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  1. Article ; Online: Using a Medical Intranet of Things System to Prevent Bed Falls in an Acute Care Hospital: A Pilot Study.

    Balaguera, Henri U / Wise, Diana / Ng, Chun Yin / Tso, Han-Wen / Chiang, Wan-Lin / Hutchinson, Aimee M / Galvin, Tracy / Hilborne, Lee / Hoffman, Cathy / Huang, Chi-Cheng / Wang, C Jason

    Journal of medical Internet research

    2017  Volume 19, Issue 5, Page(s) e150

    Abstract: Background: Hospitalized patients in the United States experience falls at a rate of 2.6 to 17.1 per 1000 patient-days, with the majority occurring when a patient is moving to, from, and around the bed. Each fall with injury costs an average of US $14, ... ...

    Abstract Background: Hospitalized patients in the United States experience falls at a rate of 2.6 to 17.1 per 1000 patient-days, with the majority occurring when a patient is moving to, from, and around the bed. Each fall with injury costs an average of US $14,000.
    Objective: The aim was to conduct a technology evaluation, including feasibility, usability, and user experience, of a medical sensor-based Intranet of things (IoT) system in facilitating nursing response to bed exits in an acute care hospital.
    Methods: Patients 18 years and older with a Morse fall score of 45 or greater were recruited from a 35-bed medical-surgical ward in a 317-bed Massachusetts teaching hospital. Eligible patients were recruited between August 4, 2015 and July 31, 2016. Participants received a sensor pad placed between the top of their mattress and bed sheet. The sensor pad was positioned to monitor movement from patients' shoulders to their thighs. The SensableCare System was evaluated for monitoring patient movement and delivering timely alerts to nursing staff via mobile devices when there appeared to be a bed-exit attempt. Sensor pad data were collected automatically from the system. The primary outcomes included number of falls, time to turn off bed-exit alerts, and the number of attempted bed-exit events. Data on patient falls were collected by clinical research assistants and confirmed with the unit nurse manager. Explanatory variables included room locations (zones 1-3), day of the week, nursing shift, and Morse Fall Scale (ie, positive fall history, positive secondary diagnosis, positive ambulatory aid, weak impaired gait/transfer, positive IV/saline lock, mentally forgets limitations). We also assessed user experience via nurse focus groups. Qualitative data regarding staff interactions with the system were collected during two focus groups with 25 total nurses, each lasting approximately 1.5 hours.
    Results: A total of 91 patients used the system for 234.0 patient-days and experienced no bed falls during the study period. On average, patients were assisted/returned to bed 46 seconds after the alert system was triggered. Response times were longer during the overnight nursing shift versus day shift (P=.005), but were independent of the patient's location on the unit. Focus groups revealed that nurses found the system integrated well into the clinical nursing workflow and the alerts were helpful in patient monitoring.
    Conclusions: A medical IoT system can be integrated into the existing nursing workflow and may reduce patient bed fall risk in acute care hospitals, a high priority but an elusive patient safety challenge. By using an alerting system that sends notifications directly to nurses' mobile devices, nurses can equally respond to unassisted bed-exit attempts wherever patients are located on the ward. Further study, including a fully powered randomized controlled trial, is needed to assess effectiveness across hospital settings.
    MeSH term(s) Accidental Falls/prevention & control ; Aged ; Aged, 80 and over ; Computer Communication Networks/utilization ; Female ; Hospitals ; Humans ; Male ; Middle Aged ; Patient Safety ; Pilot Projects ; United States
    Language English
    Publishing date 2017-05-04
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1439-4456
    ISSN (online) 1438-8871
    ISSN 1439-4456
    DOI 10.2196/jmir.7131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of pediatric patients with mild-to-moderate hypertension: yield of diagnostic testing.

