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  1. Book: Produktion des Insektenmetalloprotease Inhibitors in Escherichia coli

    Hoffmann, Daniel

    Neuartige Plattformtechnologie für die inclusion body-basierte Produktaufarbeitung

    (Schriftenreihe des Institutes für Bioverfahrenstechnik und Pharmazeutische Technologie ; 12)

    2019  

    Abstract: Die Bekämpfung antibiotikaresistenter Krankheitserreger, deren Verbreitung immer weiter zunimmt, könnte zukünftig durch antimikrobielle Peptide (AMPs) gelingen. Insbesondere AMPs aus Insekten sind aufgrund ihrer Diversität vielversprechende ... ...

    Series title Schriftenreihe des Institutes für Bioverfahrenstechnik und Pharmazeutische Technologie ; 12
    Abstract Die Bekämpfung antibiotikaresistenter Krankheitserreger, deren Verbreitung immer weiter zunimmt, könnte zukünftig durch antimikrobielle Peptide (AMPs) gelingen. Insbesondere AMPs aus Insekten sind aufgrund ihrer Diversität vielversprechende pharmazeutische Kandidatenmoleküle. Die potentielle pharmazeutische Anwendung erfordert für entsprechende Charakterisierungen und klinische Studien eine Produktion der AMPs in ausreichenden Mengen und hoher Reinheit. Die rekombinante Proteinproduktion mit ...
    Keywords Rekombinante Proteinproduktion ; Crossflow-Filtration ; Downstream-Processing ; Antimikrobielle Peptide ; Chromatographie
    Language German
    Size 237 p.
    Edition 1
    Publisher Shaker Verlag
    Document type Book
    Note Hochschulschriften Medizin
    Format 148 x 210
    ISBN 9783844066777 ; 3844066772
    Database PDA

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  2. Book ; Thesis: Charakterisierung des Enzyms FAPalpha im Herzen nach Myokardinfarkt

    Hoffmann, Daniel Bernd

    2012  

    Author's details von Daniel Bernd Hoffmann
    Language German
    Size 60 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 2012
    HBZ-ID HT017544968
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 D 147 order for loan Magazin

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  3. Article ; Online: Which Factors Are Associated With Rerupture After Superior Capsular Reconstruction of the Shoulder With Autologous Long Biceps Tendon? - A Systematic Review.

    von Knoch, Marius / Hoffmann, Daniel B / Baums, Mike H

    Zeitschrift fur Orthopadie und Unfallchirurgie

    2023  

    Abstract: Based on a systematic review, the present work analyses factors associated with the rerupture rate or non-healing after superior capsular reconstruction with autologous long biceps tendon in the reconstruction of the rotator cuff of the shoulder.A ... ...

    Title translation Welche Faktoren sind mit einer Reruptur nach superiorer Kapselrekonstruktion der Schulter mit autologer langer Bizepssehne assoziiert? – Ein systematischer Review.
    Abstract Based on a systematic review, the present work analyses factors associated with the rerupture rate or non-healing after superior capsular reconstruction with autologous long biceps tendon in the reconstruction of the rotator cuff of the shoulder.A systematic review of the U.S. National Library of Medicine/National Institutes of Health (PubMed) database and the Cochrane Library was conducted in September 2021 using the PRISMA checklist. Articles were identified and analysed that contained data on the rerupture rate after superior capsular reconstruction with autologous long biceps tendon in reconstruction of the rotator cuff of the shoulder. The aim was to identify factors associated with rerupture or non-healing. The risk of bias was determined using the Newcastle-Ottawa scale.Primarily 86 hits could be generated. Seven articles from 2020 and 2021 met the inclusion criteria and were further analysed in terms of content. The evidence level was III to IV. Follow-up was between 12 (minimum) and 24 to 48 months. The risk of bias was not low. Factors that may be associated with rerupture or non-healing are diabetes mellitus and high-grade fatty degeneration of the subscapularis, infraspinatus, or teres minor as preoperative factors. Age, percent footprint coverage, tear size, symptom duration, number of bundles, acromioplasty performed, and tear configuration were not significant factors. Gender, degree of fatty degeneration of the supraspinatus and lesions of the subscapularis tendon were rated differently.According to the literature, but still currently with short-term observation periods, superior capsular reconstruction with an autologous long biceps tendon is another treatment option in the case of massive tears and elderly patients, if there is no high-grade fatty degeneration of the subscapularis, infraspinatus or teres minor. Diabetes mellitus has an unfavorable prognosis. Additional acromioplasty has so far not been associated with better outcomes.
    Language German
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-2195-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Classifier uncertainty: evidence, potential impact, and probabilistic treatment.

