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Article ; Online: The role of molecular tumor boards in neuro-oncology: a nationwide survey.

Hönikl, Lisa S / Lange, Sebastian / Butenschoen, Vicki M / Delbridge, Claire / Meyer, Bernhard / Combs, Stephanie E / Illert, Anna Lena / Schmidt-Graf, Friederike

BMC cancer

2024 Volume 24, Issue 1, Page(s) 108

Abstract: Background: In neuro-oncology, the inclusion of tumor patients in the molecular tumor board has only become increasingly widespread in recent years, but so far there are no standards for indication, procedure, evaluation, therapy recommendations and ... ...

Abstract	Background: In neuro-oncology, the inclusion of tumor patients in the molecular tumor board has only become increasingly widespread in recent years, but so far there are no standards for indication, procedure, evaluation, therapy recommendations and therapy implementation of neuro-oncological patients. The present work examines the current handling of neuro-oncological patients included in molecular tumor boards in Germany. Methods: We created an online based survey with questions covering the handling of neuro-oncologic patient inclusion, annotation of genetic analyses, management of target therapies and the general role of molecular tumor boards in neuro-oncology in Germany. We contacted all members of the Neuro-Oncology working group (NOA) of the German Cancer Society (DKG) by e-mail. Results: 38 responses were collected. The majority of those who responded were specialists in neurosurgery or neurology with more than 10 years of professional experience working at a university hospital. Molecular tumor boards (MTB) regularly take place once a week and all treatment disciplines of neuro-oncology patients take part. The inclusions to the MTB are according to distinct tumors and predominantly in case of tumor recurrence. An independently MTB member mostly create the recommendations, which are regularly implemented in the tumor treatment. Recommendations are given for alteration classes 4 and 5. Problems exist mostly within the cost takeover of experimental therapies. The experimental therapies are mostly given in the department of medical oncology. Conclusions: Molecular tumor boards for neuro-oncological patients, by now, are not standardized in Germany. Similarities exists for patient inclusion and interpretation of molecular alterations; the time point of inclusion and implementation during the patient treatment differ between the various hospitals. Further studies for standardization and harmonisation are needed. In summary, most of the interviewees envision great opportunities and possibilities for molecular-based neuro-oncological therapy in the future.
MeSH term(s)	Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Surveys and Questionnaires ; Medical Oncology/methods ; Hospitals, University ; Germany
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11858-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Postoperative Communicating Hydrocephalus Following Grade 2/3 Glioma Resection: Incidence, Timing and Risk Factors.

Hönikl, Lisa S / Lange, Nicole / Meyer, Bernhard / Gempt, Jens / Meyer, Hanno S

Cancers

2023 Volume 15, Issue 14

Abstract: Background: In diffusely infiltrating gliomas, the maximum extent of tumor resection is an important predictor of overall survival, irrespective of histological or molecular subtype or tumor grade. For glioblastoma WHO grade 4 (GBM), it has been shown ... ...

Abstract	Background: In diffusely infiltrating gliomas, the maximum extent of tumor resection is an important predictor of overall survival, irrespective of histological or molecular subtype or tumor grade. For glioblastoma WHO grade 4 (GBM), it has been shown that resection-related events, such as ventricular opening and ventriculitis, increase the risk for development of communicating hydrocephalus (CH) requiring cerebrospinal fluid (CSF) diversion surgery. Risk factors for the development and the incidence of hydrocephalus following resection of other types of infiltrating gliomas are less well established. In this study, we evaluated the incidence and timing of occurrence of different types of hydrocephalus and potential risk factors for the development of CH following resection of grade 2 and 3 gliomas. Methods: 346 patients who underwent tumor resection (WHO grade 2: 42.2%; 3: 57.8%) at our department between 2006 and 2019 were analyzed retrospectively. For each patient, age, sex, WHO grade, histological type, IDH mutation and 1p/19q codeletion status, tumor localization, number of resections, rebleeding, ventriculitis, ventricular opening during resection and postoperative CSF leak were determined. Uni- as well as multivariate analyses were performed to identify associations with CH and independent risk factors. Results: 24 out of 346 (6.9%) patients needed CSF diversion surgery (implantation of a ventriculoperitoneal or ventriculoatrial shunt) following resection. Nineteen patients (5.5%) had CH, on median, 44 days after the last resection (interquartile range: 18-89 days). Two patients had obstructive hydrocephalus (OH), and three patients had other CSF circulation disorders. CH was more frequent in grade 3 compared to grade 2 gliomas (8.5 vs. 1.4%). WHO grade 3 (odds ratio (OR) 7.5, Conclusion: Physicians treating brain tumor patients should be aware that postoperative CH requiring CSF shunting occurs not only in GBM but also after resection of lower-grade gliomas, especially in grade 3 tumors. It usually occurs several weeks after resection. Rebleeding and postoperative ventriculitis are independent risk factors.
Language	English
Publishing date	2023-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15143548
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Article: Clinical, radiological and pathological features of temporomesial tumors in the adult. A single center experience from 15 years.