    Wiesen, Jonathan / Adkins, Matthew / Fortune, Sherwin / Horowitz, Judah / Pincus, Nava / Frank, Rachel / Vento, Suzanne / Hoffman, Cathy / Goilav, Beatrice / Trachtman, Howard

    Pediatrics

    2008  Volume 122, Issue 5, Page(s) e988–93

    Abstract: Objective: Children and adolescents with newly diagnosed hypertension undergo various tests to define the cause and target organ consequences of the elevated blood pressure. We tested the hypothesis that the diagnostic yield of individual components of ... ...

    Abstract Objective: Children and adolescents with newly diagnosed hypertension undergo various tests to define the cause and target organ consequences of the elevated blood pressure. We tested the hypothesis that the diagnostic yield of individual components of the currently recommended assessment does not justify performance for all patients with mild-to-moderate hypertension.
    Methods: A retrospective chart review was conducted of patients who were referred between July 2002 and June 2007 for mild-to-moderate hypertension, defined as maximum blood pressure at >or=95% + 20/10 mmHg. The assessment included history and physical examination, nutritional assessment, urinalysis, biochemical and fasting lipid profile, renal ultrasound, echocardiogram, and 24-hour ambulatory blood pressure monitoring.
    Results: A total of 249 patients were identified, and charts for 220 (88%) were available for review. There were 156 boys and 64 girls aged 13.3 +/- 4.4 years. BMI was 26.1 +/- 6.7 kg/m(2), and 143 (65%) had a BMI of >or=90%. Results of urinalysis and serum biochemical testing were clinically normal in all cases. Among those with a lipid profile, 59 (42%) had total cholesterol values of >170 mg/dL, and 26 (19%) had severe hypercholesterolemia (>200 mg/dL). Renal sonography revealed findings plausibly associated with hypertension in 14 (8%) patients; 4 (2%) had renovascular abnormalities. Yield of echocardiography was 17%. On ambulatory blood pressure monitoring, 47 (60%) children had systolic readings of >95% at least 20% of the time, and 28 (36%) had diastolic readings of >95% at least 20% of the time.
    Conclusions: For children and adolescents with mild-to-moderate hypertension, on the basis of a cutoff of 5% to 20% abnormal results to define a useful test, the initial evaluation can range from a serum cholesterol level and ambulatory blood pressure monitoring to a panel that consists of a fasting lipid profile, renal ultrasound, echocardiogram, and ambulatory blood pressure monitoring. Additional assessment should be guided by specific clinical features and the nature of the patient population.
    MeSH term(s) Adolescent ; Adult ; Blood Urea Nitrogen ; Child ; Comorbidity ; Creatinine/blood ; Diagnostic Tests, Routine/utilization ; Echocardiography/utilization ; Female ; Humans ; Hyperlipidemias/epidemiology ; Hypertension/blood ; Hypertension/epidemiology ; Kidney/diagnostic imaging ; Male ; Medical History Taking ; Physical Examination ; Retrospective Studies ; Urinalysis/utilization
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2008-0365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic yield of renal biopsies

    Goilav Beatrice / Charney Douglas / Valderrama Elsa / Hoffman Cathy / Vento Suzanne / Frank Rachel / Tarapore Freya / Rube Jacob / Peyser Alexandra / Scheckner Bari / Trachtman Howard

    BMC Nephrology, Vol 10, Iss 1, p

    a retrospective single center review

    2009  Volume 11

    Abstract: Abstract Background Previous studies have examined the spectrum of diseases identified with a kidney biopsy and the complications of the procedure. However, few studies have examined the utility of the test to clarify the diagnosis and guide treatment of ...

