

    HeartRhythm case reports

    2022  Volume 9, Issue 2, Page(s) 67–69

    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2022.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Stepwise ablation strategy for post-myocardial infarction ventricular fibrillation: From arrhythmia suppression to ablation.

    Charton, Jan / Tixier, Romain / Sacher, Frederic / Hocini, Meleze / Haissaguerre, Michel / Duchateau, Josselin

    HeartRhythm case reports

    2022  Volume 9, Issue 3, Page(s) 133–137

    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2022.10.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Detection of focal source and arrhythmogenic substrate from body surface potentials to guide atrial fibrillation ablation.

    Feng, Yingjing / Roney, Caroline H / Bayer, Jason D / Niederer, Steven A / Hocini, Mélèze / Vigmond, Edward J

    PLoS computational biology

    2022  Volume 18, Issue 3, Page(s) e1009893

    Abstract: Focal sources (FS) are believed to be important triggers and a perpetuation mechanism for paroxysmal atrial fibrillation (AF). Detecting FS and determining AF sustainability in atrial tissue can help guide ablation targeting. We hypothesized that ... ...

    Abstract Focal sources (FS) are believed to be important triggers and a perpetuation mechanism for paroxysmal atrial fibrillation (AF). Detecting FS and determining AF sustainability in atrial tissue can help guide ablation targeting. We hypothesized that sustained rotors during FS-driven episodes indicate an arrhythmogenic substrate for sustained AF, and that non-invasive electrical recordings, like electrocardiograms (ECGs) or body surface potential maps (BSPMs), could be used to detect FS and AF sustainability. Computer simulations were performed on five bi-atrial geometries. FS were induced by pacing at cycle lengths of 120-270 ms from 32 atrial sites and four pulmonary veins. Self-sustained reentrant activities were also initiated around the same 32 atrial sites with inexcitable cores of radii of 0, 0.5 and 1 cm. FS fired for two seconds and then AF inducibility was tested by whether activation was sustained for another second. ECGs and BSPMs were simulated. Equivalent atrial sources were extracted using second-order blind source separation, and their cycle length, periodicity and contribution, were used as features for random forest classifiers. Longer rotor duration during FS-driven episodes indicates higher AF inducibility (area under ROC curve = 0.83). Our method had accuracy of 90.6±1.0% and 90.6±0.6% in detecting FS presence, and 93.1±0.6% and 94.2±1.2% in identifying AF sustainability, and 80.0±6.6% and 61.0±5.2% in determining the atrium of the focal site, from BSPMs and ECGs of five atria. The detection of FS presence and AF sustainability were insensitive to vest placement (±9.6%). On pre-operative BSPMs of 52 paroxysmal AF patients, patients classified with initiator-type FS on a single atrium resulted in improved two-to-three-year AF-free likelihoods (p-value < 0.01, logrank tests). Detection of FS and arrhythmogenic substrate can be performed from ECGs and BSPMs, enabling non-invasive mapping towards mechanism-targeted AF treatment, and malignant ectopic beat detection with likely AF progression.
    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation ; Electrocardiography ; Heart Atria ; Humans ; Pulmonary Veins
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1009893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: How to perform Purkinje tissue ablation for the treatment of idiopathic VF.

    Duchateau, Josselin / Krisai, Philipp / Charton, Jan / Benali, Karim / Cheniti, Ghassen / Surget, Elodie / Sacher, Frédéric / Hocini, Mélèze / Haïssaguerre, Michel

    Heart rhythm

    2023  Volume 20, Issue 10, Page(s) 1408–1413

    MeSH term(s) Humans ; Ventricular Fibrillation/therapy ; Tachycardia, Ventricular/surgery ; Catheter Ablation ; Purkinje Fibers/surgery ; Electrocardiography
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.07.055
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    Zs.A 6278: Show issues Location:
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  9. Article ; Online: Pulsed field ablation for atrial fibrillation in real-life settings: Efficacy, safety, and lesion durability in patients with recurrences.

    Benali, Karim / Vlachos, Konstantinos / Reddy, Vivek Y / Verma, Atul / Chun, Julian / Andrade, Jason / Macle, Laurent / Da Costa, Antoine / Jaïs, Pierre / Hocini, Mélèze

    Heart rhythm

    2024  

    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6278: Show issues Location:
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  10. Article ; Online: Distinct Electrogram Features and Ventricular Arrhythmia Induction Modes Between Repolarization and Conduction Heterogeneities.

    Renard, Estelle / Surget, Elodie / Walton, Richard D / Michel, Cindy / Benoist, David / Dubes, Virginie / Guillot, Bastien / Martinez, Marine E / Hocini, Mélèze / Haïssaguerre, Michel / Bernus, Olivier

    JACC. Clinical electrophysiology

    2024  

    Abstract: Background: Recent clinical studies have indicated the presence of localized electrical abnormalities in idiopathic ventricular fibrillation and J-wave syndrome patients.: Objectives: This study aims to characterize the specific electrical signatures ...

    Abstract Background: Recent clinical studies have indicated the presence of localized electrical abnormalities in idiopathic ventricular fibrillation and J-wave syndrome patients.
    Objectives: This study aims to characterize the specific electrical signatures of localized repolarization and conduction heterogeneities and their respective role in vulnerability to arrhythmias.
    Methods: Optical mapping was performed in porcine right ventricles with local: 1) repolarization shortening; 2) conduction slowing; or 3) structural heterogeneity induced by locally perfusing: 1) pinacidil (20 μmol/L, n = 13); or 2) flecainide (2 μmol/L, n = 13) via an epicardial catheter; or 3) by local epicardial tissue destruction (9 radiofrequency lesions n = 12). Electrograms were recorded (n = 5 in each group) and spontaneous and induced arrhythmias were quantified and optically mapped.
    Results: Electrograms were normal in (1) but showed local fragmentation in 40% of preparations in (2) with greater effects observed at high pacing frequencies dependent on the wavefront direction. In (3), the structural substrate alone increased the width and number of peaks in the electrograms, and addition of flecainide induced pronounced fragmentation (≥3 peaks and ≥70 ms) in all cases. Occurrence of spontaneous arrhythmias was significantly increased in (1) and (2) (P < 0.0001 and 0.05, respectively, vs baseline) and were triggered by ectopies. Vulnerability to arrhythmias at high pacing frequencies (≥2 Hz) was the lowest in (1) and greatest in (2).
    Conclusions: Microstructural substrates have the most pronounced impact on electrograms, especially when combined with sodium channel blockers, whereas local action potential duration shortening does not lead to electrogram fragmentation even though it is associated with the highest prevalence of spontaneous arrhythmias.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2024.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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