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  1. AU="Hodane Yonis"
  2. AU="Boggiano, César"
  3. AU="Gainor, Justin F"
  4. AU="Scurr, David J"
  5. AU="Mahuran, Don J"
  6. AU="Dominguez, Dana A"
  7. AU=Mota Gustavo R
  8. AU="Pandey, Gayathri"
  9. AU=Kiesslich Ralf
  10. AU="Wiskar, Katie"
  11. AU=Bennett Kaila M.
  12. AU=Bacci Jennifer L
  13. AU="Wildman, Ricky D."
  14. AU="Alshibani, Nouf"
  15. AU="Loens, Christopher"
  16. AU="Friedman, Lawrence M."
  17. AU="Johnstone, Damian"
  18. AU="Maleki, Shayan"
  19. AU="G. E-S. Batiha"
  20. AU=Johnson Guyla G
  21. AU="Patel, Parth H"
  22. AU="Manassero, Carlo"
  23. AU="Kirk, Tom"
  24. AU="Bezabih, Yihienew Mequanint"
  25. AU="Hirsinger, Estelle"
  26. AU="Robles-Musso Castillo, Emilio"
  27. AU="Vahdatihassani, Faezeh"
  28. AU="Maria Pala"
  29. AU=Singh Indra
  30. AU="Gallacher, Nicola"
  31. AU="Chen, Pei-Min"
  32. AU=Andre L
  33. AU="Aleksandra I. Pivovarova"
  34. AU="Cruz, Thainá Gabriele Camargo da"
  35. AU="Atkins, Peter"

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  1. Artikel ; Online: Transpulmonary pressures in obese and non-obese COVID-19 ARDS

    Mehdi Mezidi / Florence Daviet / Paul Chabert / Sami Hraiech / Laurent Bitker / Jean-Marie Forel / Hodane Yonis / Ines Gragueb / Francois Dhelft / Laurent Papazian / Jean-Christophe Richard / Christophe Guervilly

    Annals of Intensive Care, Vol 10, Iss 1, Pp 1-

    2020  Band 5

    Abstract: Abstract Background Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients. Methods We investigated esophageal ... ...

    Abstract Abstract Background Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients. Methods We investigated esophageal pressure allowing determination of transpulmonary pressures (PL ) and elastances (EL) during a decremental PEEP trial from 20 to 6 cm H2O in a cohort of COVID-19 ARDS patients. Results Fifteen patients were investigated, 8 obese and 7 non-obese patients. PEEP ≥ 16 cm H2O for obese patients and PEEP ≥10 cm H2O for non-obese patients were necessary to obtain positive expiratory P L . Change of PEEP did not alter significantly ΔP L or elastances in obese patients. However, in non-obese patients lung EL and ΔP L increased significantly with PEEP increase. Chest wall EL was not affected by PEEP variations in both groups.
    Schlagwörter Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS

    Jean-Christophe Richard / Hodane Yonis / Laurent Bitker / Sylvain Roche / Florent Wallet / Claire Dupuis / Hassan Serrier / Laurent Argaud / Guillaume Thiery / Bertrand Delannoy / Christian Pommier / Paul Abraham / Michel Muller / Frederic Aubrun / Florian Sigaud / Guillaume Rigault / Emilie Joffredo / Mehdi Mezidi / Nicolas Terzi /
    Muriel Rabilloud

    Trials, Vol 22, Iss 1, Pp 1-

    study protocol for the VT4COVID trial

    2021  Band 14

    Abstract: Abstract Background Acute respiratory distress syndrome (ARDS) is a severe complication of COVID-19 pneumonia, with a mortality rate amounting to 34–50% in moderate and severe ARDS, and is associated with prolonged duration of invasive mechanical ... ...

