LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 15

Search options

  1. Article ; Online: Cyanoacrylate glue as part of a new bundle to decrease neonatal PICC-related complications.

    Piersigilli, Fiammetta / Iacona, Giulia / Yazami, Sarah / Carkeek, Katherine / Hocq, Catheline / Auriti, Cinzia / Danhaive, Olivier

    European journal of pediatrics

    2023  Volume 182, Issue 12, Page(s) 5607–5613

    Abstract: A "bundle" is defined as a combination of evidence-based interventions that, if followed collectively and reliably, improve patient outcomes. The aim of this quasi-experimental study, conducted in a level-III NICU in Belgium, was to assess the impact of ... ...

    Abstract A "bundle" is defined as a combination of evidence-based interventions that, if followed collectively and reliably, improve patient outcomes. The aim of this quasi-experimental study, conducted in a level-III NICU in Belgium, was to assess the impact of central line dressing and maintenance bundle implementation on the rate of catheter-related mechanical complications. We performed a quality improvement (QI) project. Prior to bundle implementation, neonatal PICC lines were secured by Steri-Strip
    Conclusion: The implementation of the new bundle to secure neonatal PICCs in our NICU was associated with a significant reduction in CLABSI and dislodgment rates, without glue-related complications. Active surveillance of CVC placement procedure, positioning, and management, as well as analysis of related complications is crucial for improving patient safety. Continuous implementation of up-to-date central line bundles based on best practice recommendations is a key for quality improvement in NICUs.
    What is known: • Stable vascular access is crucial in the NICU. Neonatal PICC securement issues can have serious consequences and are associated with device failure.
    What is new: • Catheter securement with tissue adhesive is safe and effective in reducing failure and complication rates in the neonatal population.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Catheterization, Central Venous/methods ; Catheter-Related Infections/etiology ; Catheter-Related Infections/prevention & control ; Catheter-Related Infections/epidemiology ; Cyanoacrylates/adverse effects ; Central Venous Catheters ; Intensive Care Units, Neonatal
    Chemical Substances Cyanoacrylates
    Language English
    Publishing date 2023-10-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05253-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle.

    Piersigilli, Fiammetta / Van Grambezen, Bénédicte / Hocq, Catheline / Danhaive, Olivier

    Nutrients

    2020  Volume 12, Issue 2

    Abstract: Cardiorespiratory function is not only the foremost determinant of life after premature birth, but also a major factor of long-term outcomes. However, the path from placental disconnection to nutritional autonomy is enduring and challenging for the ... ...

    Abstract Cardiorespiratory function is not only the foremost determinant of life after premature birth, but also a major factor of long-term outcomes. However, the path from placental disconnection to nutritional autonomy is enduring and challenging for the preterm infant and, at each step, will have profound influences on respiratory physiology and disease. Fluid and energy intake, specific nutrients such as amino-acids, lipids and vitamins, and their ways of administration -parenteral or enteral-have direct implications on lung tissue composition and cellular functions, thus affect lung development and homeostasis and contributing to acute and chronic respiratory disorders. In addition, metabolomic signatures have recently emerged as biomarkers of bronchopulmonary dysplasia and other neonatal diseases, suggesting a profound implication of specific metabolites such as amino-acids, acylcarnitine and fatty acids in lung injury and repair, inflammation and immune modulation. Recent advances have highlighted the profound influence of the microbiome on many short- and long-term outcomes in the preterm infant. Lung and intestinal microbiomes are deeply intricated, and nutrition plays a prominent role in their establishment and regulation. There is an emerging evidence that human milk prevents bronchopulmonary dysplasia in premature infants, potentially through microbiome composition and/or inflammation modulation. Restoring antibiotic therapy-mediated microbiome disruption is another potentially beneficial action of human milk, which can be in part emulated by pre- and probiotics and supplements. This review will explore the many facets of the gut-lung axis and its pathophysiology in acute and chronic respiratory disorders of the prematurely born infant, and explore established and innovative nutritional approaches for prevention and treatment.
    MeSH term(s) Female ; Gastrointestinal Microbiome/physiology ; Humans ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Infant, Premature/growth & development ; Infant, Premature, Diseases/etiology ; Infant, Premature, Diseases/metabolism ; Infant, Premature, Diseases/microbiology ; Lung/growth & development ; Lung/microbiology ; Lung Diseases/etiology ; Lung Diseases/microbiology ; Lung Diseases/physiopathology ; Male ; Microbiota/physiology ; Milk, Human/microbiology ; Nutrients/metabolism ; Placenta/microbiology ; Pregnancy ; Premature Birth/microbiology ; Premature Birth/physiopathology
    Language English
    Publishing date 2020-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12020469
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle

    Piersigilli, Fiammetta / Van Grambezen, Bénédicte / Hocq, Catheline / Danhaive, Olivier

    Nutrients. 2020 Feb. 13, v. 12, no. 2

    2020  

    Abstract: Cardiorespiratory function is not only the foremost determinant of life after premature birth, but also a major factor of long-term outcomes. However, the path from placental disconnection to nutritional autonomy is enduring and challenging for the ... ...