    Tötsch, Niklas / Hoffmann, Daniel

    PeerJ. Computer science

    2021  Volume 7, Page(s) e398

    Abstract: Classifiers are often tested on relatively small data sets, which should lead to uncertain performance metrics. Nevertheless, these metrics are usually taken at face value. We present an approach to quantify the uncertainty of classification performance ... ...

    Abstract Classifiers are often tested on relatively small data sets, which should lead to uncertain performance metrics. Nevertheless, these metrics are usually taken at face value. We present an approach to quantify the uncertainty of classification performance metrics, based on a probability model of the confusion matrix. Application of our approach to classifiers from the scientific literature and a classification competition shows that uncertainties can be surprisingly large and limit performance evaluation. In fact, some published classifiers may be misleading. The application of our approach is simple and requires only the confusion matrix. It is agnostic of the underlying classifier. Our method can also be used for the estimation of sample sizes that achieve a desired precision of a performance metric.
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2376-5992
    ISSN (online) 2376-5992
    DOI 10.7717/peerj-cs.398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Einfluß chronisch-hypoxischer, adaptiver Hypoxie auf den Gangliosidgehalt und die Gangliosidzusammensetzung der Myelinscheide des zentralen Nervensystems

    Hoffmann, Daniel

    1993  

    Author's details vorgelegt von Daniel Hoffmann
    Language German
    Size 56 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1994
    HBZ-ID HT006312188
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  6. Article ; Online: How Do Molecular Tweezers Bind to Proteins? Lessons from X-ray Crystallography.

    Porfetye, Arthur T / Stege, Patricia / Rebollido-Rios, Rocio / Hoffmann, Daniel / Schrader, Thomas / Vetter, Ingrid R

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 8

    Abstract: To understand the biological relevance and mode of action of artificial protein ligands, crystal structures with their protein targets are essential. Here, we describe and investigate all known crystal structures that contain a so-called "molecular ... ...

    Abstract To understand the biological relevance and mode of action of artificial protein ligands, crystal structures with their protein targets are essential. Here, we describe and investigate all known crystal structures that contain a so-called "molecular tweezer" or one of its derivatives with an attached natural ligand on the respective target protein. The aromatic ring system of these compounds is able to include lysine and arginine side chains, supported by one or two phosphate groups that are attached to the half-moon-shaped molecule. Due to their marked preference for basic amino acids and the fully reversible binding mode, molecular tweezers are able to counteract pathologic protein aggregation and are currently being developed as disease-modifying therapies against neurodegenerative diseases such as Alzheimer's and Parkinson's disease. We analyzed the corresponding crystal structures with 14-3-3 proteins in complex with mono- and diphosphate tweezers. Furthermore, we solved crystal structures of two different tweezer variants in complex with the enzyme Δ
    MeSH term(s) Crystallography, X-Ray ; Protein Binding ; Ligands ; Humans ; Models, Molecular ; 14-3-3 Proteins/chemistry ; 14-3-3 Proteins/metabolism ; Binding Sites ; Proteins/chemistry ; Protein Conformation
    Chemical Substances Ligands ; 14-3-3 Proteins ; Proteins
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29081764
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  7. Book ; Online ; Thesis: Die Auswirkung vom 5- Lipoxygenaseinhibitor Zileuton auf osteoporotische Wirbelkörper im Rattenmodell

    Hennig, Hoai-Huong [Verfasser] / Hoffmann, Daniel [Akademischer Betreuer] / Hoffmann, Daniel [Gutachter] / Siggelkow, Heide [Gutachter]