    Abstract Abstract Background Acute respiratory distress syndrome (ARDS) is a severe complication of COVID-19 pneumonia, with a mortality rate amounting to 34–50% in moderate and severe ARDS, and is associated with prolonged duration of invasive mechanical ventilation. Such as in non-COVID ARDS, harmful mechanical ventilation settings might be associated with worse outcomes. Reducing the tidal volume down to 4 mL kg−1 of predicted body weight (PBW) to provide ultra-low tidal volume ventilation (ULTV) is an appealing technique to minimize ventilator-inducted lung injury. Furthermore, in the context of a worldwide pandemic, it does not require any additional material and consumables and may be applied in low- to middle-income countries. We hypothesized that ULTV without extracorporeal circulation is a credible option to reduce COVID-19-related ARDS mortality and duration of mechanical ventilation. Methods The VT4COVID study is a randomized, multi-centric prospective open-labeled, controlled superiority trial. Adult patients admitted in the intensive care unit with COVID-19-related mild to severe ARDS defined by a PaO2/FiO2 ratio ≤ 150 mmHg under invasive mechanical ventilation for less than 48 h, and consent to participate to the study will be eligible. Patients will be randomized into two balanced parallels groups, at a 1:1 ratio. The control group will be ventilated with protective ventilation settings (tidal volume 6 mL kg−1 PBW), and the intervention group will be ventilated with ULTV (tidal volume 4 mL kg−1 PBW). The primary outcome is a composite score based on 90-day all-cause mortality as a prioritized criterion and the number of ventilator-free days at day 60 after inclusion. The randomization list will be stratified by site of recruitment and generated using random blocks of sizes 4 and 6. Data will be analyzed using intention-to-treat principles. Discussion The purpose of this manuscript is to provide primary publication of study protocol to prevent selective reporting of outcomes, data-driven analysis, and to ...
    Schlagwörter COVID-19 ; SARS-CoV-2 ; Acute respiratory distress syndrome ; Mechanical ventilation ; Ultraprotective ventilation ; Ultra-low tidal volume ventilation ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

    Claire Tardiveau / Guillaume Monneret / Anne-Claire Lukaszewicz / Valérie Cheynet / Elisabeth Cerrato / Katia Imhoff / Estelle Peronnet / Maxime Bodinier / Louis Kreitmann / Sophie Blein / Jean-François Llitjos / Filippo Conti / Morgane Gossez / Marielle Buisson / Hodane Yonis / Martin Cour / Laurent Argaud / Marie-Charlotte Delignette / Florent Wallet /
    Frederic Dailler / Céline Monard / Karen Brengel-Pesce / Fabienne Venet / the RICO study group

    Frontiers in Immunology, Vol

    2022  Band 13

    Abstract: Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex ...

    Abstract Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex transcriptomic panel prototype termed Immune Profiling Panel (IPP) could capture the dysregulation of immune responses of ICU COVID-19 patients at admission. Nine transcripts were associated with mortality in univariate analysis and this 9-mRNA signature remained significantly associated with mortality in a multivariate analysis that included age, SOFA and Charlson scores. Using a machine learning model with these 9 mRNA, we could predict the 28-day survival status with an Area Under the Receiver Operating Curve (AUROC) of 0.764. Interestingly, adding patients’ age to the model resulted in increased performance to predict the 28-day mortality (AUROC reaching 0.839). This prototype IPP demonstrated that such a tool, upon clinical/analytical validation and clearance by regulatory agencies could be used in clinical routine settings to quickly identify patients with higher risk of death requiring thus early aggressive intensive care.
    Schlagwörter transcriptomic multiplex tool ; SARS-CoV-2 infection ; immune response ; 28-day mortality prediction ; personalized medicine ; Immunologic diseases. Allergy ; RC581-607
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Risk factors associated with day-30 mortality in patients over 60 years old admitted in ICU for severe COVID-19

    Thomas Rimmele / Julien Berthiller / Anne-Claire Lukaszewicz / Laurent Jallades / Jean-Baptiste Pialat / Céline Monard / Christophe Leroy / Vincent Collange / Arnaud Friggeri / Mélanie Roche / Christine Ravot / Amélie Malapert / Max Haïne / David Dayde / Claire Falandry / Marie Simon / Céline Guichon / Paul Abraham / Camille Boin /
    Justine Dubreuil / Laurent Bitker / Baptiste Balança / Sylvie Goutte / Emilie Gadea / Alain Lepape / Fabrice Thiollière / Hodane Yonis / Antoine Garnier-Crussard / Loredana Baboi / Valérie Cerro / Carlos El Khoury / Emilie Gadéa-Deschamps / Marie-Catherine Fromont / Audrey Gelot / Anthéa Loïez / Maya Perrou / Laetitia Paradisi-Prieur / Marion Provent / Gulsum Sahin / Ghyslaine Thao / Marine Thieux