    Abstract Cardiorespiratory function is not only the foremost determinant of life after premature birth, but also a major factor of long-term outcomes. However, the path from placental disconnection to nutritional autonomy is enduring and challenging for the preterm infant and, at each step, will have profound influences on respiratory physiology and disease. Fluid and energy intake, specific nutrients such as amino-acids, lipids and vitamins, and their ways of administration —parenteral or enteral—have direct implications on lung tissue composition and cellular functions, thus affect lung development and homeostasis and contributing to acute and chronic respiratory disorders. In addition, metabolomic signatures have recently emerged as biomarkers of bronchopulmonary dysplasia and other neonatal diseases, suggesting a profound implication of specific metabolites such as amino-acids, acylcarnitine and fatty acids in lung injury and repair, inflammation and immune modulation. Recent advances have highlighted the profound influence of the microbiome on many short- and long-term outcomes in the preterm infant. Lung and intestinal microbiomes are deeply intricated, and nutrition plays a prominent role in their establishment and regulation. There is an emerging evidence that human milk prevents bronchopulmonary dysplasia in premature infants, potentially through microbiome composition and/or inflammation modulation. Restoring antibiotic therapy-mediated microbiome disruption is another potentially beneficial action of human milk, which can be in part emulated by pre- and probiotics and supplements. This review will explore the many facets of the gut-lung axis and its pathophysiology in acute and chronic respiratory disorders of the prematurely born infant, and explore established and innovative nutritional approaches for prevention and treatment.
    Keywords amino acids ; antibiotics ; biomarkers ; breast milk ; bronchopulmonary dysplasia ; cardiorespiratory fitness ; energy intake ; fatty acids ; homeostasis ; immunomodulation ; inflammation ; intestinal microorganisms ; lungs ; metabolites ; metabolomics ; microbiome ; nutrients ; pathophysiology ; premature birth ; probiotics ; respiratory physiology ; vitamins
    Language English
    Dates of publication 2020-0213
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12020469
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  4. Article ; Online: Implementing intact cord resuscitation in very preterm infants: feasibility and pitfalls.

    Hocq, Catheline / Van Grambezen, Aurianne / Carkeek, Katherine / Van Grambezen, Bénédicte / Yoxall, Charles William / Debiève, Frédéric / Piersigilli, Fiammetta / Danhaive, Olivier

    European journal of pediatrics

    2022  Volume 182, Issue 3, Page(s) 1105–1113

    Abstract: The purpose of this study is to evaluate the feasibility of intact cord resuscitation (ICR) in very preterm infants using a custom-equipped mobile resuscitation trolley ( ... ...

    Abstract The purpose of this study is to evaluate the feasibility of intact cord resuscitation (ICR) in very preterm infants using a custom-equipped mobile resuscitation trolley (LifeStart
    MeSH term(s) Infant, Newborn ; Humans ; Pregnancy ; Female ; Infant, Premature ; Feasibility Studies ; Umbilical Cord ; Placenta ; Resuscitation/methods ; Infant, Premature, Diseases ; Constriction
    Language English
    Publishing date 2022-12-28
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-022-04776-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Early diagnosis and targeted approaches to pulmonary vascular disease in bronchopulmonary dysplasia.

    Hocq, Catheline / Vanhoutte, Laetitia / Guilloteau, Axelle / Massolo, Anna Claudia / Van Grambezen, Bénédicte / Carkeek, Kate / Piersigilli, Fiammetta / Danhaive, Olivier

    Pediatric research

    2021  Volume 91, Issue 4, Page(s) 804–815

    Abstract: Pulmonary hypertension has emerged as a life-threatening disease in preterm infants suffering from bronchopulmonary dysplasia (BPD). Its development is closely linked to respiratory disease, as vasculogenesis and alveologenesis are closely interconnected. ...