Meyer, Hanno S / Wiestler, Benedikt / Hönikl, Lisa S / Delbridge, Claire / Ketterer, Carl / Gempt, Jens / Meyer, Bernhard

Frontiers in oncology

2023 Volume 13, Page(s) 1236269

Abstract: Introduction: The mesial temporal lobe plays a distinct role in epileptogenesis, and tumors in this part of the brain potentially have specific clinical and radiological features. Differentiating high-grade from lower-grade tumors or non-neoplastic ... ...

Abstract	Introduction: The mesial temporal lobe plays a distinct role in epileptogenesis, and tumors in this part of the brain potentially have specific clinical and radiological features. Differentiating high-grade from lower-grade tumors or non-neoplastic lesions can be challenging, preventing the decision for early resection that can be critical in high-grade tumors. Methods: A brain tumor database was analyzed retrospectively to identify patients with temporomesial tumors. We determined clinical features (age, sex, symptoms leading to clinical presentation) as well as neuroradiological (tumor location and the presence of contrast enhancement on initial magnetic resonance imaging (MRI)) and neuropathological findings. Results: We identified 324 temporal tumors. 39 involved the mesial temporal lobe. 77% of temporomesial tumors occured in males, and 77% presented with seizures, regardless of tumor type or grade. In patients 50 years or older, 90% were male and 80% had glioblastoma (GBM); there was no GBM in patients younger than 50 years. 50% of GBMs lacked contrast enhancement. Male sex was significantly associated with GBM. In both contrast-enhancing and non-enhancing tumors, age of 50 years or older was also significantly associated with GBM. Conclusion: In middle-aged and older patients with a mesial temporal lobe tumor, GBM is the most likely diagnosis even when there is no MRI contrast enhancement. Prolonged diagnostic workup or surveillance strategies should be avoided and early resection may be justified in these patients.
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1236269
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Article ; Online: A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis.

Aftahy, A Kaywan / Butenschoen, Vicki M / Hoenikl, Lisa / Liesche-Starnecker, Friederike / Wiestler, Benedikt / Schmidt-Graf, Friederike / Meyer, Bernhard / Gempt, Jens

BMC neurology

2023 Volume 23, Issue 1, Page(s) 87

Abstract: Background: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.: Case presentation: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented ...

Abstract	Background: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. Case presentation: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating. Conclusions: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.
MeSH term(s)	Child ; Male ; Young Adult ; Humans ; Adult ; Spinal Neoplasms/complications ; Spinal Neoplasms/diagnostic imaging ; Diagnosis, Differential ; Bone and Bones ; Antineoplastic Combined Chemotherapy Protocols ; Glioma
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-023-03135-4
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Article ; Online: Correction to: Bilateral thoracic disc herniation with abdominal wall paresis: a case report.