    BMJ Open, Vol 11, Iss

    the Senior-COVID-Rea Multicentre Survey protocol

    2021  Band 7

    Abstract: Introduction With the spread of COVID-19 epidemic, health plans must be adapted continuously. There is an urgent need to define the best care courses of patients with COVID-19, especially in intensive care units (ICUs), according to their individualised ... ...

    Abstract Introduction With the spread of COVID-19 epidemic, health plans must be adapted continuously. There is an urgent need to define the best care courses of patients with COVID-19, especially in intensive care units (ICUs), according to their individualised benefit/risk ratio. Since older age is associated with poorer short-term and long-term outcomes, prediction models are needed, that may assist clinicians in their ICU admission decision. Senior-COVID-Rea was designed to evaluate, in patients over 60 years old admitted in ICU for severe COVID-19 disease, the impact of age and geriatric and paraclinical parameters on their mortality 30 days after ICU admission.Methods and analysis This is a multicentre survey protocol to be conducted in seven hospitals of the Auvergne-Rhône-Alpes region, France. All patients over 60 years old admitted in ICU for severe COVID-19 infection (or their legally acceptable representative) will be proposed to enter the study and to fill in a questionnaire regarding their functional and nutritional parameters 1 month before COVID-19 infection. Paraclinical parameters at ICU admission will be collected: lymphocytes and neutrophils counts, high-fluorescent lymphoid cells and immature granulocytes percentages (Sysmex data), D-dimers, C-reactive protein, lactate dehydrogenase (LDH), creatinine, CT scan for lung extension rate as well as clinical resuscitation scores, and the delay between the first signs of infection and ICU admission. The primary outcome will be the overall survival at day 30 post-ICU admission. The analysis of factors predicting mortality at day 30 will be carried out using univariate and multivariate logistic regressions. Multivariate logistic regression will consider up to 15 factors.The ambition of this trial, which takes into account the different approaches of geriatric vulnerability, is to define the respective abilities of different operational criteria of frailty to predict patients’ outcomes.Ethics and dissemination The study protocol was ethically approved. The ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Type I IFN immunoprofiling in COVID-19 patients

    Trouillet-Assant, Sophie / Viel, Sebastien / Gaymard, Alexandre / Pons, Sylvie / Richard, Jean-Christophe / Perret, Magali / Villard, Marine / Brengel-Pesce, Karen / Lina, Bruno / Mezidi, Mehdi / Bitker, Laurent / Belot, Alexandre / Mouton, William / Oriol, Guy / Compagnon, Christelle / Generenaz, Laurence / Cheynet, Valérie / Ader, Florence / Becker, Agathe /
    Benech, Nicholas / Chauvelot, Pierre / Chidiac, Christian / Conrad, Anne / Ferry, Tristan / Miailhes, Patrick / Perpoint, Thomas / Perry, Marielle / Pouderoux, Cécile / Roux, Sandrine / Triffault-Fillit, Claire / Valour, Florent / Hodane, Yonis / Chauvelot, Louis / Chabert, Paul / Provoost, Judith / David, Guillaume / Folliet, Laure / Lecam, Pierre / Billaud, Geneviève / Bouscambert, Maude / Escuret, Vanessa / Frobert, Emilie / Bal, Antonin / Destras, Grégory / Josset, Laurence / Morfin, Florence / Munier, Clément / Valette, Martine / Venet, Fabienne / Garnier, Lorna / Pescarmona, Rémi / Lombard, Christine / Walzer, Thierry

    Journal of Allergy and Clinical Immunology

    2020  Band 146, Heft 1, Seite(n) 206–208.e2

    Schlagwörter Immunology ; Immunology and Allergy ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 121011-7
    ISSN 1085-8725 ; 1097-6825 ; 0091-6749
    ISSN (online) 1085-8725 ; 1097-6825
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.04.029
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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