    Abstract Abstract Background Previous studies have examined the spectrum of diseases identified with a kidney biopsy and the complications of the procedure. However, few studies have examined the utility of the test to clarify the diagnosis and guide treatment of pediatric patients. This retrospective, single-center chart review was performed to test the hypothesis that at least 80% of native kidney biopsies provide clinically valuable information that rationally guides diagnosis and patient management. Methods 200 biopsies performed between January 1, 2000 and June 30, 2008 were reviewed. A scheme composed of six categories was devised to classify the utility of each kidney biopsy. Results 196 complete case files were available for review. Twenty-four (12.2%) biopsies did not shed light on the diagnosis and were unhelpful in patient management – 21 biopsies (10.7%) were non-diagnostic and 3 (1.5%) failed to yield enough tissue for examination. The number of unhelpful biopsies did not cluster in any specific disease entity. Conclusion Our findings provide guidance to nephrologists about the total risk of a kidney biopsy, including uninformative results, when seeking informed consent for the procedure. The results suggest an appropriate balance has been reached which maximizes the use of kidney biopsies while minimizing the risk of this invasive procedure (word count: 202).
    Keywords Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2009-05-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: IgA nephropathy: a twenty year retrospective single center experience.

    Rube, Jacob / Peyser, Alexandra / Tarapore, Freya / Scheckner, Bari / Frank, Rachel / Vento, Suzanne / Hoffman, Cathy / Charney, Douglas / Valderamma, Elsa / Goilav, Beatrice / Trachtman, Howard

    Clinical medicine. Pediatrics

    2009  Volume 3, Page(s) 19–22

    Abstract: IgA nephropathy (IgAN) is a common glomerular disease whose etiology is unknown. Previous studies have described the clinical and laboratory features but none have specifically compared patients during different time periods. This 20 year retrospective ... ...

    Abstract IgA nephropathy (IgAN) is a common glomerular disease whose etiology is unknown. Previous studies have described the clinical and laboratory features but none have specifically compared patients during different time periods. This 20 year retrospective study was performed to assess trends in the severity of IgAN from 1989-2008. We reviewed 57 patient charts that contained a confirmed biopsy diagnosis of IgAN and recorded data at the time of diagnosis and the final follow-up appointment. Clinical data included physical examination, urine, and blood tests. Patients were separated into two cohorts, Cohort 1 1989-1998 and Cohort 2 1999-2008. An increase in severity was noted in Cohort 2 based on a significantly higher Up/c and lower serum albumin level. Other prognostic indicators including GFRe, hematocrit, and glomerular injury score also demonstrated a trend towards more severe disease over the past 20 years. The patients in both Cohorts received similar treatments and had comparable renal function at the last follow-up visit. Based on our findings, we suggest that although a kidney biopsy is required to diagnose IgAN, the procedure may not be necessary in patients clinically suspected of having the disease but who have normal kidney function and minimal urine abnormalities.
    Language English
    Publishing date 2009-02-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452926-6
    ISSN 1178-220X
    ISSN 1178-220X
    DOI 10.4137/cmped.s2224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diagnostic yield of renal biopsies: a retrospective single center review.

    Scheckner, Bari / Peyser, Alexandra / Rube, Jacob / Tarapore, Freya / Frank, Rachel / Vento, Suzanne / Hoffman, Cathy / Valderrama, Elsa / Charney, Douglas / Goilav, Beatrice / Trachtman, Howard

    BMC nephrology

    2009  Volume 10, Page(s) 11

    Abstract: Background: Previous studies have examined the spectrum of diseases identified with a kidney biopsy and the complications of the procedure. However, few studies have examined the utility of the test to clarify the diagnosis and guide treatment of ... ...