    2023  

    Author's details Hoai-Huong Hennig ; Gutachter: Daniel Hoffmann, Heide Siggelkow ; Betreuer: Daniel Hoffmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  8. Book ; Online ; Thesis: Produktion des Insektenmetalloprotease Inhibitors in Escherichia coli

    Hoffmann, Daniel [Verfasser]

    Neuartige Plattformtechnologie für die inclusion body-basierte Produktaufarbeitung

    2019  

    Author's details Daniel Hoffmann
    Keywords Technische Chemie ; Technical Chemistry
    Subject code sg660
    Language German
    Publisher Shaker
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    ISBN 978-3-8440-6677-7 ; 3-8440-6677-2
    Database Digital theses on the web

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  9. Article ; Online: Efficacy of laparotomy sponges to reduce bacterial contamination using an in vitro gastrointestinal surgery model.

    Bezhentseva, Alla / St Germaine, Lindsay L / Hoffmann, Daniel E

    PloS one

    2022  Volume 17, Issue 4, Page(s) e0267293

    Abstract: Use of laparotomy sponges to protect abdominal viscera during gastrointestinal surgery is described in nonspecific terms by various sources, but no definitive guidelines have been established in veterinary literature. The objective of this study was to ... ...

    Abstract Use of laparotomy sponges to protect abdominal viscera during gastrointestinal surgery is described in nonspecific terms by various sources, but no definitive guidelines have been established in veterinary literature. The objective of this study was to compare the in vitro efficacy of various layer-densities of laparotomy sponges at reducing bacterial contamination from multiple contaminant volumes during multiple exposure times. A standardized Escherichia coli inoculum water solution was applied over sterile laparotomy sponges overlying blood agar plates. Four laparotomy sponge layer-densities, 4 volumes of E. coli inoculum water solution, and 4 exposure times were evaluated. All blood agar plates were incubated for 48 hours followed by surface area measurements of colonization of each blood agar plate at 24 and 48 hours. The procedure was repeated thrice. Bacterial colonization occurred on 100% (192/192) of inoculated blood agar plates. There was a statistically significant decrease in colonized area with increasing layer-density of laparotomy sponges (P<0.0001). Comparison between the layer-density of sponges were statistically significant in resulting infected area (P<0.01), except comparison between 6- and 8-layers (P = 0.9490). Colonized area was not significantly altered by time of exposure. Results suggested that increasing the layer-density of laparotomy sponges has significant effect on reducing strikethrough bacterial colonization in an in vitro model. The results of this study can be used when performing gastrointestinal surgery to help guide laparotomy sponge use to reduce peritoneal bacterial contamination.
    MeSH term(s) Agar ; Bacteria ; Digestive System Surgical Procedures ; Escherichia coli ; Laparotomy ; Water
    Chemical Substances Water (059QF0KO0R) ; Agar (9002-18-0)
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267293
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  10. Article ; Online: IgGeneUsage: differential gene usage in immune repertoires.

    Kitanovski, Simo / Hoffmann, Daniel

    Bioinformatics (Oxford, England)

    2020  Volume 36, Issue 11, Page(s) 3590–3591

    Abstract: Summary: Decoding the properties of immune repertoires is key to understanding the adaptive immune response to challenges such as viral infection. One important quantitative property is differential usage of Ig genes between biological conditions. Yet, ... ...

    Abstract Summary: Decoding the properties of immune repertoires is key to understanding the adaptive immune response to challenges such as viral infection. One important quantitative property is differential usage of Ig genes between biological conditions. Yet, most analyses for differential Ig gene usage are performed qualitatively or with inadequate statistical methods. Here we introduce IgGeneUsage, a computational tool for the analysis of differential Ig gene usage. IgGeneUsage employs Bayesian inference with hierarchical models to analyze complex gene usage data from high-throughput sequencing experiments of immune repertoires. It quantifies differential Ig gene usage probabilistically and avoids some common problems related to the current practice of null-hypothesis significance testing.
    Availability and implementation: IgGeneUsage is an R-package freely available as part of Bioconductor at: https://bioconductor.org/packages/IgGeneUsage/.
    Contact: simo.kitanovski@uni-due.de.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Bayes Theorem ; High-Throughput Nucleotide Sequencing ; Software
    Language English
    Publishing date 2020-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btaa174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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