    Abstract Pulmonary hypertension has emerged as a life-threatening disease in preterm infants suffering from bronchopulmonary dysplasia (BPD). Its development is closely linked to respiratory disease, as vasculogenesis and alveologenesis are closely interconnected. Once clinically significant, BPD-associated pulmonary hypertension (BPD-PH) can be challenging to manage, due to poor reversibility and multiple comorbidities frequently associated. The pulmonary vascular disease process underlying BPD-PH is the result of multiple innate and acquired factors, and emerging evidence suggests that it progressively develops since birth and, in certain instances, may begin as early as fetal life. Therefore, early recognition and intervention are of great importance in order to improve long-term outcomes. Based on the most recent knowledge of BPD-PH pathophysiology, we review state-of-the-art screening and diagnostic imaging techniques currently available, their utility for clinicians, and their applicability and limitations in this specific population. We also discuss some biochemical markers studied in humans as a possible complement to imaging for the detection of pulmonary vascular disease at its early stages and the monitoring of its progression. In the second part, we review pharmacological agents currently available for BPD-PH treatment or under preclinical investigation, and discuss their applicability, as well as possible approaches for early-stage interventions in fetuses and neonates. IMPACT: BPD-associated PH is a complex disease involving genetic and epigenetic factors, as well as environmental exposures starting from fetal life. The value of combining multiple imaging and biochemical biomarkers is emerging, but requires larger, multicenter studies for validation and diffusion. Since "single-bullet" approaches have proven elusive so far, combined pharmacological regimen and cell-based therapies may represent important avenues for research leading to future cure and prevention.
    MeSH term(s) Bronchopulmonary Dysplasia/complications ; Bronchopulmonary Dysplasia/diagnosis ; Bronchopulmonary Dysplasia/therapy ; Early Diagnosis ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Infant ; Infant, Newborn ; Infant, Premature ; Vascular Diseases/diagnosis ; Vascular Diseases/therapy
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-021-01413-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: COVID-19 in a 26-week preterm neonate.

    Piersigilli, Fiammetta / Carkeek, Katherine / Hocq, Catheline / van Grambezen, Bénédicte / Hubinont, Corinne / Chatzis, Olga / Van der Linden, Dimitri / Danhaive, Olivier

    The Lancet. Child & adolescent health

    2020  Volume 4, Issue 6, Page(s) 476–478

    MeSH term(s) COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Female ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(20)30140-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: COVID-19 in a 26-week preterm neonate

    Piersigilli, Fiammetta / Carkeek, Katherine / Hocq, Catheline / van Grambezen, Bénédicte / Hubinont, Corinne / Chatzis, Olga / Van der Linden, Dimitri / Danhaive, Olivier

    Lancet Child Adolesc Health

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #197864
    Database COVID19

    Kategorien

  8. Article ; Online: COVID-19 in a 26-week preterm neonate.

    Piersigilli, Fiammetta / Carkeek, Katherine / Hocq, Catheline / van Grambezen, Bénédicte / Hubinont, Corinne / Chatzis, Olga / Van der Linden, Dimitri / Danhaive, Olivier

    The Lancet. Child & adolescent health, Vol. 4, no.6, p. 476-

    2020  Volume 478

    Keywords covid19
    Language English
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Article ; Online: COVID-19 in a 26-week preterm neonate.

    Piersigilli, Fiammetta / Carkeek, Katherine / Hocq, Catheline / Van Grambezen, Bénédicte / Hubinont, Corinne / Chatzis, Olga / Van der Linden, Dimitri / Danhaive, Olivier

    The Lancet. Child & adolescent health, Vol. 4, no.6, p. 476-

    2020  Volume 478

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December, 2019, in Wuhan, China, and has spread all over the world. This virus is responsible for a range of clinical manifestations in adults and children, ranging from mild ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December, 2019, in Wuhan, China, and has spread all over the world. This virus is responsible for a range of clinical manifestations in adults and children, ranging from mild respiratory symptoms to severe acute respiratory distress syndrome (ARDS) with clinical and radiological signs of severe bilateral pneumonia. Mortality rates range between 0·12% in the paediatric population and 14·8% in individuals aged 80 years and older. [.]
    Keywords Coronavirus Infections ; Female ; Humans ; Infant ; Extremely Premature ; Newborn ; Infectious Disease Transmission ; Vertical ; Pandemics ; Pneumonia ; Viral ; covid19
    Language English
    Publisher Elsevier Ltd.
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article ; Online: COVID-19 in a 26-week preterm neonate.

    Piersigilli, Fiammetta / Carkeek, Katherine / Hocq, Catheline / van Grambezen, Bénédicte / Hubinont, Corinne / Chatzis, Olga / Van der Linden, Dimitri / Danhaive, Olivier

    The Lancet. Child & adolescent health, Vol. 4, no.6, p. 476-

    2020  Volume 478

    Keywords covid19
    Language English
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top