    Abstract Background: Previous studies have examined the spectrum of diseases identified with a kidney biopsy and the complications of the procedure. However, few studies have examined the utility of the test to clarify the diagnosis and guide treatment of pediatric patients. This retrospective, single-center chart review was performed to test the hypothesis that at least 80% of native kidney biopsies provide clinically valuable information that rationally guides diagnosis and patient management.
    Methods: 200 biopsies performed between January 1, 2000 and June 30, 2008 were reviewed. A scheme composed of six categories was devised to classify the utility of each kidney biopsy.
    Results: 196 complete case files were available for review. Twenty-four (12.2%) biopsies did not shed light on the diagnosis and were unhelpful in patient management - 21 biopsies (10.7%) were non-diagnostic and 3 (1.5%) failed to yield enough tissue for examination. The number of unhelpful biopsies did not cluster in any specific disease entity.
    Conclusion: Our findings provide guidance to nephrologists about the total risk of a kidney biopsy, including uninformative results, when seeking informed consent for the procedure. The results suggest an appropriate balance has been reached which maximizes the use of kidney biopsies while minimizing the risk of this invasive procedure (word count: 202).
    MeSH term(s) Biopsy, Needle/adverse effects ; Biopsy, Needle/statistics & numerical data ; Child ; Female ; Humans ; Incidence ; Kidney/pathology ; Kidney Diseases/pathology ; Male ; New York/epidemiology ; Reproducibility of Results ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Sensitivity and Specificity
    Language English
    Publishing date 2009-05-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/1471-2369-10-11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome.

    Thurman, Joshua M / Marians, Russell / Emlen, Woodruff / Wood, Susan / Smith, Christopher / Akana, Hillary / Holers, V Michael / Lesser, Martin / Kline, Myriam / Hoffman, Cathy / Christen, Erica / Trachtman, Howard

    Clinical journal of the American Society of Nephrology : CJASN

    2009  Volume 4, Issue 12, Page(s) 1920–1924

    Abstract: Background and objectives: Diarrhea-associated hemolytic uremic syndrome (D+HUS) is a common cause of acute kidney injury in children. Mutations in alternative pathway (AP) complement regulatory proteins have been identified in severe cases of ... ...

    Abstract Background and objectives: Diarrhea-associated hemolytic uremic syndrome (D+HUS) is a common cause of acute kidney injury in children. Mutations in alternative pathway (AP) complement regulatory proteins have been identified in severe cases of thrombotic microangiopathy, but the role of the AP in D+HUS has not been studied. Therefore, we determined whether plasma levels of markers of activation of the AP are increased in D+HUS and are biomarkers of the severity of renal injury that predict the need for dialysis.
    Design, setting, participants, & measurements: Patients were randomly selected from among participants in the HUS-SYNSORB Pk trial. Plasma samples were collected on days 1, 4, 7, and 10 after enrollment and day 28 after discharge from the hospital. Levels of two complement pathway products, Bb and SC5b-9, were determined by ELISA.
    Results: Seventeen children (6 boys and 11 girls; age, 5.4 +/- 3.5 yr) were studied. Eight (47%) required dialysis support, and two had serious extrarenal events. On the day of enrollment, plasma levels of Bb and SC5b-9 were significantly increased in all patients compared with healthy controls (P < 0.01). The elevated concentrations normalized by day 28 after discharge. Circulating levels of complement pathway fragments did not correlate with severity of renal injury or occurrence of complications.
    Conclusions: Patients with acute-onset D+HUS manifest activation of the AP of complement that is temporally related to the onset of disease and that resolves within 1 mo. Therapies to inhibit the AP of complement may be useful in attenuating the severity of renal injury and extrarenal complications.
    MeSH term(s) Acute Kidney Injury/blood ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Adolescent ; Biomarkers/blood ; Child ; Child, Preschool ; Complement Factor B/metabolism ; Complement Membrane Attack Complex/metabolism ; Complement Pathway, Alternative ; Diarrhea/blood ; Diarrhea/physiopathology ; Female ; Hemolytic-Uremic Syndrome/blood ; Hemolytic-Uremic Syndrome/physiopathology ; Hemolytic-Uremic Syndrome/therapy ; Humans ; Infant ; Male ; Renal Dialysis ; Severity of Illness Index ; Thrombotic Microangiopathies/blood ; Thrombotic Microangiopathies/physiopathology
    Chemical Substances Biomarkers ; Complement Membrane Attack Complex ; SC5b-9 protein complex ; Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2009-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.02730409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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