Butenschoen, Vicki Marie / Hoenikl, Lisa / Deschauer, Marcus / Meyer, Bernhard / Gempt, Jens

Acta neurochirurgica

2021 Volume 163, Issue 8, Page(s) 2369–2370

Language	English
Publishing date	2021-06-23
Publishing country	Austria
Document type	Published Erratum
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-021-04898-w
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Article: Postoperative communicating hydrocephalus following glioblastoma resection: Incidence, timing and risk factors.

Hönikl, Lisa S / Lange, Nicole / Barz, Melanie / Negwer, Chiara / Meyer, Bernhard / Gempt, Jens / Meyer, Hanno S

Frontiers in oncology

2022 Volume 12, Page(s) 953784

Abstract: Introduction: Glioblastoma (GBM) is the most common malignant primary brain tumor. Treatment includes maximally safe surgical resection followed by radiation and/or chemotherapy. However, resection can lead to ventricular opening, potentially increasing ...

Abstract	Introduction: Glioblastoma (GBM) is the most common malignant primary brain tumor. Treatment includes maximally safe surgical resection followed by radiation and/or chemotherapy. However, resection can lead to ventricular opening, potentially increasing the risk for development of communicating hydrocephalus (CH). Complications such as rebleeding and infection may also lead to CH and, eventually, the need for cerebrospinal fluid (CSF) diversion surgery. In this study, we evaluated the incidence of different types of hydrocephalus and potential risk factors for the development of CH following glioblastoma resection. Methods: 726 GBM patients who underwent tumor resection at our department between 2006 and 2019 were analyzed retrospectively. Potential risk factors that were determined for each patient were age, sex, tumor location, the number of resection surgeries, ventricular opening during resection, postoperative CSF leak, ventriculitis, and rebleeding. Uni- as well as multivariate analyses were performed to identify associations with CH and independent risk factors. Results: 55 patients (7.6%) needed CSF diversion surgery (implantation of a ventriculoperitoneal or ventriculoatrial shunt) following resection surgery. 47 patients (6.5%) had CH, on median, 24 days after the last resection (interquartile range: 17-52 days). 3 patients had obstructive hydrocephalus (OH) and 5 patients had other CSF circulation disorders. Ventricular opening (odds ratio (OR): 7.9; p=0.000807), ventriculitis (OR 3.3; p=0.000754), and CSF leak (OR 2.3; p=0.028938) were identified as significant independent risk factors for the development of post-resection CH. Having more than one resection surgery was associated with CH as well (OR 2.1; p=0.0128), and frontal tumors were more likely to develop CH (OR 2.4; p=0.00275), while temporal tumors were less likely (OR 0.41; p=0.0158); However, none of those were independent risk factors. Age, sex, or rebleeding were not associated with postoperative CH. Conclusion: Postoperative CH requiring CSF shunting is not infrequent following GBM resection and is influenced by surgery-related factors. It typically occurs several weeks after resection. If multiple risk factors are present, one should discuss the possibility of postoperative CH with the patient and maybe even consider pre-emptive shunt implantation to avoid interruption of adjuvant tumor therapy. The incidence of CH requiring shunting in GBM patients could rise in the future.
Language	English
Publishing date	2022-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.953784
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Conference proceedings: Functional outcome in patients with dural arteriovenous fistulae after surgical treatment

Hostettler, Isabel / Hönikl, Lisa / Meyer, Bernhard / Wostrack, Maria

2020 , Page(s) V159

Title translation	Funktionelles Outcome nach chirurgischer Therapie spinaler duraler arteriovenöser Fisteln
Event/congress	71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2020
Keywords	Medizin, Gesundheit
Publishing date	2020-06-26
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/20dgnc157
Database	German Medical Science

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Article ; Online: Bilateral thoracic disc herniation with abdominal wall paresis: a case report.

Butenschoen, Vicki Marie / Hoenikl, Lisa / Deschauer, Marcus / Meyer, Bernhard / Gempt, Jens

Acta neurochirurgica

2020 Volume 162, Issue 9, Page(s) 2055–2059

Abstract: We present a rare case of a patient initially presenting with unilateral abdominal wall bulging and radicular pain caused by a lateral disc herniation at Th11/12, later suffering from a hernia recurrence with bilateral disc prolapse and motor deficits. ... ...

Abstract	We present a rare case of a patient initially presenting with unilateral abdominal wall bulging and radicular pain caused by a lateral disc herniation at Th11/12, later suffering from a hernia recurrence with bilateral disc prolapse and motor deficits. The patient underwent sequesterectomy via a right hemilaminectomy at Th11, and after 8 weeks, a bilateral sequesterectomy with semirigid fusion Th11/12 was performed. Unilateral motor deficits at the thoracic level have been discussed in case reports; a bilateral disc protrusion with abdominal wall bulging occurring as a recurrent disc herniation has never been described before.
MeSH term(s)	Abdominal Wall/pathology ; Humans ; Intervertebral Disc Degeneration/complications ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Degeneration/surgery ; Intervertebral Disc Displacement/complications ; Intervertebral Disc Displacement/pathology ; Intervertebral Disc Displacement/surgery ; Laminectomy/methods ; Male ; Middle Aged ; Paresis/etiology
Language	English
Publishing date	2020-06-04
Publishing country	Austria
Document type	Case Reports ; Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-020-04431-5
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Article ; Online: High expression of estrogen receptor alpha and aromatase in glial tumor cells is associated with gender-independent survival benefits in glioblastoma patients.

Hönikl, Lisa Stefanie / Lämmer, Friederike / Gempt, Jens / Meyer, Bernhard / Schlegel, Jürgen / Delbridge, Claire

Journal of neuro-oncology

2020 Volume 147, Issue 3, Page(s) 567–575

Abstract: Introduction: Glioblastoma multiforme (GBM) is a highly malignant glial tumor, affecting men more often than women. The reason for this gender-specific predominance remains unclear, raising the question whether these effects are subject to hormonal ... ...

Abstract	Introduction: Glioblastoma multiforme (GBM) is a highly malignant glial tumor, affecting men more often than women. The reason for this gender-specific predominance remains unclear, raising the question whether these effects are subject to hormonal control. The purpose of this study was to examine the expression of estrogen receptor alpha (ERα) and aromatase in human GBM tissue samples in relation to patient survival and furthermore to investigate the effect of standard chemotherapy in combination with estradiol treatment on glioblastoma tumor cell lines in vitro. Methods: 60 tissue samples (31 male, 29 female) of GBM patients were analysed with immunohistochemistry for ERα and aromatase for survival analyses. The cell lines LN18 and LN229 were treated with 17β-estradiol (E2) in different dosing regimens and the cell viability was measured with MTT assay. After estradiol pre-treatment Temozolomide was added and tested again. Results: High expression of ERα and aromatase in the GBM tissue samples was associated with significantly longer survival times of GBM patients, regardless of gender and body-mass-index. The treatment with high concentrations of estradiol resulted in lower tumor cell viability, compared to control. The cells significantly showed a stronger sensitivity against Temozolomid (TMZ) after estradiol pre-treatment. Conclusion: ERα-expression of glial tumour cells seems to play an important prognostic role as a biomarker in GBM, as well as the expression of the enzyme Aromatase. The combined treatment of GBM with standard chemotherapy and estradiol may be beneficial to patient's survival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aromatase/metabolism ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Estrogen Receptor alpha/metabolism ; Female ; Glioblastoma/metabolism ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neuroglia/metabolism ; Sex Characteristics
Chemical Substances	Estrogen Receptor alpha ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-020-03467-y
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Conference proceedings: Risk factors for postoperative communicating hydrocephalus in glioma resection surgery

Hönikl, Lisa S. / Lange, Nicole / Barz, Melanie / Meyer, Bernhard / Gempt, Jens / Meyer, Hanno S.

2021 , Page(s) V228

Title translation	Risikofaktoren für einen postoperativen Hydrozephalus malresorptivus bei der Resektion von Gliomen
Event/congress	72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2021
Keywords	Medizin, Gesundheit
Publishing date	2021-06-04
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/21dgnc219
Database	German Medical Science

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